Stroke Research

Prevention Clinical Trials
Recovery Trials
Acute Ischemic Stroke Trials
Acute Brain Hemorrhage Trials
Subarachnoid Hemorrhage Trials

Stroke Prevention Trials

START – Optimal Delay Time to Initiate Anticoagulation after Ischemic Stroke in Atrial Fibrillation

Investigator: Abdelhamid, Noureldin

Lead CR: Cooksey, Gabretta

SLEEP-SMART – Sleep for Stroke Management and Recovery Trial

Investigator: Sudha Tallavajhula, MD and Anjail Sharrief, MD

Lead CR: Cohen, Audrey S

Sleep apnea in TIA/AIS.

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ARCADIA – AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke

Investigator: Anjail Sharrief, MD

Lead CR: Cooksey, Gabretta

Summary non- lacunar with atrial cardiopathy.

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STOP STROKE – Stroke Telemedicine Outpatient Prevention Program for Blood Pressure Reduction

Investigator: Sharrief, Anjail

Lead CR: Cooksey, Gabretta

Ischemic and hemorrhagic stroke.

Enrollment Status: Actively enrolling

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AXIOMATIC – A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel

Investigator: Sharrief, Anjail

Lead CR: Cohen, Audrey S

Factor XIa inhibitor in non-lacunar AIS or TIA.

Enrollment Status: Enrollment beginning in the near future.

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WVACHII obs – Registry for Women’s Vascular and Cardiac Health Interdisciplinary Initiative

Investigator: Gonzales, Nicole R

Lead CR: Tulod, Kathleen B

Enrollment Status: Actively enrolling

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Recovery Trials

MicroRNAs, Mitochondria and the Blood-Brain Barrier – Therapeutic Targets for Stroke

Investigator: Xuefang Ren, MD, PhD

Purpose: The objective of this proposal is to investigate if endothelial specific miR-34a affects stroke outcomes in the aged brain. We hypothesize that endothelial miR-34a regulates BBB permeability, ischemic damage, hemorrhagic transformation, and stroke-induced deficits by inhibiting translation of LETM1 and LETMD1 leading to impaired mitochondrial bioenergetics in CECs.

PREDICT – ICH obs – Predicting Upper Extremity Motor Recovery in Subcortical Hemorrhagic Stroke Using DTI and TMS

Investigator: Sean Savitz, MD (Zafer/Shayan/Aronowski)

Lead CRC: Dorothea Parker

Diagnostics TMS in ICH

LAPHI obs – Lesion size and Brain Atrophy changes in Patients with Hemorrhagic and Ischemic Stroke (LAPHI)

Investigator: Muhammad Haque, MD

Lead CRC: George, Sarah

Summary Assessment of MRI after stroke

TRANSPORT-2 – TRANScranial direct current stimulation for Post-stroke motor Recovery – a phase II study

Investigator: Gerard Francisco, MD

Lead CRC: Parker, Dorothea M

Purpose: Upper extremity recovery after ischemic stroke

Key Inclusion Criteria: 1st ever, unilateral ischemic stroke; at least 10 degrees of wrist extension

tDCS+CIMT for with 6 months of 1st ever, unihemispheric AIS.

PISCES – A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03 DP) in subjects with Disability Following an Ischemic Stroke

Investigator: Savitz, Sean I

Lead CRC: Dorothea Parker

Purpose: Motor recovery

Key Inclusion Criteria: ischemic stroke, wrist extension and shoulder shrug present

Enrollment Status: Actively enrolling
Summary IV Stem cell therapy for chronic IS

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iACQUIRE – Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation

Investigator: Nivedita Thakur, MD

Lead CRC: Dorothea Parker

Purpose: Recovery of upper extremity weakness in neonatal stroke

Key Inclusion Criteria: 8-36 months with unilateral upper extremity deficit

In-home CIMT in chronic pediatric AIS.

Enrollment Status: Actively enrolling

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Study Name VAST-rehab (Obs) – Virtually Assisted home rehabilitation after Acute Stroke

Investigator: Sean Savitz, MD

Lead CRC: Dorothea Parker

Summary Home-based telerehab after acute stroke (AIS / ICH)

Enrollment Status: On hold

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COPOR Obs Clinical Outcome and Patient Factors in Patient’s outcomes admitted to inpatient rehabilitation facility

Investigator: Sean Savitz, MD

Lead CRC: Dorothea Parker

Purpose: Evaluating the effect of IPR on stroke recovery

Key Inclusion Criteria: admitted to IPR facility within MH system

Retrospective analysis of inpatient rehab and recovery data

Enrollment Status: Actively enrolling

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EnRICH – Efficient Resource Utilization for Patients with Intra Cerebral Hemorrhage

Investigator: Sean Savitz, MD

Lead CRC: Dorothea Parker

Assesses regional patterns of care for ICH

Enrollment Status: Actively enrolling

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NCS-01

Investigator: Anjail Sharrief, MD

Lead CRC: Dorothea Parker

Purpose: Recovery

Key Inclusion Criteria: Ischemic stroke; NIHSS 6-18 w/ or w/o TPA/IAT (maintains score after intervention); pre-stroke mRS <3; LSN < 32 hours from planned infusion

Assesses regional patterns of care for ICH

Enrollment Status: Actively enrolling

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BIONICS

Investigator: Sean Savitz, MD

Lead CRC: Dorothea Parker

Purpose: Machine learning

Key Inclusion Criteria: Cleared to participate in rehab activity

Enrollment Status: Actively enrolling

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Acute Ischemic Stroke (AIS)