Selected Publications

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge.
Nohara K¹, Mallampalli V¹, Nemkov T², Wirianto M¹, Yang J¹, Ye Y¹, Sun Y³, Han L¹, Esser KA⁴, Mileykovskaya E¹, D’Allesandro A², Green CB⁵, Takahashi JS⁵⁶, Dowhan W¹, Yoo SH¹, and Chen Z¹.
Nature Communications 10: 3923, 2019.
PMID: 31462679

Temporal control of appetite by AgRP clocks.
Chen Z.
Cell Metabolism 29: 1022-1023, 2019.
PMID: 31067447

The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy.
Ye Y, Xiang Y, Ozguz FM, Kim Y, Liu C, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo A-Y, Zhou B, Wang L, Chen Z, Takahashi JS, Mills GB, Yoo, SH and Han L.
Cell Systems. 6: 314-328, 2018.
PMCID: PMC6056007

Period2 3′-UTR and microRNA-24 regulate circadian rhythms by repressing PERIOD2 protein accumulation.
Yoo SH, Kojima S, Shimomura K, Koike N, Buhr E, Furukawa T, Ko C, Gloston G, Ayoub C, Nohara K, Reyes B, Tsuchiya Y, Yoo O-J, Yagita K, Lee C, Chen Z, Yamakazi S, Green CB, and Takahashi JS.
Proc Natl Acad Sci USA. 114(42): E8855-E8864, 2017.
PMCID: PMC5651750

The small molecule Nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome.
He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH and Chen Z.
Cell Metabolism. 23: 610-21, 2016.
PMCID: PMC4832569

Transmissible microbial and metabolomic remodeling by soluble dietary fiber improves metabolic homeo
He B¹, Nohara K¹, Ajami NJ², Michalek RD³, Tian X², Wong M², Losee-Olson SH⁴, Petrosino JF², Yoo SH¹, Shimomura K⁵, Chen Z¹
Sci Rep. 5: 10604, 2015.
PMCID:PMC4455235

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Yoo SH, Mohawk JA, Siepka SM, Shan Y, Huh SK, Hong HK, Kornblum I, Kumar V, Koike N, Xu M, Nussbaum J, Liu X, Chen Z, Chen ZJ, Green CB, Takahashi JS.
Cell. 152(5):1091-105, 2013.
PMID: 23452855

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening.
Chen Z, Yoo SH, Park YS, Kim KH, Wei S, Buhr E, Ye ZY, Pan HL, Takahashi JS.
Proc Natl Acad Sci U S A. 109(1):101-6, 2012.
PMCID: PMC3252927