CCGR Research

Basic research in our laboratory encompasses three groups:

Human Molecular Genetic Studies

  • To identify the causal and modifier genes for various forms of cardiomyopathies
  • To identify causal and susceptibility alleles for premature myocardial infarction, atherosclerosis, and low high-density lipoprotein-cholesterol

Functional Studies

  • To delineate the molecular mechanisms involved in the pathogenesis of cardiomyopathies
  • Various in vitro studies in cultured myocytes and other cells
  • Studies in genetically modified animal models

Rescue, reversal, and attenuation

  • of the phenotype in cultured cells in genetically modified animal models

The ongoing clinical research in our laboratory is:

  • Recruitment and phenotyping of individuals and families with various genetic cardiovascular diseases
  • Identification of diagnostic markers and biomarkers for various cardiovascular diseases
  • Pharmacological intervention to prevent, attenuate and reverse the evolving phenotype in cardiomyopathies