Selected Publications and Recent Preprints
Yu, Y., Alvarado, R., Petty, L.E., Bohlender, R.J., Shaw, D.M., Below, J.E., Bejar, N., Ruiz, O.E., Tandon, B., Eisenhoffer, G.T., Kiss, D.L., Huff, C.D., Letra, A., Hecht, J.T.: Polygenic risk impacts PDGFRA mutation penetrance in non-syndromic cleft lip and palate. Hum Mol Genet. 2022 Feb 11:ddac037. doi: 10.1093/hmg/ddac037. Online ahead of print. PMID: 35147171 PMCID:PMC:9307317
Howe, B.J., Pendleton, C., Withanage M.H.H., Childs, C.A., Zeng, E., van Wijk, A., Hermus, R., Padilla, C., Hecht, J.T., Poletta, F.A., Orioli, I.M., Buxo, C.J., Deleyiannis, F., Vieira, A.R., Butali, A., Valencia-Ramirez, L.C., Restrepo Muneton, C.P., Wehby, G., Weinberg, S.M., Marazita, M.L., Moreno Uribe, L.M., Xie, X.J.: Meta-Analysis of Tooth Agenesis Patterns in Orofacial Clefting 2 Using Tooth Agenesis Code. Dent J, 2022 https://doi.org/10.3390/dj10070128 PMCID:PMC In progress
Maili, L.M., Ruiz, O.E., Kahan, P., Larson, S.T., Hashmi, S.S., Hecht, J.T., Eisenhoffer, G.T.: zFace: Facial analytics from a co-ordinate extrapolation system for developing zebrafish. Dis Model Mech. 2023 Jun 1;16(6):dmm049868. doi: 10.1242/dmm.049868. Epub 2023 Jun 2. PMID:37102214 bioRxiv 2022.07.26.501188; doi: https://doi.org/10.1101/2022.07.26.501188
Nahm, N.J., Mackenzie, W.G.S., Mackenzie, W.G, Gough, Hashmi, S.S., Hecht, J.T., Legare, J.M., Little, M.E., Modaff. P., Pauli, R.M., Rodriguez-Buritica, D.F., Serna, M.E., Smid, C.J., Hoover-Fong, J., Bober, M.B.: Achondroplasia Natural History Study (CLARITY): 60-year experience in orthopedic surgery from four skeletal dysplasia centers. In press Orphaner J Rare Dis 2023 Jun 6;18(1):139. doi: 10.1186/s13023-023-02738-x.PMID:37280669.
Hecht, J.T., Veerisetty, A.C., Hossain, M.G., Chiu, F., Posey, K.L.: CurcQ+, a next-generation formulation of curcumin, ameliorates growth plate chondrocyte stress and increases limb growth in a mouse model of pseudoachondroplasia. Int J Mol Sci. 2023 Feb 14;24(4):3845. doi: 10.3390/ijms24043845, PMCID: PMC9959842.
Hecht, J.T., Veerisetty, A.C., Hossain, M.G., Chiu, F., Posey, K.L.: Matrix in Medicine: Health Consequences of Mutant Cartilage Oligomeric Matrix Protein and its relationship abnormal growth and to joint degeneration. Matrix Biol 119:101-111, 2023; https://doi.org/10.1016/j.matbio.2023.03.008.
Maili, L.M., Tandon, B., YYuan, Q., Menezes, S., Hashmi, S.S., Letra, A., Eisenhoffer, G.T., Hecht, J.T., Disruption of fos causes craniofacial anomalies in developing zebrafish. BioRiv doi: https://doi.org/10.1101/2022.12.06.519379, Front Cell Dev Biol 2023 DOI: 10.3389/fcell.2023.1141893 PMID:37664458.
Diaz Perez, K.K., Chung, S., Epstein, M.P, Hecht, J.T., Wehby, G.L., Weinberg, S.M., Murray, J.C., Marazita, M.L., Leslie, E.J.: Rare variants in multiplex orofacial clefts: Does expanding the phenotype make a difference? Am J Med Genet, 2023;191A:2558–2570; medRxiv. 2023 Feb 7:2023.02.01.23285340. doi: 10.1101/2023.02.01.23285340. Preprint. PMID:36798250
Robinson, K., Mosley, T., Curtis, S., Beaty, T.H., Butali, A., Cutler, D.J., Epstein, M.P., Buxo-Martinez, C.J., Shaw, G.M., Hecht, J.T., Moreno Uribe, L., Murray, J.C., Brand, H., Weinberg, S.M., Marazita, M.L., Leslie, E.J.: Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate. medRxiv. medrxiv.org/content/10.1101/2023.03.01.23286642v1: submitted Plos Genet 2024.
Hecht, J.T., Veerisetty, A.C., Patra, D., Hossain, M.G., Chiu, F., Mobed, C., Gannon, F.H.,Posey, K.L.: Early resveratrol treatment mitigates joint degeneration and dampens pain in a mouse model of pseudoachondroplasia (PSACH). Biomolecules 2023 doi:10.3390/biom13101553, PMCID:PMC10605626