Selected Publications

Visit Dr. Jayaraman’s NCBI page (external link) for a complete list of publications

• Activity Dependent Inhibition of AMPA Receptors by Zn²⁺. (external link) Carrillo E., Bhatia K., Akimzhanov, A.M., and Jayaraman V.,  J Neuroscience 2020. 40(45):8629-8636.
• Conformational Spread and Dynamics in Allostery of NMDA Receptors. (external link) Durham R.J., Paudyal, N., Carrillo E, Bhatia, N. K., MacLean D.M., Berka V, Dolino D. M., Gorfe, A. A., and Jayaraman V., Proc Natl Acad Sci U S A, 2020 117 (7) 3839-3847.
• Mapping the Conformational Landscape of Glutamate Receptors Using Single Molecule FRET. (external link) MacLean DM, Durham RJ, Jayaraman V.
  Trends Neurosci.  2018.  Oct 29 pii:  S0166-2236(18)30274-1.  doi:  10. 1016/j.tins. 2018. 10.003 [Epub ahead of print] Review  (PMID:  30385052)
• The Structure-Energy Landscape of NMDA Receptor Gating. (external link) Dolino DM, Chatterjee S, MacLean DM, Flatebo C, Bishop LDC, Shaikh SA, Landes CF, Jayaraman V.
  Nat Chem Biol.  2017.  Dec; 13(12):1232-1238.  doi: 10.1038/nchembio 2487.  Epub 2017 Oct 9. (PMID:  28991238)
• Deactivation Kinetics of Acid-Sensing Ion Channel 1a are Strongly pH-Sensitive. (external link)
  MacLean DM, Jayaraman V. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2504-E2513. doi: 10.1073/pnas.1620508114. Epub 2017 Mar 6. PMID:28265090
• Stargazin Modulation of AMPA Receptors.  (external link)Shaikh SA¹, Dolino DM², Lee G¹, Chatterjee S³, MacLean DM¹, Flatebo C⁴, Landes CF⁵, Jayaraman V⁶.
  Cell Rep. 2016 Oct 4;17(2):328-335. doi: 10.1016/j.celrep.2016.09.014. PMID:27705782
• Conformational Selection and Submillisecond Dynamics of the Ligand-binding Domain of the N-Methyl-d-aspartate Receptor. (external link)
  Dolino DM, Rezaei Adariani S, Shaikh SA, Jayaraman V, Sanabria H.
  J Biol Chem.  2016.  Jul29;291(31):16175-85.  doi:  10:1074/jbc:M116.721274.  Epub 2016 May 21  (PMID:  27226581)
• Acid-sensing Ion Channels are Tuned to Follow High-Frequency Stimuli (external link)
  MacLean DM, Jayaraman V. J Physiol.  2016.  May 15; 594(10):2629-45.  doi: 10.1113/JP271915.  Epub 2016 Apr 10
• Dynamic Membrane Protein Topological Switching upon Changes in Phospholipid Environment. (external link)Vitrac H (external link)¹, MacLean DM (external link)², Jayaraman V (external link)², Bogdanov M (external link)², Dowhan W (external link)¹.
  Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):13874-9. doi: 10.1073/pnas.1512994112. Epub 2015 Oct 28. PMID:26512118
• A Conserved Structural Mechanism of NMDA Receptor Inhibition: A Comparison of Ifenprodil and Zinc (external link)Sirrieh RE, MacLean DM, Jayaraman V
  J Gen Physiol. 2015 Aug;146(2):173-81. Epub 2015 Jul 13. PMID:  26170175
• Conformational transitions in the Glycine-Bound GluN1 NMDA Receptor LBD via Single-Molecule FRET. (external link)
  Cooper DR, Dolino DM, Jaurich H, Shuang B, Ramaswamy S, Nurik CE, Chen J, Jayaraman V, Landes CF.  Biophys J. 2015.   Jul 7; 109(1):66-75.  doi: 10.1016/j.bpj.2015.05.025.  (PMID: 26153703)
• Subtype-Dependent N-methyl-D-aspartate Receptor Amino-Terminal Domain Conformations and Modulation by Spermine (external link)Sirrieh RE, MacLean DM, Jayaraman V
  J Biol Chem. 2015 May 15;290(20):12812-20. doi: 10.1074/jbc.M115.649723. Epub 2015 Mar 31 PMCID: PMC4432297
• Stargazin Promotes Closure of the AMPA Receptor Ligand-Binding Domain (external link)MacLean DM, Ramaswamy SS, Du M, Howe JR, Jayaraman V
  J Gen Physiol. 2014 Dec;144(6):503-12. PMCID: PMC4242809
• Structural Dynamics of the Glycine-Binding Domain of the N-methyl-D-aspartate Receptor (external link)Dolino DM, Cooper D, Ramaswamy S, Jaurich H, Landes CF, Jayaraman V
  J Biol Chem. 2015 Jan 9;290(2):797-804. doi: 10.1074/jbc.M114.605436. Epub 2014 Nov 17 PMCID: PMC4294502
• Luminescence Resonance Energy Transfer to Study Conformational Changes in Membrane Proteins Expressed in Mammalian Cells. (external link)  Dolino DM, Ramaswamy SS, Jayaraman V.  J Vis Exp.  2014.  Sept 16;(91):51895.  doi:  10.3791/51895.  (PMID:  25285993)
• RNA Based Antagonist of NMDA Receptors. (external link) Lee G, MacLean DM, Ulrich H, Zhao X, Aronowski J, Jayaraman V.
  ACS Chem Neurosci.  2014.  Jul 16; 5(7):559-67.  doi: 10.1021/cn500041k.  Epub 2014 16.  (PMID:  24708087)
• Proton-mediated Conformational Changes in an Acid-Sensing Ion Channel. (external link) Ramaswamy SS, MacLean DM, Gorfe AA, Jayaraman V.
  J Biol Chem.  2013. Dec 13; 288(50):35896-903. doi:  10.1074/jbc.M113.478982. Epub 2013 Nov 6.  (PMID:  24196950)
• Amino-terminal Domain Tetramer Organization and Structural Effects of Zinc Binding in the N-Methyl-D-aspartate (NMDA) Receptor.  (external link)Sirrieh RE, Maclean DM, Jayaraman V.
  J Biol Chem. 2013 Aug 2;288(31):22555-64. Epub 2013 Jun 21. PMID: 23792960
• Role of Conformational Dynamics in α-amino-3-hydroxy-5-methylisoxazole-4-propionic Acid (AMPA) Receptor Partial Agonism. (external link) Ramaswamy S, Cooper D, Poddar N, MacLean DM, Rambhadran A, Taylor JN, Uhm H, Landes CF,Jayaraman V. J Biol Chem. 2012 Dec 21;287(52):43557-64. Epub 2012 Oct 31. PMID: 23115239
• Conformational Changes at the Agonist Binding Domain of the N-methyl-D-aspartic Acid Receptor. (external link)Rambhadran A, Gonzalez J, Jayaraman V.
  J Biol Chem. 2011 May 13;286(19):16953-7. doi: 10.1074/jbc.M111.224576. Epub 2011 Mar 24. PMID: 21454656
• Structural Landscape of Isolated Agonist-Binding Domains from Single AMPA Receptors. (external link)Landes CF, Rambhadran A, Taylor JN, Salatan F, Jayaraman V.
  Nat Chem Biol. 2011 Mar;7(3):168-73. Epub 2011 Feb 6. PMID: 21297640
• Structural Landscape of Isolated Agonist-Binding Domains from Single AMPA receptors. (external link)Landes CF (external link)¹, Rambhadran A (external link), Taylor JN (external link), Salatan F (external link), Jayaraman V (external link).
  Nat Chem Biol. 2011 Mar;7(3):168-73. doi: 10.1038/nchembio.523. Epub 2011 Feb 6 PMID:21297640
• Role of Dimer Interface in Activation and Desensitization in AMPA Receptors. (external link)Gonzalez J, Du M, Parameshwaran K, Suppiramaniam V, Jayaraman V.
  Proc Natl Acad Sci U S A. 2010 May 25;107(21):9891-6. doi: 10.1073/pnas.0911854107. Epub 2010 May 10. PMID: 20457909
• Subunit Arrangement in N-methyl-D-aspartate (NMDA) Receptors. (external link)Rambhadran A, Gonzalez J, Jayaraman V.
  J Biol Chem. 2010 May 14;285(20):15296-301. doi: 10.1074/jbc.M109.085035. Epub 2010 Mar 19. PMID: 20304927
• Vibrational Spectroscopic Investigation of the Ligand Binding Domain of Kainate Receptors. (external link)Du M, Rambhadran A, Jayaraman V.
  Protein Sci. 2009 Aug;18(8):1585-91. doi: 10.1002/pro.174. PMID: 19544581
• LRET Investigations of Conformational Changes in the Ligand Binding Domain of a Functional AMPA Receptor. (external link)Gonzalez J, Rambhadran A, Du M, Jayaraman V.
  Biochemistry. 2008 Sep 23;47(38):10027-32. doi: 10.1021/bi800690b. Epub 2008 Aug 30. PMID: 18759455
• Allosteric Mechanism in AMPA Receptors: A FRET-based Investigation of Conformational Changes. (external link)Ramanoudjame G, Du M, Mankiewicz KA, Jayaraman V.
  Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10473-8. Epub 2006 Jun 22. PMID: 16793923
• Evolution of Glutamate Interactions During Binding to a Glutamate Receptor. (external link)Cheng Q, Du M, Ramanoudjame G, Jayaraman V.
  Nat Chem Biol. 2005 Nov;1(6):329-32. Epub 2005 Sep 25. PMID: 16408071