Career Opportunities

TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL FELLOW POSITION IN STRUCTURAL BIOLOGY

An exciting opportunity for a postdoctoral fellow is currently open to contribute to groundbreaking research in vaccine and antibody therapeutic development within the Structural Biology Section at the Institute of Molecular Medicine. Our laboratory is at the forefront of understanding fundamental mechanisms governing viral entry and immune recognition, employing a multidisciplinary approach encompassing immunology, virology, and advanced structural biology techniques such as electron microscopy and X-ray crystallography. We leverage this knowledge to design innovative countermeasures using structure-assisted methods. In addition to our primary focus on infectious diseases, we are expanding our research scope to include non-infectious diseases, such as cancer and Alzheimer’s disease.

The successful candidate will play a pivotal role in advancing our understanding and application of structural biology principles to design therapeutics across a broad spectrum of health challenges. Join our dynamic team and contribute to groundbreaking research at the intersection of structural biology and medical innovation.

Minimum Requirements:

– Ph.D. in a relevant field (e.g., Structural Biology, Biochemistry, Molecular Biology, or a related discipline).

– Demonstrated expertise and a minimum of three years of experience in the field of structural biology, with a strong focus on techniques such as electron microscopy and X-ray crystallography.

Description of Qualified Candidates:

We are seeking highly motivated and qualified candidates with the following attributes:

– A Ph.D. in a relevant field (e.g., Structural Biology, Biochemistry, Molecular Biology, or a related discipline).

– Substantial hands-on experience in structural biology, specifically in techniques such as electron microscopy and X-ray crystallography, with a minimum of 3 years of demonstrated expertise.

– Proven track record of impactful research in structural biology, as evidenced by publications, conference presentations, or other significant achievements.

– Strong background or a keen interest in immunology, virology, or related disciplines, with the passion to apply this knowledge to the development of vaccines and antibody therapeutics.

– Capacity for interdisciplinary collaboration and effective communication within a team setting.

– Demonstrated ability to design and execute experiments independently.

The successful candidate will play a key role in advancing our research objectives, contributing to the cutting-edge work at the forefront of structural biology and therapeutic development.

To Apply:

Interested applicants should send a cover letter stating their research interests, a curriculum vitae, and relevant reprints to: Dr. Kai Xu, (kai.xu@uth.tmc.edu)

UTHealth is committed to providing equal opportunity in all employment-related activities without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status or any other basis prohibited by law or university policy. Reasonable accommodation, based on disability or religious observances, will be considered in accordance with applicable law and UTHealth policy. The University maintains affirmative action programs with respect to women, minorities, individuals with disabilities, and eligible veterans in accordance with applicable law

CENTER FOR TRANSLATIONAL CANCER RESEARCH
POST-DOCTORAL RESEARCH FELLOW

A postdoctoral fellow position in radiopharmaceuticals discovery is available within Dr Federica Pisaneschi’s team, in the Center of Translational Cancer Research, Institute of Molecular Medicine. A recent PhD in chemistry or equivalent in a related scientific field is required.

The successful candidate will perform multistep syntheses of anticancer drugs, and their radiolabeling with diagnostic and therapeutic radioisotopes.

Salary and benefits will follow National Institutes of Health and UTHealth guidelines. UTHealth Houston is located at the world-renowned Texas Medical Center (TMC). The vast resources within the TMC make it an ideal place to provide avenues for collaborations with other laboratories and nurture career development.

Minimum Requirements:

PhD in chemistry or equivalent in a related scientific field is required

Description of Qualified Candidates

The candidate needs to be able to conduct multistep syntheses, purifications and characterization of organic compounds, independently with minimal supervision. Radiochemistry skills are NOT required, but the candidate needs to be interested in learning how to handle radiation, automated and hands-on radiolabeling techniques and the basis of molecular imaging and radiotherapy.

Cover letter
CV
1-2 relevant papers that the candidate has published (not need for first authorship)
2-3 reference letters

UTHealth is committed to providing equal opportunity in all employment-related activities without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status or any other basis prohibited by law or university policy. Reasonable accommodation, based on disability or religious observances, will be considered in accordance with applicable law and UTHealth policy. The University maintains affirmative action programs with respect to women, minorities, individuals with disabilities, and eligible veterans in accordance with applicable law.

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL FELLOW-Brain control of body weight and glucose homeostasis

A postdoctoral position is available immediately at The Institute of Molecular Medicine of The University of Texas Health Science Center at Houston. The position involves studies on central mechanisms of feeding, energy and glucose homeostasis as well as related behaviors. A recent PhD in biology or a related field is required. Highly motivated individuals with experience in brain slice recording are preferred. Projects will be centered on understanding neurocircuitry in the brain controlling energy balance using existing animal models with neuron-specific manipulations. Viral tracing, optogenetic, chemogenetic and in vivo live Ca2+ imaging will be used. Applicant review will begin immediately and continue until the position is filled.

Interested applicants should send a cover letter stating their research interests, a curriculum vitae, and relevant reprints to:

Qingchun Tong, Ph.D.
Institute of Molecular Medicine of McGovern Medical School
The University of Texas Health Science Center at Houston
1825 Pressler Street
Houston, TX 77030
E-mail: qingchun.tong@uth.tmc.edu
Lab: www.tong-laboratory.com

Women and minority candidates are strongly encourage to apply. This is a security sensitive position.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status, or any other basis prohibited by law or university policy. EOE/M/F/Disabled/Vet.

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL FELLOW POSITION – brain control of metabolism, feeding and related behaviors

A postdoctoral position is available immediately at The Institute of Molecular Medicine of The University of Texas Health Science Center at Houston (UTHealth Houston). The position involves studies on central mechanisms of feeding, energy homeostasis and glucose homeostasis. A recent PhD in biology or a related field is required. Highly motivated individuals with experience in animal physiology, molecular biology and neuroscience are desired. The ideal candidates should be skilled in handling animals, mouse genetics, brain anatomy and basic biochemical methods. Projects will be centered on mapping and understanding neurocircuitry in the brain controlling body weight, feeding and related stress and anxiety behaviors using advanced tracing, optogenetics, chemogenetics, in vivo Ca2+ imaging, stereotaxic viral delivery and mouse genetics. Salary and benefits will follow National Institutes of Health and UTHealth guidelines. The Tong lab is located in the Institute of Molecular Medicine of McGovern Medical School at UTHealth Houston. UTHealth Houston is one of the several institutions located at the world-renowned Texas Medical Center (TMC). The vast resources within the TMC make it an ideal place to facilitate the success of projects, provide avenues for collaborations with other laboratories and nurture career development. Please refer to our recent publications (Xu et al., Cell Metabolism 2013; Mangieri et al., Nature Communications 2018; Xu et al., Nature Communications 2019; Cassidy et al. Science Advances 2019; Zhu et al., Nature Metabolism 2020; and Fan et al., Nature Communications, 2021) for specific research directions in the lab. Application review will begin immediately and continue until the position is filled.

Interested applicants should send a cover letter stating their research interests, a curriculum vitae, and relevant reprints to:

UTHealth Houston is an EEO/AA employer. UTHealth Houston does not discriminate on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status, or any other basis prohibited by law or university policy. EOE/M/F/Disabled/Vet.

CENTER FOR CARDIOVASCULAR GENETICS
POSTDOCTORAL RESEARCH FELLOW POSITION

Description:

A research post-doctoral position is available for an energetic individual with research experience in genomics and/or molecular biology of myocardium
The position is in molecular genetics, genomics and molecular biology of cardiovascular diseases
The candidate must have the ability to work independently as well as collaboratively

Qualifications:

Experience in Genetics and Bioinformatics Analysis of Whole Exome Sequencing data is required
Applicants should have completed a PhD in molecular genetics, genomics, molecular biology or related field.
Interested candidates should send a cover letter, their CV, and the names and contact information of three references electronically to: Ali.J.Marian@uth.tmc.edu

(No Phone Calls Please)

The University of Texas is an EO/AA employer. M/F/D/V. This is a security-sensitive position and thereby subject to Texas Education Code §51.215. A background check will be required for the final candidate.

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL FELLOW POSITION

A postdoctoral position is available immediately at The Institute of Molecular Medicine of The University of Texas Health Science Center at Houston (UTHealth). The position involves studies related to circadian regulation of healthy metabolism and disease prevention. A recent PhD in biology or a related field is required.

A highly motivated individuals with experience in animal physiology and biochemistry are desired. The ideal candidates should be skilled in handling animals, mouse genetics, microscopy, and basic biochemical methods. Projects in the laboratory are centered on elucidating the cellular mechanisms of the circadian clock involved in regulation of metabolic tissues, including liver, muscle, adipose tissue, and brain.

Salary and benefits will follow National Institutes of Health and UTHealth guidelines. The Eckel-Mahan laboratory is located in the Institute of Molecular Medicine of McGovern Medical School at UTHealth Houston. UTHealth Houston is located at the world-renowned Texas Medical Center (TMC). The vast resources within the TMC make it an ideal place to provide avenues for collaborations with other laboratories and nurture career development.

Please refer to our recent publications (Ribas-Latre et al., Nature Communications 2021; Fekry et al., Nature Communications 2018; Fekry et al., FASEB J 2022;) for current and specific research directions in the laboratory. Application review will begin immediately and continue until the position is filled.

Minimum Requirements

PhD or equivalent in a related scientific field is required

Description of Qualified Candidates

We are seeking candidates who are highly motivated, science-driven, collaborative, and have excellent writing and verbal communication skills to join our research team. An ideal candidate will have a strong background in animal physiology, and possess hands-on experience in biochemistry and microscopy. Previous experience with metabolomics, molecular biology, and cell culture will be considered as additional advantages.

To Apply

To apply, please email CV, contact information for three references, and a brief statement of research experience and goals to: Kristin.l.mahan@uth.tmc.edu

UTHealth is committed to providing equal opportunity in all employment-related activities without regard to race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status or any other basis prohibited by law or university policy. Reasonable accommodation, based on disability or religious observances, will be considered in accordance with applicable law and UTHealth policy. The University maintains affirmative action programs with respect to women, minorities, individuals with disabilities, and eligible veterans in accordance with applicable law.

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL FELLOW POSITION

Applications are invited for a Postdoc position in the Center for Metabolic and Degenerative Diseases in the Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth). Ph.D. or equivalent in a related scientific field is required. The laboratory discovers and investigates novel factors that regulate the dynamics of adipose tissue remodeling during obesity development. The long-term goal of the research is to address the clinical significance of these factors in human obesity, diabetes, cardiovascular disease and cancer.

The focus of the immediate project is to study several newly identified enzymes that play key roles in lipid metabolism. Particularly, we take advantage of genetic and pharmacological tools to address the specific functions of the enzymes on lipogenesis and lipolysis in adipose tissue and liver. We further characterize the consequent metabolic outcomes in the whole body.

We are seeking talent candidates who are highly motivated, science-driven, collaborative, and have excellent writing and verbal communication skills to join our research team. An ideal candidate will have a strong background in animal studies on metabolism, and possess hands-on experience in metabolic characterization on mouse models. Previous experience with data analysis for lipid omics and metabolomics, molecular biology, cell culture and biochemical assays will be considered as additional advantages.

To apply, please email CV, contact information for three references, and a statement of research interest to: kai.sun@uth.tmc.edu

CENTER FOR TRANSLATIONAL CANCER RESEARCH
POSTDOCTORAL RESERCH FELLOW-PROTEOMICS

Applications are invited for a postdoctoral position in proteomics in the Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth). PhD or equivalent in a related scientific field is required. The lab’s research centers on development and application of mass spectrometry-based proteomics and other molecular techniques to study cancer, neurodegeneration and other diseases.

As a postdoctoral fellow, you will work with a collaborative and cross functional team of scientists from the university and other institutions. You will have a unique opportunity to develop innovative proteomic approaches to study molecular mechanisms underlying key protein networks and factors implicated in pancreatic cancer and other diseases using a combined approach of proteomics and systems biology, while being a key contributor to advancing research projects supported by NIH and CPRIT.

We are seeking candidates who are highly motivated, science-driven, collaborative, and have excellent writing and verbal communication skills to join our research team. An ideal candidate will have a strong background in proteomics, and possess hands-on experience in HPLC and mass spectrometry. Previous experience with metabolomics, bioinformatics, functional genomics, molecular biology, cell culture and biological assays will be considered as additional advantages.

The salary will be based on the NIH postdoctoral salary guideline.

To apply, please email CV, contact information for three references, and a statement of research experience and goals to: proteomics@uth.tmc.edu

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION IN MUSCLE BIOLOGY, EXERCISE, DIABETES AND PERIPHERAL ARTERIAL DISEASE

NIH-funded post-doctoral position is available to study the transcriptional regulation of skeletal muscle homeostasis in exercise, diabetes and diabetic complication of peripheral arterial disease (PAD). For this project, we will use molecular targeting in in vitro cellular systems (e.g. muscle and endothelial cells), high-throughput transcriptional analysis, genetically targeted mouse models, and skeletal muscle disease models (e.g. diet-induced obesity, PAD hindlimb ischemia) to understand the role of orphan nuclear receptors and their co-regulators in skeletal muscle homeostasis.

Information on our research program can be obtained at: https://www.uth.edu/imm/faculty/profile?id=7db27eb9-5758-4584-877f-adaa60dbbecb

This position has the following requirements :

A recent or graduating PhD candidate with peer-reviewed 1^st author publications in topics related to skeletal muscle biology, diabetes, metabolism or peripheral arterial disease.
Extensive experience and hands-on technical training one or more of the following areas: (i) Histo-morphological and physiological analysis, skeletal muscle cell culture, molecular biology and cloning; (ii) In vivo models of exercise training, hindlimb ischemia and other models of hindlimb ischemia; (iii) Endothelial cell biology and models of angiogenesis.
Multi-tasking, creativity, independence, methodical approach to experimental design, excellent written and oral communication skills, and good interpersonal skills, along with strong commitment to succeeding in a research-oriented career.

Interested candidates meeting the above requirement should apply by email (Vihang.a.narkar@uth.tmc.edu) to Vihang Narkar, Ph.D., Associate Professor, Hamman Foundation Distinguished Professorship in Cardiovascular Research, Brown Foundation Institute of Molecular Medicine, The University of Texas McGovern Medical School in Houston, TX, 77030. Please include a cover letter briefly describing research interest and future goals, detailed CV, and contact information for 3 referees.

CENTER FOR HUMAN GENETICS
POST-DOCTORAL FELLOW IN HUMAN GENETICS/GENOMICS

An open position for a postdoctoral fellow in human molecular genetics/genomics field is available on a NIH-funded project in the laboratory of Ashish Kapoor at the University of Texas Health Science Center at Houston (UTHealth).

Overview:
Our lab focuses on understanding the role of variable gene expression driven by non-coding cis-regulatory sequence variation in human disease/trait risk, with its application to uncover the molecular mechanisms underlying genome-wide association studies (GWAS) loci. We utilize a wide array of genetic, biochemical, cellular, functional genomic, epigenomic and computational approaches to identify the molecular components and the structure of the regulatory apparatus underlying gene expression variation in humans, and thus capable of explaining observed GWAS signals. For more information, please visit: https://www.uth.edu/imm/faculty/profile?id=19e3224f-26cc-4a97-8735-27a359e81c9c

Application requirements:
We are seeking a talented and highly motivated individual with a Ph.D. in human genetics, genomics, or other relevant fields to join the lab. The candidate must demonstrate scientific productivity, rigor and creativity with a strong publication record in peer-reviewed scientific journals, and demonstrate the initiative and the capacity to conduct independent research. Excellent communication and organizational skills are required. The successful candidate will be leading projects on functional characterization of GWAS signals to understand the molecular basis of observed genetic associations.

Experiments involved in these projects are diverse and include, but not limited to, massively-parallel reporter assays in cell lines, transient enhancer assays in zebrafish embryos, identification of enhancer-TF interactions, target gene identification using eQTL mapping, CRISPR-based genome-editing and gene activation/repression in model systems including human induced-pluripotent stem cells derived cardiomyocytes (iPSC-CMs), in addition to transcriptomic and epigenomic profiling of cell types/tissues. Experience with animal (rodents and zebrafish) and cellular (iPSCs) models, and gene delivery systems (lentiviral and AAV) are preferred, and experience with computational/statistical methods in genomics will be a plus.

Salary and benefits will follow National Institutes of Health and UTHealth guidelines. UTHealth offers limited housing opportunities for postdoctoral fellows and a large number of benefits. The Kapoor lab is located in the Center for Human Genetics at the Institute of Molecular Medicine, McGovern Medical School, UTHealth. UTHealth is one of the several institutions located at the world-renowned Texas Medical Center. The vast resources within UTHealth and other institutions at the Texas Medical Center make it an ideal place to facilitate the success of projects and provide avenues for collaborations with other laboratories.

How to apply:
Applicants should submit their CV, along with a letter outlining their interests and contact information of three references to ashish.kapoor@uth.tmc.edu with “Human Genetics/Genomics Postdoc” in the subject line.

TEXAS THERAPEUTICS INSTITUTE
POSTDOCTORAL RESEARCH FELLOW POSITIONS AVAILBLE IN THE GE LAB

Supported by NIGMS MIRA (R35), DoD CDMRP, NIAID R21, and endowment funds

Position Description: Three postdoctoral researcher positions are available in Dr. Xin Ge’s Laboratory at University of Texas Health Science Center at Houston (UTHealth), to study protease inhibitory monoclonal antibodies (mAbs) for therapeutics development (PNAS 2016,113:14970; PNAS 2019,116:16314). The successful candidates will utilize novel protein engineering approaches for the discovery, characterization, and optimization of mAbs specifically inhibiting proteases of medical importance for the treatments of indications such as cancer, obesity, snake envenomation, and diabetic neuropathy.

Qualification and Experience: Applicants should have recently received (or expect soon) a Ph.D. in biochemistry, molecular biology, biochemical engineering or related disciplines. Highly motivated candidates with strong background and experience in protein science and engineering are encouraged to apply. Good publication record and prior experience in protein engineering techniques (e.g. library construction, phage display, FACS) are highly desirable. Qualified individuals should possess the ability to design experiments, interpret and track results, and utilize this information to enable hypothesis generation. Good written and oral communication skills and the ability to work well in a collaborative environment are also required.

Research Environment: Located in the heart of the Texas Medical Center, the Brown Foundation Institute of Molecular Medicine (IMM) is a translational research institute that focuses on studying and preventing diseases at the genetic, cellular and molecular levels. As one of eight research centers within the IMM, the Texas Therapeutics Institute (TTI) particularly encourages drug discovery. The Ge Lab, newly relocated from UC Riverside in summer 2021, aims to develop enabling technologies for facile discovery and engineering of bio-pharmaceuticals, such as inhibitory and neutralizing antibodies and therapeutic enzymes, which are important but challenging for current technologies. The successful candidates will have extensive opportunities for multiple collaborations with scientists at UTHealth and worldwide working in diverse areas of biology and drug discovery.

Application: Please send a single PDF file including a personal statement, a full CV, contact information of references to: Prof. Xin Ge at xin.ge@uth.tmc.edu. Applications will be reviewed as they are received. Positions will remain open until filled.

For more information on Dr. Ge’s research, please visit: https://www.ncbi.nlm.nih.gov/sites/myncbi/xin.ge.1/bibliography/public/

CENTER FOR MOLECULAR IMAGING
POST-DOCTORAL RESEARCH FELLOW

Overview

A CPRIT-funded position is immediately available for a postdoctoral researcher in the Center for Molecular Imaging. The project focuses on lymphatic delivery of cancer immunotherapies to tumor draining lymph nodes to provide robust anti-tumor immunity without causing immune related adverse events that currently limit effectiveness. A successful candidate would be deploying numerous techniques in orthotopic tumor models to track lymphatic delivery, evaluate tumor and immune cell response, and elucidate immune escape mechanisms. In addition, there are opportunities for a successful candidate to participate in clinical studies of lymphatic delivery systems.

Qualification

A PhD in molecular biology, genetics, cancer biology, immunology, or other relevant field. Experience in animal models of cancer, flow cytometry, and molecular biology techniques are necessary and a desire to learn new imaging approaches. The candidate should be highly motivated, able to work independently, and demonstrate excellent communication and writing skills.

Application

Qualified candidates are encouraged to contact Dr. Eva Sevick directly at Eva.Sevick@uth.tmc.edu. In the email, please attach your CV, and a cover letter briefly describing your accomplishments and research interests and how those are a good fit for the position. In addition, include contact information for 3 references. Please use subject title “Postdoc Application”.

TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITIONS in immunology, cancer biology, protein engineering, and antibody drug discovery

We are recruiting multiple postdoctoral fellows with experience in immunology, cancer biology, and/or protein engineering to study cancer antibody drug resistance mechanisms, validate cancer drug targets, and develop antibody-based immunotherapies which include monoclonal and bispecific mabs, antibody drug conjugates (ADC), and antibody-protein fusions. Some of our work was published in competitive peer reviewed journals such as Nature, Cell Metabolism, Clinical Cancer Research, Cancer immunology Research, Nature Communications, JCI Insights, Cell Reports, Plos Pathogens and many others. Qualified individuals should possess 1) the ability to design experiments, interpret and track results, and utilize this information to enable hypothesis generation, and 2) the ability to work in a multidisciplinary team environment with strong communication andwriting skills. Applicants should submit a CV, a brief research statement with career goal, and contact information for three references to: Dr. Zhiqiang An at zhiqiang.an@uth.tmc.edu. Visit https://www.uth.edu/imm/core-facilities/therapeutic-antibody-core/index.htm for more information on Dr. An’s research program.

UTHealth is an affirmative action, equal opportunity employer.. UTHealth does not discriminate on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender identity or expression, veteran status, or any other basis prohibited by law or university policy. EOE/M/F/Disabled/Vet.

CENTER FOR TRANSLATIONAL CANCER RESEARCH
POST-DOCTORAL RESEARCH ASSOCIATE

Applications are invited for a postdoctoral position in proteomics in the Institute of Molecular Medicine, University of Texas Health Science Center at Houston (UTHealth). Ph.D. or equivalent in a related scientific field is required. The lab focuses on development and application of proteomics and other molecular techniques to study cancer and other diseases.

We are seeking candidates who are highly motivated, science-driven, collaborative, and have excellent writing and verbal communication skills to join our research team. An ideal candidate will have a strong background in proteomics, and possess hands-on experience in HPLC and mass spectrometry. Previous experience with bioinformatics, metabolomics, functional genomics, glycobiology, cell culture and biological assays will be considered as additional advantages.

To apply, please email CV, contact information for three references, and a statement of research experience and goals to Dr. Sheng Pan at: proteomics@uth.tmc.edu

TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITION in Medicinal Chemistry

We are looking for postdoctoral fellows with experience in organic chemistry and/or medicinal chemistry. Our lab is focused on the development of novel antibody-drug conjugates (ADCs) for effective cancer treatment in collaboration with immunologists, cancer biologists, and clinicians in the Texas Medical Center (TMC) area and others. We are currently working on (1) chemical synthesis and evaluation of novel chemical linkers for efficient construction of ADCs; and (2) design, synthesis, and in-vitro/in-vivo evaluation of multifunctional ADCs. Read our recent publication in Nature Communications (https://doi.org/10.1038/s41467-018-04982-3) and visit our lab website (https://www.tsuchikamalab.org/) for details. This is a unique opportunity to work at the interface of chemistry and biology, which includes not only chemical synthesis and biological studies, but also cross-disciplinary collaboration with clinical researchers and pharmaceutical industries.

Applicants should be independent, highly motivated individuals with a strong organic chemistry and/or medicinal chemistry background and excellent research qualifications. In particular, we prioritize candidates with experience in enzyme-based and cell-based assays and protein chemistry (protein expression, purification, and modification). Successful candidates must hold a doctoral degree, have an excellent publication record, and demonstrate excellent communication and writing skills.

To apply submit a compiled PDF file including:

CV
A brief research statement with your career goal
A list of publication
Contact information for three references

To: Dr. Kyoji Tsuchikama, Kyoji.Tsuchikama@uth.tmc.edu Please write “Postdoc Application” in the subject of your e-mail.

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, sex, sexual orientation, national origin, age, disability, genetic information, gender

identity or expression, veteran status, or any other basis prohibited by law or university policy. EOE/M/F/Disabled/Vet.

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL FELLOW-Brain control of body weight and glucose homeostasis

Interested applicants should send a cover letter stating their research interests, a curriculum vitae, and relevant reprints to:

Women and minority candidates are strongly encourage to apply. This is a security sensitive position.

CENTER FOR HUMAN GENETICS
POST-DOCTORAL FELLOW IN STATISTICAL AND COMPUTATIONAL GENOMICS, HOUSTON, TEXAS

A position at the University of Texas Health Science Center at Houston is available for a Postdoctoral fellow in Statistical and Computational Genomics. The position will provide opportunities for a talented individual interested in working with large-scale genomic data in in a collaborative research setting of international studies on cerebrovascular disease and dementia.

The postdoctoral position will be supported by NIH grants that seek to identify the genetic and epigenetic determinants of cerebrovascular disease and dementia. The project will focus on utilizing whole genome sequence and genome-wide genotype data and DNA methylation array data on several large epidemiologic cohort samples to identify biomarkers influencing risk of disease. As part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium, we are performing integrative analysis of functional omics data, whole genome sequence, and clinical data in population-based cohorts. The successful candidate will be primarily responsible for: (1) computational analyses of whole-genome/exome sequencing datasets and genome-wide SNP array; and (2) computational analyses of DNA methylation array data and their integration with genetic data, with the aim to identify novel mechanisms in neurological diseases.

Responsibilities for this position include:

1) Study coordination and oversight of study procedures
2) Development and implementation of data analysis plans. In particular, analyze whole genome/exome sequencing and genome-wide SNP array data.
3) Develop and implement algorithms, statistical methods and software to analyze large-scale human sequencing data and DNA methylation array and perform integrative functional analysis.
4) Communication and participation in meetings with collaborators
5) Preparation of manuscripts for publication and grant applications

Job requirements:

The candidate should have completed a PhD in Statistical Genetics, Computational Biology, Population Genetics/Genomics, Computer Science, or a related discipline, and have experience in the field of complex disease research. The candidate should have expertise in genetics and statistical methods for genome data analysis. Experience with large-scale biological datasets, next-generation sequencing and epigenetic data is advantageous. Strong programming skills in the R language on a Linux environment is required. The candidate should have demonstrated scientific productivity, have excellent organizational, communication, and problem-solving skills, and have the ability to work, both independently and as part of a multi-disciplinary team.

Interested applicants should forward a CV and a statement of qualifications and research interests for this position, as well as the names and contact information for three professional references.

Myriam Fornage, Ph.D.
Professor of Molecular Medicine and Human Genetics
Laurence and Johanna Favrot Distinguished Professor
Myriam.Fornage@uth.tmc.edu

UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V.

CENTER FOR STEM CELL AND REGENERATIVE MEDICINE
POST-DOCTORAL POSITION

A postdoctoral position is available in the laboratory of Dr. Radbod Darabi, at Center for Stem Cell and Regenerative Medicine in University of Texas Health Science Center at Houston. The project is focused on skeletal myogenic differentiation of ES/iPS cells and gene correction of patient cells to be applicable for muscle regeneration.

The areas of laboratory’s interests include developmental biology of skeletal muscle progenitors, stem cell biology and regenerative medicine in general. Studies are performed on genetically modified cells or mouse models, and involve the cutting edge approaches, such as cell lineage tracing, gene editing and in vivo experiments.

Hard working fresh PhD graduates and junior postdocs (less than 3 yrs.) who look for a vigorous and dynamic program on stem cell biology are encouraged to apply.

Requirements

PhD degree with experience in stem cell biology, molecular cloning, advanced cell culture, animal modeling and/or bioinformatics.
Fresh PhD graduate or junior postdoc (less than 3 yrs.)
Be able to meet in person for interview and provide a scientific presentation

Please send your cover letter outlining your research interests, curriculum vitae and names (with e-mails) of 3-4 references to Dr. Darabi at Radbod.darabi@uth.tmc.edu

“UTHealth is an EEO/AA employer. UTHealth does not discriminate on the basis of race, color, religion, gender, sexual orientation, national origin, disability, age or any other basis prohibited by law. EOE/M/D/F/V”.

TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITION (in tumor evasion of antibody immunity)

We are looking for a postdoctoral fellow with experience in tumor microenvironment, cancer biology, antibody engineering, and/or immunology to study the concept that tumor associated proteinases can cause an impairment of IgG function through a limited cleavage in the hinge domain and thereby compromise antibody mediated immunity against cancer. Supported by a grant from CPRIT, the postdoc will establish the prevalence of IgG cleavage in clinical tumor samples followed by defining an anti-hinge antibody approach to “rescue” the functional activity of cleaved anticancer antibodies in vitro and in vivo. Qualified individuals should possess

the ability to design experiments, interpret and track results, and utilize this information to enable hypothesis generation;
the ability to work in a multidisciplinary team environment with strong communication skills.
Applicants should submit a CV, a brief research statement with career goal, contact information and three references to: Dr. Zhiqiang An at Zhiqiang.An@uth.tmc.edu. Visit Dr. An’s webpage for more information on his research program.

>>Click here Dr. Zhiqiang An

TEXAS THERAPEUTICS INSTITUTE
POST-DOCTORAL POSITION (in antibody response to viral infection and vaccination and the development of antiviral antibody therapies)

We are looking for two postdoctoral fellows with experience in virology, antibody engineering, and/or immunology to study the humoral response to viral infection and vaccination. Working closely with Merck Research Laboratories which partially fund the project, the postdoc will play a key role in addressing critical biological questions which will results in the discovery and development of vaccines and antibody therapies with a focus on HCMV and flu. Qualified individuals should possess

The ability to design experiments, interpret and track results, and utilize this information to enable hypothesis generation;
The ability to work in a multidisciplinary team environment with strong communication skills. Applicants should submit a CV, a brief research statement with career goal,
Your contact information and three references to: Dr. Zhiqiang An at zhiqiang.an@uth.tmc.edu. Visit Dr. An’s webpage for more information on his research program.

>>Click here Dr. Zhiqiang An

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION

A postdoctoral position is available in the Dr. Eckel-Mahan lab at the The Brown Foundation Institute of Molecular Medicine (“IMM”) within the University of Texas Health Sciences Center in Houston (“UTHealth”). Postdoctoral candidates with extensive experience with metabolic characterization of mouse models and some background in molecular and cell biology is strongly preferred. Central research interests of the lab include the role of the circadian clock in metabolically healthy and diseased states. The postdoctoral candidate will utilize genomic approaches to study tissue-specific clock response to zeitgebers and manipulations that produce phenotypes mimicking human metabolic disorders. Experimentation centered on understanding the molecular mechanisms underlying tissue-specific clock activity will rely on a myriad of biochemical and molecular techniques. The successful postdoctoral candidate will be part of a larger group of scientists at the Center for Metabolic and Degenerative Diseases (MDD) who use integrative approaches to study metabolic and degenerative disorders.

The City of Houston houses a large and thriving research environment at the Texas Medical Center, which is composed of MD Anderson Cancer Center, UTHealth Sciences Center,and Baylor College of Medicine, among numerous other internationally-recognized research and medical institutions, mostly within walking distance of the IMM.

For further information regarding the advertised position, please contact: Kristin.L.Mahan@uth.tmc.edu. Interested candidates should send a cover letter describing research interests, a resume/CV, and the names and contact information for three references.

The position is open until filled.

CENTER FOR METABOLIC AND DEGENERATIVE DISEASES
POST-DOCTORAL POSITION

A postdoctoral research position is open for a PhD. with expertise in (1) metabolic characterization of mouse models, and (2) molecular studies of adipose tissue biology and pathology. The project will focus on adipose tissue remodeling during obesity development.

Research focuses:

Hypoxia stimulated fibrosis and local inflammation in adipose tissue.
Mechanisms by which angiogenic factors stimulate white adipocytes “browning” during early stage of obesity development (healthy expansion).
The effects of antiangiogenic action by blocking VEGF-A and/or its receptors in the context of preexisting adipose tissue (unhealthy expansion).
Reversibility of adipose tissue fibrosis by MT1-MMP (MMP14) and novel anti-fibrotic therapies for the treatment and prevention of obesity and diabetes.
The mechanisms by which MT1-MMT exerts profound pathophysiological effects in preexisted unhealthy fat tissue.

Qualifications: We welcome applications from highly qualified and motivated early-career scientists of all countries who have received a PhD degree within the last three years or who will receive their PhD degree by the start of the recruitment. Previous experience with animal work will be a big plus.

Please submit personal statement, CV, and three letters of references to:

kai.sun@uth.tmc.edu

Kai Sun, MD, PhD
Assistant Professor
Center For Metabolic and Degenerative Diseases
The Brown Foundation Institute of Molecular Medicine
University of Texas Health Science Center at Houston
1825 Pressler st., Houston, TX 77030
Office: 713-500-3190

Visit our webpage at – The Center for Metabolic and Degenerative Diseases

TEXAS THERAPEUTICS INSTITUTE
POSTDOCTORAL RESEARCH FELLOW POSITIONS

Positions for postdoctoral fellows to study novel molecular mechanisms of cancer metastasis are available in Dr. Wenliang Li’s lab at the Institute of Molecular Medicine (IMM) of UTHealth-Houston.

Metastasis is responsible for over 90% of cancer death but its mechanisms are still poorly understood. Research in Dr. Li’s lab is to identify and study novel regulators of cancer metastasis, cancer stem cell, epithelial-mesenchymal transition (EMT), and drug resistance through a unique combination of RNAi/cDNA screens, cancer genomics, molecular cell biology, mouse models and patient specimens. The goals of the research are to gain new knowledge of metastasis and to identify novel cancer drug targets for the development of better therapeutics.

Qualified candidates should have a doctoral degree, strong background and good first-author publications in cancer biology, molecular cell biology, or signal transduction. Prior experience in mouse xenograft models is desirable but not required. The postdoc fellows are expected to have strong work ethic, high self-motivation, critical thinking abilities, excellent organizational and communication skills.

For those interested, please send a CV, contact information of three references, and a brief research statement describing past achievements, skills and research interests to Dr. Wenliang Li at email at: wenliang.li@uth.tmc.edu.

Faculty Profile:
Dr. Wenliang Li

TEXAS THERAPEUTICS INSTITUTE at

UTHealth – Houston
The Brown Foundation Institute of Molecular Medicine
for the Preventative of Human Diseases
1825 Pressler Street
Houston, TX 77030