CRS & Nasal Microbiome

CRS and Nasal Microbiome There is growing evidence that the nasal microbiome plays a major role in the development and course of CRS. Microbial diversity and composition have been linked to chronic sinonasal inflammation, and it is thus essential to understand how these alterations influence disease. We have shown microbial dysbiosis in CRS to be linked with reduced diversity and with microbial community imbalance, potentially to increase chronic mucosal inflammation as well as to add to greater symptoms. In response, this study measures longitudinal change in the nasal microbiome in subjects with CRS undergoing endoscopic sinus surgery (ESS) versus controls undergoing ESS for pituitary tumor resection to isolate surgery-related effects from disease-related alterations. This research aims to gain a deeper understanding of how therapeutic interventions, such as surgery, topical steroid irrigations, and proton pump inhibitors (PPIs), affect the nasal microbial ecosystem over the long term. Aids to the development of targeted microbiome-directed methods for the improvement of CRS management and patient outcomes can be gleaned from these findings.