Analysis for Common Cellular Targets

VEGFB COL18A1 FLT1 VEGF contraction apoptosis ROR1 NRCAM secretion assemble maturation metabolism CREG cell survival differentiation proliferation depolymerize mitogenesis CD44 - amplify amplify endocytosis integrity angiogenesis phospholipase C map kinase catabolism NPC1 - endocytosis NRCAM - maturation VEGFB - VEGF VEGFB - FLT1 NPC1 - integrity VEGFB - SERPINE1 GYPC - AKR1B1 COMP - cell survival AKAP12 - apoptosis CD44 - phospholipase C NTE - cell survival COMP - differentiation NTE - differentiation CD44 - map kinase VEGFB - angiogenesis DAF - phospholipase C HNMT - catabolism COMP - assemble ROR1 - differentiation AKAP12 - VEGF NSMAF - apoptosis MT1A - apoptosis ADH5 - catabolism CD44 - actin MAFG - apoptosis COMP - metabolism AKAP12 - SERPINE1 ALDH2 - maturation CD44 - depolymerize CREG - differentiation CD44 - angiogenesis HNMT - metabolism HNMT - secretion ADH5 - AKR1B1 CD44 - metabolism ADH5 - growth rate MT1A - phospholipase C MT1A - contraction MT1A — map kinase CD44 - apoptosis CD44 - mitogenesis KIF4A - assemble DAF - contraction HNRPC - apoptosis PGS1 - metabolism NEDD4 - apoptosis CREG - proliferation DSTN - depolymerize LSAMP - apoptosis NSE1 - proliferation PGS1 - differentiation COL18A1 - map kinase ARK5 - TP53 COL18A1 - FLT1 NSE1 - cell survival SLC40A1 - secretion RAC2 - contraction PGS1 - proliferation PON2 - secretion CD44 - endocytosis SGK - apoptosis RAC2 - apoptosis SLC40A1 - assemble CD44 - maturation COMP - secretion PGS1 - assemble DSP - assemble SGK - contraction AKR1C2 - metabolism NPC1 - amplify COMP - proliferation CD44 - assemble PFKFB3 - proliferation CD44 - cell survival COL18A1 - growth rate CD44 - contraction INPP1 - mitogenesis DSTN - actin PON2 - assemble CD44 - proliferation CD44 - differentiation MT1A - TP53 COL18A1 - apoptosis GYPC - apoptosis CD44 - secretion TRAP1 - apoptosis COL18A1 - contraction DAF - integrity growth rate actin NPC1 ARK5 PGS1 TRAP1 NSE1 NTE RAC2 PON2 INPP1 HNRPC GYPC SLC40A1 DSP DSTN AKR1B1 ADH5 NSMAF AKR1C2 PFKFB3 KIF4A AKAP12 HNMT MAFG DAF LSAMP ALDH2 SGK NEDD4 CD44 COMP TP53 SERPINE1 MT1A

FIGURE 3A. Analysis for common cellular targets. First 71 genes differentially expressed during class comparisons was used in this analysis (nominal p=0.006). Pathway Assist (Ariadne Genomics, Rockville, MD) a software tool for biological pathway analysis was used. It relies on ResNet, a database specifically targeted at the extracting data from the language of scientific abstracts from PubMed in order to identify relationships among genes, visualize pathways, gene regulation networks and protein interactions. This analysis used ResNet 3.0 (Medline August, 24,2004). To simplify the network, genes that could not be linked together were removed. Genes that are increased in SSc fibroblasts are colored red, and genes that are decreased colored pink. Cellular processes that  inserted by Pathway Assist to link the genetic networks are colored gray. The boxes on the arrows are hyperlinks indicating relationships of the genes and targets.

Analysis for Common Cellular Targets