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CCGR Research
Basic research in our laboratory encompasses three groups:
Human Molecular Genetic Studies
- To identify the causal and modifier genes for various forms of cardiomyopathies
- To identify causal and susceptibility alleles for premature myocardial infarction, atherosclerosis, and low high-density lipoprotein-cholesterol
Functional Studies
- To delineate the molecular mechanisms involved in the pathogenesis of cardiomyopathies
- Various in vitro studies in cultured myocytes and other cells
- Studies in genetically modified animal models
Rescue, reversal, and attenuation
- of the phenotype in cultured cells in genetically modified animal models
The ongoing clinical research in our laboratory is:
- Recruitment and phenotyping of individuals and families with various genetic cardiovascular diseases
- Identification of diagnostic markers and biomarkers for various cardiovascular diseases
- Pharmacological intervention to prevent, attenuate and reverse the evolving phenotype in cardiomyopathies