Selected Publications

• Conformational motions and ligand-binding underlying gating and regulation of IP₃R channel. Fan G, Baker MR, Terry LE, Arige V, Chen M, Seryshev AB, Baker ML, Ludtke SJ, Yule DI, Serysheva II. Nat Commun. 2022 Nov 14;13(1):6942. doi: 10.1038/s41467-022-34574-1.PMID: 36376291
• Disrupted Ca²⁺ homeostasis and immunodeficiency in patients with functional IP₃ receptor subtype 3 defects. Neumann J, Van Nieuwenhove E, Terry LE, Staels F, Knebel TR, Welkenhuyzen K, Ahmadzadeh K, Baker MR, Gerbaux M, Willemsen M, Barber JS, Serysheva II, De Waele L, Vermeulen F, Schlenner S, Meyts I, Yule DI, Bultynck G, Schrijvers R, Humblet-Baron S, Liston A.Cell Mol Immunol. 2022 Oct 27. doi: 10.1038/s41423-022-00928-4. Online ahead of print.PMID: 36302985
• Functional determination of calcium binding sites required for the activation of iositol 1,4,5-trisphosphate receptors. Arige V, Terry LE, Wagner LE 2nd, Malik S, Baker MR, Fan G, Joseph SK, Serysheva II, Yule DI.Proc Natl Acad Sci U S A. 2022 Sep 27;119(39):e2209267119. doi: 10.1073/pnas.2209267119. 
• In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution.Chen M, Shi X, Yu Z, Fan G, Serysheva II, Baker ML, Luisi BF, Ludtke SJ, Wang Z. Structure. 2022 Jan 6;30(1):107-113.e3. doi: 10.1016/j.str.2021.08.008. 
• Cryo-EM structure of type 1 IP₃R channel in a lipid bilayer. Baker, M.R., Fan, G., Seryshev, A.B., Agosto M.A., Baker M.L., Serysheva I.I. Commun Biol 4, 625 (2021).
• Bcl-2-Protein Family as Modulators of IP₃ Receptors and Other Organellar Ca²⁺ Channels. Ivanova H, Vervliet T, Monaco G, Terry LE, Rosa N, Baker MR, Parys JB, Serysheva II, Yule DI, Bultynck G. Cold Spring Harb Perspect Biol. 2020 Apr 1;12(4):a035089. doi: 10.1101/cshperspect.a035089.PMID: 31501195
• Structures of TRPV2 in distinct conformations provide insight into role of the pore turret.
  Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG.Nat Struct Mol Biol. 2019 Jan;26(1):40-49. doi: 10.1038/s41594-018-0168-8. PMID: 30598551
• Cryo-EM reveals ligand induced allostery underlying InsP₃R channel gating. Fan G, Baker MR, Wang Z, Seryshev AB, Ludtke SJ, Baker ML, Serysheva II. Cell Res. 2018 Dec;28(12):1158-1170. doi: 10.1038/s41422-018-0108-5. 
• Structure of IP₃R channel: high-resolution insights from cryo-EM. Baker MR, Fan G, Serysheva II. Curr Opin Struct Biol. 2017 Jun 12;46:38-47. doi: 10.1016/j.sbi.2017.05.014.
• An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D. Elife. 2017 Mar 29;6. pii: e24905. doi: 10.7554/eLife.24905.
• Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy. Jarius S, Ringelstein M, Haas J, Serysheva II, Komorowski L, Fechner K, Wandinger KP, Albrecht P, Hefter H, Moser A, Neuen-Jacob E, Hartung HP, Wildemann B, Aktas O. J Neuroinflammation. 2016 Oct 24;13(1):278.
• Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Nature. 2015 Oct 12. doi: 10.1038/nature15249.
• Single-particle cryo-EM of the ryanodine receptor channel in an aqueous environment. Baker MR, Fan G, Serysheva II. Eur J Transl Myology. 2015;25(1):35-48. PMID: 438180
• Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Jarius S, Scharf M, Begemann N, Stöcker W, Probst C, Serysheva II, Nagel S, Graus F, Psimaras D, Wildemann B and Komorowski L. Journal of Neuroinflammation (2014) 11:206. DOI 10.1186/s12974-014-0206-3. PMID: 4300617
• Toward a high-resolution structure of IP3R channel. Serysheva II. Cell Calcium. 2014 Sep;56(3):125-132. doi: 10.1016/j.ceca.2014.08.002
• Validation of cryo-EM structure of IP₃R1 channel. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II. Structure. 2013 Jun 4;21(6):900-9. PMID: 3696195
• Single-particle Cryo-EM of calcium release channels: structural validation. Ludtke SJ, Serysheva II. Curr Opin Struct Biol. 2013 Oct;23(5):755-62. doi: 10.1016/j.sbi.2013.06.003. PMID: 23831288
• Validation of Cryo-EM Structure of IP3R1 Channel. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II.
  Structure. 2013 Jun 4;21(6):900-9. doi: 10.1016/j.str.2013.04.016. PMID: 23707684
• Identification of ATP-binding regions in the RyR1 Ca²⁺ release channel. Popova OB, Baker MR, Tran TP, Le T, Serysheva II.
  PLoS One. 2012;7(11):e48725. doi: 10.1371/journal.pone.0048725. PMID: 23144945
• Flexible architecture of IP3R1 by Cryo-EM. Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II. Structure. 2011 Aug 10;19(8):1192-9. doi: 10.1016/j.str.2011.05.003. PMID: 21827954
• Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9610-5. doi: 10.1073/pnas.0803189105. PMID: 18621707
• Structure of TRPV1 channel revealed by electron cryomicroscopy. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG.
  Proc Natl Acad Sci U S A. 2008 May 27;105(21):7451-5. doi: 10.1073/pnas.0711835105. PMID: 18490661
• The pore structure of the closed RyR1 channel. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. Structure. 2005 Aug;13(8):1203-11.PMID: 16084392
• Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Serysheva II, Ludtke SJ, Baker MR, Chiu W, Hamilton SL.
  Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10370-5. Epub 2002 Jul 29. PMID: 12149473
• Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Biophys J. 1999 Oct;77(4):1936-44. PMID: 10512814
• Two structural configurations of the skeletal muscle calcium release channel. Orlova EV, Serysheva II, van Heel M, Hamilton SL, Chiu W.
  Nat Struct Biol. 1996 Jun;3(6):547-52. PMID: 8646541
• Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Serysheva II, Orlova EV, Chiu W, Sherman MB, Hamilton SL, van Heel M. Nat Struct Biol. 1995 Jan;2(1):18-24. PMID: 7719847