Welcome to the Center for Membrane Biology (CMB) at the University of Texas Medical School.

 

YfkE (Wu et al. PNAS 2013)The CMB, housed in the Department of Biochemistry & Molecular Biology, with participation also of the Departments of Integrative Biology & Pharmacology, and Microbiology & Molecular Genetics, provides a highly interactive environment with outstanding investigators with complementary research strengths.

CMB is dedicated to advancing our understanding of the structure, function, evolution, and roles of biological membranes in cells and organelles. It is our mission to conduct membrane research, basic and translational, on the cutting edge, stimulate and coordinate graduate education in membrane biology, and foster career development of membrane scientists in a world-class center of research excellence.

 

 

Faculty Members

 

Structure and function of photoactive membrane receptors and signal transduction triggered by light; rhodopsins and related heptahelical receptors.

Macromolecular transport across prokaryotic and eukaryotic membranes; bacterial pathogenicity.

G protein mediated signal transduction; regulation of adenylyl cyclase and production of cyclic AMP; regulators of G protein signaling (RGS proteins); relaxin.

Structure, function and assembly of cell membranes; lipid-assisted protein folding.

Use of computer simulations to study the organization of cell signaling components, interfacial interactions and allostery to aid in the development of treatments for unsolved health challenges

Plasma membrane nanostructure and signal transduction

Structure and function of ligand gated ion channels; spectroscopic investigations of membrane proteins.

Membrane structure and post-translational lipidation

Structural and molecular biology of calcium-signaling mechanisms including cardiac muscle contraction, Ca2+ channels, and calmodulin and regulators of calmodulin signaling.

 Structure and function of integral membrane protein complexes; structural basis of ion transport across cell  membranes; calcium channels.

Structural biology of membrane proteins; ion transport and regulation; X-ray Crystallography.

 

Research Faculty