MAGIC Study
Milk and Growth in Children Born Very Preterm (MAGIC Study)
Very preterm babies (born between 27–31 weeks) need extra nutrition to grow and develop well after birth. However, doctors and nurses are unsure how much human milk to provide.
This study is being conducted to determine whether providing a higher volume of human milk (180–200 mL/kg/day) compared with a lower volume (140–160 mL/kg/day) via tube feedings will improve growth, body composition, gut health, and long-term development in very preterm infants.
Purpose & Aim
Population of the study: Very preterm infants born between 27–31 weeks’ gestation with birthweight ≤1500 grams, receiving human milk, who achieve full enteral feeding within 14 days of birth
Comparisons: Higher target feeding volume of human milk (180–200 mL/kg/day) versus lower target (140–160 mL/kg/day)
Outcome: Fat-free mass, growth, body composition, gut microbiome, metabolomics, neurodevelopmental assessment at 22–26 months
Trial Information
Recruitment Target: 486 infants (200 at UTHealth Houston/Memorial Hermann)
Sponsor: National Institute of Child Health and Human Development (NICHD)
Duration of Study: 36 months recruitment + follow-up
Study Principal Investigator
Maria del Mar Romero Lopez, MD, MS, PhD
Assistant Professor
Department of Pediatrics, Division of Neonatology
Institute for Clinical Research and Learning Health Care
6431 Fannin, MSB 2.104. Houston, TX 77030
[email protected]