Clinical Research Curriculum
The Clinical Research Curriculum (CRC) is a two-year introductory series of evening courses designed to promote clinical research expertise among clinical investigators at the fellow and junior faculty levels.
The classes are open to all clinical researchers at McGovern Medical School and, as space allows, to researchers from affiliated institutions. These courses are offered at no charge to UTHealth faculty and fellows. Since the CRC program began in 1999, we have had over 1000 participants from a variety of Texas Medical Center institutions including McGovern Medical School, The University of Texas M.D. Anderson Cancer Center, Memorial Hermann Hospital, UTHealth School of Dentistry, Cizik School of Nursing, UTHealth School of Public Health, and Baylor College of Medicine. A certificate of completion will be issued to participants who enroll in the curriculum, attend most or all of the classes, and successfully complete the homework assignments and tests. These courses are given in a revolving 2-year schedule with the understanding that participants may begin the curriculum at any point in the 2 year cycle. Master’s degree program students may transfer up to 12 credit hours from the CRC towards their degree requirements.
(classes held every Wednesday from 5-6:30 pm, MSB 2.103, except as noted)
Academic Year: 2020-2021
Biostatistics for Clinical Investigators (09/02/20 – 11/11/20)
This course begins with an overview of descriptive statistics and provides students with the tools to perform univariate analyses using parametric and non-parametric methods for paired and unpaired designs. Emphasis is placed on choosing appropriate tests, evaluating assumptions for the tests, understanding the limitations of statistical tests, and appropriate interpretation of test results. Survival analysis and multiple regression techniques are introduced to familiarize the student with the availability and limitations of these tests. See syllabus from previous class cycle.
Academic Success as a Clinical/Translational Investigator (11/18/20)
This seminar will cover the principles and pragmatic realities of academic career advancement/promotion. Successful senior faculty will offer advice for participants at the fellow and junior faculty levels.
Literature Appraisal (12/02/20 – 2/10/21)
In this course, the students have an opportunity to learn rules of evidence and demonstrate critical evaluation of the medical literature. Students will be expected to demonstrate these concepts and skills by appraising the evidence in their areas of clinical research interest. This critical appraisal of existing evidence will be used to determine fruitful areas for new investigation. See syllabus from previous class cycle.
Ethical Aspects of Clinical Research (2/17/21 – 4/07/21)
This course introduces the fundamental ethical principles of autonomy, beneficence, nonmaleficence, and justice and applies these principles to clinical research involving human subjects. The use of unproven therapies, the use of placebos, the consent process, institutional review board submission and review processes, conflict of interests, and the costs of clinical research are covered. See syllabus from previous class cycle.
Introduction to Translational Research (4/14/21 – 5/26/21)
This course is an overview of the clinical research that bridges basic science and patient-based research. Topics include pharmaceutical research, genetic research, gene therapy, and genomics. See class schedule from previous cycle.
Clinical Research Design Workshop (06/02/21 – 8/18/21)
In this problem-based course, each student is expected to build a clinical research proposal in his/her field of interest. Each week, students are asked to present specific parts of their protocols to facilitate the discussion of successive stages in study design. This course is run in small group sessions (10-12 students per group) to facilitate active participation and interaction.
Translational Research Workshop (06/09/21 – 8/18/21)
This workshop course provides a hands-on venue to introduce fundamentals of genetics, epigenetics, and gene expression profiling to clinicians. The goal is to provide clinical researchers with a good understanding of the high-throughput molecular technologies that are needed to conduct clinically relevant translational research. This course is run in a small group format (10 students) to facilitate active participation and interaction.
Academic Year: 2021-2022
Introduction to Clinical Research (to be scheduled)
This lecture is given every year and provides an overview of the clinical research curriculum program, insights into the opportunities for young clinical investigators, and suggestions on getting started in clinical research.
Introduction to Epidemiology Research (August 2021-November 2021)
This course provides a basis for an understanding of the concepts and methodological skills necessary for designing and interpreting observational studies. These include validity (random error, bias and confounding), measures of disease occurrence and impact, measures of association, reliability and generalizability, causal inference, and critically reviewing evidence. Current or anticipated Master’s Degree students are required to participate in the Honors section for this course.
Clinical Trial Design (November 2021-February 2022)
This course prepares the student to design and analyze randomized trials of medical interventions. Covered topics include basic study design, recruitment, randomization, masking, data collection and quality control, participant adherence, sample size considerations, data monitoring and analysis, and meta-analysis. Current or anticipated Master’s Degree students are required to participate in the Honors section for this course. See syllabus from previous class cycle.
Clinical Research Design Workshop (February 2022-May 2022)
In this problem-based course, each student is expected to build a clinical research proposal in his/her field of interest. Each week, students are asked to present specific parts of their protocols to facilitate the discussion of successive stages in study design. Participation in this course is limited due to small group format; admittance to the course will be based on an abstract to be submitted with registration form.
Social and Behavioral Aspects of Clinical Research (May 2022-July 2022)
The health and well-being of individual patients and of society as a whole may be more related to social and behavioral factors than to purely medical factors. This course will promote understanding of the design, implementation, analysis and interpretation of studies of social and behavioral determinants of disease, interactions between these determinants and medical treatment, or interventions to improve health problems.
Healthcare Quality and Safety (July 2022-August 2022)
This course begins with an overview of health services research. Subsequent classes will focus on either important topics within HSR or methods used in HSR; conceptualization of healthcare quality and safety; quality of care measurements; improvement science; and introductions to survey research and qualitative research. See syllabus from previous class cycle.
Click here to view prior lectures by videostream. (Look for course under “CRC Courses” in the menu on the left side.)
A limited number of applicants (6-8 per year) are accepted into an intensive mentoring program that complements the above coursework. A methodologic mentor from the Center is selected for each mentee. Acceptance into the program requires the commitment of at least one departmental mentor for the mentee and adequate protected time for the mentee to fulfill the requirements of the program. Over the course of the two-year program, each mentee is expected to design a research protocol that is of sufficient quality and sophistication for competitive grant submission.
For more information regarding the Clinical Research Curriculum, or to subscribe to the CRC distribution list to receive updates about upcoming courses, please email Deborah Garcia, CRC and MS Program Coordinator, or call our office at (713) 500-6708.