Biography

Dr. Udo is a Brazilian pharmacist with master’s and Ph.D. in toxicology whose work centers on how disruption in cerebral blood flow drives cognitive decline in aging and disease. Her research focuses on vascular dementia, brain hypoperfusion, neuroinflammation, and Alzheimer’s disease. She integrates vascular and metabolic profiling approaches to identify new therapeutic targets that could help protect the brain from decline. Dr. Udo currently leads an American Heart Association-funded project on PRMT4-Adenosine pathway in vascular dementia and contributes to NIH- and AHA-supported studies investigating cerebral blood flow, blood-brain barrier integrity, and neurovascular dysfunction, using pharmacological approaches to improve brain health in Alzheimer’s disease.

Education

Bachelor's Degree
Pharmaceutical Sciences, Methodist University of Piracicaba - Piracicaba, Sao Paulo, Brazil
Master's Degree
Clinical and Toxicological Analysis/ University of Sao Paulo - Sao Paulo, Brazil
Doctorate Degree
Toxicology, University of Sao Paulo - Sao Paulo, Brazil.

Areas of Interest

Research Interests

  • Vascular dementia
  • Alzheimer’s disease
  • Brain hypoperfusion, inflammation and cognitive impairment

Publications

Visit the PubMed profile page

1.Udo,MSB; Magalhaes, JZ; Citadin, CT; Matuguma, L; Langman, J; Smith, D; LIN, HW. Blockade of A2AR Improved Brain Perfusion and Cognitive Function in a Mouse Model of Alzheimer’s Disease. Geroscience. 2025 Jun;47(3):4153-4167.

2. ZaccarelliI-Magalhaes, J; Citadin, CT; Langman, J; Smith, DJ; Matuguma, LH; Udo, MSB. Protein Arginine Methyltransferases as Cellular Stress Regulators. Experimental Neurology. 2024 Nov 15:115060. 115060.

3. Perovic, M; Pavlovic, D; Palmer, Z; Udo, MSB; Citadin, CT; Rodgers, KM; Wu, CYC; Lee, RHC; Zhang, Q; Lin, HW. Modulation of GABAergic System as a Therapeutic Option in Stroke. Exp Neurol. 2024 Nov 8;384:115050

4. Acosta CH, Clemons GA, Citadin CT, Carr WC, Udo MSB, Tesic V, Sanicola HW, Freelin AH, Toms JB, Jordan JD, Guthikonda B, Rodgers KM, Wu CY, Lee RH, Lin HW. PRMT7 can prevent neurovascular uncoupling, blood-brain barrier permeability, and mitochondrial dysfunction in repetitive and mild traumatic brain injury. Exp Neurol. 2023. Aug; 366:114445. PMID: 37196697.

5. Clemons GA, Silva ACE, Acosta CH, Udo MSB, Tesic V, Rodgers KM, et al. Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer’s disease. J Cell Physiol. 2022