Stroke Research
- Prevention Clinical Trials
- Recovery Trials
- Acute Ischemic Stroke Trials
- Acute Brain Hemorrhage Trials
- Subarachnoid Hemorrhage Trials
Stroke Prevention Trials
START – Optimal Delay Time to Initiate Anticoagulation after Ischemic Stroke in Atrial Fibrillation
Investigator: Abdelhamid, Noureldin
Lead CR: Cooksey, Gabretta
SLEEP-SMART – Sleep for Stroke Management and Recovery Trial
Investigator: Sudha Tallavajhula, MD and Anjail Sharrief, MD
Lead CR: Cohen, Audrey S
Sleep apnea in TIA/AIS.
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ARCADIA – AtRial Cardiopathy and Antithrombotic Drugs In prevention After cryptogenic stroke
Investigator: Anjail Sharrief, MD
Lead CR: Cooksey, Gabretta
Summary non- lacunar with atrial cardiopathy.
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STOP STROKE – Stroke Telemedicine Outpatient Prevention Program for Blood Pressure Reduction
Investigator: Sharrief, Anjail
Lead CR: Cooksey, Gabretta
Ischemic and hemorrhagic stroke.
Enrollment Status: Actively enrolling
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AXIOMATIC – A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel
Investigator: Sharrief, Anjail
Lead CR: Cohen, Audrey S
Factor XIa inhibitor in non-lacunar AIS or TIA.
Enrollment Status: Enrollment beginning in the near future.
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WVACHII obs – Registry for Women’s Vascular and Cardiac Health Interdisciplinary Initiative
Investigator: Gonzales, Nicole R
Lead CR: Tulod, Kathleen B
Enrollment Status: Actively enrolling
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Recovery Trials
MicroRNAs, Mitochondria and the Blood-Brain Barrier – Therapeutic Targets for Stroke
Investigator: Xuefang Ren, MD, PhD
Purpose: The objective of this proposal is to investigate if endothelial specific miR-34a affects stroke outcomes in the aged brain. We hypothesize that endothelial miR-34a regulates BBB permeability, ischemic damage, hemorrhagic transformation, and stroke-induced deficits by inhibiting translation of LETM1 and LETMD1 leading to impaired mitochondrial bioenergetics in CECs.
PREDICT – ICH obs – Predicting Upper Extremity Motor Recovery in Subcortical Hemorrhagic Stroke Using DTI and TMS
Investigator: Sean Savitz, MD (Zafer/Shayan/Aronowski)
Lead CRC: Dorothea Parker
Diagnostics TMS in ICH
LAPHI obs – Lesion size and Brain Atrophy changes in Patients with Hemorrhagic and Ischemic Stroke (LAPHI)
Investigator: Muhammad Haque, MD
Lead CRC: George, Sarah
Summary Assessment of MRI after stroke
TRANSPORT-2 – TRANScranial direct current stimulation for Post-stroke motor Recovery – a phase II study
Investigator: Gerard Francisco, MD
Lead CRC: Parker, Dorothea M
Purpose: Upper extremity recovery after ischemic stroke
Key Inclusion Criteria: 1st ever, unilateral ischemic stroke; at least 10 degrees of wrist extension
tDCS+CIMT for with 6 months of 1st ever, unihemispheric AIS.
PISCES – A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03 DP) in subjects with Disability Following an Ischemic Stroke
Investigator: Savitz, Sean I
Lead CRC: Dorothea Parker
Purpose: Motor recovery
Key Inclusion Criteria: ischemic stroke, wrist extension and shoulder shrug present
Enrollment Status: Actively enrolling
Summary IV Stem cell therapy for chronic IS
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iACQUIRE – Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation
Investigator: Nivedita Thakur, MD
Lead CRC: Dorothea Parker
Purpose: Recovery of upper extremity weakness in neonatal stroke
Key Inclusion Criteria: 8-36 months with unilateral upper extremity deficit
In-home CIMT in chronic pediatric AIS.
Enrollment Status: Actively enrolling
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Study Name VAST-rehab (Obs) – Virtually Assisted home rehabilitation after Acute Stroke
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Summary Home-based telerehab after acute stroke (AIS / ICH)
Enrollment Status: On hold
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COPOR Obs Clinical Outcome and Patient Factors in Patient’s outcomes admitted to inpatient rehabilitation facility
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Purpose: Evaluating the effect of IPR on stroke recovery
Key Inclusion Criteria: admitted to IPR facility within MH system
Retrospective analysis of inpatient rehab and recovery data
Enrollment Status: Actively enrolling
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EnRICH – Efficient Resource Utilization for Patients with Intra Cerebral Hemorrhage
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Assesses regional patterns of care for ICH
Enrollment Status: Actively enrolling
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NCS-01
Investigator: Anjail Sharrief, MD
Lead CRC: Dorothea Parker
Purpose: Recovery
Key Inclusion Criteria: Ischemic stroke; NIHSS 6-18 w/ or w/o TPA/IAT (maintains score after intervention); pre-stroke mRS <3; LSN < 32 hours from planned infusion
Assesses regional patterns of care for ICH
Enrollment Status: Actively enrolling
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BIONICS
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Purpose: Machine learning
Key Inclusion Criteria: Cleared to participate in rehab activity
Enrollment Status: Actively enrolling
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Acute Ischemic Stroke (AIS)
MOST – Multi-arm Optimization of Stroke Thrombolysis
Investigator: Barreto, Andrew D
Lead CRC: Franklin, Jamey D
Argatroban or eptifibatide IV after tPA for AIS
Enrollment Status: Actively Enrolling
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SELECT-2 – A Randomized Controlled Trial to Optimize Patient’s Selection for Endovascular Treatment in Acute Ischemic Stroke
Investigator: Amrou Sarraj, MD
Lead CRC: Pujara, Deep K
EVT for large core
Enrollment Status: Actively Enrolling
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TESLA – Thrombectomy for Emergent Salvage of Large Anterior Circulation
Ischemic Stroke
Investigator: Sunil Sheth, MD
Lead CRC: Lopez Rivera, Victor S
EVT for large core
Enrollment Status: Actively Enrolling
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SEGA – Sedation Versus General Anesthesia for Endovascular Therapy in Acute Ischemic Stroke
Investigator: Peng R. Chen, MD
Lead CRC: Ambrocik, Alexander
GA or Conscious sedation during EVT for anterior circulation large vessel occlusions
Enrollment Status: Actively Enrolling
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ZODIAC – Zero degree head positioning in hyperacute large artery ischemic Stroke
Investigator: Gonzales, Nicole R
Lead CRC: Tulod, Kathleen B
Large artery ischemic stroke
Enrollment Status: Actively Enrolling
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TIMELESS – Tenecteplase in Stroke Patients Between 4.5 and 24 Hours
Investigator: Andrew Barreto, MD
Lead CRC: Franklin, Jamey D
TNK after AIS
Enrollment Status: Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator: HuiMahn Alex Choi, MD
Lead CRC: Glenda L Torres
IS, ICH, SAH
Enrollment Status: Actively Enrolling
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Stroke (AIS) Bio-Repository
Investigator: Aronowski, J
Lead CRC: Satani, Nikunj
Biorepository of specimens including blood, CSF and brain tissue
Enrollment Status: Actively Enrolling
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Acute Brain Hemorrhage Trials
FASTEST (start up pending) – Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
Investigator: James Grotta
Lead CR: Bratina, Patti L
Enrollment Status: Actively Enrolling
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Novartis
Investigator: HuiMahn Alex Choi, MD
Lead CRC: Glenda Torres
Enrollment Status: Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator: HuiMahn Alex Choi, MD
Lead CRC: Torres, Glenda L
AIS, ICH, SAH
Enrollment Status: Actively Enrolling
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CAA-ICH – Developing a Biochemical Test to Differentiate Cerebral Amyloid Angiopathy-Intracerebral Hemorrhage from Hypertensive Hemorrhage (obs)
Investigator: Gonzales, Nicole R
Lead CRC: Kathleen Tulod
Enrollment Status: Actively Enrolling
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Hemostasis obs
Investigator: Chang, Tiffany R
Lead CRC: Torres, Glenda L
Enrollment Status: Actively Enrolling
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Subarachnoid Hemorrhage Trials
PILLAR – Prospective Trial of Cerebrospinal Fluid Filtration After Aneurysmal
Subarachnoid Hemorrhage via Lumbar Catheter
Investigator: Spiros Blackburn
Enrollment Status: Actively Enrolling
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iVAST – The Intra-arterial Vasospasm Trial
Investigator: Peng R. Chen
Lead CR: Alexander Ambrocik
Comparing medication tx for vasospasms. In pt post surgery only.
Enrollment Status: Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator: HuiMahn Alex Choi
Lead CR: Glenda L Torres
Enrollment Status: Actively Enrolling
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Mani bio-Repository
Investigators: Huimahn Alex Choi/Tiffany Chang
Lead CR: Glenda L Torres
Enrollment Status: Actively Enrolling
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Clinical Trials
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