Gene Ontology Comparison Results

Number of investigated GO categories: 1200

GO categories which discriminate among classes:

Table – Sorted by p-value of the LS permutation test.
The first 12 GO categories are significant at the nominal 0.01 level of the LS permutation test or KS permutation test

	GO category	GO description	Number of genes	LS Permutation p-value	KS Permutation p-value
1	5581	collagen	18	0.00289	0.01794
2	5201	extracellular matrix structural constituent	35	0.00612	0.02334
3	776	kinetochore	9	0.00655	0.00447
4	6401	RNA catabolism	9	0.00701	0.14152
5	5520	insulin-like growth factor binding	7	0.00806	0.04783
6	4252	serine-type endopeptidase activity	33	0.01633	0.00489
7	8287	protein serine/threonine phosphatase complex	16	0.04178	0.00162
8	4295	trypsin activity	25	0.04551	0.00922
9	43087	regulation of GTPase activity	6	0.05519	0.00484
10	6687	glycosphingolipid metabolism	6	0.20802	0.00758
11	30148	sphingolipid biosynthesis	5	0.218	0.00791
12	6664	glycolipid metabolism	8	0.24384	0.00228

Table Significant GO categories consist of the following genes:

	GO category	GO description	Qiagen Oligo ID	Description	GB acc	UG cluster	Gene symbol	Geometric mean of ratios in Norm	Geometric mean of ratios in SSc	Fold difference of Geometric means	p-value
1	5581	collagen	H001909_01	Collagen, type IV, alpha 2	X05610 (external link)	75617	COL4A2 (external link)	0.774	1.455	1.88	0.16588
2	5581	collagen	H001981_01	Collagen, type VI, alpha 3	X52022 (external link)	80988	COL6A3 (external link)	13.102	14.887	1.14	0.3969
3	5581	collagen	H002090_01	Collagen, type XVI, alpha 1	M92642 (external link)	26208	COL16A1 (external link)	1.487	0.807	0.54	0.01286
4	5581	collagen	H002160_01	Collagen, type V, alpha 2	Y14690 (external link)	82985	COL5A2 (external link)	2.909	7.335	2.52	0.02257
5	5581	collagen	H002647_01	Collagen, type XV, alpha 1	L25286 (external link)	83164	COL15A1 (external link)	2.556	1.679	0.66	0.06883
6	5581	collagen	H002655_01	Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)	L02870 (external link)	1640	COL7A1 (external link)	1.353	1.381	1.02	0.90084
7	5581	collagen	H002915_01	Collagen, type VIII, alpha 1	X57527 (external link)	114599	COL8A1 (external link)	1.699	4.652	2.74	0.00779
8	5581	collagen	H002994_01	Collagen, type XVIII, alpha 1	AF018081 (external link)	78409	COL18A1 (external link)	1.233	1.081	0.88	0.55803
9	5581	collagen	H003072_01	Collagen, type I, alpha 2	J03464 (external link)	179573	COL1A2 (external link)	2.917	9.772	3.35	0.00199
10	5581	collagen	H003413_01	Lumican	U21128 (external link)	79914	LUM (external link)	5.429	6.831	1.26	0.38015
11	5581	collagen	H003504_01	Collagen, type I, alpha 1	Z74615 (external link)	172928	COL1A1 (external link)	1.499	1.334	0.89	0.5702
12	5581	collagen	H003593_01	Collagen, type VI, alpha 2	AL096746 (external link)	159263	COL6A2 (external link)	11.306	8.367	0.74	0.19054
13	5581	collagen	H006623_01	Homo sapiens clone HB-2 mRNA sequence	AF216077 (external link)	48376		1.078	1.072	0.99	0.98024
14	5581	collagen	H000708_01	Collagen, type XIX, alpha 1	D38163 (external link)	89457	COL19A1 (external link)	1.008	1.613	1.60	0.15001
15	5581	collagen	H000774_01	Collagen, type VI, alpha 1	X15880 (external link)	108885	COL6A1 (external link)	7.419	14.402	1.94	0.01162
16	5581	collagen	H012686_01	Collagen, type XIII, alpha 1	NM_005203 (external link)	211933	COL13A1 (external link)	3.087	6.268	2.03	0.12493
17	5581	collagen	H015060_01	Smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64	NM_020351 (external link)	283100	LOC57086 (external link)	0.419	0.612	1.46	0.01543
18	5581	collagen	H001198_01	Homo sapiens, alpha-1 (VI) collagen	M20776 (external link)	25459		7.041	6.65	0.94	0.79953
19	5201	extracellular matrix structural constituent	H001909_01	Collagen, type IV, alpha 2	X05610 (external link)	75617	COL4A2 (external link)	0.774	1.455	1.88	0.16588
20	5201	extracellular matrix structural constituent	H001981_01	Collagen, type VI, alpha 3	X52022 (external link)	80988	COL6A3 (external link)	13.102	14.887	1.14	0.3969
21	5201	extracellular matrix structural constituent	H002090_01	Collagen, type XVI, alpha 1	M92642 (external link)	26208	COL16A1 (external link)	1.487	0.807	0.54	0.01286
22	5201	extracellular matrix structural constituent	H002143_01	Fibrillin 1 (Marfan syndrome)	X63556 (external link)	750	FBN1 (external link)	8.277	5.989	0.72	0.1062
23	5201	extracellular matrix structural constituent	H002160_01	Collagen, type V, alpha 2	Y14690 (external link)	82985	COL5A2 (external link)	2.909	7.335	2.52	0.02257
24	5201	extracellular matrix structural constituent	H002196_01	Nidogen (enactin)	M30269 (external link)	62041	NID (external link)	1.534	1.486	0.97	0.80662
25	5201	extracellular matrix structural constituent	H002647_01	Collagen, type XV, alpha 1	L25286 (external link)	83164	COL15A1 (external link)	2.556	1.679	0.66	0.06883
26	5201	extracellular matrix structural constituent	H002655_01	Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)	L02870 (external link)	1640	COL7A1 (external link)	1.353	1.381	1.02	0.90084
27	5201	extracellular matrix structural constituent	H002915_01	Collagen, type VIII, alpha 1	X57527 (external link)	114599	COL8A1 (external link)	1.699	4.652	2.74	0.00779
28	5201	extracellular matrix structural constituent	H002994_01	Collagen, type XVIII, alpha 1	AF018081 (external link)	78409	COL18A1 (external link)	1.233	1.081	0.88	0.55803
29	5201	extracellular matrix structural constituent	H003066_01	Biglycan	J04599 (external link)	821	BGN (external link)	3.118	3.278	1.05	0.87448
30	5201	extracellular matrix structural constituent	H003072_01	Collagen, type I, alpha 2	J03464 (external link)	179573	COL1A2 (external link)	2.917	9.772	3.35	0.00199
31	5201	extracellular matrix structural constituent	H003413_01	Lumican	U21128 (external link)	79914	LUM (external link)	5.429	6.831	1.26	0.38015
32	5201	extracellular matrix structural constituent	H003504_01	Collagen, type I, alpha 1	Z74615 (external link)	172928	COL1A1 (external link)	1.499	1.334	0.89	0.5702
33	5201	extracellular matrix structural constituent	H003593_01	Collagen, type VI, alpha 2	AL096746 (external link)	159263	COL6A2 (external link)	11.306	8.367	0.74	0.19054
34	5201	extracellular matrix structural constituent	H004275_01	Elastin microfibril interface located protein	AL050138 (external link)	63348	EMILIN (external link)	1.261	1.004	0.80	0.16069
35	5201	extracellular matrix structural constituent	H005515_01	EGF-containing fibulin-like extracellular matrix protein 2	AJ132819 (external link)	6059	EFEMP2 (external link)	5.651	4.95	0.88	0.56638
36	5201	extracellular matrix structural constituent	H006167_01	Mucin 4, tracheobronchial	AJ242549 (external link)	198267	MUC4 (external link)	1.088	1.118	1.03	0.87749
37	5201	extracellular matrix structural constituent	H006182_01	Matrilin 3	AJ224741 (external link)	278461	MATN3 (external link)	1.019	0.762	0.75	0.04621
38	5201	extracellular matrix structural constituent	H006243_01	Matrilin 4	AJ007581 (external link)	278489	MATN4 (external link)	1.13	1.322	1.17	0.55955
39	5201	extracellular matrix structural constituent	H006623_01	Homo sapiens clone HB-2 mRNA sequence	AF216077 (external link)	48376		1.078	1.072	0.99	0.98024
40	5201	extracellular matrix structural constituent	H000708_01	Collagen, type XIX, alpha 1	D38163 (external link)	89457	COL19A1 (external link)	1.008	1.613	1.60	0.15001
41	5201	extracellular matrix structural constituent	H000774_01	Collagen, type VI, alpha 1	X15880 (external link)	108885	COL6A1 (external link)	7.419	14.402	1.94	0.01162
42	5201	extracellular matrix structural constituent	H011464_01	Microfibrillar-associated protein 3	AL049404 (external link)	28785	MFAP3 (external link)	1.662	1.851	1.11	0.59568
43	5201	extracellular matrix structural constituent	H012686_01	Collagen, type XIII, alpha 1	NM_005203 (external link)	211933	COL13A1 (external link)	3.087	6.268	2.03	0.12493
44	5201	extracellular matrix structural constituent	H000992_01	Fibulin 2	X82494 (external link)	198862	FBLN2 (external link)	19.293	19.864	1.03	0.92471
45	5201	extracellular matrix structural constituent	H013067_01	Amelogenin (Y chromosome)	M86933 (external link)	1238	AMELY (external link)	1.331	1.265	0.95	0.79442
46	5201	extracellular matrix structural constituent	H014507_01	P3ECSL	NM_022164 (external link)	173508	LIECG3 (external link)	0.929	0.847	0.91	0.51546
47	5201	extracellular matrix structural constituent	H015060_01	Smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64	NM_020351 (external link)	283100	LOC57086 (external link)	0.419	0.612	1.46	0.01543
48	5201	extracellular matrix structural constituent	H001146_01	Opticin	AJ133790 (external link)	241413	OPTC (external link)	2.525	5.605	2.22	0.06954
49	5201	extracellular matrix structural constituent	H001149_01	Microfibrillar-associated protein 2	U19718 (external link)	83551	MFAP2 (external link)	3.978	6.902	1.74	0.00148
50	5201	extracellular matrix structural constituent	H001198_01	Homo sapiens, alpha-1 (VI) collagen	M20776 (external link)	25459		7.041	6.65	0.94	0.79953
51	5201	extracellular matrix structural constituent	H001200_01	Microfibril-associated glycoprotein-2	NM_003480 (external link)	300946	MAGP2 (external link)	10.634	11.229	1.06	0.87915
52	5201	extracellular matrix structural constituent	H016066_01	Homo sapiens mRNA for MSF-FN70 (FN gene)	AJ276395 (external link)	321592		6.836	13.007	1.90	0.07589
53	5201	extracellular matrix structural constituent	H016249_01	Homo sapiens, Similar to laminin, alpha 4, clone MGC:10389, mRNA, complete CDS	BC004241 (external link)	327703		1.019	0.689	0.68	0.05838
54	776	kinetochore	H002651_01	Presenilin 1 (Alzheimer disease 3)	L76517 (external link)	3260	PSEN1 (external link)	1.674	1.337	0.80	0.38047
55	776	kinetochore	H003796_01	Centromere protein F (350/400kD, mitosin)	U30872 (external link)	77204	CENPF (external link)	0.908	1.193	1.31	0.40243
56	776	kinetochore	H004455_01	SMT3 (suppressor of mif two 3, yeast) homolog 1	X99584 (external link)	85119	SMT3H1 (external link)	1.312	0.851	0.65	0.03052
57	776	kinetochore	H000555_01	MAD2 (mitotic arrest deficient, yeast, homolog)-like 1	U65410 (external link)	79078	MAD2L1 (external link)	3.691	14.522	3.93	0.00753
58	776	kinetochore	H007906_01	Kinesin-like 4	AB017430 (external link)	119324	KNSL4 (external link)	0.484	0.313	0.65	0.15055
59	776	kinetochore	H009464_01	Centromere protein F (350/400kD, mitosin)	NM_016343 (external link)	77204	CENPF (external link)	0.806	0.968	1.20	0.10591
60	776	kinetochore	H010859_01	BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog	AF047472 (external link)	40323	BUB3 (external link)	0.88	0.571	0.65	0.01436
61	776	kinetochore	H014640_01	Kinetochore protein CENP-H	NM_022909 (external link)	200395	CENPH (external link)	0.515	0.361	0.70	0.16289
62	776	kinetochore	H001444_01	Dynactin 2 (p50)	U50733 (external link)	84153	DCTN2 (external link)	1.693	2.254	1.33	0.05946
63	6401	RNA catabolism	H001873_01	Zinc finger protein homologous to Zfp-36 in mouse	M92843 (external link)	1665	ZFP36 (external link)	1.293	1.109	0.86	0.47715
64	6401	RNA catabolism	H004497_01	KIAA0116 protein	D29958 (external link)	182877	KIAA0116 (external link)	0.341	0.537	1.57	0.00154
65	6401	RNA catabolism	H006056_01	Regulator of nonsense transcripts 1	D86988 (external link)	12719	RENT1 (external link)	1.267	1.299	1.03	0.90558
66	6401	RNA catabolism	H006885_01	Ribonuclease 6 precursor	NM_003730 (external link)	8297	RNASE6PL (external link)	0.712	0.438	0.62	0.03907
67	6401	RNA catabolism	H008151_01	Heat shock 70kD protein 1B	NM_005346 (external link)	274402	HSPA1B (external link)	1.036	0.533	0.51	0.01103
68	6401	RNA catabolism	H008749_01	PRO2047 protein	NM_014110 (external link)	284136	PRO2047 (external link)	0.948	1.128	1.19	0.35127
69	6401	RNA catabolism	H010646_01	Ribonuclease 6 precursor	AK001769 (external link)	8297	RNASE6PL (external link)	0.862	0.836	0.97	0.71042
70	6401	RNA catabolism	H010958_01	Poly(A)-binding protein, cytoplasmic 4 (inducible form)	U75686 (external link)	169900	PABPC4 (external link)	1.3	0.758	0.58	0.00593
71	6401	RNA catabolism	H011931_01	Protein phosphatase 1, regulatory (inhibitor) subunit 8	U14575 (external link)	78961	PPP1R8 (external link)	1.351	0.949	0.70	0.21242
72	5520	insulin-like growth factor binding	H002800_01	Connective tissue growth factor	X78947 (external link)	75511	CTGF (external link)	3.098	14.225	4.59	0.00073
73	5520	insulin-like growth factor binding	H003420_01	Insulin-like growth factor binding protein 6	M62402 (external link)	274313	IGFBP6 (external link)	2.297	1.431	0.62	0.06015
74	5520	insulin-like growth factor binding	H003735_01	Insulin-like growth factor binding protein 5	AF055033 (external link)	107169	IGFBP5 (external link)	1.33	1.69	1.27	0.46462
75	5520	insulin-like growth factor binding	H003777_01	Insulin-like growth factor binding protein 2 (36kD)	X16302 (external link)	162	IGFBP2 (external link)	0.195	0.401	2.06	0.09799
76	5520	insulin-like growth factor binding	H000589_01	Cysteine-rich, angiogenic inducer, 61	Y11307 (external link)	8867	CYR61 (external link)	5.224	7.438	1.42	0.31927
77	5520	insulin-like growth factor binding	H007289_01	Insulin-like growth factor binding protein 7	S75725 (external link)	119206	IGFBP7 (external link)	1.036	1.769	1.71	0.20545
78	5520	insulin-like growth factor binding	H012536_01	Human insulin-like growth factor binding protein 5 (IGFBP5) mRNA	L27560 (external link)	103391		0.841	1.699	2.02	0.02933
79	4252	serine-type endopeptidase activity	H001768_01	Protease, serine, 2 (trypsin 2)	M27602 (external link)	241561	PRSS2 (external link)	0.224	0.131	0.58	0.23624
80	4252	serine-type endopeptidase activity	H001780_01	Protease, serine, 4 (trypsin 4, brain)	X72781 (external link)	58247	PRSS4 (external link)	0.566	0.794	1.40	0.28828
81	4252	serine-type endopeptidase activity	H001785_01	Hepsin (transmembrane protease, serine 1)	X07732 (external link)	823	HPN (external link)	0.834	1.882	2.26	0.01749
82	4252	serine-type endopeptidase activity	H001797_01	Protease, serine, 1 (trypsin 1)	M22612 (external link)	241395	PRSS1 (external link)	2.029	2.174	1.07	0.5579
83	4252	serine-type endopeptidase activity	H001828_01	Pancreatic elastase IIB	M16653 (external link)	169234	LOC51032 (external link)	1.085	1.765	1.63	0.12304
84	4252	serine-type endopeptidase activity	H001830_01	Transmembrane protease, serine 2	U75329 (external link)	318545	TMPRSS2 (external link)	1.334	1.114	0.84	0.54555
85	4252	serine-type endopeptidase activity	H001920_01	Coagulation factor VII (serum prothrombin conversion accelerator)	M13232 (external link)	36989	F7 (external link)	0.98	1.638	1.67	0.05764
86	4252	serine-type endopeptidase activity	H001925_01	Granzyme M (lymphocyte met-ase 1)	NM_005317 (external link)	268531	GZMM (external link)	0.644	1.061	1.65	0.03318
87	4252	serine-type endopeptidase activity	H002030_01	Tryptase, alpha	M30038 (external link)	278528	TPS1 (external link)	1.225	0.924	0.75	0.07983
88	4252	serine-type endopeptidase activity	H002188_01	Lipoprotein, Lp(a)	X06290 (external link)	119520	LPA (external link)	0.655	1.066	1.63	0.06567
89	4252	serine-type endopeptidase activity	H002460_01	Plasminogen activator, tissue	M15518 (external link)	274404	PLAT (external link)	0.852	0.76	0.89	0.58882
90	4252	serine-type endopeptidase activity	H002509_01	D component of complement (adipsin)	M84526 (external link)	155597	DF (external link)	1.468	0.957	0.65	0.02192
91	4252	serine-type endopeptidase activity	H002528_01	Granzyme K (serine protease, granzyme 3; tryptase II)	U26174 (external link)	3066	GZMK (external link)	0.919	1.163	1.27	0.33764
92	4252	serine-type endopeptidase activity	H002553_01	Serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),	M14083 (external link)	82085	SERPINE1 (external link)	0.841	1.12	1.33	0.01068
93	4252	serine-type endopeptidase activity	H002605_01	Mannan-binding lectin serine protease 2	X98400 (external link)	119983	MASP2 (external link)	0.608	0.51	0.84	0.42079
94	4252	serine-type endopeptidase activity	H002927_01	Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2	Y00630 (external link)	75716	SERPINB2 (external link)	0.558	0.682	1.22	0.60481
95	4252	serine-type endopeptidase activity	H003011_01	Complement component 1, s subcomponent	J04080 (external link)	169756	C1S (external link)	16.305	18.098	1.11	0.78389
96	4252	serine-type endopeptidase activity	H003053_01	Kallikrein 11	AB012917 (external link)	57771	KLK11 (external link)	0.416	0.554	1.33	0.27282
97	4252	serine-type endopeptidase activity	H003287_01	Kallikrein 5	NM_012427 (external link)	50915	KLK5 (external link)	1.005	1.643	1.63	0.08562
98	4252	serine-type endopeptidase activity	H003337_01	B-factor, properdin	L15702 (external link)	69771	BF (external link)	0.614	0.963	1.57	0.11883
99	4252	serine-type endopeptidase activity	H003368_01	Kallikrein 1, renal/pancreas/salivary	M25629 (external link)	123107	KLK1 (external link)	0.86	0.863	1.00	0.9892
100	4252	serine-type endopeptidase activity	H003754_01	ClpP (caseinolytic protease, ATP-dependent, proteolytic subunit, E. coli) homolog	Z50853 (external link)	74362	CLPP (external link)	1.219	0.922	0.76	0.0866
101	4252	serine-type endopeptidase activity	H003865_01	Lactotransferrin	X53961 (external link)	105938	LTF (external link)	0.65	0.466	0.72	0.17982
102	4252	serine-type endopeptidase activity	H003877_01	Paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)	X17094 (external link)	59242	PACE (external link)	1.199	0.917	0.76	0.21199
103	4252	serine-type endopeptidase activity	H004648_01	Tryptase gamma 1	NM_012467 (external link)	278275	TPSG1 (external link)	0.816	1.161	1.42	0.06632
104	4252	serine-type endopeptidase activity	H000491_01	Proprotein convertase subtilisin/kexin type 7	U33849 (external link)	32978	PCSK7 (external link)	1.697	1.141	0.67	0.01513
105	4252	serine-type endopeptidase activity	H005647_01	Membrane-bound transcription factor protease, site 1	D42053 (external link)	75890	MBTPS1 (external link)	1.72	2.046	1.19	0.61228
106	4252	serine-type endopeptidase activity	H006381_01	Protease, serine, 23	AF015287 (external link)	325820	SPUVE (external link)	1.423	2.047	1.44	0.18652
107	4252	serine-type endopeptidase activity	H007042_01	Complement C1r-like proteinase precursor,	AF178985 (external link)	98571	LOC51279 (external link)	1.077	0.984	0.91	0.48438
108	4252	serine-type endopeptidase activity	H013087_01	Rhomboid (veinlet, Drosophila)-like	Y17108 (external link)	137572	RHBDL (external link)	0.891	0.853	0.96	0.86092
109	4252	serine-type endopeptidase activity	H015697_01	Transmembrane protease, serine 3	NM_024022 (external link)	298241	TMPRSS3 (external link)	0.984	0.702	0.71	0.11262
110	4252	serine-type endopeptidase activity	H001308_01	Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)	X55668 (external link)	928	PRTN3 (external link)	0.819	1.211	1.48	0.216
111	4252	serine-type endopeptidase activity	H001448_01	HtrA-like serine protease	NM_013247 (external link)	115721	OMI (external link)	1.18	1.41	1.19	0.18541
112	8287	protein serine/threonine phosphatase complex	H002974_01	KIAA0015 gene product	D13640 (external link)	278441	KIAA0015 (external link)	1.756	1.368	0.78	0.23236
113	8287	protein serine/threonine phosphatase complex	H003020_01	Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform	S87759 (external link)	57764	PPM1A (external link)	2.483	4.223	1.70	0.1493
114	8287	protein serine/threonine phosphatase complex	H003074_01	Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	M64929 (external link)	179574	PPP2R2A (external link)	0.9	0.594	0.66	0.17157
115	8287	protein serine/threonine phosphatase complex	H003642_01	Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	Y13936 (external link)	17883	PPM1G (external link)	0.759	0.902	1.19	0.29144
116	8287	protein serine/threonine phosphatase complex	H000413_01	Protein phosphatase 2, regulatory subunit B (B56), epsilon isoform	L76703 (external link)	173328	PPP2R5E (external link)	1.03	0.825	0.80	0.24141
117	8287	protein serine/threonine phosphatase complex	H000464_01	Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform	M65254 (external link)	108705	PPP2R1B (external link)	1.156	1.334	1.15	0.47031
118	8287	protein serine/threonine phosphatase complex	H005412_01	Protein phosphatase 2, regulatory subunit B (B56), delta isoform	L76702 (external link)	118244	PPP2R5D (external link)	1.372	1.085	0.79	0.21517
119	8287	protein serine/threonine phosphatase complex	H006260_01	Protein phosphatase 2A 48 kDa regulatory subunit	NM_013239 (external link)	124942	PR48 (external link)	0.8	0.978	1.22	0.40781
120	8287	protein serine/threonine phosphatase complex	H000599_01	Protein phosphatase 1D magnesium-dependent, delta isoform	U78305 (external link)	100980	PPM1D (external link)	1.16	0.724	0.62	0.15614
121	8287	protein serine/threonine phosphatase complex	H000617_01	Protein phosphatase 2, regulatory subunit B (B56), beta isoform	L42374 (external link)	75199	PPP2R5B (external link)	1.334	2.159	1.62	0.15054
122	8287	protein serine/threonine phosphatase complex	H000644_01	Protein phosphatase 2, regulatory subunit B (B56), alpha isoform	L42373 (external link)	155079	PPP2R5A (external link)	0.581	0.802	1.38	0.12309
123	8287	protein serine/threonine phosphatase complex	H008583_01	Homo sapiens mRNA; cDNA DKFZp761E0711 (from clone DKFZp761E0711)	AL157449 (external link)	110095		1.677	1.242	0.74	0.1797
124	8287	protein serine/threonine phosphatase complex	H010455_01	KIAA1348 protein	AB037769 (external link)	232696	KIAA1348 (external link)	1.084	0.986	0.91	0.23445
125	8287	protein serine/threonine phosphatase complex	H014726_01	Pyruvate dehydrogenase phosphatase	NM_018444 (external link)	22265	PDP (external link)	1.946	1.113	0.57	0.00658
126	8287	protein serine/threonine phosphatase complex	H001703_01	Protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), bet	L07590 (external link)	28219	PPP2R3 (external link)	1.489	1.204	0.81	0.40966
127	8287	protein serine/threonine phosphatase complex	H001704_01	Protein phosphatase 2, regulatory subunit B (B56), gamma isoform	U37352 (external link)	171734	PPP2R5C (external link)	1.056	1.61	1.52	0.01011
128	4295	trypsin activity	H001768_01	Protease, serine, 2 (trypsin 2)	M27602 (external link)	241561	PRSS2 (external link)	0.224	0.131	0.58	0.23624
129	4295	trypsin activity	H001780_01	Protease, serine, 4 (trypsin 4, brain)	X72781 (external link)	58247	PRSS4 (external link)	0.566	0.794	1.40	0.28828
130	4295	trypsin activity	H001785_01	Hepsin (transmembrane protease, serine 1)	X07732 (external link)	823	HPN (external link)	0.834	1.882	2.26	0.01749
131	4295	trypsin activity	H001797_01	Protease, serine, 1 (trypsin 1)	M22612 (external link)	241395	PRSS1 (external link)	2.029	2.174	1.07	0.5579
132	4295	trypsin activity	H001828_01	Pancreatic elastase IIB	M16653 (external link)	169234	LOC51032 (external link)	1.085	1.765	1.63	0.12304
133	4295	trypsin activity	H001830_01	Transmembrane protease, serine 2	U75329 (external link)	318545	TMPRSS2 (external link)	1.334	1.114	0.84	0.54555
134	4295	trypsin activity	H001920_01	Coagulation factor VII (serum prothrombin conversion accelerator)	M13232 (external link)	36989	F7 (external link)	0.98	1.638	1.67	0.05764
135	4295	trypsin activity	H001925_01	Granzyme M (lymphocyte met-ase 1)	NM_005317 (external link)	268531	GZMM (external link)	0.644	1.061	1.65	0.03318
136	4295	trypsin activity	H002030_01	Tryptase, alpha	M30038 (external link)	278528	TPS1 (external link)	1.225	0.924	0.75	0.07983
137	4295	trypsin activity	H002188_01	Lipoprotein, Lp(a)	X06290 (external link)	119520	LPA (external link)	0.655	1.066	1.63	0.06567
138	4295	trypsin activity	H002460_01	Plasminogen activator, tissue	M15518 (external link)	274404	PLAT (external link)	0.852	0.76	0.89	0.58882
139	4295	trypsin activity	H002509_01	D component of complement (adipsin)	M84526 (external link)	155597	DF (external link)	1.468	0.957	0.65	0.02192
140	4295	trypsin activity	H002528_01	Granzyme K (serine protease, granzyme 3; tryptase II)	U26174 (external link)	3066	GZMK (external link)	0.919	1.163	1.27	0.33764
141	4295	trypsin activity	H002605_01	Mannan-binding lectin serine protease 2	X98400 (external link)	119983	MASP2 (external link)	0.608	0.51	0.84	0.42079
142	4295	trypsin activity	H003011_01	Complement component 1, s subcomponent	J04080 (external link)	169756	C1S (external link)	16.305	18.098	1.11	0.78389
143	4295	trypsin activity	H003053_01	Kallikrein 11	AB012917 (external link)	57771	KLK11 (external link)	0.416	0.554	1.33	0.27282
144	4295	trypsin activity	H003287_01	Kallikrein 5	NM_012427 (external link)	50915	KLK5 (external link)	1.005	1.643	1.63	0.08562
145	4295	trypsin activity	H003337_01	B-factor, properdin	L15702 (external link)	69771	BF (external link)	0.614	0.963	1.57	0.11883
146	4295	trypsin activity	H003368_01	Kallikrein 1, renal/pancreas/salivary	M25629 (external link)	123107	KLK1 (external link)	0.86	0.863	1.00	0.9892
147	4295	trypsin activity	H004648_01	Tryptase gamma 1	NM_012467 (external link)	278275	TPSG1 (external link)	0.816	1.161	1.42	0.06632
148	4295	trypsin activity	H006381_01	Protease, serine, 23	AF015287 (external link)	325820	SPUVE (external link)	1.423	2.047	1.44	0.18652
149	4295	trypsin activity	H007042_01	Complement C1r-like proteinase precursor,	AF178985 (external link)	98571	LOC51279 (external link)	1.077	0.984	0.91	0.48438
150	4295	trypsin activity	H015697_01	Transmembrane protease, serine 3	NM_024022 (external link)	298241	TMPRSS3 (external link)	0.984	0.702	0.71	0.11262
151	4295	trypsin activity	H001308_01	Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)	X55668 (external link)	928	PRTN3 (external link)	0.819	1.211	1.48	0.216
152	4295	trypsin activity	H001448_01	HtrA-like serine protease	NM_013247 (external link)	115721	OMI (external link)	1.18	1.41	1.19	0.18541
153	43087	regulation of GTPase activity	H004224_01	Hypothetical protein FLJ10767	AK001629 (external link)	25584	FLJ10767 (external link)	1.675	1.3	0.78	0.04097
154	43087	regulation of GTPase activity	H004509_01	KIAA0782 protein	AB018325 (external link)	21264	KIAA0782 (external link)	1.008	0.783	0.78	0.1811
155	43087	regulation of GTPase activity	H008446_01	KIAA0167 gene product	D79989 (external link)	184884	KIAA0167 (external link)	0.828	0.72	0.87	0.28232
156	43087	regulation of GTPase activity	H009484_01	G protein-coupled receptor kinase-interactor 1	NM_014030 (external link)	318339	GIT1 (external link)	0.932	1.279	1.37	0.16443
157	43087	regulation of GTPase activity	H001587_01	GDP dissociation inhibitor 1	X79353 (external link)	74576	GDI1 (external link)	1.606	1.015	0.63	0.03322
158	43087	regulation of GTPase activity	H001635_01	GDP dissociation inhibitor 2	Y13286 (external link)	56845	GDI2 (external link)	1.474	1.137	0.77	0.12277
159	6687	glycosphingolipid metabolism	H003235_01	GM2 ganglioside activator protein	X62078 (external link)	69743	GM2A (external link)	1.515	1.201	0.79	0.31178
160	6687	glycosphingolipid metabolism	H004193_01	Sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)	AB018356 (external link)	225939	SIAT9 (external link)	1.124	0.714	0.64	0.07436
161	6687	glycosphingolipid metabolism	H006323_01	CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI	AB035173 (external link)	109672	VI (external link)	3.293	2.391	0.73	0.27588
162	6687	glycosphingolipid metabolism	H000076_01	UDP-glucose ceramide glucosyltransferase	D50840 (external link)	152601	UGCG (external link)	1.149	1.557	1.36	0.27117
163	6687	glycosphingolipid metabolism	H000887_01	Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)	J03077 (external link)	78575	PSAP (external link)	5.938	4.713	0.79	0.08217
164	6687	glycosphingolipid metabolism	H001450_01	Globotriaosylceramide/CD77 synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl	NM_017436 (external link)	105956	A14GALT (external link)	3.059	2.119	0.69	0.26431
165	30148	sphingolipid biosynthesis	H004193_01	Sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)	AB018356 (external link)	225939	SIAT9 (external link)	1.124	0.714	0.64	0.07436
166	30148	sphingolipid biosynthesis	H006323_01	CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI	AB035173 (external link)	109672	VI (external link)	3.293	2.391	0.73	0.27588
167	30148	sphingolipid biosynthesis	H000076_01	UDP-glucose ceramide glucosyltransferase	D50840 (external link)	152601	UGCG (external link)	1.149	1.557	1.36	0.27117
168	30148	sphingolipid biosynthesis	H015734_01	Sphingosine kinase type 2 isoform	AL136701 (external link)	301305	SPHK2 (external link)	1.457	0.927	0.64	0.1341
169	30148	sphingolipid biosynthesis	H001450_01	Globotriaosylceramide/CD77 synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl	NM_017436 (external link)	105956	A14GALT (external link)	3.059	2.119	0.69	0.26431
170	6664	glycolipid metabolism	H003235_01	GM2 ganglioside activator protein	X62078 (external link)	69743	GM2A (external link)	1.515	1.201	0.79	0.31178
171	6664	glycolipid metabolism	H004193_01	Sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)	AB018356 (external link)	225939	SIAT9 (external link)	1.124	0.714	0.64	0.07436
172	6664	glycolipid metabolism	H006323_01	CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI	AB035173 (external link)	109672	VI (external link)	3.293	2.391	0.73	0.27588
173	6664	glycolipid metabolism	H006408_01	Alpha2,3-sialyltransferase	AK001922 (external link)	34578	ST3GALVI (external link)	0.717	0.581	0.81	0.33202
174	6664	glycolipid metabolism	H000076_01	UDP-glucose ceramide glucosyltransferase	D50840 (external link)	152601	UGCG (external link)	1.149	1.557	1.36	0.27117
175	6664	glycolipid metabolism	H000887_01	Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)	J03077 (external link)	78575	PSAP (external link)	5.938	4.713	0.79	0.08217
176	6664	glycolipid metabolism	H001148_01	Galactosylceramidase (Krabbe disease)	NM_000153 (external link)	273	GALC (external link)	1.388	1.872	1.35	0.2603
177	6664	glycolipid metabolism	H001450_01	Globotriaosylceramide/CD77 synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl	NM_017436 (external link)	105956	A14GALT (external link)	3.059	2.119	0.69	0.26431