CCGR Research

Basic research in our laboratory encompasses three groups:

Human Molecular Genetic Studies

To identify the causal and modifier genes for various forms of cardiomyopathies
To identify causal and susceptibility alleles for premature myocardial infarction, atherosclerosis, and low high-density lipoprotein-cholesterol

Functional Studies

To delineate the molecular mechanisms involved in the pathogenesis of cardiomyopathies
Various in vitro studies in cultured myocytes and other cells
Studies in genetically modified animal models

Rescue, reversal, and attenuation

of the phenotype in cultured cells in genetically modified animal models

The ongoing clinical research in our laboratory is:

Recruitment and phenotyping of individuals and families with various genetic cardiovascular diseases
Identification of diagnostic markers and biomarkers for various cardiovascular diseases
Pharmacological intervention to prevent, attenuate and reverse the evolving phenotype in cardiomyopathies