Gene Ontology Comparison Results

Number of investigated GO categories: 1200

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GO categories which discriminate among classes:

Table – Sorted by p-value of the LS permutation test.
The first 12 GO categories are significant at the nominal 0.01 level of the LS permutation test or KS permutation test

	GO category	GO description	Number of genes	LS Permutation p-value	KS Permutation p-value
1	5581	collagen	18	0.00289	0.01794
2	5201	extracellular matrix structural constituent	35	0.00612	0.02334
3	776	kinetochore	9	0.00655	0.00447
4	6401	RNA catabolism	9	0.00701	0.14152
5	5520	insulin-like growth factor binding	7	0.00806	0.04783
6	4252	serine-type endopeptidase activity	33	0.01633	0.00489
7	8287	protein serine/threonine phosphatase complex	16	0.04178	0.00162
8	4295	trypsin activity	25	0.04551	0.00922
9	43087	regulation of GTPase activity	6	0.05519	0.00484
10	6687	glycosphingolipid metabolism	6	0.20802	0.00758
11	30148	sphingolipid biosynthesis	5	0.218	0.00791
12	6664	glycolipid metabolism	8	0.24384	0.00228

Table Significant GO categories consist of the following genes:

	GO category	GO description	Qiagen Oligo ID	Description	GB acc	UG cluster	Gene symbol	Geometric mean of ratios in Norm	Geometric mean of ratios in SSc	Fold difference of Geometric means	p-value
1	5581	collagen	H001909_01	Collagen, type IV, alpha 2	X05610	75617	COL4A2	0.774	1.455	1.88	0.16588
2	5581	collagen	H001981_01	Collagen, type VI, alpha 3	X52022	80988	COL6A3	13.102	14.887	1.14	0.3969
3	5581	collagen	H002090_01	Collagen, type XVI, alpha 1	M92642	26208	COL16A1	1.487	0.807	0.54	0.01286
4	5581	collagen	H002160_01	Collagen, type V, alpha 2	Y14690	82985	COL5A2	2.909	7.335	2.52	0.02257
5	5581	collagen	H002647_01	Collagen, type XV, alpha 1	L25286	83164	COL15A1	2.556	1.679	0.66	0.06883
6	5581	collagen	H002655_01	Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)	L02870	1640	COL7A1	1.353	1.381	1.02	0.90084
7	5581	collagen	H002915_01	Collagen, type VIII, alpha 1	X57527	114599	COL8A1	1.699	4.652	2.74	0.00779
8	5581	collagen	H002994_01	Collagen, type XVIII, alpha 1	AF018081	78409	COL18A1	1.233	1.081	0.88	0.55803
9	5581	collagen	H003072_01	Collagen, type I, alpha 2	J03464	179573	COL1A2	2.917	9.772	3.35	0.00199
10	5581	collagen	H003413_01	Lumican	U21128	79914	LUM	5.429	6.831	1.26	0.38015
11	5581	collagen	H003504_01	Collagen, type I, alpha 1	Z74615	172928	COL1A1	1.499	1.334	0.89	0.5702
12	5581	collagen	H003593_01	Collagen, type VI, alpha 2	AL096746	159263	COL6A2	11.306	8.367	0.74	0.19054
13	5581	collagen	H006623_01	Homo sapiens clone HB-2 mRNA sequence	AF216077	48376		1.078	1.072	0.99	0.98024
14	5581	collagen	H000708_01	Collagen, type XIX, alpha 1	D38163	89457	COL19A1	1.008	1.613	1.60	0.15001
15	5581	collagen	H000774_01	Collagen, type VI, alpha 1	X15880	108885	COL6A1	7.419	14.402	1.94	0.01162
16	5581	collagen	H012686_01	Collagen, type XIII, alpha 1	NM_005203	211933	COL13A1	3.087	6.268	2.03	0.12493
17	5581	collagen	H015060_01	Smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64	NM_020351	283100	LOC57086	0.419	0.612	1.46	0.01543
18	5581	collagen	H001198_01	Homo sapiens, alpha-1 (VI) collagen	M20776	25459		7.041	6.65	0.94	0.79953
19	5201	extracellular matrix structural constituent	H001909_01	Collagen, type IV, alpha 2	X05610	75617	COL4A2	0.774	1.455	1.88	0.16588
20	5201	extracellular matrix structural constituent	H001981_01	Collagen, type VI, alpha 3	X52022	80988	COL6A3	13.102	14.887	1.14	0.3969
21	5201	extracellular matrix structural constituent	H002090_01	Collagen, type XVI, alpha 1	M92642	26208	COL16A1	1.487	0.807	0.54	0.01286
22	5201	extracellular matrix structural constituent	H002143_01	Fibrillin 1 (Marfan syndrome)	X63556	750	FBN1	8.277	5.989	0.72	0.1062
23	5201	extracellular matrix structural constituent	H002160_01	Collagen, type V, alpha 2	Y14690	82985	COL5A2	2.909	7.335	2.52	0.02257
24	5201	extracellular matrix structural constituent	H002196_01	Nidogen (enactin)	M30269	62041	NID	1.534	1.486	0.97	0.80662
25	5201	extracellular matrix structural constituent	H002647_01	Collagen, type XV, alpha 1	L25286	83164	COL15A1	2.556	1.679	0.66	0.06883
26	5201	extracellular matrix structural constituent	H002655_01	Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive)	L02870	1640	COL7A1	1.353	1.381	1.02	0.90084
27	5201	extracellular matrix structural constituent	H002915_01	Collagen, type VIII, alpha 1	X57527	114599	COL8A1	1.699	4.652	2.74	0.00779
28	5201	extracellular matrix structural constituent	H002994_01	Collagen, type XVIII, alpha 1	AF018081	78409	COL18A1	1.233	1.081	0.88	0.55803
29	5201	extracellular matrix structural constituent	H003066_01	Biglycan	J04599	821	BGN	3.118	3.278	1.05	0.87448
30	5201	extracellular matrix structural constituent	H003072_01	Collagen, type I, alpha 2	J03464	179573	COL1A2	2.917	9.772	3.35	0.00199
31	5201	extracellular matrix structural constituent	H003413_01	Lumican	U21128	79914	LUM	5.429	6.831	1.26	0.38015
32	5201	extracellular matrix structural constituent	H003504_01	Collagen, type I, alpha 1	Z74615	172928	COL1A1	1.499	1.334	0.89	0.5702
33	5201	extracellular matrix structural constituent	H003593_01	Collagen, type VI, alpha 2	AL096746	159263	COL6A2	11.306	8.367	0.74	0.19054
34	5201	extracellular matrix structural constituent	H004275_01	Elastin microfibril interface located protein	AL050138	63348	EMILIN	1.261	1.004	0.80	0.16069
35	5201	extracellular matrix structural constituent	H005515_01	EGF-containing fibulin-like extracellular matrix protein 2	AJ132819	6059	EFEMP2	5.651	4.95	0.88	0.56638
36	5201	extracellular matrix structural constituent	H006167_01	Mucin 4, tracheobronchial	AJ242549	198267	MUC4	1.088	1.118	1.03	0.87749
37	5201	extracellular matrix structural constituent	H006182_01	Matrilin 3	AJ224741	278461	MATN3	1.019	0.762	0.75	0.04621
38	5201	extracellular matrix structural constituent	H006243_01	Matrilin 4	AJ007581	278489	MATN4	1.13	1.322	1.17	0.55955
39	5201	extracellular matrix structural constituent	H006623_01	Homo sapiens clone HB-2 mRNA sequence	AF216077	48376		1.078	1.072	0.99	0.98024
40	5201	extracellular matrix structural constituent	H000708_01	Collagen, type XIX, alpha 1	D38163	89457	COL19A1	1.008	1.613	1.60	0.15001
41	5201	extracellular matrix structural constituent	H000774_01	Collagen, type VI, alpha 1	X15880	108885	COL6A1	7.419	14.402	1.94	0.01162
42	5201	extracellular matrix structural constituent	H011464_01	Microfibrillar-associated protein 3	AL049404	28785	MFAP3	1.662	1.851	1.11	0.59568
43	5201	extracellular matrix structural constituent	H012686_01	Collagen, type XIII, alpha 1	NM_005203	211933	COL13A1	3.087	6.268	2.03	0.12493
44	5201	extracellular matrix structural constituent	H000992_01	Fibulin 2	X82494	198862	FBLN2	19.293	19.864	1.03	0.92471
45	5201	extracellular matrix structural constituent	H013067_01	Amelogenin (Y chromosome)	M86933	1238	AMELY	1.331	1.265	0.95	0.79442
46	5201	extracellular matrix structural constituent	H014507_01	P3ECSL	NM_022164	173508	LIECG3	0.929	0.847	0.91	0.51546
47	5201	extracellular matrix structural constituent	H015060_01	Smooth muscle cell-expressed and macrophage conditioned medium-induced protein smag-64	NM_020351	283100	LOC57086	0.419	0.612	1.46	0.01543
48	5201	extracellular matrix structural constituent	H001146_01	Opticin	AJ133790	241413	OPTC	2.525	5.605	2.22	0.06954
49	5201	extracellular matrix structural constituent	H001149_01	Microfibrillar-associated protein 2	U19718	83551	MFAP2	3.978	6.902	1.74	0.00148
50	5201	extracellular matrix structural constituent	H001198_01	Homo sapiens, alpha-1 (VI) collagen	M20776	25459		7.041	6.65	0.94	0.79953
51	5201	extracellular matrix structural constituent	H001200_01	Microfibril-associated glycoprotein-2	NM_003480	300946	MAGP2	10.634	11.229	1.06	0.87915
52	5201	extracellular matrix structural constituent	H016066_01	Homo sapiens mRNA for MSF-FN70 (FN gene)	AJ276395	321592		6.836	13.007	1.90	0.07589
53	5201	extracellular matrix structural constituent	H016249_01	Homo sapiens, Similar to laminin, alpha 4, clone MGC:10389, mRNA, complete CDS	BC004241	327703		1.019	0.689	0.68	0.05838
54	776	kinetochore	H002651_01	Presenilin 1 (Alzheimer disease 3)	L76517	3260	PSEN1	1.674	1.337	0.80	0.38047
55	776	kinetochore	H003796_01	Centromere protein F (350/400kD, mitosin)	U30872	77204	CENPF	0.908	1.193	1.31	0.40243
56	776	kinetochore	H004455_01	SMT3 (suppressor of mif two 3, yeast) homolog 1	X99584	85119	SMT3H1	1.312	0.851	0.65	0.03052
57	776	kinetochore	H000555_01	MAD2 (mitotic arrest deficient, yeast, homolog)-like 1	U65410	79078	MAD2L1	3.691	14.522	3.93	0.00753
58	776	kinetochore	H007906_01	Kinesin-like 4	AB017430	119324	KNSL4	0.484	0.313	0.65	0.15055
59	776	kinetochore	H009464_01	Centromere protein F (350/400kD, mitosin)	NM_016343	77204	CENPF	0.806	0.968	1.20	0.10591
60	776	kinetochore	H010859_01	BUB3 (budding uninhibited by benzimidazoles 3, yeast) homolog	AF047472	40323	BUB3	0.88	0.571	0.65	0.01436
61	776	kinetochore	H014640_01	Kinetochore protein CENP-H	NM_022909	200395	CENPH	0.515	0.361	0.70	0.16289
62	776	kinetochore	H001444_01	Dynactin 2 (p50)	U50733	84153	DCTN2	1.693	2.254	1.33	0.05946
63	6401	RNA catabolism	H001873_01	Zinc finger protein homologous to Zfp-36 in mouse	M92843	1665	ZFP36	1.293	1.109	0.86	0.47715
64	6401	RNA catabolism	H004497_01	KIAA0116 protein	D29958	182877	KIAA0116	0.341	0.537	1.57	0.00154
65	6401	RNA catabolism	H006056_01	Regulator of nonsense transcripts 1	D86988	12719	RENT1	1.267	1.299	1.03	0.90558
66	6401	RNA catabolism	H006885_01	Ribonuclease 6 precursor	NM_003730	8297	RNASE6PL	0.712	0.438	0.62	0.03907
67	6401	RNA catabolism	H008151_01	Heat shock 70kD protein 1B	NM_005346	274402	HSPA1B	1.036	0.533	0.51	0.01103
68	6401	RNA catabolism	H008749_01	PRO2047 protein	NM_014110	284136	PRO2047	0.948	1.128	1.19	0.35127
69	6401	RNA catabolism	H010646_01	Ribonuclease 6 precursor	AK001769	8297	RNASE6PL	0.862	0.836	0.97	0.71042
70	6401	RNA catabolism	H010958_01	Poly(A)-binding protein, cytoplasmic 4 (inducible form)	U75686	169900	PABPC4	1.3	0.758	0.58	0.00593
71	6401	RNA catabolism	H011931_01	Protein phosphatase 1, regulatory (inhibitor) subunit 8	U14575	78961	PPP1R8	1.351	0.949	0.70	0.21242
72	5520	insulin-like growth factor binding	H002800_01	Connective tissue growth factor	X78947	75511	CTGF	3.098	14.225	4.59	0.00073
73	5520	insulin-like growth factor binding	H003420_01	Insulin-like growth factor binding protein 6	M62402	274313	IGFBP6	2.297	1.431	0.62	0.06015
74	5520	insulin-like growth factor binding	H003735_01	Insulin-like growth factor binding protein 5	AF055033	107169	IGFBP5	1.33	1.69	1.27	0.46462
75	5520	insulin-like growth factor binding	H003777_01	Insulin-like growth factor binding protein 2 (36kD)	X16302	162	IGFBP2	0.195	0.401	2.06	0.09799
76	5520	insulin-like growth factor binding	H000589_01	Cysteine-rich, angiogenic inducer, 61	Y11307	8867	CYR61	5.224	7.438	1.42	0.31927
77	5520	insulin-like growth factor binding	H007289_01	Insulin-like growth factor binding protein 7	S75725	119206	IGFBP7	1.036	1.769	1.71	0.20545
78	5520	insulin-like growth factor binding	H012536_01	Human insulin-like growth factor binding protein 5 (IGFBP5) mRNA	L27560	103391		0.841	1.699	2.02	0.02933
79	4252	serine-type endopeptidase activity	H001768_01	Protease, serine, 2 (trypsin 2)	M27602	241561	PRSS2	0.224	0.131	0.58	0.23624
80	4252	serine-type endopeptidase activity	H001780_01	Protease, serine, 4 (trypsin 4, brain)	X72781	58247	PRSS4	0.566	0.794	1.40	0.28828
81	4252	serine-type endopeptidase activity	H001785_01	Hepsin (transmembrane protease, serine 1)	X07732	823	HPN	0.834	1.882	2.26	0.01749
82	4252	serine-type endopeptidase activity	H001797_01	Protease, serine, 1 (trypsin 1)	M22612	241395	PRSS1	2.029	2.174	1.07	0.5579
83	4252	serine-type endopeptidase activity	H001828_01	Pancreatic elastase IIB	M16653	169234	LOC51032	1.085	1.765	1.63	0.12304
84	4252	serine-type endopeptidase activity	H001830_01	Transmembrane protease, serine 2	U75329	318545	TMPRSS2	1.334	1.114	0.84	0.54555
85	4252	serine-type endopeptidase activity	H001920_01	Coagulation factor VII (serum prothrombin conversion accelerator)	M13232	36989	F7	0.98	1.638	1.67	0.05764
86	4252	serine-type endopeptidase activity	H001925_01	Granzyme M (lymphocyte met-ase 1)	NM_005317	268531	GZMM	0.644	1.061	1.65	0.03318
87	4252	serine-type endopeptidase activity	H002030_01	Tryptase, alpha	M30038	278528	TPS1	1.225	0.924	0.75	0.07983
88	4252	serine-type endopeptidase activity	H002188_01	Lipoprotein, Lp(a)	X06290	119520	LPA	0.655	1.066	1.63	0.06567
89	4252	serine-type endopeptidase activity	H002460_01	Plasminogen activator, tissue	M15518	274404	PLAT	0.852	0.76	0.89	0.58882
90	4252	serine-type endopeptidase activity	H002509_01	D component of complement (adipsin)	M84526	155597	DF	1.468	0.957	0.65	0.02192
91	4252	serine-type endopeptidase activity	H002528_01	Granzyme K (serine protease, granzyme 3; tryptase II)	U26174	3066	GZMK	0.919	1.163	1.27	0.33764
92	4252	serine-type endopeptidase activity	H002553_01	Serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1),	M14083	82085	SERPINE1	0.841	1.12	1.33	0.01068
93	4252	serine-type endopeptidase activity	H002605_01	Mannan-binding lectin serine protease 2	X98400	119983	MASP2	0.608	0.51	0.84	0.42079
94	4252	serine-type endopeptidase activity	H002927_01	Serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2	Y00630	75716	SERPINB2	0.558	0.682	1.22	0.60481
95	4252	serine-type endopeptidase activity	H003011_01	Complement component 1, s subcomponent	J04080	169756	C1S	16.305	18.098	1.11	0.78389
96	4252	serine-type endopeptidase activity	H003053_01	Kallikrein 11	AB012917	57771	KLK11	0.416	0.554	1.33	0.27282
97	4252	serine-type endopeptidase activity	H003287_01	Kallikrein 5	NM_012427	50915	KLK5	1.005	1.643	1.63	0.08562
98	4252	serine-type endopeptidase activity	H003337_01	B-factor, properdin	L15702	69771	BF	0.614	0.963	1.57	0.11883
99	4252	serine-type endopeptidase activity	H003368_01	Kallikrein 1, renal/pancreas/salivary	M25629	123107	KLK1	0.86	0.863	1.00	0.9892
100	4252	serine-type endopeptidase activity	H003754_01	ClpP (caseinolytic protease, ATP-dependent, proteolytic subunit, E. coli) homolog	Z50853	74362	CLPP	1.219	0.922	0.76	0.0866
101	4252	serine-type endopeptidase activity	H003865_01	Lactotransferrin	X53961	105938	LTF	0.65	0.466	0.72	0.17982
102	4252	serine-type endopeptidase activity	H003877_01	Paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein)	X17094	59242	PACE	1.199	0.917	0.76	0.21199
103	4252	serine-type endopeptidase activity	H004648_01	Tryptase gamma 1	NM_012467	278275	TPSG1	0.816	1.161	1.42	0.06632
104	4252	serine-type endopeptidase activity	H000491_01	Proprotein convertase subtilisin/kexin type 7	U33849	32978	PCSK7	1.697	1.141	0.67	0.01513
105	4252	serine-type endopeptidase activity	H005647_01	Membrane-bound transcription factor protease, site 1	D42053	75890	MBTPS1	1.72	2.046	1.19	0.61228
106	4252	serine-type endopeptidase activity	H006381_01	Protease, serine, 23	AF015287	325820	SPUVE	1.423	2.047	1.44	0.18652
107	4252	serine-type endopeptidase activity	H007042_01	Complement C1r-like proteinase precursor,	AF178985	98571	LOC51279	1.077	0.984	0.91	0.48438
108	4252	serine-type endopeptidase activity	H013087_01	Rhomboid (veinlet, Drosophila)-like	Y17108	137572	RHBDL	0.891	0.853	0.96	0.86092
109	4252	serine-type endopeptidase activity	H015697_01	Transmembrane protease, serine 3	NM_024022	298241	TMPRSS3	0.984	0.702	0.71	0.11262
110	4252	serine-type endopeptidase activity	H001308_01	Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)	X55668	928	PRTN3	0.819	1.211	1.48	0.216
111	4252	serine-type endopeptidase activity	H001448_01	HtrA-like serine protease	NM_013247	115721	OMI	1.18	1.41	1.19	0.18541
112	8287	protein serine/threonine phosphatase complex	H002974_01	KIAA0015 gene product	D13640	278441	KIAA0015	1.756	1.368	0.78	0.23236
113	8287	protein serine/threonine phosphatase complex	H003020_01	Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform	S87759	57764	PPM1A	2.483	4.223	1.70	0.1493
114	8287	protein serine/threonine phosphatase complex	H003074_01	Protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	M64929	179574	PPP2R2A	0.9	0.594	0.66	0.17157
115	8287	protein serine/threonine phosphatase complex	H003642_01	Protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform	Y13936	17883	PPM1G	0.759	0.902	1.19	0.29144
116	8287	protein serine/threonine phosphatase complex	H000413_01	Protein phosphatase 2, regulatory subunit B (B56), epsilon isoform	L76703	173328	PPP2R5E	1.03	0.825	0.80	0.24141
117	8287	protein serine/threonine phosphatase complex	H000464_01	Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform	M65254	108705	PPP2R1B	1.156	1.334	1.15	0.47031
118	8287	protein serine/threonine phosphatase complex	H005412_01	Protein phosphatase 2, regulatory subunit B (B56), delta isoform	L76702	118244	PPP2R5D	1.372	1.085	0.79	0.21517
119	8287	protein serine/threonine phosphatase complex	H006260_01	Protein phosphatase 2A 48 kDa regulatory subunit	NM_013239	124942	PR48	0.8	0.978	1.22	0.40781
120	8287	protein serine/threonine phosphatase complex	H000599_01	Protein phosphatase 1D magnesium-dependent, delta isoform	U78305	100980	PPM1D	1.16	0.724	0.62	0.15614
121	8287	protein serine/threonine phosphatase complex	H000617_01	Protein phosphatase 2, regulatory subunit B (B56), beta isoform	L42374	75199	PPP2R5B	1.334	2.159	1.62	0.15054
122	8287	protein serine/threonine phosphatase complex	H000644_01	Protein phosphatase 2, regulatory subunit B (B56), alpha isoform	L42373	155079	PPP2R5A	0.581	0.802	1.38	0.12309
123	8287	protein serine/threonine phosphatase complex	H008583_01	Homo sapiens mRNA; cDNA DKFZp761E0711 (from clone DKFZp761E0711)	AL157449	110095		1.677	1.242	0.74	0.1797
124	8287	protein serine/threonine phosphatase complex	H010455_01	KIAA1348 protein	AB037769	232696	KIAA1348	1.084	0.986	0.91	0.23445
125	8287	protein serine/threonine phosphatase complex	H014726_01	Pyruvate dehydrogenase phosphatase	NM_018444	22265	PDP	1.946	1.113	0.57	0.00658
126	8287	protein serine/threonine phosphatase complex	H001703_01	Protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), bet	L07590	28219	PPP2R3	1.489	1.204	0.81	0.40966
127	8287	protein serine/threonine phosphatase complex	H001704_01	Protein phosphatase 2, regulatory subunit B (B56), gamma isoform	U37352	171734	PPP2R5C	1.056	1.61	1.52	0.01011
128	4295	trypsin activity	H001768_01	Protease, serine, 2 (trypsin 2)	M27602	241561	PRSS2	0.224	0.131	0.58	0.23624
129	4295	trypsin activity	H001780_01	Protease, serine, 4 (trypsin 4, brain)	X72781	58247	PRSS4	0.566	0.794	1.40	0.28828
130	4295	trypsin activity	H001785_01	Hepsin (transmembrane protease, serine 1)	X07732	823	HPN	0.834	1.882	2.26	0.01749
131	4295	trypsin activity	H001797_01	Protease, serine, 1 (trypsin 1)	M22612	241395	PRSS1	2.029	2.174	1.07	0.5579
132	4295	trypsin activity	H001828_01	Pancreatic elastase IIB	M16653	169234	LOC51032	1.085	1.765	1.63	0.12304
133	4295	trypsin activity	H001830_01	Transmembrane protease, serine 2	U75329	318545	TMPRSS2	1.334	1.114	0.84	0.54555
134	4295	trypsin activity	H001920_01	Coagulation factor VII (serum prothrombin conversion accelerator)	M13232	36989	F7	0.98	1.638	1.67	0.05764
135	4295	trypsin activity	H001925_01	Granzyme M (lymphocyte met-ase 1)	NM_005317	268531	GZMM	0.644	1.061	1.65	0.03318
136	4295	trypsin activity	H002030_01	Tryptase, alpha	M30038	278528	TPS1	1.225	0.924	0.75	0.07983
137	4295	trypsin activity	H002188_01	Lipoprotein, Lp(a)	X06290	119520	LPA	0.655	1.066	1.63	0.06567
138	4295	trypsin activity	H002460_01	Plasminogen activator, tissue	M15518	274404	PLAT	0.852	0.76	0.89	0.58882
139	4295	trypsin activity	H002509_01	D component of complement (adipsin)	M84526	155597	DF	1.468	0.957	0.65	0.02192
140	4295	trypsin activity	H002528_01	Granzyme K (serine protease, granzyme 3; tryptase II)	U26174	3066	GZMK	0.919	1.163	1.27	0.33764
141	4295	trypsin activity	H002605_01	Mannan-binding lectin serine protease 2	X98400	119983	MASP2	0.608	0.51	0.84	0.42079
142	4295	trypsin activity	H003011_01	Complement component 1, s subcomponent	J04080	169756	C1S	16.305	18.098	1.11	0.78389
143	4295	trypsin activity	H003053_01	Kallikrein 11	AB012917	57771	KLK11	0.416	0.554	1.33	0.27282
144	4295	trypsin activity	H003287_01	Kallikrein 5	NM_012427	50915	KLK5	1.005	1.643	1.63	0.08562
145	4295	trypsin activity	H003337_01	B-factor, properdin	L15702	69771	BF	0.614	0.963	1.57	0.11883
146	4295	trypsin activity	H003368_01	Kallikrein 1, renal/pancreas/salivary	M25629	123107	KLK1	0.86	0.863	1.00	0.9892
147	4295	trypsin activity	H004648_01	Tryptase gamma 1	NM_012467	278275	TPSG1	0.816	1.161	1.42	0.06632
148	4295	trypsin activity	H006381_01	Protease, serine, 23	AF015287	325820	SPUVE	1.423	2.047	1.44	0.18652
149	4295	trypsin activity	H007042_01	Complement C1r-like proteinase precursor,	AF178985	98571	LOC51279	1.077	0.984	0.91	0.48438
150	4295	trypsin activity	H015697_01	Transmembrane protease, serine 3	NM_024022	298241	TMPRSS3	0.984	0.702	0.71	0.11262
151	4295	trypsin activity	H001308_01	Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen)	X55668	928	PRTN3	0.819	1.211	1.48	0.216
152	4295	trypsin activity	H001448_01	HtrA-like serine protease	NM_013247	115721	OMI	1.18	1.41	1.19	0.18541
153	43087	regulation of GTPase activity	H004224_01	Hypothetical protein FLJ10767	AK001629	25584	FLJ10767	1.675	1.3	0.78	0.04097
154	43087	regulation of GTPase activity	H004509_01	KIAA0782 protein	AB018325	21264	KIAA0782	1.008	0.783	0.78	0.1811
155	43087	regulation of GTPase activity	H008446_01	KIAA0167 gene product	D79989	184884	KIAA0167	0.828	0.72	0.87	0.28232
156	43087	regulation of GTPase activity	H009484_01	G protein-coupled receptor kinase-interactor 1	NM_014030	318339	GIT1	0.932	1.279	1.37	0.16443
157	43087	regulation of GTPase activity	H001587_01	GDP dissociation inhibitor 1	X79353	74576	GDI1	1.606	1.015	0.63	0.03322
158	43087	regulation of GTPase activity	H001635_01	GDP dissociation inhibitor 2	Y13286	56845	GDI2	1.474	1.137	0.77	0.12277
159	6687	glycosphingolipid metabolism	H003235_01	GM2 ganglioside activator protein	X62078	69743	GM2A	1.515	1.201	0.79	0.31178
160	6687	glycosphingolipid metabolism	H004193_01	Sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)	AB018356	225939	SIAT9	1.124	0.714	0.64	0.07436
161	6687	glycosphingolipid metabolism	H006323_01	CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI	AB035173	109672	VI	3.293	2.391	0.73	0.27588
162	6687	glycosphingolipid metabolism	H000076_01	UDP-glucose ceramide glucosyltransferase	D50840	152601	UGCG	1.149	1.557	1.36	0.27117
163	6687	glycosphingolipid metabolism	H000887_01	Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)	J03077	78575	PSAP	5.938	4.713	0.79	0.08217
164	6687	glycosphingolipid metabolism	H001450_01	Globotriaosylceramide/CD77 synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl	NM_017436	105956	A14GALT	3.059	2.119	0.69	0.26431
165	30148	sphingolipid biosynthesis	H004193_01	Sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)	AB018356	225939	SIAT9	1.124	0.714	0.64	0.07436
166	30148	sphingolipid biosynthesis	H006323_01	CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI	AB035173	109672	VI	3.293	2.391	0.73	0.27588
167	30148	sphingolipid biosynthesis	H000076_01	UDP-glucose ceramide glucosyltransferase	D50840	152601	UGCG	1.149	1.557	1.36	0.27117
168	30148	sphingolipid biosynthesis	H015734_01	Sphingosine kinase type 2 isoform	AL136701	301305	SPHK2	1.457	0.927	0.64	0.1341
169	30148	sphingolipid biosynthesis	H001450_01	Globotriaosylceramide/CD77 synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl	NM_017436	105956	A14GALT	3.059	2.119	0.69	0.26431
170	6664	glycolipid metabolism	H003235_01	GM2 ganglioside activator protein	X62078	69743	GM2A	1.515	1.201	0.79	0.31178
171	6664	glycolipid metabolism	H004193_01	Sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)	AB018356	225939	SIAT9	1.124	0.714	0.64	0.07436
172	6664	glycolipid metabolism	H006323_01	CMP-NeuAC:(beta)-N-acetylgalactosaminide (alpha)2,6-sialyltransferase member VI	AB035173	109672	VI	3.293	2.391	0.73	0.27588
173	6664	glycolipid metabolism	H006408_01	Alpha2,3-sialyltransferase	AK001922	34578	ST3GALVI	0.717	0.581	0.81	0.33202
174	6664	glycolipid metabolism	H000076_01	UDP-glucose ceramide glucosyltransferase	D50840	152601	UGCG	1.149	1.557	1.36	0.27117
175	6664	glycolipid metabolism	H000887_01	Prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy)	J03077	78575	PSAP	5.938	4.713	0.79	0.08217
176	6664	glycolipid metabolism	H001148_01	Galactosylceramidase (Krabbe disease)	NM_000153	273	GALC	1.388	1.872	1.35	0.2603
177	6664	glycolipid metabolism	H001450_01	Globotriaosylceramide/CD77 synthase; Gb3/CD77 synthase; alpha1,4-galactosyltransferase; 4-N-acetylgl	NM_017436	105956	A14GALT	3.059	2.119	0.69	0.26431