Selected Publications

• Understanding IP₃R channels: From structural underpinnings to ligand-dependent conformational landscape. Baker MR, Fan G, Arige V, Yule DI, Serysheva II. Cell Calcium. 2023 Jun 22;114:102770. doi: 10.1016/j.ceca.2023.102770.
• Conformational motions and ligand-binding underlying gating and regulation of IP₃R channel. Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II. Nat Commun. 2022 Nov 14;13(1):6942. doi: 10.1038/s41467-022-34574-1.PMID: 36376291
  • Commentaries in: PNAS, Cell Calcium 2022, Cell Calcium 2023
• Functional determination of calcium binding sites required for the activation of iositol 1,4,5-trisphosphate receptors. Arige V, Terry LE, Wagner LE 2nd, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI.Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119. doi: 10.1073/pnas.2209267119. 
• Cryo-EM structure of type 1 IP₃R channel in a lipid bilayer. Baker, M.R., Fan, G., Seryshev, A.B., Agosto M.A., Baker M.L., Serysheva I.I. Commun Biol 4, 625 (2021).
• Cryo-EM reveals ligand induced allostery underlying InsP₃R channel gating. Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II. Cell Res. 2018 Dec;28(12):1158-1170. doi: 10.1038/s41422-018-0108-5. 
• Structure of IP₃R channel: high-resolution insights from cryo-EM. Baker MR, Fan G, Serysheva II. Curr Opin Struct Biol. 2017 Jun 12;46:38-47. doi: 10.1016/j.sbi.2017.05.014.
• Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Nature. 2015 Oct 12. doi: 10.1038/nature15249.
• Validation of cryo-EM structure of IP₃R1 channel. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II. Structure. 2013 Jun 4;21(6):900-9. PMID: 3696195
• Single-particle Cryo-EM of calcium release channels: structural validation. Ludtke SJ, Serysheva II. Curr Opin Struct Biol. 2013 Oct;23(5):755-62. doi: 10.1016/j.sbi.2013.06.003. PMID: 23831288
• Flexible architecture of IP3R1 by Cryo-EM. Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II. Structure. 2011 Aug 10;19(8):1192-9. doi: 10.1016/j.str.2011.05.003. PMID: 21827954
• Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9610-5. doi: 10.1073/pnas.0803189105. PMID: 18621707
• The pore structure of the closed RyR1 channel. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. Structure. 2005 Aug;13(8):1203-11.PMID: 16084392
• Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Biophys J. 1999 Oct;77(4):1936-44. PMID: 10512814
• Two structural configurations of the skeletal muscle calcium release channel. Orlova EV, Serysheva II, van Heel M, Hamilton SL, Chiu W.
  Nat Struct Biol. 1996 Jun;3(6):547-52. PMID: 8646541
• Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Serysheva II, Orlova EV, Chiu W, Sherman MB, Hamilton SL, van Heel M. Nat Struct Biol. 1995 Jan;2(1):18-24. PMID: 7719847