Biography

Dr. Marrelli received a BA in Chemistry from the University of Houston and then a PhD in Cardiovascular Sciences from Baylor College of Medicine. His lab is funded through the NIH and AHA to study multiple aspects of cerebral blood flow in normal and post-stroke conditions.

 

 

 

Education

Doctorate Degree
Baylor College of Medicine - Houston, TX

Areas of Interests

Research Interests

Regulation of cerebral blood flow in healthy and post-stroke conditions; Therapeutic targeting of post-stroke thrombosis; Novel methods of promoting therapeutic hypothermia following stroke

Publications

Publication Information

  1. Sancho M, Samson NC, Hald BO, Hashad AM, Marrelli SP, Brett SE, Welsh DG.K(IR) channels tune electrical communication in cerebral arteries. J Cereb Blood Flow Metab. 2017 Jun;37(6):2171-2184. doi: 10.1177/0271678X16662041. Epub 2016 Jan 1. PubMed PMID: 27466375; PubMed Central PMCID: PMC5464710.
  2. Feketa VV, Marrelli SP. Induction of therapeutic hypothermia by pharmacological modulation of temperature-sensitive TRP channels: theoretical framework and practical considerations. Temperature (Austin). 2015 Apr 27;2(2):244-57. doi: 10.1080/23328940.2015.1024383. eCollection 2015 Apr-Jun.  Review. PubMed PMID: 27227027; PubMed Central PMCID: PMC4844121.
  3. Kochukov MY, Balasubramanian A, Abramowitz J, Birnbaumer L, Marrelli SP.Activation of endothelial transient receptor potential C3 channel is required for small conductance calcium-activated potassium channel activation and sustained endothelial hyperpolarization and vasodilation of cerebral artery. J Am Heart Assoc. 2014 Aug 20;3(4). pii: e000913. doi: 10.1161/JAHA.114.000913. PubMed PMID:25142058; PubMed Central PMCID: PMC4310376.
  4. Cao Z, Balasubramanian A, Marrelli SP. Pharmacologically induced hypothermia via TRPV1 channel agonism provides neuroprotection following ischemic stroke when initiated 90 min after reperfusion. Am J Physiol Regul Integr Comp Physiol. 2014 Jan 15;306(2):R149-56. doi: 10.1152/ajpregu.00329.2013. Epub 2013 Dec 4. PubMed PMID: 24305062; PubMed Central PMCID: PMC3921315.
  5. Feketa VV, Balasubramanian A, Flores CM, Player MR, Marrelli SP. Shivering and tachycardic responses to external cooling in mice are substantially suppressed by TRPV1 activation but not by TRPM8 inhibition. Am J Physiol Regul Integr Comp Physiol. 2013 Nov 1;305(9):R1040-50.doi: 10.1152/ajpregu.00296.2013. Epub 2013 Sep 4. PubMed PMID: 24005250; PubMed Central PMCID: PMC3840321.