Pathway Comparison
Description of the problem:
Number of classes: 2
Column of the Experiment Descriptors sheet that defines class variable: Group
Number of genes used for random variance estimation: 8541
Number of genes that passed filtering criteria: 8541
Number of investigated pathways: 426 Broad/MIT
Random variance model was used
Pathways which have more genes differentially expressed among the phenotype classes than expected by chance
Table – The first 21 Pathway are significant at the nominal 0.005 level of the LS permutation test or KS permutation test (sorted by p-values of the LS permutation test).
| Broad Pathway | Pathway description | Number of genes | LS Permutation p-value | KS Permutation p-value | |
|---|---|---|---|---|---|
| 1 | h_egfPathway | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | 11 | 0.0001781 | 0.0007173 |
| 2 | h_at1rPathway | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | 19 | 0.0004368 | 0.0095861 |
| 3 | h_igf1Pathway | BioCarta | 9 | 0.0006275 | 0.0004011 |
| 4 | h_ghPathway | BioCarta | 11 | 0.0010702 | 0.0324908 |
| 5 | h_pyk2Pathway | BioCarta | 17 | 0.0011765 | 0.0104516 |
| 6 | h_spryPathway | BioCarta | 7 | 0.0012316 | 0.0038862 |
| 7 | MAPK_Cascade_h | GO | 10 | 0.0012932 | 0.0167688 |
| 8 | h_radiation_sensitivity | BioCarta | 20 | 0.0013331 | 0.0149414 |
| 9 | h_insulinPathway | BioCarta | 9 | 0.0014628 | 0.0090869 |
| 10 | h_cellcyclePathway | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | 17 | 0.0016052 | 0.004197 |
| 11 | HOXA9_DOWN_h | Dorsam_et_al_2004 | 25 | 0.0016679 | 0.0428986 |
| 12 | h_gata3Pathway | BioCarta | 8 | 0.0022081 | 0.0692661 |
| 13 | h_ctla4Pathway | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | 11 | 0.0027336 | 0.0673271 |
| 14 | cell_cycle_checkpointII_h | GO | 7 | 0.0031081 | 0.0028034 |
| 15 | h_g1Pathway | BioCarta | 17 | 0.0042274 | 0.0077604 |
| 16 | EMT_UP_h | Jechlinger_et_al_2003 | 32 | 0.0042758 | 0.0361 |
| 17 | h_tumor_supressor | BioCarta | 15 | 0.0044661 | 0.0847671 |
| 18 | h_drug_resistance_and_metabolism | BioCarta | 62 | 0.0045301 | 0.0571057 |
| 19 | h_pmlPathway | BioCarta | 10 | 0.0048356 | 0.0997659 |
| 20 | h_EGF_receptor_signaling_pathway | BioCarta | 9 | 0.0071864 | 0.0032054 |
| 21 | GPCRs_Class_A_Rhodopsin-like_h | GO | 58 | 0.0716031 | 0.0022145 |
The significant genes can be found by clicking the link here.
Pathways which discriminate among classes by running the Hotelling T-square test for testing the hypothesis that for each pathway no genes in the set are differentially expressed between classes:
The number of principal components: 3
Table – The first 109 pathways are significant at the nominal 0.005 level of the Hotelling T-square test (sorted by p-values).
| Broad Pathway | Pathway description | Number of genes | Hotelling test p-value | |
|---|---|---|---|---|
| 1 | h_spryPathway | BioCarta | 7 | 1.1e-06 |
| 2 | h_ST_p38_MAPK_Pathway | Signalling Transduction KE | 20 | 6.9e-06 |
| 3 | EMT_UP_h | Jechlinger_et_al_2003 | 32 | 1.34e-05 |
| 4 | h_egfPathway | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | 11 | 1.92e-05 |
| 5 | h_insulinPathway | BioCarta | 9 | 3.63e-05 |
| 6 | h_igf1Pathway | BioCarta | 9 | 3.67e-05 |
| 7 | h_il6Pathway | BioCarta | 10 | 5.91e-05 |
| 8 | GLUCOSE_DOWN_h | Peng_et_al_2002 | 89 | 6.99e-05 |
| 9 | h_ghPathway | BioCarta | 11 | 9.38e-05 |
| 10 | h_il2rbPathway | BioCarta | 22 | 9.39e-05 |
| 11 | ST_T_Cell_Signal_Transduction_h | Signalling Transduction KE | 24 | 9.47e-05 |
| 12 | h_pdgfPathway | BioCarta | 12 | 0.0001013 |
| 13 | h_igf1rPathway | BioCarta | 8 | 0.0001044 |
| 14 | MAPK_Cascade_h | GO | 10 | 0.0001361 |
| 15 | FRASOR_ER_DOWN_h | Frasor_et_al_2004 | 37 | 0.0001462 |
| 16 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES_h | Signalling Alliance | 13 | 0.0001492 |
| 17 | h_mapkPathway | BioCarta | 54 | 0.0001557 |
| 18 | MAP00010_Glycolysis_Gluconeogenesis_h | GenMAPP | 23 | 0.0001634 |
| 19 | h_pyk2Pathway | BioCarta | 17 | 0.0001722 |
| 20 | h_mta3Pathway | BioCarta | 5 | 0.0001966 |
| 21 | h_gata3Pathway | BioCarta | 8 | 0.0002448 |
| 22 | h_fcer1Pathway | In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. | 19 | 0.0002452 |
| 23 | h_metPathway | BioCarta | 16 | 0.0002699 |
| 24 | cell_motility_h | Any process involved in the controlled movement of a cell. | 58 | 0.0002877 |
| 25 | ca_nf_at_signalling_h | GEArray | 58 | 0.0002992 |
| 26 | h_nfatPathway | BioCarta | 29 | 0.0003129 |
| 27 | h_il3Pathway | BioCarta | 8 | 0.0003487 |
| 28 | FETAL_LIVER_HS_ENRICHED_TF_JP_h | Manually Curated | 46 | 0.0004007 |
| 29 | h_epoPathway | Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. | 8 | 0.0004264 |
| 30 | h_nthiPathway | BioCarta | 15 | 0.0004378 |
| 31 | HOXA9_DOWN_h | Dorsam_et_al_2004 | 25 | 0.0004546 |
| 32 | fmlppathway_h | The fMLP receptor is a G-protein coupled receptor in neutrophiles that recognizes formylated bacterial peptides and activates NADPH oxidase. | 20 | 0.0004828 |
| 33 | h_at1rPathway | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | 19 | 0.000559 |
| 34 | h_tumor_supressor | BioCarta | 15 | 0.0005798 |
| 35 | NFKB_INDUCED_h | Hinata_et_al_2003 | 60 | 0.000606 |
| 36 | DNA_DAMAGE_SIGNALLING_h | GO | 66 | 0.0006144 |
| 37 | GPCRs_Class_A_Rhodopsin-like_h | GO | 58 | 0.0007054 |
| 38 | MAP00230_Purine_metabolism_h | GenMAPP | 50 | 0.0007068 |
| 39 | h_raccycdPathway | BioCarta | 15 | 0.0007662 |
| 40 | h_stressPathway | BioCarta | 15 | 0.0008401 |
| 41 | MAP00190_Oxidative_phosphorylation_h | GenMAPP | 20 | 0.0009015 |
| 42 | h_atrbrcaPathway | BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. | 12 | 0.0009417 |
| 43 | EMT_DOWN_h | Jechlinger_et_al_2003 | 21 | 0.0009966 |
| 44 | h_ngfPathway | BioCarta | 8 | 0.0010117 |
| 45 | CR_TRANSCRIPTION_FACTORS_h | PNAS_2013 | 46 | 0.0011226 |
| 46 | h_erkPathway | Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. | 17 | 0.0011573 |
| 47 | h_ST_G_alpha_i_Pathway_ | Signalling Transduction KE | 20 | 0.0011874 |
| 48 | h_tpoPathway | BioCarta | 8 | 0.0012393 |
| 49 | h_gleevecPathway | BioCarta | 12 | 0.0012794 |
| 50 | h_il2Pathway | BioCarta | 13 | 0.0013664 |
| 51 | h_pparaPathway | BioCarta | 34 | 0.0014403 |
| 52 | GNF_FEMALE_GENES_h | na | 50 | 0.0016619 |
| 53 | MAP00510_N_Glycans_biosynthesis_h | GenMAPP | 11 | 0.0016653 |
| 54 | CR_PROTEIN_MOD_h | PNAS_2010 | 96 | 0.0017479 |
| 55 | h_p27Pathway | BioCarta | 10 | 0.0017628 |
| 56 | SA_PTEN_PATHWAY_h | SigmaAldrich | 10 | 0.0018065 |
| 57 | CR_TRANSPORT_OF_VESICLES_h | PNAS_2015 | 18 | 0.002019 |
| 58 | h_il1rPathway | BioCarta | 15 | 0.002075 |
| 59 | h_tollPathway | BioCarta | 19 | 0.0022275 |
| 60 | MAP00240_Pyrimidine_metabolism_h | GenMAPP | 29 | 0.0023595 |
| 61 | h_g2Pathway | BioCarta | 18 | 0.002402 |
| 62 | h_gabaPathway | BioCarta | 5 | 0.002409 |
| 63 | h_keratinocytePathway | BioCarta | 26 | 0.0024116 |
| 64 | h_lairPathway | BioCarta | 9 | 0.0024136 |
| 65 | MAP00030_Pentose_phosphate_pathway_h | GenMAPP | 11 | 0.0024356 |
| 66 | ANDROGEN_UP_GENES_h | na | 32 | 0.0025209 |
| 67 | h_SIG_InsulinReceptorPathwayInCardiacMyocytes | Signalling Alliance | 29 | 0.0025548 |
| 68 | h_crebPathway | CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. | 14 | 0.0027324 |
| 69 | h_ST_JNK_MAPK_Pathway | Signalling Transduction KE | 24 | 0.0027719 |
| 70 | h_radiation_sensitivity | BioCarta | 20 | 0.0027867 |
| 71 | h_mtorPathway | BioCarta | 14 | 0.0028072 |
| 72 | h_glycolysisPathway | BioCarta | 5 | 0.0029056 |
| 73 | shh_lisa_h | Manually Curated | 13 | 0.0030194 |
| 74 | h_ST_G_alpha_5_Pathway | Signalling Transduction KE | 7 | 0.0030305 |
| 75 | h_ptdinsPathway | BioCarta | 16 | 0.0030497 |
| 76 | h_insulin_signalling | BioCarta | 58 | 0.0030521 |
| 77 | h_biopeptidesPathway | Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. | 19 | 0.0030677 |
| 78 | h_ST_Ga13_Pathway | Signalling Transduction KE | 25 | 0.0031494 |
| 79 | h_ST_Dictyostelium_discoideum_cAMP_Chemotaxis_Pathway | Signalling Transduction KE | 22 | 0.0031671 |
| 80 | cell_adhesion_h | The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules. | 97 | 0.0032822 |
| 81 | h_ceramidePathway | Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. | 16 | 0.0033054 |
| 82 | h_eea1Pathway | The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. | 7 | 0.0033393 |
| 83 | ST_B_Cell_Antigen_Receptor_h | Signalling Transduction KE | 24 | 0.0033761 |
| 84 | h_tidPathway | BioCarta | 9 | 0.0033789 |
| 85 | DOWNREG_BY_HOXA9_h | Manually Curated | 22 | 0.0034111 |
| 86 | ST_GRANULE_CELL_SURVIVAL_PATHWAY_h | Signalling Transduction KE | 19 | 0.0035205 |
| 87 | h_bcrPathway | B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. | 17 | 0.0035561 |
| 88 | h_egfr_smrtePathway | EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. | 6 | 0.0035752 |
| 89 | HEMO_TF_LIST_JP_h | Manually Curated | 45 | 0.0036197 |
| 90 | h_hcmvPathway | BioCarta | 11 | 0.0036815 |
| 91 | MAP00051_Fructose_and_mannose_metabolism_h | GenMAPP | 12 | 0.003728 |
| 92 | MAP_kinase_kinase_activity_h | GenMAPP | 5 | 0.0038348 |
| 93 | LEU_UP_h | Peng_et_al_2002 | 77 | 0.0038565 |
| 94 | h_p53Pathway | BioCarta | 11 | 0.0038582 |
| 95 | h_ppargPathway | BioCarta | 6 | 0.0038969 |
| 96 | h_ST_ERK1_ERK2_MAPK_Pathway | Signalling Transduction KE | 20 | 0.0039951 |
| 97 | MAP00710_Carbon_fixation_h | GenMAPP | 8 | 0.004022 |
| 98 | h_drug_resistance_and_metabolism | BioCarta | 62 | 0.0040238 |
| 99 | h_il10Pathway | BioCarta | 7 | 0.0041077 |
| 100 | h_rbPathway | BioCarta | 9 | 0.0041223 |
| 101 | h_mprPathway | BioCarta | 14 | 0.0041417 |
| 102 | h_S1P_Signaling | BioCarta | 17 | 0.0042391 |
| 103 | MAP00600_Sphingoglycolipid_metabolism_h | GenMAPP | 8 | 0.0043908 |
| 104 | h_ST_Differentiation_Pathway_in_PC12_Cells | Signalling Transduction KE | 24 | 0.0044761 |
| 105 | h_integrinPathway | BioCarta | 24 | 0.0046608 |
| 106 | h_longevityPathway | BioCarta | 5 | 0.0047172 |
| 107 | h_p53_signalling | BioCarta | 58 | 0.0048118 |
| 108 | ST_ADRENERGIC_h | Signalling Transduction KE | 24 | 0.0048368 |
| 109 | h_ptenPathway | BioCarta | 9 | 0.004882 |
The significant genes can be found by clicking the link here.
Table – Significant pathway which have more genes differentially expressed among the phenotype classes than expected by chance consist of the following genes (sorted by p-values).
| Broad Pathway | Pathway description | Unique id | Annotations | Description | Clone | GB acc | UG cluster | Gene symbol | Defined gene lists | Parametric p-value | Geometric mean of ratios (class Disease /class Normal ) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H002040_01 | Info | Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | H002040_01 | X00588 | 77432 | EGFR | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc | 0.0004362 | 0.669 |
| 2 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H002186_01 | Info | Serum response factor (c-fos serum response element-binding transcription factor) | H002186_01 | J03161 | 155321 | SRF | EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription | 0.0017465 | 0.722 |
| 3 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 4 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 5 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H003611_01 | Info | Mitogen-activated protein kinase kinase 4 | H003611_01 | L36870 | 75217 | MAP2K4 | Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system | 0.012502 | 0.753 |
| 6 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H001365_01 | Info | Protein kinase C, beta 1 | H001365_01 | X07109 | 77202 | PRKCB1 | Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction | 0.0304335 | 1.379 |
| 7 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 8 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H001600_01 | Info | RAS p21 protein activator (GTPase activating protein) 1 | H001600_01 | M23379 | 758 | RASA1 | EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction | 0.1015906 | 0.844 |
| 9 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H003158_01 | Info | Mitogen-activated protein kinase 8 | H003158_01 | L26318 | 190913 | MAPK8 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … | 0.1287835 | 1.166 |
| 10 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H001349_01 | Info | Janus kinase 1 (a protein tyrosine kinase) | H001349_01 | M64174 | 50651 | JAK1 | EGF Signaling Pathway, IFN alpha signaling pathway, IFN gamma signaling pathway , IL 2 signaling pathway, IL 4 signaling pathway, IL-10 Anti-inflammatory Signaling Pathway, IL-2 Receptor Beta Chain in T cell Activation, IL-7 Signal Transduction, PDGF Signaling Pathway, cell_cycle, cell_signaling, immunology, signal_transduction | 0.2754104 | 1.129 |
| 11 | egfPathway_h | The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 12 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002040_01 | Info | Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | H002040_01 | X00588 | 77432 | EGFR | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc | 0.0004362 | 0.669 |
| 13 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 14 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 15 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H003006_01 | Info | Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8 | H003006_01 | K02215 | 3697 | SERPINA8 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Angiotensin-converting enzyme 2 regulates heart function, Bioactive Peptide Induced Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, immunology | 0.0063778 | 1.296 |
| 16 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002573_01 | Info | Protein tyrosine kinase 2 beta | H002573_01 | U43522 | 20313 | PTK2B | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CXCR4 Signaling Pathway, IL-7 Signal Transduction, Ion Channel and Phorbol Esters Signaling Pathway, Links between Pyk2 and Map Kinases, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of nicotinic acetylcholine receptors in the regulation of apoptosis, Signaling of Hepatocyte Growth Factor Receptor, Thrombin signaling and protease-activated receptors, angiogenesis, immunology, signal_transduction | 0.0091935 | 1.367 |
| 17 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H003611_01 | Info | Mitogen-activated protein kinase kinase 4 | H003611_01 | L36870 | 75217 | MAP2K4 | Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system | 0.012502 | 0.753 |
| 18 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H003493_01 | Info | MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) | H003493_01 | X63380 | 78881 | MEF2B | 0.0145042 | 1.328 | |
| 19 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H001992_01 | Info | Activating transcription factor 2 | H001992_01 | X15875 | 198166 | ATF2 | ALK in cardiac myocytes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , The 4-1BB-dependent immune response, The information-processing pathway at the IFN-beta enhancer | 0.0178377 | 0.749 |
| 20 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H001365_01 | Info | Protein kinase C, beta 1 | H001365_01 | X07109 | 77202 | PRKCB1 | Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction | 0.0304335 | 1.379 |
| 21 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 22 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002287_01 | Info | P21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) | H002287_01 | U24152 | 62402 | PAK1 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, FAS signaling pathway ( CD95 ), fMLP induced chemokine gene expression in HMC-1 cells, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Rac 1 cell motility signaling pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, TNFR1 Signaling Pathway | 0.1104284 | 0.815 |
| 23 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H003158_01 | Info | Mitogen-activated protein kinase 8 | H003158_01 | L26318 | 190913 | MAPK8 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … | 0.1287835 | 1.166 |
| 24 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002501_01 | Info | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | H002501_01 | D25274 | 173737 | RAC1 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, fMLP induced chemokine gene expression in HMC-1 cells, How does salmonella hijack a cell, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , Phosphoinositides and their downstream targets., Phospholipids as signalling intermediaries, Rac 1 cell motility signaling pathway, Ras Signaling Pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of MAL in Rho-Mediated Activation of SRF, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, T Cell Receptor Signaling Pathway, Transcription factor CREB and its extracellular signals, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, uCalpain and friends in Cell spread, Y branching of actin filaments | 0.1980127 | 1.118 |
| 25 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002112_01 | Info | PTK2 protein tyrosine kinase 2 | H002112_01 | L13616 | 740 | PTK2 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Apoptotic Signaling in Response to DNA Damage, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, CCR3 signaling in Eosinophils, Cell to Cell Adhesion Signaling, CXCR4 Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, HIV-I Nef: negative effector of Fas and TNF, Integrin Signaling Pathway, mCalpain and friends in Cell motility, Phospholipids as signalling intermediaries, PTEN dependent cell cycle arrest and apoptosis, Role of nicotinic acetylcholine receptors in the regulation of apoptosis, Signaling of Hepatocyte Growth Factor Receptor, Trefoil Factors Initiate Mucosal Healing, uCalpain and friends in Cell spread, VEGF, Hypoxia, and Angiogenesis, angiogenesis, signal_transduction | 0.2346929 | 0.896 |
| 26 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002405_01 | Info | Mitogen-activated protein kinase kinase 2 | H002405_01 | L11285 | 72241 | MAP2K2 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Bioactive Peptide Induced Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, fMLP induced chemokine gene expression in HMC-1 cells, Human Cytomegalovirus and Map Kinase Pathways, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway, Role of MAL in Rho-Mediated Activation of SRF, Role of �-arrestins in the activation and targeting of MAP kinases, Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling, Signaling of Hepatocyte Growth Factor Receptor | 0.3118803 | 1.093 |
| 27 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H011336_01 | Info | Guanine nucleotide binding protein (G protein), q polypeptide | H011336_01 | U43083 | 296261 | GNAQ | Activation of PKC through G protein coupled receptor, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CCR3 signaling in Eosinophils, CXCR4 Signaling Pathway, Effects of calcineurin in Keratinocyte Differentiation, G-Protein Signaling Through Tubby Proteins, Links between Pyk2 and Map Kinases, Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, Signaling Pathway from G-Protein Families, Thrombin signaling and protease-activated receptors, immunology | 0.3713616 | 0.89 |
| 28 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 29 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H002404_01 | Info | Synaptotagmin I | H002404_01 | M55047 | 154679 | SYT1 | 0.8170962 | 0.971 | |
| 30 | at1rPathway_h | Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. | H000579_01 | Info | Calmodulin 2 (phosphorylase kinase, delta) | H000579_01 | D45887 | 182278 | CALM2 | 0.9689776 | 1.004 | |
| 31 | igf1Pathway_h | BioCarta | H000732_01 | Info | Insulin receptor substrate 1 | H000732_01 | S62539 | 96063 | IRS1 | Perou’s – Intrinsic- Breast-Cancer-Genes, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 4 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Insulin Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of eIF4e and p70 S6 Kinase, immunology | 0.0013348 | 0.643 |
| 32 | igf1Pathway_h | BioCarta | H002186_01 | Info | Serum response factor (c-fos serum response element-binding transcription factor) | H002186_01 | J03161 | 155321 | SRF | EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription | 0.0017465 | 0.722 |
| 33 | igf1Pathway_h | BioCarta | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 34 | igf1Pathway_h | BioCarta | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 35 | igf1Pathway_h | BioCarta | H002473_01 | Info | Insulin-like growth factor 1 receptor | H002473_01 | NM_000875 | 239176 | IGF1R | Perou’s – Intrinsic- Breast-Cancer-Genes, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Erk1/Erk2 Mapk Signaling pathway, IGF-1 Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Telomeres, Telomerase, Cellular Aging, and Immortality, The IGF-1 Receptor and Longevity, immunology | 0.079692 | 1.158 |
| 36 | igf1Pathway_h | BioCarta | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 37 | igf1Pathway_h | BioCarta | H001600_01 | Info | RAS p21 protein activator (GTPase activating protein) 1 | H001600_01 | M23379 | 758 | RASA1 | EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction | 0.1015906 | 0.844 |
| 38 | igf1Pathway_h | BioCarta | H003158_01 | Info | Mitogen-activated protein kinase 8 | H003158_01 | L26318 | 190913 | MAPK8 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … | 0.1287835 | 1.166 |
| 39 | igf1Pathway_h | BioCarta | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 40 | ghPathway_h | BioCarta | H000732_01 | Info | Insulin receptor substrate 1 | H000732_01 | S62539 | 96063 | IRS1 | Perou’s – Intrinsic- Breast-Cancer-Genes, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 4 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Insulin Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of eIF4e and p70 S6 Kinase, immunology | 0.0013348 | 0.643 |
| 41 | ghPathway_h | BioCarta | H002186_01 | Info | Serum response factor (c-fos serum response element-binding transcription factor) | H002186_01 | J03161 | 155321 | SRF | EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription | 0.0017465 | 0.722 |
| 42 | ghPathway_h | BioCarta | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 43 | ghPathway_h | BioCarta | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 44 | ghPathway_h | BioCarta | H002890_01 | Info | Ribosomal protein S6 kinase, 90kD, polypeptide 1 | H002890_01 | L07597 | 149957 | RPS6KA1 | Cell Cycle: G2/M Checkpoint, Erk1/Erk2 Mapk Signaling pathway, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, MAP Kinase Signaling Pathway, Melanocyte Development and Pigmentation Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Role of Erk5 in Neuronal Survival, Transcription factor CREB and its extracellular signals, Phosphatidylinositol signaling system | 0.0138896 | 1.42 |
| 45 | ghPathway_h | BioCarta | H001365_01 | Info | Protein kinase C, beta 1 | H001365_01 | X07109 | 77202 | PRKCB1 | Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction | 0.0304335 | 1.379 |
| 46 | ghPathway_h | BioCarta | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 47 | ghPathway_h | BioCarta | H002624_01 | Info | Insulin receptor | H002624_01 | X02160 | 89695 | INSR | Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Growth Hormone Signaling Pathway, Insulin Signaling Pathway, immunology | 0.433218 | 0.919 |
| 48 | ghPathway_h | BioCarta | H002261_01 | Info | Signal transducer and activator of transcription 5B | H002261_01 | U47686 | 244613 | STAT5B | 0.441402 | 1.071 | |
| 49 | ghPathway_h | BioCarta | H009068_01 | Info | Homo sapiens mRNA; cDNA DKFZp586N1323 (from clone DKFZp586N1323) | H009068_01 | AL080218 | 24064 | 0.509279 | 1.056 | ||
| 50 | ghPathway_h | BioCarta | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 51 | pyk2Pathway_h | BioCarta | H003200_01 | Info | Mitogen-activated protein kinase kinase 3 | H003200_01 | D87116 | 180533 | MAP2K3 | fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, Signal transduction through IL1R, TNF/Stress Related Signaling, Toll-Like Receptor Pathway | 0.0009666 | 1.561 |
| 52 | pyk2Pathway_h | BioCarta | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 53 | pyk2Pathway_h | BioCarta | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 54 | pyk2Pathway_h | BioCarta | H002895_01 | Info | Mitogen-activated protein kinase 14 | H002895_01 | L35263 | 79107 | MAPK14 | BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, Map Kinase Inactivation of SMRT Corepressor, MAP Kinase Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), NFkB activation by Nontypeable Hemophilus influenzae, Oxidative Stress Induced Gene Expression Via Nrf2, p38 MAPK Signaling Pathway , Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Regulation of eIF4e and p70 S6 Kinase, Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, SARS Coronavirus Protease, Signal transduction through IL1R, TACI and BCMA stimulation of B cell imm … | 0.0086925 | 1.429 |
| 55 | pyk2Pathway_h | BioCarta | H002573_01 | Info | Protein tyrosine kinase 2 beta | H002573_01 | U43522 | 20313 | PTK2B | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CXCR4 Signaling Pathway, IL-7 Signal Transduction, Ion Channel and Phorbol Esters Signaling Pathway, Links between Pyk2 and Map Kinases, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of nicotinic acetylcholine receptors in the regulation of apoptosis, Signaling of Hepatocyte Growth Factor Receptor, Thrombin signaling and protease-activated receptors, angiogenesis, immunology, signal_transduction | 0.0091935 | 1.367 |
| 56 | pyk2Pathway_h | BioCarta | H003611_01 | Info | Mitogen-activated protein kinase kinase 4 | H003611_01 | L36870 | 75217 | MAP2K4 | Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system | 0.012502 | 0.753 |
| 57 | pyk2Pathway_h | BioCarta | H003332_01 | Info | V-crk avian sarcoma virus CT10 oncogene homolog-like | H003332_01 | X59656 | 37078 | CRKL | IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, Signaling of Hepatocyte Growth Factor Receptor, tsonc | 0.0164206 | 0.675 |
| 58 | pyk2Pathway_h | BioCarta | H001365_01 | Info | Protein kinase C, beta 1 | H001365_01 | X07109 | 77202 | PRKCB1 | Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction | 0.0304335 | 1.379 |
| 59 | pyk2Pathway_h | BioCarta | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 60 | pyk2Pathway_h | BioCarta | H002287_01 | Info | P21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) | H002287_01 | U24152 | 62402 | PAK1 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, FAS signaling pathway ( CD95 ), fMLP induced chemokine gene expression in HMC-1 cells, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Rac 1 cell motility signaling pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, TNFR1 Signaling Pathway | 0.1104284 | 0.815 |
| 61 | pyk2Pathway_h | BioCarta | H003158_01 | Info | Mitogen-activated protein kinase 8 | H003158_01 | L26318 | 190913 | MAPK8 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … | 0.1287835 | 1.166 |
| 62 | pyk2Pathway_h | BioCarta | H002501_01 | Info | Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | H002501_01 | D25274 | 173737 | RAC1 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, fMLP induced chemokine gene expression in HMC-1 cells, How does salmonella hijack a cell, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , Phosphoinositides and their downstream targets., Phospholipids as signalling intermediaries, Rac 1 cell motility signaling pathway, Ras Signaling Pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of MAL in Rho-Mediated Activation of SRF, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, T Cell Receptor Signaling Pathway, Transcription factor CREB and its extracellular signals, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, uCalpain and friends in Cell spread, Y branching of actin filaments | 0.1980127 | 1.118 |
| 63 | pyk2Pathway_h | BioCarta | H002405_01 | Info | Mitogen-activated protein kinase kinase 2 | H002405_01 | L11285 | 72241 | MAP2K2 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Bioactive Peptide Induced Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, fMLP induced chemokine gene expression in HMC-1 cells, Human Cytomegalovirus and Map Kinase Pathways, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway, Role of MAL in Rho-Mediated Activation of SRF, Role of �-arrestins in the activation and targeting of MAP kinases, Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling, Signaling of Hepatocyte Growth Factor Receptor | 0.3118803 | 1.093 |
| 64 | pyk2Pathway_h | BioCarta | H011336_01 | Info | Guanine nucleotide binding protein (G protein), q polypeptide | H011336_01 | U43083 | 296261 | GNAQ | Activation of PKC through G protein coupled receptor, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CCR3 signaling in Eosinophils, CXCR4 Signaling Pathway, Effects of calcineurin in Keratinocyte Differentiation, G-Protein Signaling Through Tubby Proteins, Links between Pyk2 and Map Kinases, Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, Signaling Pathway from G-Protein Families, Thrombin signaling and protease-activated receptors, immunology | 0.3713616 | 0.89 |
| 65 | pyk2Pathway_h | BioCarta | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 66 | pyk2Pathway_h | BioCarta | H002404_01 | Info | Synaptotagmin I | H002404_01 | M55047 | 154679 | SYT1 | 0.8170962 | 0.971 | |
| 67 | pyk2Pathway_h | BioCarta | H000579_01 | Info | Calmodulin 2 (phosphorylase kinase, delta) | H000579_01 | D45887 | 182278 | CALM2 | 0.9689776 | 1.004 | |
| 68 | spryPathway_h | BioCarta | H002040_01 | Info | Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | H002040_01 | X00588 | 77432 | EGFR | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc | 0.0004362 | 0.669 |
| 69 | spryPathway_h | BioCarta | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 70 | spryPathway_h | BioCarta | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 71 | spryPathway_h | BioCarta | H002847_01 | Info | Protein tyrosine phosphatase, receptor type, B | H002847_01 | X54131 | 123641 | PTPRB | Sprouty regulation of tyrosine kinase signals, cell_cycle, cell_signaling | 0.0110757 | 1.299 |
| 72 | spryPathway_h | BioCarta | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 73 | spryPathway_h | BioCarta | H001600_01 | Info | RAS p21 protein activator (GTPase activating protein) 1 | H001600_01 | M23379 | 758 | RASA1 | EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction | 0.1015906 | 0.844 |
| 74 | spryPathway_h | BioCarta | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 75 | MAPK_Cascade_h | GO | H003200_01 | Info | Mitogen-activated protein kinase kinase 3 | H003200_01 | D87116 | 180533 | MAP2K3 | fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, Signal transduction through IL1R, TNF/Stress Related Signaling, Toll-Like Receptor Pathway | 0.0009666 | 1.561 |
| 76 | MAPK_Cascade_h | GO | H001648_01 | Info | Myelin basic protein | H001648_01 | M13577 | 69547 | MBP | 0.0014651 | 0.667 | |
| 77 | MAPK_Cascade_h | GO | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 78 | MAPK_Cascade_h | GO | H002895_01 | Info | Mitogen-activated protein kinase 14 | H002895_01 | L35263 | 79107 | MAPK14 | BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, Map Kinase Inactivation of SMRT Corepressor, MAP Kinase Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), NFkB activation by Nontypeable Hemophilus influenzae, Oxidative Stress Induced Gene Expression Via Nrf2, p38 MAPK Signaling Pathway , Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Regulation of eIF4e and p70 S6 Kinase, Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, SARS Coronavirus Protease, Signal transduction through IL1R, TACI and BCMA stimulation of B cell imm … | 0.0086925 | 1.429 |
| 79 | MAPK_Cascade_h | GO | H003611_01 | Info | Mitogen-activated protein kinase kinase 4 | H003611_01 | L36870 | 75217 | MAP2K4 | Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system | 0.012502 | 0.753 |
| 80 | MAPK_Cascade_h | GO | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 81 | MAPK_Cascade_h | GO | H000029_01 | Info | Mitogen-activated protein kinase kinase kinase 3 | H000029_01 | U78876 | 29282 | MAP3K3 | MAP Kinase Signaling Pathway, Phosphatidylinositol signaling system | 0.2027051 | 1.138 |
| 82 | MAPK_Cascade_h | GO | H002943_01 | Info | V-raf murine sarcoma viral oncogene homolog B1 | H002943_01 | M95712 | 622 | BRAF | MAP Kinase Signaling Pathway, cell_cycle, cell_signaling, immunology, signal_transduction, tsonc | 0.2376595 | 0.895 |
| 83 | MAPK_Cascade_h | GO | H003309_01 | Info | Mitogen-activated protein kinase kinase 7 | H003309_01 | AF013589 | 110299 | MAP2K7 | Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Keratinocyte Differentiation, MAP Kinase Signaling Pathway | 0.3044184 | 1.088 |
| 84 | MAPK_Cascade_h | GO | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 85 | radiation_sensitivity_h | BioCarta | H001935_01 | Info | Glyceraldehyde-3-phosphate dehydrogenase | H001935_01 | U34995 | 169476 | GAPD | 0.0001082 | 1.485 | |
| 86 | radiation_sensitivity_h | BioCarta | H002040_01 | Info | Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | H002040_01 | X00588 | 77432 | EGFR | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc | 0.0004362 | 0.669 |
| 87 | radiation_sensitivity_h | BioCarta | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 88 | radiation_sensitivity_h | BioCarta | H002681_01 | Info | Cyclin D3 | H002681_01 | M92287 | 83173 | CCND3 | Cyclins and Cell Cycle Regulation, cell_cycle | 0.0084801 | 1.28 |
| 89 | radiation_sensitivity_h | BioCarta | H002092_01 | Info | Ataxia telangiectasia and Rad3 related | H002092_01 | U49844 | 77613 | ATR | Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Regulation of cell cycle progression by Plk3, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Phosphatidylinositol signaling system, DNA_replication, immunology | 0.0105491 | 0.753 |
| 90 | radiation_sensitivity_h | BioCarta | H003739_01 | Info | Cell division cycle 2, G1 to S and G2 to M | H003739_01 | X05360 | 184572 | CDC2 | Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, cdc25 and chk1 Regulatory Pathway in response to DNA damage, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Protein Kinase A at the Centrosome, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of Splicing through Sam68, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, Phosphatidylinositol signaling system, cell_cycle | 0.0222229 | 0.733 |
| 91 | radiation_sensitivity_h | BioCarta | H002789_01 | Info | Tumor protein p53 (Li-Fraumeni syndrome) | H002789_01 | NM_000546 | 1846 | TP53 | Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc | 0.0273242 | 1.207 |
| 92 | radiation_sensitivity_h | BioCarta | H002149_01 | Info | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | H002149_01 | U03106 | 179665 | CDKN1A | ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc | 0.0349766 | 1.236 |
| 93 | radiation_sensitivity_h | BioCarta | H002473_01 | Info | Insulin-like growth factor 1 receptor | H002473_01 | NM_000875 | 239176 | IGF1R | Perou’s – Intrinsic- Breast-Cancer-Genes, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Erk1/Erk2 Mapk Signaling pathway, IGF-1 Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Telomeres, Telomerase, Cellular Aging, and Immortality, The IGF-1 Receptor and Longevity, immunology | 0.079692 | 1.158 |
| 94 | radiation_sensitivity_h | BioCarta | H002987_01 | Info | Cyclin B2 | H002987_01 | AK001404 | 194698 | CCNB2 | Estrogen-responsive protein Efp controls cell cycle and breast tumors growth | 0.0829851 | 0.84 |
| 95 | radiation_sensitivity_h | BioCarta | H002323_01 | Info | Cyclin E1 | H002323_01 | M74093 | 9700 | CCNE1 | Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle | 0.1107382 | 0.884 |
| 96 | radiation_sensitivity_h | BioCarta | H002760_01 | Info | RAD51 (S. cerevisiae) homolog (E coli RecA homolog) | H002760_01 | D14134 | 23044 | RAD51 | ATM Signaling Pathway, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, DNA_replication | 0.1212274 | 1.154 |
| 97 | radiation_sensitivity_h | BioCarta | H003605_01 | Info | BCL2-associated X protein | H003605_01 | L22474 | 159428 | BAX | Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology | 0.253339 | 0.907 |
| 98 | radiation_sensitivity_h | BioCarta | H003644_01 | Info | Tumor necrosis factor receptor superfamily, member 6 | H003644_01 | X63717 | 82359 | TNFRSF6 | apoptosis, immunology | 0.4621499 | 0.927 |
| 99 | radiation_sensitivity_h | BioCarta | H003538_01 | Info | Actin, beta | H003538_01 | NM_001101 | 288061 | ACTB | Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes | 0.6253266 | 0.956 |
| 100 | radiation_sensitivity_h | BioCarta | H003542_01 | Info | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene | H003542_01 | M11730 | 323910 | ERBB2 | Perou’s – Intrinsic- Breast-Cancer-Genes, Role of ERBB2 in Signal Transduction and Oncology, Trefoil Factors Initiate Mucosal Healing, immunology, signal_transduction, tsonc | 0.7160857 | 1.031 |
| 101 | radiation_sensitivity_h | BioCarta | H006841_01 | Info | Homo sapiens mRNA; cDNA DKFZp564P073 (from clone DKFZp564P073) | H006841_01 | AL049301 | 278577 | Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology | 0.7810094 | 0.98 | |
| 102 | radiation_sensitivity_h | BioCarta | H003766_01 | Info | Mouse double minute 2, human homolog of; p53-binding protein | H003766_01 | M92424 | 170027 | MDM2 | ATM Signaling Pathway, Cell Cycle: G2/M Checkpoint, CTCF: First Multivalent Nuclear Factor, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Sumoylation by RanBP2 Regulates Transcriptional Repression, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, gene_regulation, transcription, tsonc | 0.8018001 | 0.978 |
| 103 | radiation_sensitivity_h | BioCarta | H003816_01 | Info | Caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) | H003816_01 | M87507 | 2490 | CASP1 | Caspase Cascade in Apoptosis, D4-GDI Signaling Pathway, IL 18 Signaling Pathway, apoptosis, immunology | 0.9157209 | 1.011 |
| 104 | radiation_sensitivity_h | BioCarta | H003027_01 | Info | Cyclin D2 | H003027_01 | D13639 | 75586 | CCND2 | Cyclins and Cell Cycle Regulation, cell_cycle | 0.9682473 | 0.996 |
| 105 | insulinPathway_h | BioCarta | H000732_01 | Info | Insulin receptor substrate 1 | H000732_01 | S62539 | 96063 | IRS1 | Perou’s – Intrinsic- Breast-Cancer-Genes, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 4 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Insulin Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of eIF4e and p70 S6 Kinase, immunology | 0.0013348 | 0.643 |
| 106 | insulinPathway_h | BioCarta | H002186_01 | Info | Serum response factor (c-fos serum response element-binding transcription factor) | H002186_01 | J03161 | 155321 | SRF | EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription | 0.0017465 | 0.722 |
| 107 | insulinPathway_h | BioCarta | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 108 | insulinPathway_h | BioCarta | H002893_01 | Info | V-raf-1 murine leukemia viral oncogene homolog 1 | H002893_01 | X03484 | 85181 | RAF1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … | 0.0062484 | 1.596 |
| 109 | insulinPathway_h | BioCarta | H003178_01 | Info | Mitogen-activated protein kinase 3 | H003178_01 | X60188 | 861 | MAPK3 | Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … | 0.0986041 | 1.184 |
| 110 | insulinPathway_h | BioCarta | H001600_01 | Info | RAS p21 protein activator (GTPase activating protein) 1 | H001600_01 | M23379 | 758 | RASA1 | EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction | 0.1015906 | 0.844 |
| 111 | insulinPathway_h | BioCarta | H003158_01 | Info | Mitogen-activated protein kinase 8 | H003158_01 | L26318 | 190913 | MAPK8 | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … | 0.1287835 | 1.166 |
| 112 | insulinPathway_h | BioCarta | H002624_01 | Info | Insulin receptor | H002624_01 | X02160 | 89695 | INSR | Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Growth Hormone Signaling Pathway, Insulin Signaling Pathway, immunology | 0.433218 | 0.919 |
| 113 | insulinPathway_h | BioCarta | H002722_01 | Info | Mitogen-activated protein kinase kinase 1 | H002722_01 | L11284 | 3446 | MAP2K1 | Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … | 0.7377933 | 0.973 |
| 114 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 115 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H002412_01 | Info | Cyclin-dependent kinase 2 | H002412_01 | M68520 | 19192 | CDK2 | CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, immunology, signal_transduction | 0.0040171 | 0.711 |
| 116 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H002681_01 | Info | Cyclin D3 | H002681_01 | M92287 | 83173 | CCND3 | Cyclins and Cell Cycle Regulation, cell_cycle | 0.0084801 | 1.28 |
| 117 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H000136_01 | Info | Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | H000136_01 | AF041248 | 4854 | CDKN2C | Cyclins and Cell Cycle Regulation, immunology | 0.0088074 | 0.705 |
| 118 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H005436_01 | Info | Homo sapiens cDNA FLJ20653 fis, clone KAT01739 | H005436_01 | AK000660 | 180059 | Perou’s – Intrinsic- Breast-Cancer-Genes, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Influence of Ras and Rho proteins on G1 to S Transition, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction | 0.0126769 | 0.793 | |
| 119 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003739_01 | Info | Cell division cycle 2, G1 to S and G2 to M | H003739_01 | X05360 | 184572 | CDC2 | Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, cdc25 and chk1 Regulatory Pathway in response to DNA damage, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Protein Kinase A at the Centrosome, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of Splicing through Sam68, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, Phosphatidylinositol signaling system, cell_cycle | 0.0222229 | 0.733 |
| 120 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003410_01 | Info | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | H003410_01 | U26727 | 1174 | CDKN2A | Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0245577 | 0.782 |
| 121 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003759_01 | Info | Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | H003759_01 | U40343 | 29656 | CDKN2D | Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation | 0.0311312 | 1.253 |
| 122 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H002149_01 | Info | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | H002149_01 | U03106 | 179665 | CDKN1A | ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc | 0.0349766 | 1.236 |
| 123 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H002371_01 | Info | Cyclin B1 | H002371_01 | M25753 | 23960 | CCNB1 | Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, cell_cycle | 0.037756 | 0.797 |
| 124 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H002323_01 | Info | Cyclin E1 | H002323_01 | M74093 | 9700 | CCNE1 | Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle | 0.1107382 | 0.884 |
| 125 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H001999_01 | Info | Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | H001999_01 | X59798 | 82932 | CCND1 | Perou’s – Intrinsic- Breast-Cancer-Genes, BTG family proteins and cell cycle regulation, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, WNT Signaling Pathway, cell_cycle, tsonc | 0.3215316 | 0.898 |
| 126 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003750_01 | Info | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | H003750_01 | AF004819 | 72901 | CDKN2B | Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, cell_cycle, cell_signaling, signal_transduction, tsonc | 0.3235256 | 0.886 |
| 127 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H000126_01 | Info | Retinoblastoma-like 1 (p107) | H000126_01 | L14812 | 87 | RBL1 | Cyclins and Cell Cycle Regulation, METS affect on Macrophage Differentiation, cell_cycle | 0.4736162 | 1.053 |
| 128 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003162_01 | Info | Transcription factor Dp-1 | H003162_01 | L23959 | 279576 | TFDP1 | Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, Regulation of p27 Phosphorylation during Cell Cycle Progression | 0.6646128 | 0.958 |
| 129 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H002606_01 | Info | Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) | H002606_01 | L20320 | 184298 | CDK7 | Perou’s – Intrinsic- Breast-Cancer-Genes, Cyclins and Cell Cycle Regulation, Degradation of the RAR and RXR by the proteasome, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction | 0.9364784 | 0.991 |
| 130 | cellcyclePathway_h | Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. | H003027_01 | Info | Cyclin D2 | H003027_01 | D13639 | 75586 | CCND2 | Cyclins and Cell Cycle Regulation, cell_cycle | 0.9682473 | 0.996 |
| 131 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H003124_01 | Info | Fc fragment of IgG, receptor, transporter, alpha | H003124_01 | U12255 | 111903 | FCGRT | 2.86e-05 | 1.917 | |
| 132 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H000825_01 | Info | S100 calcium-binding protein A8 (calgranulin A) | H000825_01 | X06234 | 100000 | S100A8 | immunology | 0.0001788 | 2.746 |
| 133 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H002406_01 | Info | Jun B proto-oncogene | H002406_01 | X51345 | 198951 | JUNB | GATA3 participate in activating the Th2 cytokine genes expression, tsonc | 0.0021761 | 1.408 |
| 134 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H002878_01 | Info | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | H002878_01 | M16038 | 80887 | LYN | BCR Signaling Pathway, Eph Kinases and ephrins support platelet aggregation, Fc Epsilon Receptor I Signaling in Mast Cells, Phosphoinositides and their downstream targets., immunology, signal_transduction, tsonc | 0.0068841 | 1.545 |
| 135 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H000316_01 | Info | Delta sleep inducing peptide, immunoreactor | H000316_01 | AL110191 | 75450 | DSIPI | 0.0102545 | 1.531 | |
| 136 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H006355_01 | Info | KIAA1451 protein | H006355_01 | AL049923 | 109694 | KIAA1451 | 0.0105169 | 1.369 | |
| 137 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H000199_01 | Info | Translocated promoter region (to activated MET oncogene) | H000199_01 | X66397 | 169750 | TPR | tsonc | 0.036441 | 0.801 |
| 138 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H001971_01 | Info | Retinoblastoma-binding protein 6 | H001971_01 | X85133 | 85273 | RBBP6 | 0.0366619 | 0.747 | |
| 139 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H006255_01 | Info | Syndecan binding protein (syntenin) | H006255_01 | AF000652 | 8180 | SDCBP | 0.0567867 | 1.234 | |
| 140 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H002168_01 | Info | GATA-binding protein 2 | H002168_01 | M68891 | 760 | GATA2 | gene_regulation, misc, transcription | 0.0841754 | 0.806 |
| 141 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H004936_01 | Info | DKFZP564A122 protein | H004936_01 | AL110269 | 187991 | DKFZP564A122 | 0.0852946 | 1.175 | |
| 142 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H007504_01 | Info | Hemoglobin, epsilon 1 | H007504_01 | NM_005330 | 117848 | HBE1 | 0.118007 | 0.749 | |
| 143 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H002091_01 | Info | V-myc avian myelocytomatosis viral oncogene homolog | H002091_01 | K02276 | 79070 | MYC | Cadmium induces DNA synthesis and proliferation in macrophages, CTCF: First Multivalent Nuclear Factor, Erk1/Erk2 Mapk Signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, MAP Kinase Signaling Pathway, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Overview of telomerase protein component gene hTert Transcriptional Regulation , p38 MAPK Signaling Pathway , Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, WNT Signaling Pathway, gene_regulation, immunology, transcription, tsonc | 0.1797519 | 0.824 |
| 144 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H001023_01 | Info | Mannosidase, alpha, class 2A, member 2 | H001023_01 | L28821 | 295605 | MAN2A2 | ER associated degradation (ERAD) Pathway, Steps in the Glycosylation of Mammalian N-linked Oligosaccharides, N-Glycan biosynthesis | 0.2111813 | 1.139 |
| 145 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H003255_01 | Info | CDC37 (cell division cycle 37, S. cerevisiae, homolog) | H003255_01 | U43077 | 160958 | CDC37 | 0.2178008 | 0.878 | |
| 146 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H000068_01 | Info | Signal recognition particle 72kD | H000068_01 | AF069765 | 237825 | SRP72 | Perou’s – Intrinsic- Breast-Cancer-Genes | 0.2609516 | 0.897 |
| 147 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H012741_01 | Info | Glutaredoxin (thioltransferase) | H012741_01 | AF069668 | 28988 | GLRX | pharmacology | 0.2704585 | 1.145 |
| 148 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H006807_01 | Info | Cytokine inducible SH2-containing protein | H006807_01 | AF132297 | 8257 | CISH | Growth Hormone Signaling Pathway, IL-2 Receptor Beta Chain in T cell Activation, immunology | 0.3746206 | 0.888 |
| 149 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H004864_01 | Info | Ubiquitin specific protease 1 | H004864_01 | AF117386 | 35086 | USP1 | 0.3871195 | 0.908 | |
| 150 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H006584_01 | Info | Splicing factor, arginine/serine-rich 11 | H006584_01 | M74002 | 11482 | SFRS11 | 0.4576641 | 1.062 | |
| 151 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H010826_01 | Info | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide | H010826_01 | AB024334 | 25001 | YWHAG | 0.6175419 | 1.047 | |
| 152 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H016588_01 | Info | Hypothetical protein DKFZp761B2423 | H016588_01 | AK026954 | 91065 | DKFZp761B2423 | 0.6339659 | 1.046 | |
| 153 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H010792_01 | Info | Dynein, cytoplasmic, light intermediate polypeptide 2 | H010792_01 | AF035812 | 194625 | DNCLI2 | 0.6511108 | 1.058 | |
| 154 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H002850_01 | Info | Murine leukemia viral (bmi-1) oncogene homolog | H002850_01 | L13689 | 431 | BMI1 | Perou’s – Intrinsic- Breast-Cancer-Genes, The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails, immunology, tsonc | 0.7846354 | 0.976 |
| 155 | HOXA9_DOWN_h | Dorsam_et_al_2004 | H003618_01 | Info | Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) | H003618_01 | D17547 | 301865 | DCT | Tyrosine metabolism | 0.9648525 | 0.996 |
| 156 | gata3Pathway_h | BioCarta | H003200_01 | Info | Mitogen-activated protein kinase kinase 3 | H003200_01 | D87116 | 180533 | MAP2K3 | fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, Signal transduction through IL1R, TNF/Stress Related Signaling, Toll-Like Receptor Pathway | 0.0009666 | 1.561 |
| 157 | gata3Pathway_h | BioCarta | H002406_01 | Info | Jun B proto-oncogene | H002406_01 | X51345 | 198951 | JUNB | GATA3 participate in activating the Th2 cytokine genes expression, tsonc | 0.0021761 | 1.408 |
| 158 | gata3Pathway_h | BioCarta | H003415_01 | Info | Protein kinase, cAMP-dependent, catalytic, beta | H003415_01 | M34181 | 87773 | PRKACB | Perou’s – Intrinsic- Breast-Cancer-Genes, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction | 0.0048904 | 0.647 |
| 159 | gata3Pathway_h | BioCarta | H002895_01 | Info | Mitogen-activated protein kinase 14 | H002895_01 | L35263 | 79107 | MAPK14 | BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, Map Kinase Inactivation of SMRT Corepressor, MAP Kinase Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), NFkB activation by Nontypeable Hemophilus influenzae, Oxidative Stress Induced Gene Expression Via Nrf2, p38 MAPK Signaling Pathway , Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Regulation of eIF4e and p70 S6 Kinase, Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, SARS Coronavirus Protease, Signal transduction through IL1R, TACI and BCMA stimulation of B cell imm … | 0.0086925 | 1.429 |
| 160 | gata3Pathway_h | BioCarta | H006601_01 | Info | V-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog | H006601_01 | AF055376 | 30250 | MAF | GATA3 participate in activating the Th2 cytokine genes expression, tsonc | 0.079493 | 0.812 |
| 161 | gata3Pathway_h | BioCarta | H001698_01 | Info | Protein kinase, cAMP-dependent, regulatory, type II, alpha | H001698_01 | X14968 | 289075 | PRKAR2A | AKAP95 role in mitosis and chromosome dynamics, Protein Kinase A at the Centrosome, Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation | 0.2569617 | 1.125 |
| 162 | gata3Pathway_h | BioCarta | H000645_01 | Info | Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) | H000645_01 | M33336 | 183037 | PRKAR1A | Activation of cAMP-dependent protein kinase, PKA, cell_cycle, cell_signaling, signal_transduction | 0.4305614 | 0.935 |
| 163 | gata3Pathway_h | BioCarta | H002045_01 | Info | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | H002045_01 | U80917 | 96149 | NFATC1 | BCR Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Effects of calcineurin in Keratinocyte Differentiation, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, NFAT and Hypertrophy of the heart (Transcription in the broken heart), Role of MEF2D in T-cell Apoptosis, Signaling Pathway from G-Protein Families, T Cell Receptor Signaling Pathway, immunology | 0.623508 | 1.051 |
| 164 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H001032_01 | Info | Cytotoxic T-lymphocyte-associated protein 4 | H001032_01 | L15006 | 247824 | CTLA4 | The Co-Stimulatory Signal During T-cell Activation, immunology | 0.0001134 | 0.56 |
| 165 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 166 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H001210_01 | Info | Major histocompatibility complex, class II, DR beta 3 | H001210_01 | V00522 | 279930 | HLA-DRB3 | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology | 0.0031398 | 1.8 |
| 167 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H003054_01 | Info | Major histocompatibility complex, class II, DR alpha | H003054_01 | J00194 | 76807 | HLA-DRA | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology | 0.0045394 | 1.755 |
| 168 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H002284_01 | Info | Major histocompatibility complex, class II, DR beta 5 | H002284_01 | M20430 | 308026 | HLA-DRB5 | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology | 0.0670054 | 1.503 |
| 169 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H015660_01 | Info | Major histocompatibility complex, class II, DR beta 4 | H015660_01 | NM_021983 | 293934 | HLA-DRB4 | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology | 0.2187912 | 0.885 |
| 170 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H003820_01 | Info | Lymphocyte-specific protein tyrosine kinase | H003820_01 | X05027 | 1765 | LCK | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, IL 2 signaling pathway, IL-7 Signal Transduction, Lck and Fyn tyrosine kinases in initiation of TCR Activation, T Cell Receptor Signaling Pathway, The Co-Stimulatory Signal During T-cell Activation, immunology, signal_transduction, tsonc | 0.2266863 | 0.873 |
| 171 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H000858_01 | Info | Homo sapiens, clone MGC:12387, mRNA, complete CDS | H000858_01 | M16942 | 318720 | Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology | 0.2327988 | 1.274 | |
| 172 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H001197_01 | Info | T cell receptor beta locus | H001197_01 | X00437 | 303157 | TRB@ | 0.4180662 | 0.913 | |
| 173 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H002570_01 | Info | Interleukin 2 | H002570_01 | S82692 | 89679 | IL2 | Antigen Dependent B Cell Activation, Cytokine Network, Cytokines and Inflammatory Response, IL 18 Signaling Pathway, IL 2 signaling pathway, OX40 Signaling Pathway, Regulation of hematopoiesis by cytokines, Role of Tob in T-cell activation, Selective expression of chemokine receptors during T-cell polarization, Th1/Th2 Differentiation, The 4-1BB-dependent immune response, The Co-Stimulatory Signal During T-cell Activation, immunology | 0.6483346 | 1.043 |
| 174 | ctla4Pathway_h | T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. | H001267_01 | Info | CD3Z antigen, zeta polypeptide (TiT3 complex) | H001267_01 | NM_000734 | 97087 | CD3Z | immunology | 0.8300402 | 1.024 |
| 175 | cell_cycle_checkpointII_h | GO | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 176 | cell_cycle_checkpointII_h | GO | H001983_01 | Info | Fanconi anemia, complementation group G | H001983_01 | AJ007669 | 8047 | FANCG | BRCA1-dependent Ub-ligase activity, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, immunology | 0.0098981 | 0.692 |
| 177 | cell_cycle_checkpointII_h | GO | H002092_01 | Info | Ataxia telangiectasia and Rad3 related | H002092_01 | U49844 | 77613 | ATR | Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Regulation of cell cycle progression by Plk3, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Phosphatidylinositol signaling system, DNA_replication, immunology | 0.0105491 | 0.753 |
| 178 | cell_cycle_checkpointII_h | GO | H003410_01 | Info | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | H003410_01 | U26727 | 1174 | CDKN2A | Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0245577 | 0.782 |
| 179 | cell_cycle_checkpointII_h | GO | H002789_01 | Info | Tumor protein p53 (Li-Fraumeni syndrome) | H002789_01 | NM_000546 | 1846 | TP53 | Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc | 0.0273242 | 1.207 |
| 180 | cell_cycle_checkpointII_h | GO | H001967_01 | Info | Cyclin E2 | H001967_01 | AF091433 | 30464 | CCNE2 | cell_cycle | 0.0814824 | 0.826 |
| 181 | cell_cycle_checkpointII_h | GO | H002232_01 | Info | Cell division cycle 34 | H002232_01 | L22005 | 76932 | CDC34 | Cell Cycle: G2/M Checkpoint, Cyclin E Destruction Pathway, E2F1 Destruction Pathway, Ubiquitin mediated proteolysis | 0.8799021 | 0.983 |
| 182 | g1Pathway_h | BioCarta | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 183 | g1Pathway_h | BioCarta | H002412_01 | Info | Cyclin-dependent kinase 2 | H002412_01 | M68520 | 19192 | CDK2 | CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, immunology, signal_transduction | 0.0040171 | 0.711 |
| 184 | g1Pathway_h | BioCarta | H002092_01 | Info | Ataxia telangiectasia and Rad3 related | H002092_01 | U49844 | 77613 | ATR | Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Regulation of cell cycle progression by Plk3, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Phosphatidylinositol signaling system, DNA_replication, immunology | 0.0105491 | 0.753 |
| 185 | g1Pathway_h | BioCarta | H005436_01 | Info | Homo sapiens cDNA FLJ20653 fis, clone KAT01739 | H005436_01 | AK000660 | 180059 | Perou’s – Intrinsic- Breast-Cancer-Genes, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Influence of Ras and Rho proteins on G1 to S Transition, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction | 0.0126769 | 0.793 | |
| 186 | g1Pathway_h | BioCarta | H003739_01 | Info | Cell division cycle 2, G1 to S and G2 to M | H003739_01 | X05360 | 184572 | CDC2 | Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, cdc25 and chk1 Regulatory Pathway in response to DNA damage, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Protein Kinase A at the Centrosome, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of Splicing through Sam68, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, Phosphatidylinositol signaling system, cell_cycle | 0.0222229 | 0.733 |
| 187 | g1Pathway_h | BioCarta | H003410_01 | Info | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | H003410_01 | U26727 | 1174 | CDKN2A | Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0245577 | 0.782 |
| 188 | g1Pathway_h | BioCarta | H002789_01 | Info | Tumor protein p53 (Li-Fraumeni syndrome) | H002789_01 | NM_000546 | 1846 | TP53 | Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc | 0.0273242 | 1.207 |
| 189 | g1Pathway_h | BioCarta | H002149_01 | Info | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | H002149_01 | U03106 | 179665 | CDKN1A | ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc | 0.0349766 | 1.236 |
| 190 | g1Pathway_h | BioCarta | H002323_01 | Info | Cyclin E1 | H002323_01 | M74093 | 9700 | CCNE1 | Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle | 0.1107382 | 0.884 |
| 191 | g1Pathway_h | BioCarta | H003207_01 | Info | V-abl Abelson murine leukemia viral oncogene homolog 1 | H003207_01 | NM_005157 | 146355 | ABL1 | cell_signaling, signal_transduction, tsonc | 0.1292454 | 0.826 |
| 192 | g1Pathway_h | BioCarta | H003023_01 | Info | Dihydrofolate reductase | H003023_01 | NM_000791 | 83765 | DHFR | Cell Cycle: G1/S Check Point , Folate biosynthesis, One carbon pool by folate, immunology, pharmacology | 0.1336155 | 0.862 |
| 193 | g1Pathway_h | BioCarta | H001999_01 | Info | Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | H001999_01 | X59798 | 82932 | CCND1 | Perou’s – Intrinsic- Breast-Cancer-Genes, BTG family proteins and cell cycle regulation, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, WNT Signaling Pathway, cell_cycle, tsonc | 0.3215316 | 0.898 |
| 194 | g1Pathway_h | BioCarta | H003750_01 | Info | Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) | H003750_01 | AF004819 | 72901 | CDKN2B | Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, cell_cycle, cell_signaling, signal_transduction, tsonc | 0.3235256 | 0.886 |
| 195 | g1Pathway_h | BioCarta | H009086_01 | Info | S-phase kinase-associated protein 2 (p45) | H009086_01 | U33761 | 23348 | SKP2 | Cell Cycle: G1/S Check Point , E2F1 Destruction Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression | 0.330649 | 1.089 |
| 196 | g1Pathway_h | BioCarta | H000650_01 | Info | Glycogen synthase kinase 3 beta | H000650_01 | L33801 | 78802 | GSK3B | ALK in cardiac myocytes, Cell Cycle: G1/S Check Point , Deregulation of CDK5 in Alzheimer’s Disease, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Multi-step Regulation of Transcription by Pitx2, NFAT and Hypertrophy of the heart (Transcription in the broken heart), Phosphoinositides and their downstream targets., Presenilin action in Notch and Wnt signaling, Regulation of eIF2, Segmentation Clock, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Sonic Hedgehog (Shh) Pathway, WNT Signaling Pathway, Phosphatidylinositol signaling system | 0.353328 | 1.118 |
| 197 | g1Pathway_h | BioCarta | H003162_01 | Info | Transcription factor Dp-1 | H003162_01 | L23959 | 279576 | TFDP1 | Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, Regulation of p27 Phosphorylation during Cell Cycle Progression | 0.6646128 | 0.958 |
| 198 | g1Pathway_h | BioCarta | H000578_01 | Info | Histone deacetylase 1 | H000578_01 | D50405 | 88556 | HDAC1 | immunology | 0.8155423 | 1.017 |
| 199 | EMT_UP_h | Jechlinger_et_al_2003 | H003225_01 | Info | Interferon regulatory factor 7 | H003225_01 | AF076494 | 166120 | IRF7 | gene_regulation, transcription | 6.44e-05 | 1.728 |
| 200 | EMT_UP_h | Jechlinger_et_al_2003 | H000825_01 | Info | S100 calcium-binding protein A8 (calgranulin A) | H000825_01 | X06234 | 100000 | S100A8 | immunology | 0.0001788 | 2.746 |
| 201 | EMT_UP_h | Jechlinger_et_al_2003 | H001850_01 | Info | Interferon-stimulated protein, 15 kDa | H001850_01 | M13755 | 833 | ISG15 | 0.0003862 | 1.943 | |
| 202 | EMT_UP_h | Jechlinger_et_al_2003 | H000473_01 | Info | Uridine phosphorylase | H000473_01 | X90858 | 77573 | UP | Pyrimidine metabolism | 0.0005102 | 1.339 |
| 203 | EMT_UP_h | Jechlinger_et_al_2003 | H002726_01 | Info | B-cell CLL/lymphoma 3 | H002726_01 | M31732 | 31210 | BCL3 | tsonc | 0.0147426 | 1.351 |
| 204 | EMT_UP_h | Jechlinger_et_al_2003 | H003466_01 | Info | CD68 antigen | H003466_01 | S57235 | 246381 | CD68 | angiogenesis, immunology, metastasis | 0.0179458 | 1.335 |
| 205 | EMT_UP_h | Jechlinger_et_al_2003 | H003299_01 | Info | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | H003299_01 | M59979 | 88474 | PTGS1 | Aspirin Blocks Signaling Pathway Involved in Platelet Activation, Eicosanoid Metabolism, Mechanism of Acetaminophen Activity and Toxicity, Prostaglandin and leukotriene metabolism, immunology | 0.023304 | 0.813 |
| 206 | EMT_UP_h | Jechlinger_et_al_2003 | H003029_01 | Info | Disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) | H003029_01 | U53446 | 81988 | DAB2 | 0.0291633 | 0.78 | |
| 207 | EMT_UP_h | Jechlinger_et_al_2003 | H003752_01 | Info | Platelet-derived growth factor receptor, beta polypeptide | H003752_01 | J03278 | 76144 | PDGFRB | cell_cycle, cell_signaling, immunology, misc, signal_transduction | 0.0333891 | 0.832 |
| 208 | EMT_UP_h | Jechlinger_et_al_2003 | H006885_01 | Info | Ribonuclease 6 precursor | H006885_01 | NM_003730 | 8297 | RNASE6PL | 0.0955467 | 1.208 | |
| 209 | EMT_UP_h | Jechlinger_et_al_2003 | H000998_01 | Info | Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | H000998_01 | AB018010 | 79748 | SLC3A2 | Perou’s – Intrinsic- Breast-Cancer-Genes | 0.1156436 | 0.843 |
| 210 | EMT_UP_h | Jechlinger_et_al_2003 | H001908_01 | Info | Discoidin domain receptor family, member 2 | H001908_01 | X74764 | 71891 | DDR2 | 0.1167676 | 0.839 | |
| 211 | EMT_UP_h | Jechlinger_et_al_2003 | H001001_01 | Info | Procollagen C-endopeptidase enhancer | H001001_01 | NM_002593 | 202097 | PCOLCE | 0.1228497 | 0.868 | |
| 212 | EMT_UP_h | Jechlinger_et_al_2003 | H000774_01 | Info | Collagen, type VI, alpha 1 | H000774_01 | X15880 | 108885 | COL6A1 | 0.1448402 | 0.841 | |
| 213 | EMT_UP_h | Jechlinger_et_al_2003 | H002775_01 | Info | Platelet-derived growth factor receptor, alpha polypeptide | H002775_01 | M21574 | 74615 | PDGFRA | Perou’s – Intrinsic- Breast-Cancer-Genes, CBL mediated ligand-induced downregulation of EGF receptors, Erk1/Erk2 Mapk Signaling pathway, PDGF Signaling Pathway, Phospholipids as signalling intermediaries, Rac 1 cell motility signaling pathway, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, immunology, signal_transduction | 0.1636921 | 1.107 |
| 214 | EMT_UP_h | Jechlinger_et_al_2003 | H010646_01 | Info | Ribonuclease 6 precursor | H010646_01 | AK001769 | 8297 | RNASE6PL | 0.1872503 | 1.127 | |
| 215 | EMT_UP_h | Jechlinger_et_al_2003 | H002295_01 | Info | Adenosine deaminase | H002295_01 | X02994 | 1217 | ADA | Purine metabolism, gene_regulation, immunology, transcription | 0.1882263 | 0.871 |
| 216 | EMT_UP_h | Jechlinger_et_al_2003 | H012626_01 | Info | Beta-2-microglobulin | H012626_01 | AB021288 | 75415 | B2M | Antigen Processing and Presentation, CTL mediated immune response against target cells , Ras-Independent pathway in NK cell-mediated cytotoxicity, immunology | 0.1923361 | 1.156 |
| 217 | EMT_UP_h | Jechlinger_et_al_2003 | H003645_01 | Info | Interleukin 11 | H003645_01 | X58377 | 1721 | IL11 | Cytokines and Inflammatory Response, Erythrocyte Differentiation Pathway, Regulation of hematopoiesis by cytokines, immunology | 0.2074062 | 1.116 |
| 218 | EMT_UP_h | Jechlinger_et_al_2003 | H003593_01 | Info | Collagen, type VI, alpha 2 | H003593_01 | AL096746 | 159263 | COL6A2 | 0.300891 | 1.098 | |
| 219 | EMT_UP_h | Jechlinger_et_al_2003 | H001198_01 | Info | Homo sapiens, alpha-1 (VI) collagen | H001198_01 | M20776 | 25459 | 0.3632512 | 1.1 | ||
| 220 | EMT_UP_h | Jechlinger_et_al_2003 | H002451_01 | Info | Flavin containing monooxygenase 1 | H002451_01 | M64082 | 1424 | FMO1 | immunology, misc | 0.3681883 | 0.911 |
| 221 | EMT_UP_h | Jechlinger_et_al_2003 | H000592_01 | Info | Interferon-induced protein with tetratricopeptide repeats 1 | H000592_01 | X03557 | 20315 | IFIT1 | 0.4335751 | 1.121 | |
| 222 | EMT_UP_h | Jechlinger_et_al_2003 | H002713_01 | Info | Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) | H002713_01 | U24577 | 93304 | PLA2G7 | Glycerophospholipid metabolism | 0.4631812 | 0.89 |
| 223 | EMT_UP_h | Jechlinger_et_al_2003 | H010497_01 | Info | Interferon induced transmembrane protein 3 (1-8U) | H010497_01 | X57352 | 182241 | IFITM3 | 0.5875785 | 1.062 | |
| 224 | EMT_UP_h | Jechlinger_et_al_2003 | H003695_01 | Info | Secreted protein, acidic, cysteine-rich (osteonectin) | H003695_01 | J03040 | 111779 | SPARC | misc | 0.6414286 | 1.051 |
| 225 | EMT_UP_h | Jechlinger_et_al_2003 | H002330_01 | Info | Cadherin 15, M-cadherin (myotubule) | H002330_01 | D83542 | 148090 | CDH15 | 0.7996949 | 0.974 | |
| 226 | EMT_UP_h | Jechlinger_et_al_2003 | H002397_01 | Info | Methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase | H002397_01 | X16396 | 154672 | MTHFD2 | Glyoxylate and dicarboxylate metabolism, One carbon pool by folate | 0.8081788 | 0.975 |
| 227 | EMT_UP_h | Jechlinger_et_al_2003 | H002672_01 | Info | G protein-coupled receptor | H002672_01 | U67784 | 23016 | RDC1 | 0.8527585 | 0.967 | |
| 228 | EMT_UP_h | Jechlinger_et_al_2003 | H002490_01 | Info | Hexabrachion (tenascin C, cytotactin) | H002490_01 | X78565 | 289114 | HXB | Perou’s – Intrinsic- Breast-Cancer-Genes | 0.856155 | 0.983 |
| 229 | EMT_UP_h | Jechlinger_et_al_2003 | H002283_01 | Info | Secretory leukocyte protease inhibitor (antileukoproteinase) | H002283_01 | X04470 | 251754 | SLPI | Perou’s – Intrinsic- Breast-Cancer-Genes, Proepithelin Conversion to Epithelin and Wound Repair Control, immunology | 0.9075348 | 1.012 |
| 230 | EMT_UP_h | Jechlinger_et_al_2003 | H004245_01 | Info | Snail 1 (drosophila homolog), zinc finger protein | H004245_01 | AF125377 | 48029 | SNAI1 | Downregulated of MTA-3 in ER-negative Breast Tumors | 0.9743253 | 1.003 |
| 231 | tumor_supressor_h | BioCarta | H001935_01 | Info | Glyceraldehyde-3-phosphate dehydrogenase | H001935_01 | U34995 | 169476 | GAPD | 0.0001082 | 1.485 | |
| 232 | tumor_supressor_h | BioCarta | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 233 | tumor_supressor_h | BioCarta | H002387_01 | Info | MutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) | H002387_01 | NM_000251 | 78934 | MSH2 | DNA_damage, tsonc | 0.004273 | 0.694 |
| 234 | tumor_supressor_h | BioCarta | H000570_01 | Info | CREB binding protein (Rubinstein-Taybi syndrome) | H000570_01 | U47741 | 23598 | CREBBP | gene_regulation, transcription | 0.0048718 | 1.469 |
| 235 | tumor_supressor_h | BioCarta | H000208_01 | Info | Breast cancer 1, early onset | H000208_01 | NM_007295 | 194143 | BRCA1 | ATM Signaling Pathway, BRCA1-dependent Ub-ligase activity, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G2/M Checkpoint, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, immunology, tsonc | 0.009032 | 0.746 |
| 236 | tumor_supressor_h | BioCarta | H002789_01 | Info | Tumor protein p53 (Li-Fraumeni syndrome) | H002789_01 | NM_000546 | 1846 | TP53 | Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc | 0.0273242 | 1.207 |
| 237 | tumor_supressor_h | BioCarta | H003759_01 | Info | Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | H003759_01 | U40343 | 29656 | CDKN2D | Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation | 0.0311312 | 1.253 |
| 238 | tumor_supressor_h | BioCarta | H002114_01 | Info | Neurofibromin 2 (bilateral acoustic neuroma) | H002114_01 | L11353 | 902 | NF2 | immunology, tsonc | 0.2904249 | 0.837 |
| 239 | tumor_supressor_h | BioCarta | H002700_01 | Info | Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) | H002700_01 | L11695 | 220 | TGFBR1 | ALK in cardiac myocytes, Function of SLRP in Bone: An Integrated View, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, p38 MAPK Signaling Pathway , TGF beta signaling pathway, Phosphatidylinositol signaling system, angiogenesis, development | 0.3279632 | 0.903 |
| 240 | tumor_supressor_h | BioCarta | H002611_01 | Info | Interferon regulatory factor 1 | H002611_01 | X14454 | 80645 | IRF1 | gene_regulation, transcription | 0.3284273 | 0.915 |
| 241 | tumor_supressor_h | BioCarta | H006635_01 | Info | Homo sapiens clone 23607 mRNA sequence | H006635_01 | AF038181 | 167825 | ALK in cardiac myocytes, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Multi-step Regulation of Transcription by Pitx2, Presenilin action in Notch and Wnt signaling, TGF beta signaling pathway, WNT Signaling Pathway, development, immunology, tsonc | 0.6181322 | 1.041 | |
| 242 | tumor_supressor_h | BioCarta | H003538_01 | Info | Actin, beta | H003538_01 | NM_001101 | 288061 | ACTB | Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes | 0.6253266 | 0.956 |
| 243 | tumor_supressor_h | BioCarta | H007492_01 | Info | Cofilin 1 (non-muscle) | H007492_01 | X95404 | 180370 | CFL1 | CCR3 signaling in Eosinophils, Rac 1 cell motility signaling pathway, Rho cell motility signaling pathway | 0.685636 | 1.038 |
| 244 | tumor_supressor_h | BioCarta | H003594_01 | Info | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | H003594_01 | U22398 | 106070 | CDKN1C | cell_cycle, immunology, tsonc | 0.7532847 | 0.968 |
| 245 | tumor_supressor_h | BioCarta | H003151_01 | Info | E1A binding protein p300 | H003151_01 | U01877 | 25272 | EP300 | Acetylation and Deacetylation of RelA in The Nucleus, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G2/M Checkpoint, Control of Gene Expression by Vitamin D Receptor, Hypoxia and p53 in the Cardiovascular system, Hypoxia-Inducible Factor in the Cardiovascular System, IL-7 Signal Transduction, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Melanocyte Development and Pigmentation Pathway, Multi-step Regulation of Transcription by Pitx2, NFkB activation by Nontypeable Hemophilus influenzae, Pelp1 Modulation of Estrogen Receptor Activity, Role of ERBB2 in Signal Transduction and Oncology, Role of MEF2D in T-cell Apoptosis, Role of PPAR-gamma Coactivators in Obesity and Thermogenesis, TGF beta signaling pathway, Transcription Regulation by Methyltransferase of CARM1, gene_regulation, transcription | 0.9607239 | 1.004 |
| 246 | drug_resistance_and_metabolism_h | BioCarta | H001935_01 | Info | Glyceraldehyde-3-phosphate dehydrogenase | H001935_01 | U34995 | 169476 | GAPD | 0.0001082 | 1.485 | |
| 247 | drug_resistance_and_metabolism_h | BioCarta | H002040_01 | Info | Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | H002040_01 | X00588 | 77432 | EGFR | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc | 0.0004362 | 0.669 |
| 248 | drug_resistance_and_metabolism_h | BioCarta | H003596_01 | Info | O-6-methylguanine-DNA methyltransferase | H003596_01 | M29971 | 1384 | MGMT | DNA_adducts, DNA_damage | 0.0006291 | 0.667 |
| 249 | drug_resistance_and_metabolism_h | BioCarta | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 250 | drug_resistance_and_metabolism_h | BioCarta | H002412_01 | Info | Cyclin-dependent kinase 2 | H002412_01 | M68520 | 19192 | CDK2 | CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, immunology, signal_transduction | 0.0040171 | 0.711 |
| 251 | drug_resistance_and_metabolism_h | BioCarta | H000872_01 | Info | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | H000872_01 | AF104942 | 108660 | ABCC5 | 0.00423 | 0.773 | |
| 252 | drug_resistance_and_metabolism_h | BioCarta | H002387_01 | Info | MutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) | H002387_01 | NM_000251 | 78934 | MSH2 | DNA_damage, tsonc | 0.004273 | 0.694 |
| 253 | drug_resistance_and_metabolism_h | BioCarta | H000208_01 | Info | Breast cancer 1, early onset | H000208_01 | NM_007295 | 194143 | BRCA1 | ATM Signaling Pathway, BRCA1-dependent Ub-ligase activity, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G2/M Checkpoint, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, immunology, tsonc | 0.009032 | 0.746 |
| 254 | drug_resistance_and_metabolism_h | BioCarta | H003606_01 | Info | Retinoid X receptor, alpha | H003606_01 | U66306 | 20084 | RXRA | Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, Control of Gene Expression by Vitamin D Receptor, Degradation of the RAR and RXR by the proteasome, FXR and LXR Regulation of Cholesterol Metabolism, Map Kinase Inactivation of SMRT Corepressor, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, Role of PPAR-gamma Coactivators in Obesity and Thermogenesis, Transcription Regulation by Methyltransferase of CARM1, Visceral Fat Deposits and the Metabolic Syndrome, development, gene_regulation, transcription | 0.0142664 | 1.308 |
| 255 | drug_resistance_and_metabolism_h | BioCarta | H001848_01 | Info | Glutathione S-transferase M1 | H001848_01 | J03817 | 324730 | GSTM1 | Glutathione metabolism, immunology, pharmacology | 0.018415 | 0.773 |
| 256 | drug_resistance_and_metabolism_h | BioCarta | H003283_01 | Info | Topoisomerase (DNA) II alpha (170kD) | H003283_01 | J04088 | 156346 | TOP2A | Apoptotic DNA fragmentation and tissue homeostasis, DNA_adducts, DNA_damage, DNA_replication | 0.0203748 | 0.733 |
| 257 | drug_resistance_and_metabolism_h | BioCarta | H002533_01 | Info | ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | H002533_01 | AF076622 | 274260 | ABCC6 | 0.0229826 | 1.478 | |
| 258 | drug_resistance_and_metabolism_h | BioCarta | H003410_01 | Info | Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | H003410_01 | U26727 | 1174 | CDKN2A | Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0245577 | 0.782 |
| 259 | drug_resistance_and_metabolism_h | BioCarta | H002789_01 | Info | Tumor protein p53 (Li-Fraumeni syndrome) | H002789_01 | NM_000546 | 1846 | TP53 | Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc | 0.0273242 | 1.207 |
| 260 | drug_resistance_and_metabolism_h | BioCarta | H003759_01 | Info | Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) | H003759_01 | U40343 | 29656 | CDKN2D | Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation | 0.0311312 | 1.253 |
| 261 | drug_resistance_and_metabolism_h | BioCarta | H002149_01 | Info | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | H002149_01 | U03106 | 179665 | CDKN1A | ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc | 0.0349766 | 1.236 |
| 262 | drug_resistance_and_metabolism_h | BioCarta | H002424_01 | Info | Bleomycin hydrolase | H002424_01 | X92106 | 78943 | BLMH | immunology, pharmacology | 0.0414602 | 0.81 |
| 263 | drug_resistance_and_metabolism_h | BioCarta | H007820_01 | Info | Retinoic acid receptor-beta associated open reading frame | H007820_01 | S82362 | 1938 | LOC51036 | Control of Gene Expression by Vitamin D Receptor, DNA_adducts, DNA_damage, gene_regulation, transcription | 0.0421365 | 0.794 |
| 264 | drug_resistance_and_metabolism_h | BioCarta | H003156_01 | Info | V-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide | H003156_01 | M83221 | 858 | RELB | tsonc | 0.0527226 | 1.209 |
| 265 | drug_resistance_and_metabolism_h | BioCarta | H007892_01 | Info | Cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19 | H007892_01 | M61854 | 198501 | CYP2C19 | Fatty acid metabolism, gamma-Hexachlorocyclohexane degradation, Tryptophan metabolism, pharmacology | 0.0560255 | 0.801 |
| 266 | drug_resistance_and_metabolism_h | BioCarta | H003713_01 | Info | Topoisomerase (DNA) II beta (180kD) | H003713_01 | X68060 | 75248 | TOP2B | Control of Gene Expression by Vitamin D Receptor, DNA_adducts, DNA_damage, gene_regulation, transcription | 0.075384 | 0.83 |
| 267 | drug_resistance_and_metabolism_h | BioCarta | H002473_01 | Info | Insulin-like growth factor 1 receptor | H002473_01 | NM_000875 | 239176 | IGF1R | Perou’s – Intrinsic- Breast-Cancer-Genes, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Erk1/Erk2 Mapk Signaling pathway, IGF-1 Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Telomeres, Telomerase, Cellular Aging, and Immortality, The IGF-1 Receptor and Longevity, immunology | 0.079692 | 1.158 |
| 268 | drug_resistance_and_metabolism_h | BioCarta | H003600_01 | Info | Epoxide hydrolase 2, cytoplasmic | H003600_01 | L05779 | 113 | EPHX2 | Tetrachloroethene degradation, immunology, metabolism, pharmacology | 0.092835 | 0.858 |
| 269 | drug_resistance_and_metabolism_h | BioCarta | H002323_01 | Info | Cyclin E1 | H002323_01 | M74093 | 9700 | CCNE1 | Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle | 0.1107382 | 0.884 |
| 270 | drug_resistance_and_metabolism_h | BioCarta | H003376_01 | Info | Aryl hydrocarbon receptor nuclear translocator | H003376_01 | M69238 | 166172 | ARNT | Ahr Signal Transduction Pathway, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia-Inducible Factor in the Cardiovascular System, VEGF, Hypoxia, and Angiogenesis, angiogenesis, immunology | 0.1249479 | 1.133 |
| 271 | drug_resistance_and_metabolism_h | BioCarta | H014546_01 | Info | Peptidylprolyl isomerase A (cyclophilin A) | H014546_01 | NM_021130 | 182937 | PPIA | IL-2 Receptor Beta Chain in T cell Activation | 0.129858 | 1.176 |
| 272 | drug_resistance_and_metabolism_h | BioCarta | H003023_01 | Info | Dihydrofolate reductase | H003023_01 | NM_000791 | 83765 | DHFR | Cell Cycle: G1/S Check Point , Folate biosynthesis, One carbon pool by folate, immunology, pharmacology | 0.1336155 | 0.862 |
| 273 | drug_resistance_and_metabolism_h | BioCarta | H003550_01 | Info | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | H003550_01 | S76638 | 73090 | NFKB2 | gene_regulation, immunology, transcription, tsonc | 0.1593331 | 1.165 |
| 274 | drug_resistance_and_metabolism_h | BioCarta | H001986_01 | Info | Aryl hydrocarbon receptor | H001986_01 | NM_001621 | 170087 | AHR | Ahr Signal Transduction Pathway, gene_regulation, immunology, transcription | 0.1792938 | 1.117 |
| 275 | drug_resistance_and_metabolism_h | BioCarta | H002091_01 | Info | V-myc avian myelocytomatosis viral oncogene homolog | H002091_01 | K02276 | 79070 | MYC | Cadmium induces DNA synthesis and proliferation in macrophages, CTCF: First Multivalent Nuclear Factor, Erk1/Erk2 Mapk Signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, MAP Kinase Signaling Pathway, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Overview of telomerase protein component gene hTert Transcriptional Regulation , p38 MAPK Signaling Pathway , Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, WNT Signaling Pathway, gene_regulation, immunology, transcription, tsonc | 0.1797519 | 0.824 |
| 276 | drug_resistance_and_metabolism_h | BioCarta | H003810_01 | Info | Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) | H003810_01 | X02317 | 75428 | SOD1 | Cardiac Protection Against ROS , Free Radical Induced Apoptosis, immunology, pharmacology | 0.1871555 | 1.13 |
| 277 | drug_resistance_and_metabolism_h | BioCarta | H003242_01 | Info | Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pig | H003242_01 | M31899 | 77929 | ERCC3 | CARM1 and Regulation of the Estrogen Receptor, Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes, Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, DNA_damage, DNA_replication, immunology | 0.2157492 | 0.873 |
| 278 | drug_resistance_and_metabolism_h | BioCarta | H003042_01 | Info | BCL2-like 1 | H003042_01 | Z23115 | 305890 | BCL2L1 | Apoptotic Signaling in Response to DNA Damage, IL-2 Receptor Beta Chain in T cell Activation, Opposing roles of AIF in Apoptosis and Cell Survival, Ras Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, immunology | 0.2336065 | 1.143 |
| 279 | drug_resistance_and_metabolism_h | BioCarta | H003605_01 | Info | BCL2-associated X protein | H003605_01 | L22474 | 159428 | BAX | Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology | 0.253339 | 0.907 |
| 280 | drug_resistance_and_metabolism_h | BioCarta | H003514_01 | Info | Cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 | H003514_01 | M55053 | 1361 | CYP1A2 | Mechanism of Acetaminophen Activity and Toxicity, Nuclear Receptors in Lipid Metabolism and Toxicity, Fatty acid metabolism, gamma-Hexachlorocyclohexane degradation, Tryptophan metabolism, immunology, pharmacology | 0.2704204 | 1.089 |
| 281 | drug_resistance_and_metabolism_h | BioCarta | H011468_01 | Info | ATP-binding cassette, sub-family G (WHITE), member 2 | H011468_01 | AF103796 | 194720 | ABCG2 | 0.2713892 | 0.876 | |
| 282 | drug_resistance_and_metabolism_h | BioCarta | H002577_01 | Info | MutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2) | H002577_01 | U07418 | 57301 | MLH1 | DNA_damage, DNA_replication, tsonc | 0.2947975 | 0.894 |
| 283 | drug_resistance_and_metabolism_h | BioCarta | H003016_01 | Info | Insulin-like growth factor 2 receptor | H003016_01 | Y00285 | 76473 | IGF2R | immunology | 0.3174469 | 1.143 |
| 284 | drug_resistance_and_metabolism_h | BioCarta | H001999_01 | Info | Cyclin D1 (PRAD1: parathyroid adenomatosis 1) | H001999_01 | X59798 | 82932 | CCND1 | Perou’s – Intrinsic- Breast-Cancer-Genes, BTG family proteins and cell cycle regulation, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, WNT Signaling Pathway, cell_cycle, tsonc | 0.3215316 | 0.898 |
| 285 | drug_resistance_and_metabolism_h | BioCarta | H002702_01 | Info | Retinoic acid receptor, gamma | H002702_01 | M38258 | 1497 | RARG | Nuclear Receptors in Lipid Metabolism and Toxicity, development, gene_regulation, transcription | 0.4297075 | 1.087 |
| 286 | drug_resistance_and_metabolism_h | BioCarta | H002294_01 | Info | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | H002294_01 | X78338 | 89433 | ABCC1 | Multi-Drug Resistance Factors | 0.4691659 | 0.928 |
| 287 | drug_resistance_and_metabolism_h | BioCarta | H002907_01 | Info | Retinoic acid receptor, alpha | H002907_01 | X06614 | 250505 | RARA | Degradation of the RAR and RXR by the proteasome, Map Kinase Inactivation of SMRT Corepressor, Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, Nuclear Receptors in Lipid Metabolism and Toxicity, Regulation of transcriptional activity by PML, Transcription Regulation by Methyltransferase of CARM1, development | 0.4825926 | 1.084 |
| 288 | drug_resistance_and_metabolism_h | BioCarta | H000149_01 | Info | Epoxide hydrolase 1, microsomal (xenobiotic) | H000149_01 | NM_000120 | 89649 | EPHX1 | Eicosanoid Metabolism, Tetrachloroethene degradation, immunology, metabolism, pharmacology | 0.512274 | 0.938 |
| 289 | drug_resistance_and_metabolism_h | BioCarta | H001952_01 | Info | Ribosomal protein L13a | H001952_01 | X56932 | 119122 | RPL13A | 0.565051 | 1.059 | |
| 290 | drug_resistance_and_metabolism_h | BioCarta | H006635_01 | Info | Homo sapiens clone 23607 mRNA sequence | H006635_01 | AF038181 | 167825 | ALK in cardiac myocytes, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Multi-step Regulation of Transcription by Pitx2, Presenilin action in Notch and Wnt signaling, TGF beta signaling pathway, WNT Signaling Pathway, development, immunology, tsonc | 0.6181322 | 1.041 | |
| 291 | drug_resistance_and_metabolism_h | BioCarta | H002777_01 | Info | Cytochrome P450, subfamily IIE (ethanol-inducible) | H002777_01 | J02625 | 75183 | CYP2E | Mechanism of Acetaminophen Activity and Toxicity, Nuclear Receptors in Lipid Metabolism and Toxicity, Fatty acid metabolism, gamma-Hexachlorocyclohexane degradation, Tryptophan metabolism | 0.6229802 | 0.953 |
| 292 | drug_resistance_and_metabolism_h | BioCarta | H003538_01 | Info | Actin, beta | H003538_01 | NM_001101 | 288061 | ACTB | Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes | 0.6253266 | 0.956 |
| 293 | drug_resistance_and_metabolism_h | BioCarta | H013267_01 | Info | Homo sapiens clone R2 ErbB-3 R2 (c-erbB-3) mRNA, partial CDS | H013267_01 | U88358 | 306251 | Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of ERBB2 in Signal Transduction and Oncology, cell_cycle, cell_signaling, signal_transduction, tsonc | 0.6380266 | 1.054 | |
| 294 | drug_resistance_and_metabolism_h | BioCarta | H001853_01 | Info | Cellular retinoic acid-binding protein 1 | H001853_01 | S74445 | 7678 | CRABP1 | Perou’s – Intrinsic- Breast-Cancer-Genes | 0.6817674 | 0.954 |
| 295 | drug_resistance_and_metabolism_h | BioCarta | H002094_01 | Info | Thymidylate synthetase | H002094_01 | X02308 | 82962 | TYMS | One carbon pool by folate, Pyrimidine metabolism, metabolism, pharmacology | 0.6945693 | 1.041 |
| 296 | drug_resistance_and_metabolism_h | BioCarta | H002029_01 | Info | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 | H002029_01 | M34309 | 199067 | ERBB3 | Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of ERBB2 in Signal Transduction and Oncology, cell_cycle, cell_signaling, signal_transduction, tsonc | 0.7019431 | 1.035 |
| 297 | drug_resistance_and_metabolism_h | BioCarta | H003542_01 | Info | V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene | H003542_01 | M11730 | 323910 | ERBB2 | Perou’s – Intrinsic- Breast-Cancer-Genes, Role of ERBB2 in Signal Transduction and Oncology, Trefoil Factors Initiate Mucosal Healing, immunology, signal_transduction, tsonc | 0.7160857 | 1.031 |
| 298 | drug_resistance_and_metabolism_h | BioCarta | H003482_01 | Info | Catechol-O-methyltransferase | H003482_01 | NM_000754 | 240013 | COMT | Tyrosine metabolism, behavior, immunology | 0.777803 | 1.026 |
| 299 | drug_resistance_and_metabolism_h | BioCarta | H006841_01 | Info | Homo sapiens mRNA; cDNA DKFZp564P073 (from clone DKFZp564P073) | H006841_01 | AL049301 | 278577 | Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology | 0.7810094 | 0.98 | |
| 300 | drug_resistance_and_metabolism_h | BioCarta | H000245_01 | Info | Peroxisome proliferative activated receptor, gamma | H000245_01 | L40904 | 100724 | PPARG | Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, Nuclear Receptors in Lipid Metabolism and Toxicity, Role of PPAR-gamma Coactivators in Obesity and Thermogenesis, Visceral Fat Deposits and the Metabolic Syndrome | 0.7837641 | 0.944 |
| 301 | drug_resistance_and_metabolism_h | BioCarta | H003772_01 | Info | Xeroderma pigmentosum, complementation group C | H003772_01 | D21089 | 320 | XPC | DNA_damage, immunology | 0.7950726 | 0.977 |
| 302 | drug_resistance_and_metabolism_h | BioCarta | H003355_01 | Info | Retinoid X receptor, gamma | H003355_01 | U38480 | 26550 | RXRG | development | 0.8348881 | 1.017 |
| 303 | drug_resistance_and_metabolism_h | BioCarta | H001977_01 | Info | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | H001977_01 | AF085692 | 90786 | ABCC3 | Multi-Drug Resistance Factors, Nuclear Receptors in Lipid Metabolism and Toxicity | 0.8363263 | 1.021 |
| 304 | drug_resistance_and_metabolism_h | BioCarta | H002350_01 | Info | Peroxisome proliferative activated receptor, alpha | H002350_01 | L02932 | 998 | PPARA | Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Nuclear Receptors in Lipid Metabolism and Toxicity, Regulation of PGC-1a, �-arrestins in GPCR Desensitization, Toll-Like Receptor Pathway | 0.8655149 | 1.015 |
| 305 | drug_resistance_and_metabolism_h | BioCarta | H003711_01 | Info | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | H003711_01 | M58603 | 83428 | NFKB1 | Acetylation and Deacetylation of RelA in The Nucleus, Activation of PKC through G protein coupled receptor, AKT Signaling Pathway, ATM Signaling Pathway, Bone Remodelling, Cadmium induces DNA synthesis and proliferation in macrophages, CD40L Signaling Pathway, Ceramide Signaling Pathway, Chaperones modulate interferon Signaling Pathway, Corticosteroids and cardioprotection, CXCR4 Signaling Pathway, Double Stranded RNA Induced Gene Expression, Erythropoietin mediated neuroprotection through NF-kB, fMLP induced chemokine gene expression in HMC-1 cells, Free Radical Induced Apoptosis, HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Induction of apoptosis through DR3 and DR4/5 Death Receptors , Influence of Ras and Rho proteins on G1 to S Transition, Keratinocyte Differentiation, MAP Kinase Signaling Pathway, Neuropeptides VIP and PACAP inhibit the apoptosis of a … | 0.8665095 | 1.017 |
| 306 | drug_resistance_and_metabolism_h | BioCarta | H002373_01 | Info | MutS (E. coli) homolog 3 | H002373_01 | U61981 | 42674 | MSH3 | DNA_damage, immunology | 0.8910817 | 0.986 |
| 307 | drug_resistance_and_metabolism_h | BioCarta | H015889_01 | Info | BCL2-like 1 | H015889_01 | NM_001191 | 305890 | BCL2L1 | Apoptotic Signaling in Response to DNA Damage, IL-2 Receptor Beta Chain in T cell Activation, Opposing roles of AIF in Apoptosis and Cell Survival, Ras Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, immunology | 0.996743 | 1.001 |
| 308 | pmlPathway_h | BioCarta | H002420_01 | Info | Promyelocytic leukemia | H002420_01 | M79462 | 89633 | PML | Regulation of transcriptional activity by PML, gene_regulation, immunology, transcription | 0.0004143 | 0.71 |
| 309 | pmlPathway_h | BioCarta | H003112_01 | Info | Retinoblastoma 1 (including osteosarcoma) | H003112_01 | L41870 | 75770 | RB1 | BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc | 0.0008596 | 0.674 |
| 310 | pmlPathway_h | BioCarta | H000570_01 | Info | CREB binding protein (Rubinstein-Taybi syndrome) | H000570_01 | U47741 | 23598 | CREBBP | gene_regulation, transcription | 0.0048718 | 1.469 |
| 311 | pmlPathway_h | BioCarta | H002789_01 | Info | Tumor protein p53 (Li-Fraumeni syndrome) | H002789_01 | NM_000546 | 1846 | TP53 | Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc | 0.0273242 | 1.207 |
| 312 | pmlPathway_h | BioCarta | H002049_01 | Info | Death-associated protein 6 | H002049_01 | AB015051 | 180224 | DAXX | FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Keratinocyte Differentiation, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , Regulation of transcriptional activity by PML, Stress Induction of HSP Regulation, apoptosis | 0.0788021 | 1.159 |
| 313 | pmlPathway_h | BioCarta | H002506_01 | Info | Tumor necrosis factor receptor superfamily, member 1B | H002506_01 | M32315 | 256278 | TNFRSF1B | TNFR2 Signaling Pathway, immunology | 0.1166754 | 1.17 |
| 314 | pmlPathway_h | BioCarta | H007835_01 | Info | Sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1 | H007835_01 | NM_012238 | 31176 | SIRT1 | Regulation of transcriptional activity by PML | 0.2402857 | 0.874 |
| 315 | pmlPathway_h | BioCarta | H003644_01 | Info | Tumor necrosis factor receptor superfamily, member 6 | H003644_01 | X63717 | 82359 | TNFRSF6 | apoptosis, immunology | 0.4621499 | 0.927 |
| 316 | pmlPathway_h | BioCarta | H002907_01 | Info | Retinoic acid receptor, alpha | H002907_01 | X06614 | 250505 | RARA | Degradation of the RAR and RXR by the proteasome, Map Kinase Inactivation of SMRT Corepressor, Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, Nuclear Receptors in Lipid Metabolism and Toxicity, Regulation of transcriptional activity by PML, Transcription Regulation by Methyltransferase of CARM1, development | 0.4825926 | 1.084 |
| 317 | pmlPathway_h | BioCarta | H000554_01 | Info | Nuclear antigen Sp100 | H000554_01 | AF056322 | 77617 | SP100 | Regulation of transcriptional activity by PML, gene_regulation, transcription | 0.8369981 | 0.979 |
| 318 | EGF_receptor_signaling_pathway_h | BioCarta | H002040_01 | Info | Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) | H002040_01 | X00588 | 77432 | EGFR | Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc | 0.0004362 | 0.669 |
| 319 | EGF_receptor_signaling_pathway_h | BioCarta | H002055_01 | Info | Growth factor receptor-bound protein 2 | H002055_01 | M96995 | 296381 | GRB2 | Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … | 0.0022348 | 1.459 |
| 320 | EGF_receptor_signaling_pathway_h | BioCarta | H011186_01 | Info | Growth factor receptor-bound protein 7 | H011186_01 | D43772 | 86859 | GRB7 | Perou’s – Intrinsic- Breast-Cancer-Genes | 0.0262471 | 0.742 |
| 321 | EGF_receptor_signaling_pathway_h | BioCarta | H000928_01 | Info | Epiregulin | H000928_01 | D30783 | 115263 | EREG | 0.1139333 | 0.813 | |
| 322 | EGF_receptor_signaling_pathway_h | BioCarta | H010696_01 | Info | NCK adaptor protein 2 | H010696_01 | AF047487 | 101695 | NCK2 | 0.1245534 | 1.19 | |
| 323 | EGF_receptor_signaling_pathway_h | BioCarta | H006546_01 | Info | Neuronal Shc | H006546_01 | D84361 | 151123 | SHC3 | 0.1304854 | 1.158 | |
| 324 | EGF_receptor_signaling_pathway_h | BioCarta | H002156_01 | Info | Epidermal growth factor receptor pathway substrate 15 | H002156_01 | Z29064 | 79095 | EPS15 | Endocytotic role of NDK, Phosphins and Dynamin, immunology, misc | 0.1357021 | 0.865 |
| 325 | EGF_receptor_signaling_pathway_h | BioCarta | H002376_01 | Info | Epidermal growth factor receptor pathway substrate 8 | H002376_01 | U12535 | 2132 | EPS8 | misc | 0.231316 | 0.841 |
| 326 | EGF_receptor_signaling_pathway_h | BioCarta | H002632_01 | Info | GRB2-associated binding protein 1 | H002632_01 | U43885 | 239706 | GAB1 | Signaling of Hepatocyte Growth Factor Receptor | 0.3021702 | 1.095 |
| 327 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002088_01 | Info | Prostaglandin E receptor 4 (subtype EP4) | H002088_01 | L25124 | 199248 | PTGER4 | Eicosanoid Metabolism | 0.0029063 | 0.734 |
| 328 | GPCRs_Class_A_Rhodopsin-like_h | GO | H004080_01 | Info | Histamine receptor H3 | H004080_01 | NM_007232 | 251399 | HRH3 | 0.0035969 | 0.66 | |
| 329 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003668_01 | Info | Histamine receptor H1 | H003668_01 | Z34897 | 1570 | HRH1 | 0.0076811 | 0.709 | |
| 330 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002813_01 | Info | 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) | H002813_01 | U68488 | 73739 | HTR7 | immunology | 0.0089719 | 1.292 |
| 331 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002667_01 | Info | Prostaglandin E receptor 1 (subtype EP1), 42kD | H002667_01 | L22647 | 159360 | PTGER1 | Eicosanoid Metabolism, Phospholipase C-epsilon pathway | 0.0102067 | 1.228 |
| 332 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003590_01 | Info | Retinal G protein coupled receptor | H003590_01 | U14910 | 1544 | RGR | 0.0153777 | 1.301 | |
| 333 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002494_01 | Info | Adrenergic, alpha-1B-, receptor | H002494_01 | U03865 | 123055 | ADRA1B | Phospholipase C d1 in phospholipid associated cell signaling | 0.0200341 | 1.572 |
| 334 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002167_01 | Info | Chemokine binding protein 2 | H002167_01 | U94888 | 117572 | CCBP2 | 0.0225142 | 0.731 | |
| 335 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002027_01 | Info | Prostaglandin I2 (prostacyclin) receptor (IP) | H002027_01 | D25418 | 393 | PTGIR | Eicosanoid Metabolism, immunology | 0.0236242 | 0.789 |
| 336 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003343_01 | Info | Galanin receptor 1 | H003343_01 | NM_001480 | 272191 | GALR1 | 0.0260438 | 0.759 | |
| 337 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002347_01 | Info | Leukotriene b4 receptor (chemokine receptor-like 1) | H002347_01 | D89078 | 28408 | LTB4R | immunology | 0.0284508 | 1.35 |
| 338 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003130_01 | Info | Interleukin 8 receptor, beta | H003130_01 | L19593 | 846 | IL8RB | immunology | 0.0345675 | 1.307 |
| 339 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002464_01 | Info | G protein-coupled receptor 2 | H002464_01 | AF215981 | 278446 | GPR2 | immunology | 0.0493902 | 0.772 |
| 340 | GPCRs_Class_A_Rhodopsin-like_h | GO | H006487_01 | Info | Neuropeptide Y receptor Y6 (pseudogene) | H006487_01 | D86519 | 73086 | NPY6R | 0.0535714 | 1.212 | |
| 341 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003428_01 | Info | 5-hydroxytryptamine (serotonin) receptor 2A | H003428_01 | X57830 | 298623 | HTR2A | immunology | 0.0558704 | 1.169 |
| 342 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002592_01 | Info | Opioid receptor, mu 1 | H002592_01 | L25119 | 2353 | OPRM1 | behavior, immunology | 0.0609704 | 0.812 |
| 343 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003745_01 | Info | Neuropeptide Y receptor Y1 | H003745_01 | NM_000909 | 169266 | NPY1R | Perou’s – Intrinsic- Breast-Cancer-Genes, immunology | 0.0754043 | 1.285 |
| 344 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002332_01 | Info | Bradykinin receptor B2 | H002332_01 | NM_000623 | 250882 | BDKRB2 | Actions of Nitric Oxide in the Heart, angiogenesis, immunology | 0.0806551 | 0.852 |
| 345 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003670_01 | Info | Adrenergic, beta-1-, receptor | H003670_01 | J03019 | 99913 | ADRB1 | behavior, immunology | 0.0878218 | 1.205 |
| 346 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002366_01 | Info | Chemokine (C-C motif) receptor 9 | H002366_01 | NM_006641 | 225946 | CCR9 | 0.0908646 | 1.196 | |
| 347 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002585_01 | Info | G protein-coupled receptor 17 | H002585_01 | Z94155 | 46453 | GPR17 | 0.1077387 | 1.234 | |
| 348 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002758_01 | Info | Chemokine-like receptor 1 | H002758_01 | U79526 | 159553 | CMKLR1 | immunology | 0.1103372 | 1.187 |
| 349 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003899_01 | Info | Chemokine (C-C motif) receptor 1 | H003899_01 | D10925 | 301921 | CCR1 | Selective expression of chemokine receptors during T-cell polarization, immunology | 0.1258208 | 1.15 |
| 350 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002321_01 | Info | G protein-coupled receptor 30 | H002321_01 | AF015257 | 113207 | GPR30 | immunology | 0.1344665 | 1.164 |
| 351 | GPCRs_Class_A_Rhodopsin-like_h | GO | H015702_01 | Info | G protein-coupled receptor 44 | H015702_01 | NM_004778 | 299567 | GPR44 | 0.1450231 | 1.171 | |
| 352 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002567_01 | Info | Thyroid stimulating hormone receptor | H002567_01 | M31774 | 123078 | TSHR | immunology | 0.1458901 | 0.876 |
| 353 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002097_01 | Info | Dopamine receptor D2 | H002097_01 | X51362 | 73893 | DRD2 | behavior, immunology | 0.1531006 | 0.865 |
| 354 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002110_01 | Info | Coagulation factor II (thrombin) receptor | H002110_01 | NM_001992 | 128087 | F2R | Perou’s – Intrinsic- Breast-Cancer-Genes, Acute Myocardial Infarction, Extrinsic Prothrombin Activation Pathway, Fibrinolysis Pathway, Intrinsic Prothrombin Activation Pathway, immunology | 0.1560498 | 0.883 |
| 355 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002476_01 | Info | Chemokine (C-C motif) receptor 5 | H002476_01 | NM_000579 | 54443 | CCR5 | HIV Induced T Cell Apoptosis, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, NO2-dependent IL 12 Pathway in NK cells, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Selective expression of chemokine receptors during T-cell polarization, immunology | 0.1574808 | 0.842 |
| 356 | GPCRs_Class_A_Rhodopsin-like_h | GO | H015524_01 | Info | AD026 protein | H015524_01 | NM_020683 | 28847 | AD026 | 0.1577677 | 1.184 | |
| 357 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002454_01 | Info | Follicle stimulating hormone receptor | H002454_01 | M65085 | 1428 | FSHR | Regulation of Spermatogenesis by CREM | 0.1580303 | 1.111 |
| 358 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002487_01 | Info | Complement component 5 receptor 1 (C5a ligand) | H002487_01 | M62505 | 2161 | C5R1 | immunology | 0.1622511 | 1.213 |
| 359 | GPCRs_Class_A_Rhodopsin-like_h | GO | H000667_01 | Info | Purinergic receptor (family A group 5) | H000667_01 | AF000546 | 189999 | P2Y5 | 0.1930389 | 0.884 | |
| 360 | GPCRs_Class_A_Rhodopsin-like_h | GO | H009013_01 | Info | Dopamine receptor D2 | H009013_01 | AF176812 | 73893 | DRD2 | behavior, immunology | 0.2238033 | 1.119 |
| 361 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003535_01 | Info | Galanin receptor 3 | H003535_01 | AF073799 | 158353 | GALR3 | 0.227577 | 1.12 | |
| 362 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003381_01 | Info | Melatonin receptor 1A | H003381_01 | U14108 | 248147 | MTNR1A | 0.3138134 | 1.113 | |
| 363 | GPCRs_Class_A_Rhodopsin-like_h | GO | H015755_01 | Info | Chemokine (C-C motif) receptor 1 | H015755_01 | NM_001295 | 301921 | CCR1 | Selective expression of chemokine receptors during T-cell polarization, immunology | 0.3366567 | 1.129 |
| 364 | GPCRs_Class_A_Rhodopsin-like_h | GO | H006918_01 | Info | Neuropeptide G protein-coupled receptor; neuropeptide FF 2 | H006918_01 | NM_004885 | 99231 | NPGPR | 0.4203767 | 0.905 | |
| 365 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002976_01 | Info | G protein-coupled receptor 9 | H002976_01 | X95876 | 198252 | GPR9 | IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, mCalpain and friends in Cell motility, NO2-dependent IL 12 Pathway in NK cells, Selective expression of chemokine receptors during T-cell polarization | 0.4390046 | 0.918 |
| 366 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002698_01 | Info | Adrenergic, beta-3-, receptor | H002698_01 | NM_000025 | 2549 | ADRB3 | behavior, immunology | 0.4399337 | 0.93 |
| 367 | GPCRs_Class_A_Rhodopsin-like_h | GO | H010325_01 | Info | Chemokine (C-C motif) receptor-like 2 | H010325_01 | AF015525 | 302043 | CCRL2 | 0.4610352 | 0.915 | |
| 368 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002378_01 | Info | Adrenergic, alpha-2C-, receptor | H002378_01 | J03853 | 123022 | ADRA2C | behavior, immunology | 0.4753686 | 1.073 |
| 369 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003577_01 | Info | Adrenergic, alpha-1A-, receptor | H003577_01 | D32202 | 52931 | ADRA1A | behavior | 0.5296756 | 1.062 |
| 370 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003424_01 | Info | Chemokine (C-C motif) receptor 3 | H003424_01 | U28694 | 158324 | CCR3 | CCR3 signaling in Eosinophils, IL 5 Signaling Pathway, Selective expression of chemokine receptors during T-cell polarization, The Role of Eosinophils in the Chemokine Network of Allergy, immunology | 0.5671442 | 1.138 |
| 371 | GPCRs_Class_A_Rhodopsin-like_h | GO | H007948_01 | Info | F-box and WD-40 domain protein 2 | H007948_01 | NM_012164 | 13755 | FBXW2 | 0.5814024 | 1.048 | |
| 372 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003584_01 | Info | Platelet-activating factor receptor | H003584_01 | D10202 | 46 | PTAFR | angiogenesis, immunology | 0.5977382 | 1.05 |
| 373 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003654_01 | Info | Coagulation factor II (thrombin) receptor-like 2 | H003654_01 | U92971 | 194351 | F2RL2 | immunology | 0.6746058 | 0.966 |
| 374 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002380_01 | Info | Chemokine (C-C motif) receptor 8 | H002380_01 | D49919 | 113222 | CCR8 | immunology | 0.6915296 | 1.035 |
| 375 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002317_01 | Info | Chemokine (C-X3-C) receptor 1 | H002317_01 | U20350 | 78913 | CX3CR1 | immunology | 0.7275779 | 1.038 |
| 376 | GPCRs_Class_A_Rhodopsin-like_h | GO | H016261_01 | Info | Putative G protein-coupled receptor 92 | H016261_01 | NM_020400 | 330563 | GPR92 | 0.7713793 | 0.962 | |
| 377 | GPCRs_Class_A_Rhodopsin-like_h | GO | H012371_01 | Info | Thyroid stimulating hormone receptor | H012371_01 | S82807 | 123078 | TSHR | immunology | 0.7783963 | 1.03 |
| 378 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003426_01 | Info | Prostaglandin D2 receptor (DP) | H003426_01 | U31099 | 158326 | PTGDR | 0.800069 | 0.971 | |
| 379 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003721_01 | Info | Dopamine receptor D4 | H003721_01 | L12398 | 99922 | DRD4 | behavior, immunology | 0.8251335 | 1.023 |
| 380 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002672_01 | Info | G protein-coupled receptor | H002672_01 | U67784 | 23016 | RDC1 | 0.8527585 | 0.967 | |
| 381 | GPCRs_Class_A_Rhodopsin-like_h | GO | H003854_01 | Info | Burkitt lymphoma receptor 1, GTP-binding protein | H003854_01 | X68149 | 113916 | BLR1 | 0.882872 | 0.982 | |
| 382 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002271_01 | Info | Neuropeptide Y receptor Y2 | H002271_01 | NM_000910 | 37125 | NPY2R | 0.9438408 | 0.993 | |
| 383 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002797_01 | Info | Adenosine A3 receptor | H002797_01 | NM_000677 | 258 | ADORA3 | 0.9481775 | 0.993 | |
| 384 | GPCRs_Class_A_Rhodopsin-like_h | GO | H002327_01 | Info | Adenosine A1 receptor | H002327_01 | L22214 | 77867 | ADORA1 | immunology | 0.9613941 | 1.005 |