Annotations – Comparative Gene Ontology (GO) Analysis – Page Three
| Gene Info | Sum Func | Function | Gene Ontology | Biocarta Pathways | Kegg Pathways |
|---|---|---|---|---|---|
| Unique id : H002487_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: receptor for the chemotactic and inflammatory peptide anaphylatoxin c5a. this receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. |
Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002585_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: putative receptor for purines coupled to g-proteins (by similarity). |
Gene Ontology:
biological process: molecular function: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002592_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. receptor for beta-endorphin. |
Gene Ontology:
biological process: biological process: cellular component: biological process: cellular component: cellular component: cellular component: molecular function: molecular function: biological process: molecular function: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002671_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM] |
SP Function: receptor for atrial natriuretic peptide. has guanylate cyclase activity on binding of anf. |
Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: molecular function: molecular function: cellular component: biological process: molecular function: biological process: biological process: biological process: molecular function: biological process: molecular function: molecular function: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002758_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: orphan receptor. could be a chemotactic peptide receptor. may have a function in bone metabolism. acts as a coreceptor for several siv strains (sivmac316, sivmac239, sivmacl7e-fr and sivsm62a), as well as a primary hiv-1 strain (92ug024-2). |
Gene Ontology:
molecular function: biological process: molecular function: biological process: biological process: cellular component: molecular function: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002813_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. |
SP Function: this is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. the activity of this receptor is mediated by g proteins that stimulate adenylate cyclase. |
Gene Ontology:
biological process: biological process: biological process: cellular component: molecular function: molecular function: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002884_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The family of natriuretic peptides (see MIM 108780) elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.[supplied by OMIM] |
SP Function: receptor for atrial natriuretic peptide. does not have guanylate cyclase activity. |
Gene Ontology:
cellular component: molecular function: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002976_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). IP10, Mig and I-TAC belong to the structural subfamily of CXC chemokines, in which a single amino acid residue separates the first two of four highly conserved Cys residues. Historically, CD183 is the third CXC chemokine receptor discovered and, therefore, commonly designated as CXCR3. Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. Signal transduction has not been further analyzed but may include the same enzymes that were identified in the signaling cascade induced by other chemokine receptors. As a consequence of chemokine-induced cellular desensitization (phosphorylation-dependent receptor internalization), cellular responses are typically rapid and short in duration. Cellular responsiveness is restored after dephosphorylation of intracellular receptors and subsequent recycling to the cell surface. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. Therefore, CD183 is a target for the development of small molecular weight antagonists, which may be used in the treatment of diverse inflammatory diseases. [PROW] |
SP Function: receptor for scyb9/mig, scyb10/inp10 and scyb11/itac. |
Gene Ontology:
molecular function: molecular function: biological process: biological process: biological process: biological process: biological process: cellular component: biological process: cellular component: molecular function: |
BioCarta Pathways:
1: IL12 and Stat4 Dependent Signaling Pathway in Th1 Development 2: mCalpain and friends in Cell motility 3: Selective expression of chemokine receptors during T-cell polarization 4: NO2-dependent IL 12 Pathway in NK cells |
KEGG Pathways: |
| Unique id : H003130_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. |
SP Function: receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. binding of il-8 to the receptor causes activation of neutrophils. this response is mediated via a g-protein that activate a phosphatidylinositol-calcium second messenger system. this receptor binds to il-8 with a high affinity and to gro/mgsa and nap-2 also with a high affinity. |
Gene Ontology:
biological process: biological process: biological process: biological process: biological process: cellular component: biological process: cellular component: molecular function: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003215_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: receptor for the c-x-c chemokine cxcl16. used as a coreceptor by sivs and by strains of hiv-2 and m-tropic hiv-1. |
Gene Ontology:
molecular function: molecular function: biological process: molecular function: cellular component: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003343_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. |
SP Function: receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: biological process: biological process: cellular component: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003424_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. |
SP Function: receptor for a c-c type chemokine. binds to eotaxin, eotaxin-3, mcp-3, mcp-4, rantes and mip-1 delta. subsequently transduces a signal by increasing the intracellular calcium ions level. alternative coreceptor with cd4 for hiv-1 infection. |
Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: biological process: biological process: biological process: cellular component: molecular function: |
BioCarta Pathways:
1: CCR3 signaling in Eosinophils 2: The Role of Eosinophils in the Chemokine Network of Allergy 3: IL 5 Signaling Pathway 4: Selective expression of chemokine receptors during T-cell polarization |
KEGG Pathways: |
| Unique id : H003535_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts |
SP Function: receptor for the hormone galanin. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: biological process: biological process: cellular component: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003654_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL2 is also a member of the protease-activated receptor family and activated by thrombin. F2RL2 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by thrombin. It mediates thrombin-triggered phosphoinositide hydrolysis and is expressed in a variety of tissues. |
SP Function: receptor for activated thrombin coupled to g proteins that stimulate phosphoinositide hydrolysis. |
Gene Ontology:
biological process: biological process: cellular component: molecular function: biological process: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003745_01 Name: Gene Symbol: Locus Link: 4886 Chromosome: |
Sum Func: | SP Function: receptor for neuropeptide y and peptide yy. the rank order of affinity of this receptor for pancreatic polypeptides is npy > [pro-34] pyy, pyy and [leu-31, pro-34] npy > npy (2-36) > [ile-31, gln-34] pp and pyy (3-36) > pp > npy free acid. |
Gene Ontology:
biological process: biological process: biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003791_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during atherosclerosis. |
SP Function: chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. signals through ccr2b and ccr3 receptors. plays a role in the accumulation of leukocytes at both sides of allergic and nonallergic inflammation. may be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. may play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: biological process: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003854_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene was identified as a gene specifically expressed in Burkitt’s lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein- coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse counterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist. |
SP Function: cytokine receptor that binds to blc. blr1 exerts possibly a regulatory function in burkitt lymphoma (bl) lymphomagenesis and/or b-cell differentiation. it is a potential candidate for cell-cell interaction, and activation of mature b- lymphocytes in lymphatic tissues. |
Gene Ontology:
biological process: molecular function: biological process: molecular function: biological process: cellular component: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003899_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. |
SP Function: receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-delta, rantes, and mcp-3 and, less efficiently, to mip-1- beta or mcp-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. responsible for affecting stem cell proliferation. |
Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: biological process: biological process: biological process: cellular component: molecular function: |
BioCarta Pathways:
1: Selective expression of chemokine receptors during T-cell polarization |
KEGG Pathways: |
| Unique id : H004053_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: cellular component: cellular component: molecular function: biological process: biological process: molecular function: molecular function: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H006487_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H006918_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: receptor for npaf (a-18-f-amide) and npff (f-8-f-amide) neuropeptides, also known as morphine-modulating peptides. can also be activated by a variety of naturally occurring or synthetic fmrf-amide like ligands. this receptor mediates its action by association with g proteins that activate a phosphatidylinositol- calcium second messenger system. |
Gene Ontology:
biological process: biological process: biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007494_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signaling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. |
SP Function: binds the receptor-associated protein (rap). may be involved in endosomal protein sorting. acts as a receptor for neurotensin. |
Gene Ontology:
biological process: cellular component: cellular component: biological process: cellular component: molecular function: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000696_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain), an helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. NPR2 is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. |
SP Function: receptor for atrial natriuretic peptide. has guanylate cyclase activity on binding of anf. seems to be stimulated more effectively by brain natriuretic peptide (bnp) than by anp. |
Gene Ontology:
molecular function: biological process: biological process: molecular function: cellular component: biological process: molecular function: molecular function: cellular component: biological process: molecular function: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010325_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. |
SP Function: | Gene Ontology:
molecular function: biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H014597_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: cellular component: molecular function: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H015053_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: biological process: biological process: cellular component: molecular function: molecular function: molecular function: biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H015702_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: G protein-coupled receptors (GPCRs), such as GPR44, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM] |
SP Function: orphan receptor. |
Gene Ontology:
biological process: molecular function: biological process: cellular component: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H015755_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. |
SP Function: receptor for a c-c type chemokine. binds to mip-1-alpha, mip-1-delta, rantes, and mcp-3 and, less efficiently, to mip-1- beta or mcp-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. responsible for affecting stem cell proliferation. |
Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: biological process: biological process: biological process: cellular component: molecular function: |
BioCarta Pathways:
1: Selective expression of chemokine receptors during T-cell polarization |
KEGG Pathways: |
| Unique id : H015778_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001491_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described. |
SP Function: regulatory subunit of the cyclin-dependent kinase pair (cdk9/cyclin t) complex, also called positive transcription elongation factor b (p-tefb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii). does not bind efficiently to the transactivation domain of the hiv-1 nuclear transcriptional activator, tat. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001738_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. |
SP Function: microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis. |
Gene Ontology:
biological process: molecular function: molecular function: cellular component: biological process: molecular function: molecular function: molecular function: molecular function: biological process: cellular component: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001967_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. Three alternatively spliced transcript variants, which encode distinct isoforms, have been reported. |
SP Function: essential for the control of the cell cycle at the late g1 and early s phase. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001988_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer’s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer’s disease. |
SP Function: p35 is a neuron specific activator of cdk5. the complex p35/cdk5 is required for neurite outgrowth and cortical lamination. activator of tpkii. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002149_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. |
SP Function: may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to dna damage. may bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: biological process: molecular function: biological process: cellular component: cellular component: molecular function: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: ATM Signaling Pathway 3: Effects of calcineurin in Keratinocyte Differentiation 4: Cyclins and Cell Cycle Regulation 5: Erythropoietin mediated neuroprotection through NF-kB 6: Cell Cycle: G1/S Check Point 7: Cell Cycle: G2/M Checkpoint 8: p53 Signaling Pathway 9: Hypoxia and p53 in the Cardiovascular system |
KEGG Pathways: |
| Unique id : H002371_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. |
SP Function: essential for the control of the cell cycle at the g2/m (mitosis) transition. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: AKAP95 role in mitosis and chromosome dynamics 2: Cyclins and Cell Cycle Regulation 3: Cell Cycle: G2/M Checkpoint 4: How Progesterone Initiates the Oocyte Maturation 5: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle 6: Activation of Src by Protein-tyrosine phosphatase alpha 7: Stathmin and breast cancer resistance to antimicrotubule agents |
KEGG Pathways: |
| Unique id : H002412_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. |
SP Function: probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2. |
Gene Ontology:
molecular function: biological process: biological process: molecular function: biological process: cellular component: biological process: cellular component: biological process: biological process: molecular function: biological process: molecular function: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: Cyclins and Cell Cycle Regulation 3: Cyclin E Destruction Pathway 4: Cell Cycle: G1/S Check Point 5: CDK Regulation of DNA Replication 6: Regulation of p27 Phosphorylation during Cell Cycle Progression 7: p53 Signaling Pathway 8: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage 9: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002606_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. |
SP Function: cyclin-dependent kinases (cdks) are activated by the binding to a cyclin and mediate the progression through the cell cycle. each different complex controls a specific transition between two subsequent phases in the cell cycle. cdk7 is the catalytic subunit of the cdk-activating kinase (cak) complex, a serine-threonine kinase. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive carboxyl-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle. |
Gene Ontology:
molecular function: biological process: molecular function: biological process: cellular component: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Degradation of the RAR and RXR by the proteasome |
KEGG Pathways: |
| Unique id : H000312_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for ‘menage a trois-1’) is involved in the assembly of the CAK complex.[supplied by OMIM] |
SP Function: stabilizes the cyclin h-cdk7 complex to form a functional cdk-activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive carboxyl-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: biological process: biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002740_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. |
SP Function: essential for the control of the cell cycle at the g1/s (start) and the g2/m (mitosis) transitions. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002889_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. |
SP Function: may play a role in growth regulation. is associated with g2/m phase arrest in response to dna damage. may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (by similarity). |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003048_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. |
SP Function: functions as a dosage-dependent inducer in mitotic control. it is a tyrosine protein phosphatase required for progression of the cell cycle. it directly dephosphorylates cdc2 and activate its kinase activity. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: molecular function: biological process: biological process: biological process: |
BioCarta Pathways:
1: How Progesterone Initiates the Oocyte Maturation 2: Regulation of cell cycle progression by Plk3 |
KEGG Pathways: |
| Unique id : H003192_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. |
SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: cellular component: biological process: biological process: biological process: molecular function: molecular function: cellular component: biological process: biological process: |
BioCarta Pathways:
1: CDK Regulation of DNA Replication |
KEGG Pathways: |
| Unique id : H003255_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. |
SP Function: co-chaperone that binds to numerous kinases and promotes their interaction with the hsp90 complex, resulting in stabilization and promotion of their activity. |
Gene Ontology:
biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003410_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
SP Function: interacts strongly with cdk4 and cdk6. inhibits their ability to interact with cyclins d. could act as a negative regulator of the proliferation of normal cells. |
Gene Ontology:
biological process: biological process: biological process: biological process: molecular function: molecular function: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis 2: Cyclins and Cell Cycle Regulation 3: CTCF: First Multivalent Nuclear Factor 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H003500_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. |
Gene Ontology:
biological process: molecular function: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003594_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate. |
SP Function: potent tight-binding inhibitor of several g1 cyclin/cdk complexes (cyclin e-cdk2, cyclin d2-cdk4, and cyclin a-cdk2) and, to lesser extent, of the mitotic cyclin b-cdc2. negative regulator of cell proliferation. may play a role in maintenance of the nonproliferative state throughout life. |
Gene Ontology:
biological process: biological process: biological process: molecular function: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003750_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
SP Function: interacts strongly with cdk4 and cdk6. potent inhibitor. potential effector of tgf-beta induced cell cycle arrest. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H003759_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. |
SP Function: interacts strongly with cdk4 and cdk6. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Cell Cycle: G2/M Checkpoint |
KEGG Pathways: |
| Unique id : H000463_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. |
SP Function: binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
Gene Ontology:
biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004911_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: molecular function: biological process: biological process: biological process: biological process: molecular function: cellular component: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007016_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
cellular component: molecular function: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007258_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. |
SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007565_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. This gene consists of 28 exons and its alternative splicing generates at least 3 transcript variants. |
SP Function: | Gene Ontology:
molecular function: biological process: molecular function: molecular function: biological process: biological process: molecular function: molecular function: molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H009291_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. This gene consists of 28 exons and its alternative splicing generates at least 3 transcript variants. |
SP Function: | Gene Ontology:
molecular function: biological process: molecular function: molecular function: biological process: biological process: molecular function: molecular function: molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010570_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined. |
SP Function: | Gene Ontology:
biological process: molecular function: biological process: cellular component: molecular function: biological process: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010633_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM] |
SP Function: | Gene Ontology:
biological process: cellular component: biological process: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001491_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described. |
SP Function: regulatory subunit of the cyclin-dependent kinase pair (cdk9/cyclin t) complex, also called positive transcription elongation factor b (p-tefb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii). does not bind efficiently to the transactivation domain of the hiv-1 nuclear transcriptional activator, tat. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001738_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. |
SP Function: microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis. |
Gene Ontology:
biological process: molecular function: molecular function: cellular component: biological process: molecular function: molecular function: molecular function: molecular function: biological process: cellular component: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001967_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. Three alternatively spliced transcript variants, which encode distinct isoforms, have been reported. |
SP Function: essential for the control of the cell cycle at the late g1 and early s phase. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001988_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer’s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer’s disease. |
SP Function: p35 is a neuron specific activator of cdk5. the complex p35/cdk5 is required for neurite outgrowth and cortical lamination. activator of tpkii. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001999_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
SP Function: essential for the control of the cell cycle at the g1/s (start) transition. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: BTG family proteins and cell cycle regulation 3: CARM1 and Regulation of the Estrogen Receptor 4: Cyclins and Cell Cycle Regulation 5: Cell Cycle: G1/S Check Point 6: Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages 7: p53 Signaling Pathway 8: WNT Signaling Pathway |
KEGG Pathways: |
| Unique id : H002149_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. |
SP Function: may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to dna damage. may bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: biological process: molecular function: biological process: cellular component: cellular component: molecular function: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: ATM Signaling Pathway 3: Effects of calcineurin in Keratinocyte Differentiation 4: Cyclins and Cell Cycle Regulation 5: Erythropoietin mediated neuroprotection through NF-kB 6: Cell Cycle: G1/S Check Point 7: Cell Cycle: G2/M Checkpoint 8: p53 Signaling Pathway 9: Hypoxia and p53 in the Cardiovascular system |
KEGG Pathways: |
| Unique id : H002232_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. |
SP Function: catalyzes the covalent attachment of ubiquitin to other proteins. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: molecular function: biological process: molecular function: |
BioCarta Pathways:
1: Cyclin E Destruction Pathway 2: Cell Cycle: G2/M Checkpoint 3: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002323_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. |
SP Function: essential for the control of the cell cycle at the g1/s (start) transition. |
Gene Ontology:
biological process: biological process: cellular component: cellular component: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: Cyclins and Cell Cycle Regulation 3: Cyclin E Destruction Pathway 4: Cell Cycle: G1/S Check Point 5: CDK Regulation of DNA Replication 6: Regulation of p27 Phosphorylation during Cell Cycle Progression 7: p53 Signaling Pathway 8: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002371_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. |
SP Function: essential for the control of the cell cycle at the g2/m (mitosis) transition. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: AKAP95 role in mitosis and chromosome dynamics 2: Cyclins and Cell Cycle Regulation 3: Cell Cycle: G2/M Checkpoint 4: How Progesterone Initiates the Oocyte Maturation 5: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle 6: Activation of Src by Protein-tyrosine phosphatase alpha 7: Stathmin and breast cancer resistance to antimicrotubule agents |
KEGG Pathways: |
| Unique id : H002412_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. |
SP Function: probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2. |
Gene Ontology:
molecular function: biological process: biological process: molecular function: biological process: cellular component: biological process: cellular component: biological process: biological process: molecular function: biological process: molecular function: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: Cyclins and Cell Cycle Regulation 3: Cyclin E Destruction Pathway 4: Cell Cycle: G1/S Check Point 5: CDK Regulation of DNA Replication 6: Regulation of p27 Phosphorylation during Cell Cycle Progression 7: p53 Signaling Pathway 8: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage 9: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002606_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. |
SP Function: cyclin-dependent kinases (cdks) are activated by the binding to a cyclin and mediate the progression through the cell cycle. each different complex controls a specific transition between two subsequent phases in the cell cycle. cdk7 is the catalytic subunit of the cdk-activating kinase (cak) complex, a serine-threonine kinase. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive carboxyl-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle. |
Gene Ontology:
molecular function: biological process: molecular function: biological process: cellular component: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Degradation of the RAR and RXR by the proteasome |
KEGG Pathways: |
| Unique id : H000312_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for ‘menage a trois-1’) is involved in the assembly of the CAK complex.[supplied by OMIM] |
SP Function: stabilizes the cyclin h-cdk7 complex to form a functional cdk-activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive carboxyl-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: biological process: biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002740_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. |
SP Function: essential for the control of the cell cycle at the g1/s (start) and the g2/m (mitosis) transitions. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002889_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. |
SP Function: may play a role in growth regulation. is associated with g2/m phase arrest in response to dna damage. may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (by similarity). |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003048_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. |
SP Function: functions as a dosage-dependent inducer in mitotic control. it is a tyrosine protein phosphatase required for progression of the cell cycle. it directly dephosphorylates cdc2 and activate its kinase activity. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: molecular function: biological process: biological process: biological process: |
BioCarta Pathways:
1: How Progesterone Initiates the Oocyte Maturation 2: Regulation of cell cycle progression by Plk3 |
KEGG Pathways: |
| Unique id : H003192_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. |
SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: cellular component: biological process: biological process: biological process: molecular function: molecular function: cellular component: biological process: biological process: |
BioCarta Pathways:
1: CDK Regulation of DNA Replication |
KEGG Pathways: |
| Unique id : H003207_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. |
SP Function: | Gene Ontology:
molecular function: molecular function: biological process: biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: biological process: biological process: molecular function: |
BioCarta Pathways:
1: Lissencephaly gene (LIS1) in neuronal migration and development 2: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis 3: ATM Signaling Pathway 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H003255_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. |
SP Function: co-chaperone that binds to numerous kinases and promotes their interaction with the hsp90 complex, resulting in stabilization and promotion of their activity. |
Gene Ontology:
biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003410_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
SP Function: interacts strongly with cdk4 and cdk6. inhibits their ability to interact with cyclins d. could act as a negative regulator of the proliferation of normal cells. |
Gene Ontology:
biological process: biological process: biological process: biological process: molecular function: molecular function: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis 2: Cyclins and Cell Cycle Regulation 3: CTCF: First Multivalent Nuclear Factor 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H000387_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of e3 ubiquitin ligase complexes, including the cbc(vhl) (cul2-elonging bc-vhl) complex, which mediates the ubiquitination of hypoxia-inducible factor (hif). may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. |
Gene Ontology:
biological process: biological process: biological process: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003500_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. |
Gene Ontology:
biological process: molecular function: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003594_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate. |
SP Function: potent tight-binding inhibitor of several g1 cyclin/cdk complexes (cyclin e-cdk2, cyclin d2-cdk4, and cyclin a-cdk2) and, to lesser extent, of the mitotic cyclin b-cdc2. negative regulator of cell proliferation. may play a role in maintenance of the nonproliferative state throughout life. |
Gene Ontology:
biological process: biological process: biological process: molecular function: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000401_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: promotes the exchange of ran-bound gdp by gtp. involved in the regulation of onset of chromosome condensation in the s phase. binds to the chromatin. rcc1/ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. |
Gene Ontology:
biological process: biological process: molecular function: biological process: molecular function: cellular component: molecular function: biological process: cellular component: cellular component: biological process: biological process: |
BioCarta Pathways:
1: Mechanism of Protein Import into the Nucleus 2: Role of Ran in mitotic spindle regulation 3: Cycling of Ran in nucleocytoplasmic transport |
KEGG Pathways: |
| Unique id : H003739_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. |
SP Function: plays a key role in the control of the eukaryotic cell cycle. it is required in higher cells for entry into s-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive carboxyl-terminus of rna polymerase ii. |
Gene Ontology:
molecular function: molecular function: biological process: biological process: cellular component: biological process: molecular function: molecular function: molecular function: biological process: |
BioCarta Pathways:
1: AKAP95 role in mitosis and chromosome dynamics 2: Protein Kinase A at the Centrosome 3: cdc25 and chk1 Regulatory Pathway in response to DNA damage 4: Cyclins and Cell Cycle Regulation 5: Cell Cycle: G1/S Check Point 6: Cell Cycle: G2/M Checkpoint 7: How Progesterone Initiates the Oocyte Maturation 8: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle 9: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage 10: Regulation of Splicing through Sam68 11: Activation of Src by Protein-tyrosine phosphatase alpha 12: Stathmin and breast cancer resistance to antimicrotubule agents |
KEGG Pathways: |
| Unique id : H003750_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
SP Function: interacts strongly with cdk4 and cdk6. potent inhibitor. potential effector of tgf-beta induced cell cycle arrest. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H003759_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. |
SP Function: interacts strongly with cdk4 and cdk6. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Cell Cycle: G2/M Checkpoint |
KEGG Pathways: |
| Unique id : H003894_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. |
SP Function: probable transcriptional activator that may be involved in dna damage-inducible cell cycle arrests (checkpoints). |
Gene Ontology:
biological process: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004513_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination |
SP Function: functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. |
Gene Ontology:
biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: cellular component: molecular function: molecular function: biological process: |
BioCarta Pathways:
1: Mechanism of Protein Import into the Nucleus 2: Role of Ran in mitotic spindle regulation |
KEGG Pathways: |
| Unique id : H000462_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000463_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. |
SP Function: binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
Gene Ontology:
biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004911_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: molecular function: biological process: biological process: biological process: biological process: molecular function: cellular component: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H005436_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. |
SP Function: probably involved in the control of the cell cycle. interacts with d-type g1 cyclins. |
Gene Ontology:
molecular function: biological process: biological process: biological process: molecular function: biological process: molecular function: |
BioCarta Pathways:
1: Estrogen-responsive protein Efp controls cell cycle and breast tumors growth 2: Influence of Ras and Rho proteins on G1 to S Transition 3: Cyclins and Cell Cycle Regulation 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H000606_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. |
SP Function: | Gene Ontology:
molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000607_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: involved in regulation of mammalian cell growth. |
Gene Ontology:
biological process: molecular function: molecular function: biological process: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007016_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
cellular component: molecular function: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007065_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: may be a transcription factor involved in regulating the expression of genes active in the s phase during cell cycle progression in t cells. may be involved in tumor progression (by similarity). represses ela2 transcription. |
Gene Ontology:
molecular function: biological process: molecular function: cellular component: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007258_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. |
SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007565_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. This gene consists of 28 exons and its alternative splicing generates at least 3 transcript variants. |
SP Function: | Gene Ontology:
molecular function: biological process: molecular function: molecular function: biological process: biological process: molecular function: molecular function: molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H008068_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of e3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. seems to be involved proteosomal degradation of p53/tp53 stimulated by adenovirus e1b-55 kda protein. may form a cell surface vasopressin receptor. |
Gene Ontology:
biological process: molecular function: biological process: biological process: biological process: molecular function: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H008496_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. |
Gene Ontology:
biological process: biological process: biological process: biological process: biological process: molecular function: biological process: |
BioCarta Pathways:
1: ER associated degradation (ERAD) Pathway 2: Cyclin E Destruction Pathway 3: Regulation of p27 Phosphorylation during Cell Cycle Progression 4: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H008575_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: may function in cell cycle regulation. |
Gene Ontology:
biological process: molecular function: molecular function: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H009086_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms. |
SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: |
BioCarta Pathways:
1: Cell Cycle: G1/S Check Point 2: Regulation of p27 Phosphorylation during Cell Cycle Progression 3: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H009232_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: molecular function: biological process: biological process: molecular function: molecular function: |
BioCarta Pathways:
1: Regulation of Splicing through Sam68 |
KEGG Pathways: |
| Unique id : H009291_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. This gene consists of 28 exons and its alternative splicing generates at least 3 transcript variants. |
SP Function: | Gene Ontology:
molecular function: biological process: molecular function: molecular function: biological process: biological process: molecular function: molecular function: molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H009950_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. |
SP Function: probable transcriptional activator that may be involved in dna damage-inducible cell cycle arrests (checkpoints). |
Gene Ontology:
biological process: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010570_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined. |
SP Function: | Gene Ontology:
biological process: molecular function: biological process: cellular component: molecular function: biological process: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010633_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM] |
SP Function: | Gene Ontology:
biological process: cellular component: biological process: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H013919_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products. |
SP Function: co-chaperone of hsc70. |
Gene Ontology:
biological process: cellular component: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001491_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin and its kinase partner CDK9 were found to be subunits of the transcription elongation factor p-TEFb. The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. Two alternatively spliced transcript variants, which encode distinct isoforms, have been described. |
SP Function: regulatory subunit of the cyclin-dependent kinase pair (cdk9/cyclin t) complex, also called positive transcription elongation factor b (p-tefb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the ctd (carboxy-terminal domain) of the large subunit of rna polymerase ii (rnap ii). does not bind efficiently to the transactivation domain of the hiv-1 nuclear transcriptional activator, tat. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001738_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Four alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. |
SP Function: microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze gtp. most probably involved in vesicular trafficking processes, in particular endocytosis. |
Gene Ontology:
biological process: molecular function: molecular function: cellular component: biological process: molecular function: molecular function: molecular function: molecular function: biological process: cellular component: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001967_01 Name: Cyclin E2 Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. Three alternatively spliced transcript variants, which encode distinct isoforms, have been reported. |
SP Function: essential for the control of the cell cycle at the late g1 and early s phase. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001988_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer’s disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer’s disease. |
SP Function: p35 is a neuron specific activator of cdk5. the complex p35/cdk5 is required for neurite outgrowth and cortical lamination. activator of tpkii. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001999_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. |
SP Function: essential for the control of the cell cycle at the g1/s (start) transition. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: BTG family proteins and cell cycle regulation 3: CARM1 and Regulation of the Estrogen Receptor 4: Cyclins and Cell Cycle Regulation 5: Cell Cycle: G1/S Check Point 6: Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages 7: p53 Signaling Pathway 8: WNT Signaling Pathway |
KEGG Pathways: |
| Unique id : H002149_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. |
SP Function: may be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to dna damage. may bind to and inhibit cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: biological process: molecular function: biological process: cellular component: cellular component: molecular function: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: ATM Signaling Pathway 3: Effects of calcineurin in Keratinocyte Differentiation 4: Cyclins and Cell Cycle Regulation 5: Erythropoietin mediated neuroprotection through NF-kB 6: Cell Cycle: G1/S Check Point 7: Cell Cycle: G2/M Checkpoint 8: p53 Signaling Pathway 9: Hypoxia and p53 in the Cardiovascular system |
KEGG Pathways: |
| Unique id : H002232_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. |
SP Function: catalyzes the covalent attachment of ubiquitin to other proteins. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: molecular function: biological process: molecular function: |
BioCarta Pathways:
1: Cyclin E Destruction Pathway 2: Cell Cycle: G2/M Checkpoint 3: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002323_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. |
SP Function: essential for the control of the cell cycle at the g1/s (start) transition. |
Gene Ontology:
biological process: biological process: cellular component: cellular component: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: Cyclins and Cell Cycle Regulation 3: Cyclin E Destruction Pathway 4: Cell Cycle: G1/S Check Point 5: CDK Regulation of DNA Replication 6: Regulation of p27 Phosphorylation during Cell Cycle Progression 7: p53 Signaling Pathway 8: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002371_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. |
SP Function: essential for the control of the cell cycle at the g2/m (mitosis) transition. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: AKAP95 role in mitosis and chromosome dynamics 2: Cyclins and Cell Cycle Regulation 3: Cell Cycle: G2/M Checkpoint 4: How Progesterone Initiates the Oocyte Maturation 5: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle 6: Activation of Src by Protein-tyrosine phosphatase alpha 7: Stathmin and breast cancer resistance to antimicrotubule agents |
KEGG Pathways: |
| Unique id : H002412_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. |
SP Function: probably involved in the control of the cell cycle. interacts with cyclins a, b3, d, or e. activity of cdk2 is maximal during s phase and g2. |
Gene Ontology:
molecular function: biological process: biological process: molecular function: biological process: cellular component: biological process: cellular component: biological process: biological process: molecular function: biological process: molecular function: biological process: |
BioCarta Pathways:
1: Influence of Ras and Rho proteins on G1 to S Transition 2: Cyclins and Cell Cycle Regulation 3: Cyclin E Destruction Pathway 4: Cell Cycle: G1/S Check Point 5: CDK Regulation of DNA Replication 6: Regulation of p27 Phosphorylation during Cell Cycle Progression 7: p53 Signaling Pathway 8: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage 9: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H002606_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. |
SP Function: cyclin-dependent kinases (cdks) are activated by the binding to a cyclin and mediate the progression through the cell cycle. each different complex controls a specific transition between two subsequent phases in the cell cycle. cdk7 is the catalytic subunit of the cdk-activating kinase (cak) complex, a serine-threonine kinase. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive carboxyl-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. its expression and activity are constant throughout the cell cycle. |
Gene Ontology:
molecular function: biological process: molecular function: biological process: cellular component: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Degradation of the RAR and RXR by the proteasome |
KEGG Pathways: |
| Unique id : H000312_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for ‘menage a trois-1’) is involved in the assembly of the CAK complex.[supplied by OMIM] |
SP Function: stabilizes the cyclin h-cdk7 complex to form a functional cdk-activating kinase (cak) enzymatic complex. cak activates the cyclin-associated kinases cdc2/cdk1, cdk2, cdk4 and cdk6 by threonine phosphorylation. cak complexed to the core-tfiih basal transcription factor activates rna polymerase ii by serine phosphorylation of the repetitive carboxyl-terminus domain (ctd) of its large subunit (polr2a), allowing its escape from the promoter and elongation of the transcripts. involved in cell cycle control and in rna transcription by rna polymerase ii. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: biological process: biological process: cellular component: molecular function: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002740_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. |
SP Function: essential for the control of the cell cycle at the g1/s (start) and the g2/m (mitosis) transitions. |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002889_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. |
SP Function: may play a role in growth regulation. is associated with g2/m phase arrest in response to dna damage. may be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation (by similarity). |
Gene Ontology:
biological process: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003048_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. |
SP Function: functions as a dosage-dependent inducer in mitotic control. it is a tyrosine protein phosphatase required for progression of the cell cycle. it directly dephosphorylates cdc2 and activate its kinase activity. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: molecular function: biological process: biological process: biological process: |
BioCarta Pathways:
1: How Progesterone Initiates the Oocyte Maturation 2: Regulation of cell cycle progression by Plk3 |
KEGG Pathways: |
| Unique id : H003192_01 Name: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. |
SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: cellular component: biological process: biological process: biological process: molecular function: molecular function: cellular component: biological process: biological process: |
BioCarta Pathways:
1: CDK Regulation of DNA Replication |
KEGG Pathways: |
| Unique id : H003207_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. |
SP Function: | Gene Ontology:
molecular function: molecular function: biological process: biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: biological process: biological process: molecular function: |
BioCarta Pathways:
1: Lissencephaly gene (LIS1) in neuronal migration and development 2: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis 3: ATM Signaling Pathway 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H003255_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. |
SP Function: co-chaperone that binds to numerous kinases and promotes their interaction with the hsp90 complex, resulting in stabilization and promotion of their activity. |
Gene Ontology:
biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003410_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
SP Function: interacts strongly with cdk4 and cdk6. inhibits their ability to interact with cyclins d. could act as a negative regulator of the proliferation of normal cells. |
Gene Ontology:
biological process: biological process: biological process: biological process: molecular function: molecular function: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Tumor Suppressor Arf Inhibits Ribosomal Biogenesis 2: Cyclins and Cell Cycle Regulation 3: CTCF: First Multivalent Nuclear Factor 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H000387_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of e3 ubiquitin ligase complexes, including the cbc(vhl) (cul2-elonging bc-vhl) complex, which mediates the ubiquitination of hypoxia-inducible factor (hif). may serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. |
Gene Ontology:
biological process: biological process: biological process: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003500_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of the core-tfiih basal transcription factor involved in nucleotide excision repair (ner) of dna and, when complexed to cak, in rna transcription by rna polymerase ii. |
Gene Ontology:
biological process: molecular function: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003594_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate. |
SP Function: potent tight-binding inhibitor of several g1 cyclin/cdk complexes (cyclin e-cdk2, cyclin d2-cdk4, and cyclin a-cdk2) and, to lesser extent, of the mitotic cyclin b-cdc2. negative regulator of cell proliferation. may play a role in maintenance of the nonproliferative state throughout life. |
Gene Ontology:
biological process: biological process: biological process: molecular function: biological process: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000401_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: promotes the exchange of ran-bound gdp by gtp. involved in the regulation of onset of chromosome condensation in the s phase. binds to the chromatin. rcc1/ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. |
Gene Ontology:
biological process: biological process: molecular function: biological process: molecular function: cellular component: molecular function: biological process: cellular component: cellular component: biological process: biological process: |
BioCarta Pathways:
1: Mechanism of Protein Import into the Nucleus 2: Role of Ran in mitotic spindle regulation 3: Cycling of Ran in nucleocytoplasmic transport |
KEGG Pathways: |
| Unique id : H003739_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. |
SP Function: plays a key role in the control of the eukaryotic cell cycle. it is required in higher cells for entry into s-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive carboxyl-terminus of rna polymerase ii. |
Gene Ontology:
molecular function: molecular function: biological process: biological process: cellular component: biological process: molecular function: molecular function: molecular function: biological process: |
BioCarta Pathways:
1: AKAP95 role in mitosis and chromosome dynamics 2: Protein Kinase A at the Centrosome 3: cdc25 and chk1 Regulatory Pathway in response to DNA damage 4: Cyclins and Cell Cycle Regulation 5: Cell Cycle: G1/S Check Point 6: Cell Cycle: G2/M Checkpoint 7: How Progesterone Initiates the Oocyte Maturation 8: Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle 9: RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage 10: Regulation of Splicing through Sam68 11: Activation of Src by Protein-tyrosine phosphatase alpha 12: Stathmin and breast cancer resistance to antimicrotubule agents |
KEGG Pathways: |
| Unique id : H003750_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. |
SP Function: interacts strongly with cdk4 and cdk6. potent inhibitor. potential effector of tgf-beta induced cell cycle arrest. |
Gene Ontology:
biological process: biological process: molecular function: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H003759_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. |
SP Function: interacts strongly with cdk4 and cdk6. |
Gene Ontology:
biological process: biological process: molecular function: cellular component: biological process: biological process: cellular component: biological process: |
BioCarta Pathways:
1: Cyclins and Cell Cycle Regulation 2: Cell Cycle: G2/M Checkpoint |
KEGG Pathways: |
| Unique id : H003894_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. |
SP Function: probable transcriptional activator that may be involved in dna damage-inducible cell cycle arrests (checkpoints). |
Gene Ontology:
biological process: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004513_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination |
SP Function: functions in nuclear protein import as an adapter protein for nuclear receptor kpnb1. binds specifically and directly to substrates containing either a simple or bipartite nls motif. docking of the importin/substrate complex to the nuclear pore complex (npc) is mediated by kpnb1 through binding to nucleoporin fxfg repeats and the complex is subsequently translocated through the pore by an energy requiring, ran- dependent mechanism. at the nucleoplasmic side of the npc, ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where gtp hydrolysis releases ran from importin. the directionality of nuclear import is thought to be conferred by an asymmetric distribution of the gtp- and gdp-bound forms of ran between the cytoplasm and nucleus. |
Gene Ontology:
biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: cellular component: molecular function: molecular function: biological process: |
BioCarta Pathways:
1: Mechanism of Protein Import into the Nucleus 2: Role of Ran in mitotic spindle regulation |
KEGG Pathways: |
| Unique id : H000462_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000463_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. |
SP Function: binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. |
Gene Ontology:
biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004911_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: molecular function: biological process: biological process: biological process: biological process: molecular function: cellular component: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H005436_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. |
SP Function: probably involved in the control of the cell cycle. interacts with d-type g1 cyclins. |
Gene Ontology:
molecular function: biological process: biological process: biological process: molecular function: biological process: molecular function: |
BioCarta Pathways:
1: Estrogen-responsive protein Efp controls cell cycle and breast tumors growth 2: Influence of Ras and Rho proteins on G1 to S Transition 3: Cyclins and Cell Cycle Regulation 4: Cell Cycle: G1/S Check Point |
KEGG Pathways: |
| Unique id : H000606_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes. |
SP Function: | Gene Ontology:
molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000607_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: involved in regulation of mammalian cell growth. |
Gene Ontology:
biological process: molecular function: molecular function: biological process: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007016_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
cellular component: molecular function: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007065_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: may be a transcription factor involved in regulating the expression of genes active in the s phase during cell cycle progression in t cells. may be involved in tumor progression (by similarity). represses ela2 transcription. |
Gene Ontology:
molecular function: biological process: molecular function: cellular component: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007258_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called cullins, which may also be involved in ubiquitin-mediated degradation. |
SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H007565_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. This gene consists of 28 exons and its alternative splicing generates at least 3 transcript variants. |
SP Function: | Gene Ontology:
molecular function: biological process: molecular function: molecular function: biological process: biological process: molecular function: molecular function: molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H008068_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: component of e3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. seems to be involved proteosomal degradation of p53/tp53 stimulated by adenovirus e1b-55 kda protein. may form a cell surface vasopressin receptor. |
Gene Ontology:
biological process: molecular function: biological process: biological process: biological process: molecular function: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H008496_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: essential component of the scf (skp1-cul1-f-box protein) e3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. in the scf complex, serves as a rigid scaffold that organizes the skp1-f-box protein and rbx1 subunits. may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. |
Gene Ontology:
biological process: biological process: biological process: biological process: biological process: molecular function: biological process: |
BioCarta Pathways:
1: ER associated degradation (ERAD) Pathway 2: Cyclin E Destruction Pathway 3: Regulation of p27 Phosphorylation during Cell Cycle Progression 4: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H008575_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: may function in cell cycle regulation. |
Gene Ontology:
biological process: molecular function: molecular function: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H009086_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates 2 transcript variants encoding different isoforms. |
SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: |
BioCarta Pathways:
1: Cell Cycle: G1/S Check Point 2: Regulation of p27 Phosphorylation during Cell Cycle Progression 3: E2F1 Destruction Pathway |
KEGG Pathways: |
| Unique id : H009232_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: molecular function: biological process: biological process: molecular function: molecular function: |
BioCarta Pathways:
1: Regulation of Splicing through Sam68 |
KEGG Pathways: |
| Unique id : H009291_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. This gene consists of 28 exons and its alternative splicing generates at least 3 transcript variants. |
SP Function: | Gene Ontology:
molecular function: biological process: molecular function: molecular function: biological process: biological process: molecular function: molecular function: molecular function: biological process: biological process: cellular component: biological process: cellular component: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H009950_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Checkpoint suppressor 1 is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. |
SP Function: probable transcriptional activator that may be involved in dna damage-inducible cell cycle arrests (checkpoints). |
Gene Ontology:
biological process: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010570_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. Multiple transcript variants exist for this gene, but the full-length natures of only two have been determined. |
SP Function: | Gene Ontology:
biological process: molecular function: biological process: cellular component: molecular function: biological process: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010633_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM] |
SP Function: | Gene Ontology:
biological process: cellular component: biological process: biological process: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H013919_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products. |
SP Function: co-chaperone of hsc70. |
Gene Ontology:
biological process: cellular component: biological process: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001599_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: nociceptin is the ligand of the opioid receptor-like receptor (oprl1). it may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. may be involved in neuronal differentiation and development (by similarity). |
Gene Ontology:
cellular component: molecular function: biological process: molecular function: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001668_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: acts as a molecular chaperone for pcsk2/pc2, preventing its premature activation in the regulated secretory pathway. binds to inactive pcsk2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. also required for cleavage of pcsk2 but does not appear to be involved in its folding. plays a role in regulating pituitary hormone secretion. the c-terminal peptide inhibits pcsk2 in vitro. |
Gene Ontology:
molecular function: molecular function: molecular function: biological process: biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H001844_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: stimulates smooth muscle contraction in a manner similar to that of bombesin. |
Gene Ontology:
biological process: molecular function: biological process: biological process: cellular component: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002042_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a member of the polycystin protein family. Expression of this gene has been linked to the Beta-catenin/TCF pathway. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains, and a cytoplasmic C-tail. The encoded protein may undergo cleavage at a G protein coupled receptor proteolytic site in a process that requires the receptor for egg jelly domain. This protein may function as an integral membrane protein involved in cell-cell/matrix interactions and may modulate intracellular calcium homoeostasis and other signal-transduction pathways. The encoded protein plays a role in renal tubular development. Interactions of this protein with polycystin 2 produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease. An alternative splice variant has been described but its biological nature has not been determined. Six pseudogenes have been described and are closely linked in a known duplicated region on chromosome 16p. |
SP Function: may be an ion-channel regulator. pkd1 and pkd2 may function through a common signaling pathway that is necessary for normal tubulogenesis. involved in adhesive protein-protein and protein-carbohydrate interactions. |
Gene Ontology:
biological process: biological process: cellular component: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002661_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. |
SP Function: could be involved in cell-cell interactions. |
Gene Ontology:
molecular function: molecular function: biological process: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H002750_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: npy is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. |
Gene Ontology:
molecular function: biological process: molecular function: biological process: cellular component: biological process: biological process: biological process: biological process: cellular component: biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003343_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. |
SP Function: receptor for the hormone galanin. the activity of this receptor is mediated by g proteins that inhibit adenylate cyclase activity. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: biological process: biological process: cellular component: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H003535_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts |
SP Function: receptor for the hormone galanin. |
Gene Ontology:
biological process: molecular function: cellular component: biological process: biological process: biological process: cellular component: molecular function: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004053_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
biological process: biological process: biological process: biological process: cellular component: cellular component: molecular function: biological process: biological process: molecular function: molecular function: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H004690_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: molecular function: cellular component: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H000542_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. |
SP Function: | Gene Ontology:
molecular function: molecular function: biological process: biological process: biological process: cellular component: biological process: molecular function: |
BioCarta Pathways:
|
KEGG Pathways: |
| Unique id : H006549_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: Agouti-related protein is an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via melanocortin receptor and/or intracellular calcium regulation. Agouti-related protein is alternatively spliced into 2 variants which differ in 5′ untranslated sequence length. |
SP Function: plays a role in weight homeostasis. may play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding. |
Gene Ontology:
cellular component: biological process: biological process: molecular function: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H008262_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: cellular component: molecular function: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H009033_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: stimulates muscle contractions of specific regions of the gastrointestinal tract. in humans, nmu stimulates contractions of the ileum and urinary bladder. |
Gene Ontology:
biological process: biological process: molecular function: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H010640_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: cellular component: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H011324_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. |
SP Function: neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. a broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. orexin-a binds to both ox1r and ox2r with a high affinity, whereas orexin-b binds only to ox2r with a similar high affinity. |
Gene Ontology:
biological process: biological process: biological process: cellular component: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H011887_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
cellular component: biological process: biological process: molecular function: cellular component: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H012342_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: cellular component: biological process: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H013560_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: G protein-coupled receptors (GPCRs) are the largest superfamily of related proteins. All have 7-transmembrane (TM) segments and allow cells to sample and respond to their environment. VLGR1 is a large, calcium-binding GPCR expressed in the central nervous system (CNS).[supplied by OMIM] |
SP Function: | Gene Ontology:
molecular function: molecular function: biological process: biological process: cellular component: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H014371_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: G protein-coupled receptors (GPCRs) are the largest superfamily of related proteins. All have 7-transmembrane (TM) segments and allow cells to sample and respond to their environment. VLGR1 is a large, calcium-binding GPCR expressed in the central nervous system (CNS).[supplied by OMIM] |
SP Function: | Gene Ontology:
molecular function: molecular function: biological process: biological process: cellular component: biological process: biological process: molecular function: |
BioCarta Pathways: | KEGG Pathways: |
| Unique id : H014648_01 Name: Gene Symbol: Locus Link: Chromosome: |
Sum Func: | SP Function: | Gene Ontology:
molecular function: biological process: biological process: biological process: biological process: biological process: biological process: cellular component: biological process: biological process: biological process: biological process: biological process: biological process: |
BioCarta Pathways: | KEGG Pathways: |