Yoo Laboratory

The Yoo Laboratory uniquely combines forward/reverse mouse genetics with molecular/physiological approaches in their impactful research. Dr. Yoo and her lab team have developed and utilized a PER2::Luciferase circadian reporter model to demonstrate the existence of independent peripheral clocks in virtually all mouse tissues. This finding has radically changed the “central dogma” of the mammalian circadian system in which the SCN (Suprachiasmatic Nuclei) in the brain functions as the master clock to drive peripheral slave oscillators. This reporter mouse line has been distributed to over 100 laboratories throughout the world and is among the most widely used and powerful tools in the field of circadian biology.