Biography
Dr. Duong earned his master’s degree in Genetics in 2012 from the University of Science, Vietnam National University, Vietnam. In 2014, he began his PhD studies in Biomedical Sciences at Tsukuba University, Japan, focusing on the role of cytoplasmic deadenylases and poly(A) tail dynamics in translation regulation, and received his doctorate in 2018. He then moved to the United States to join the Department of Microbiology and Molecular Genetics at McGovern Medical School, The University of Texas Health Science Center at Houston, as a postdoctoral researcher. His work there focused on the role of G4 DNA structures in transcriptional regulation using budding yeast as a model system. In February 2024, he was promoted to Research Assistant Professor and is now working with Professor Kevin A. Morano to explore the role of small heat shock proteins in cellular redox imbalance and proteostasis.
Areas of Interest
Research Interests
– Determine the nature and physiology of chronic sequestrase/misfolded protein assemblies in redox-imbalance cells.
– Assess the physiological overlap between chronological aging and redox imbalance.
– Regulation of unfolded protein response (UPR) pathway under redox stress.
Publications
Duong LD, West JD, Morano KA. Redox Regulation of Proteostasis. J Biol Chem (JBC). 2024; 300(12). doi:10.1016/j.jbc.2024.107977
Goncalves D, Duy DL, Peffer S, Morano KA. Cytoplasmic redox imbalance in the thioredoxin system activates Hsf1 and results in hyperaccumulation of the sequestrase Hsp42 with misfolded proteins. Mol Biol Cell. 2024;35(4):ar53. doi:10.1091/mbc.E23-07-0296
Duy DL, Kim N. Yeast transcription factor Msn2 binds to G4 DNA. Nucleic Acids Res. 2023;51(18):9643-9657. doi:10.1093/nar/gkad684
Fujii S, Duy DL, Valderrama AL, et al. Pan2-Pan3 complex, together with Ccr4-Not complex, has a role in the cell growth on non-fermentable carbon sources. Biochem Biophys Res Commun. 2021;570:125-130. doi:10.1016/j.bbrc.2021.07.007
Valderrama AL, Fujii S, Duy DL, et al. Pbp1 mediates the aberrant expression of genes involved in growth defect of ccr4∆ and pop2∆ mutants in yeast Saccharomyces cerevisiae. Genes Cells. 2021;26(6):381-398. doi:10.1111/gtc.12846
Viet NTM, Duy DL, Saito K, et al. Regulation of LRG1 expression by RNA-binding protein Puf5 in the budding yeast cell wall integrity pathway. Genes Cells. 2018;23(12):988-997. doi:10.1111/gtc.12646
Duy DL, Suda Y, Irie K. Cytoplasmic deadenylase Ccr4 is required for translational repression of LRG1 mRNA in the stationary phase. PLoS One. 2017;12(2):e0172476. Published 2017 Feb 23. doi:10.1371/journal.pone.0172476