Scleroderma CW HCC Annotations

Gene Info	Sum Func	Function	SP Local	Gene Ontology	Biocarta Pathways	Kegg Pathways
Unique ID: 161146 Name: hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse) UniGene: Hs.524513 Symbol: HSD17B6 (external link) Entrez ID: 8630 Chromosome: 12 Cytoband: 12q13 DrugBank: Query Gene Symbol:HSD17B6	Sum Func:	SP Function: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). has retinol dehydrogenase activity towards all-trans-retinol (in vitro). can convert androsterone to epiandrosterone. androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epiandrosterone. can act on both c-19 and c-21 3-alpha-hydroxysteroids.	SP Local: microsome membrane; peripheral membrane protein; lumenal side. early endosome membrane; peripheral membrane protein; lumenal side (potential).	Gene Ontology: molecular function: binding molecular function: catalytic activity molecular function: electron carrier activity molecular function: estradiol 17-beta-dehydrogenase activity molecular function: oxidoreductase activity molecular function: retinol dehydrogenase activity molecular function: testosterone 17-beta-dehydrogenase activity biological process: androgen biosynthetic process biological process: androgen catabolic process biological process: oxidation-reduction process biological process: steroid metabolic process cellular component: early endosome membrane cellular component: endoplasmic reticulum cellular component: endosome cellular component: intracellular cellular component: membrane cellular component: microsome	BioCarta Pathways:	KEGG Pathways:
Unique ID: 168187 Name: acyl-CoA synthetase medium-chain family member 2B UniGene: Hs.298252 Symbol: ACSM2B (external link) Entrez ID: 348158 Chromosome: 16 Cytoband: 16p12.3 DrugBank: Query Gene Symbol:ACSM2B	Sum Func:	SP Function: has medium-chain fatty acid:coa ligase activity with broad substrate specificity (in vitro). acts on acids from c(4) to c(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro).	SP Local: mitochondrion matrix.	Gene Ontology: molecular function: ATP binding molecular function: CoA-ligase activity molecular function: butyrate-CoA ligase activity molecular function: ligase activity molecular function: metal ion binding molecular function: nucleotide binding biological process: fatty acid metabolic process biological process: lipid metabolic process biological process: xenobiotic metabolic process cellular component: mitochondrial matrix cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161801 Name: solute carrier family 10 (sodium/bile acid cotransporter family), member 1 UniGene: Hs.952 Symbol: SLC10A1 (external link) Entrez ID: 6554 Chromosome: 14 Cytoband: 14q24.1 DrugBank: Query Gene Symbol:SLC10A1	Sum Func:	SP Function: the hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. it is strictly dependent on the extracellular presence of sodium.	SP Local: membrane; multi-pass membrane protein.	Gene Ontology: molecular function: bile acid:sodium symporter activity molecular function: symporter activity biological process: bile acid and bile salt transport biological process: bile acid metabolic process biological process: ion transport biological process: organic anion transport biological process: sodium ion transport biological process: transport cellular component: basolateral plasma membrane cellular component: integral to plasma membrane cellular component: membrane fraction cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 166007 Name: tyrosine aminotransferase UniGene: Hs.161640 Symbol: TAT (external link) Entrez ID: 6898 Chromosome: 16 Cytoband: 16q22.1 DrugBank: Query Gene Symbol:TAT	Sum Func:	SP Function: transaminase involved in tyrosine breakdown. converts tyrosine to p-hydroxyphenylpyruvate. can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). has no transaminase activity towards phenylalanine.	SP Local:	Gene Ontology: molecular function: 1-aminocyclopropane-1-carboxylate synthase activity molecular function: L-tyrosine:2-oxoglutarate aminotransferase activity molecular function: L-tyrosine:2-oxoglutarate aminotransferase activity molecular function: L-tyrosine:2-oxoglutarate aminotransferase activity molecular function: amino acid binding molecular function: pyridoxal phosphate binding molecular function: transaminase activity biological process: 2-oxoglutarate metabolic process biological process: L-phenylalanine catabolic process biological process: L-phenylalanine catabolic process biological process: biosynthetic process biological process: cellular nitrogen compound metabolic process biological process: glutamate metabolic process biological process: response to glucocorticoid stimulus biological process: response to mercury ion biological process: response to organic cyclic compound biological process: response to oxidative stress biological process: tyrosine catabolic process biological process: tyrosine catabolic process cellular component: cellular_component cellular component: cytosol cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways: 1: Phenylalanine, tyrosine and tryptophan biosynthesis (external link) 2: Tyrosine metabolism (external link) 3: Novobiocin biosynthesis (external link) 4: Phenylalanine metabolism (external link) 5: Alkaloid biosynthesis I (external link)
Unique ID: 167207 Name: flavin containing monooxygenase 3 UniGene: Hs.445350 Symbol: FMO3 (external link) Entrez ID: 2328 Chromosome: 1 Cytoband: 1q24.3 DrugBank: Query Gene Symbol:FMO3	Sum Func:	SP Function: involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. it n-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. plays an important role in the metabolism of trimethylamine (tma), via the production of tma n-oxide (tmao). is also able to perform s-oxidation when acting on sulfide compounds.	SP Local: microsome membrane. endoplasmic reticulum membrane.	Gene Ontology: molecular function: NADP binding molecular function: amino acid binding molecular function: flavin adenine dinucleotide binding molecular function: flavin-containing monooxygenase activity molecular function: monooxygenase activity biological process: drug metabolic process biological process: oxidation-reduction process biological process: xenobiotic metabolic process cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: integral to membrane cellular component: intrinsic to endoplasmic reticulum membrane cellular component: membrane cellular component: microsome	BioCarta Pathways:	KEGG Pathways:
Unique ID: 168452 Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase UniGene: Hs.652308 Symbol: MTHFD1 (external link) Entrez ID: 4522 Chromosome: 14 Cytoband: 14q24 DrugBank: Query Gene Symbol:MTHFD1	Sum Func:	SP Function:	SP Local: cytoplasm.	Gene Ontology: molecular function: ATP binding molecular function: formate-tetrahydrofolate ligase activity molecular function: hydrolase activity molecular function: ligase activity molecular function: methenyltetrahydrofolate cyclohydrolase activity molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity molecular function: methylenetetrahydrofolate dehydrogenase activity molecular function: nucleotide binding molecular function: oxidoreductase activity molecular function: protein binding biological process: cellular amino acid biosynthetic process biological process: folic acid metabolic process biological process: folic acid-containing compound biosynthetic process biological process: histidine biosynthetic process biological process: methionine biosynthetic process biological process: one-carbon metabolic process biological process: oxidation-reduction process biological process: purine nucleotide biosynthetic process biological process: vitamin metabolic process biological process: water-soluble vitamin metabolic process cellular component: cytoplasm cellular component: cytosol cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways: 1: Glyoxylate and dicarboxylate metabolism (external link) 2: One carbon pool by folate (external link)
Unique ID: 169374 Name: 4-hydroxyphenylpyruvate dioxygenase UniGene: Hs.2899 Symbol: HPD (external link) Entrez ID: 3242 Chromosome: 12 Cytoband: 12q24-qter DrugBank: Query Gene Symbol:HPD	Sum Func:	SP Function: key enzyme in the degradation of tyrosine.	SP Local:	Gene Ontology: molecular function: 4-hydroxyphenylpyruvate dioxygenase activity molecular function: 4-hydroxyphenylpyruvate dioxygenase activity molecular function: metal ion binding molecular function: oxidoreductase activity biological process: L-phenylalanine catabolic process biological process: aromatic amino acid family metabolic process biological process: cellular nitrogen compound metabolic process biological process: oxidation-reduction process biological process: tyrosine catabolic process cellular component: Golgi apparatus cellular component: Golgi membrane cellular component: cytosol cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane	BioCarta Pathways:	KEGG Pathways: 1: Tyrosine metabolism (external link) 2: Phenylalanine metabolism (external link)
Unique ID: 168756 Name: aldehyde dehydrogenase 6 family, member A1 UniGene: Hs.293970 Symbol: ALDH6A1 (external link) Entrez ID: 4329 Chromosome: 14 Cytoband: 14q24.3 DrugBank: Query Gene Symbol:ALDH6A1	Sum Func:	SP Function: plays a role in valine and pyrimidine metabolism. binds fatty acyl-coa.	SP Local: mitochondrion.	Gene Ontology: molecular function: fatty-acyl-CoA binding molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity molecular function: oxidoreductase activity molecular function: thiolester hydrolase activity biological process: beta-alanine catabolic process biological process: branched chain family amino acid catabolic process biological process: brown fat cell differentiation biological process: cellular nitrogen compound metabolic process biological process: oxidation-reduction process biological process: thymine catabolic process biological process: thymine metabolic process biological process: valine catabolic process biological process: valine metabolic process cellular component: mitochondrial matrix cellular component: mitochondrion cellular component: mitochondrion cellular component: nucleolus cellular component: nucleus	BioCarta Pathways:	KEGG Pathways: 1: Propanoate metabolism (external link) 2: Valine, leucine and isoleucine degradation (external link) 3: Inositol metabolism (external link)
Unique ID: 169717 Name: progesterone receptor membrane component 1 UniGene: Hs.90061 Symbol: PGRMC1 (external link) Entrez ID: 10857 Chromosome: X Cytoband: Xq22-q24 DrugBank: Query Gene Symbol:PGRMC1	Sum Func:	SP Function: receptor for progesterone (by similarity).	SP Local: microsome membrane; single-pass membrane protein (by similarity). endoplasmic reticulum membrane; single- pass membrane protein (by similarity).	Gene Ontology: molecular function: heme binding molecular function: protein binding molecular function: receptor activity molecular function: steroid binding cellular component: cell surface cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: integral to membrane cellular component: membrane cellular component: microsome cellular component: nucleolus cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 167792 Name: ornithine carbamoyltransferase UniGene: Hs.117050 Symbol: OTC (external link) Entrez ID: 5009 Chromosome: X Cytoband: Xp21.1 DrugBank: Query Gene Symbol:OTC	Sum Func:	SP Function:	SP Local: mitochondrion matrix.	Gene Ontology: molecular function: amino acid binding molecular function: ornithine carbamoyltransferase activity molecular function: ornithine carbamoyltransferase activity molecular function: phosphate binding molecular function: phospholipid binding molecular function: transferase activity biological process: anion homeostasis biological process: arginine biosynthetic process biological process: cellular amino acid biosynthetic process biological process: cellular nitrogen compound metabolic process biological process: citrulline biosynthetic process biological process: liver development biological process: midgut development biological process: ornithine metabolic process biological process: ornithine metabolic process biological process: protein homotrimerization biological process: response to biotin biological process: response to drug biological process: response to insulin stimulus biological process: response to nutrient levels biological process: response to zinc ion biological process: urea cycle biological process: urea cycle cellular component: cytoplasm cellular component: mitochondrial inner membrane cellular component: mitochondrial matrix cellular component: mitochondrial matrix cellular component: mitochondrion cellular component: ornithine carbamoyltransferase complex	BioCarta Pathways:	KEGG Pathways: 1: Urea cycle and metabolism of amino groups (external link) 2: Arginine and proline metabolism (external link)
Unique ID: 164998 Name: carbamoyl-phosphate synthase 1, mitochondrial UniGene: Hs.149252 Symbol: CPS1 (external link) Entrez ID: 1373 Chromosome: 2 Cytoband: 2q35 DrugBank: Query Gene Symbol:CPS1	Sum Func:	SP Function: involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.	SP Local: mitochondrion.	Gene Ontology: molecular function: ATP binding molecular function: calcium ion binding molecular function: carbamoyl-phosphate synthase (ammonia) activity molecular function: carbamoyl-phosphate synthase (ammonia) activity molecular function: carbamoyl-phosphate synthase activity molecular function: endopeptidase activity molecular function: glutamate binding molecular function: ligase activity molecular function: nucleotide binding molecular function: phospholipid binding molecular function: protein binding molecular function: protein complex binding biological process: anion homeostasis biological process: carbamoyl phosphate biosynthetic process biological process: cellular nitrogen compound metabolic process biological process: cellular response to cAMP biological process: cellular response to fibroblast growth factor stimulus biological process: cellular response to glucagon stimulus biological process: cellular response to oleic acid biological process: citrulline biosynthetic process biological process: glutamine metabolic process biological process: glycogen catabolic process biological process: hepatocyte differentiation biological process: midgut development biological process: nitric oxide metabolic process biological process: positive regulation of vasodilation biological process: response to amino acid stimulus biological process: response to dexamethasone stimulus biological process: response to drug biological process: response to food biological process: response to growth hormone stimulus biological process: response to lipopolysaccharide biological process: response to starvation biological process: response to steroid hormone stimulus biological process: response to toxin biological process: response to zinc ion biological process: triglyceride catabolic process biological process: urea cycle biological process: urea cycle cellular component: cytoplasm cellular component: mitochondrial inner membrane cellular component: mitochondrial matrix cellular component: mitochondrial nucleoid cellular component: mitochondrion cellular component: protein complex	BioCarta Pathways:	KEGG Pathways: 1: Arginine and proline metabolism (external link) 2: Nitrogen metabolism (external link) 3: Urea cycle and metabolism of amino groups (external link) 4: Glutamate metabolism (external link)
Unique ID: 165794 Name: epoxide hydrolase 2, cytoplasmic UniGene: Hs.212088 Symbol: EPHX2 (external link) Entrez ID: 2053 (external link) Chromosome: 8 Cytoband: 8p21 DrugBank: Query Gene Symbol:EPHX2	Sum Func:	SP Function: acts on epoxides (alkene oxides, oxiranes) and arene oxides. plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. also determines steady-state levels of physiological mediators. has low phosphatase activity.	SP Local: cytoplasm. peroxisome.	Gene Ontology: molecular function: epoxide hydrolase activity molecular function: hydrolase activity molecular function: metal ion binding molecular function: protein homodimerization activity biological process: aromatic compound catabolic process biological process: cellular calcium ion homeostasis biological process: drug metabolic process biological process: inflammatory response biological process: positive regulation of vasodilation biological process: regulation of blood pressure biological process: response to toxin biological process: xenobiotic metabolic process cellular component: Golgi apparatus cellular component: cytoplasm cellular component: cytosol cellular component: focal adhesion cellular component: nucleolus cellular component: peroxisome cellular component: soluble fraction	BioCarta Pathways: 1: Eicosanoid Metabolism	KEGG Pathways: 1: Arachidonic acid metabolism (external link) 2: Tetrachloroethene degradation (external link)
Unique ID: 160308 Name: cell adhesion molecule 1 UniGene: Hs.370510 Symbol: CADM1 (external link) Entrez ID: 23705 (external link) Chromosome: 11 Cytoband: 11q23.2 DrugBank: Query Gene Symbol:CADM1	Sum Func:	SP Function: mediates homophilic cell-cell adhesion in a ca(2+)- independent manner. also mediates heterophilic cell-cell adhesion with cadm3 and pvrl3 in a ca(2+)-independent manner. acts as a tumor suppressor in non-small-cell lung cancer (nsclc) cells. interaction with crtam promotes natural killer (nk) cell cytotoxicity and interferon-gamma (ifn-gamma) secretion by cd8+ cells in vitro as well as nk cell-mediated rejection of tumors expressing cadm3 in vivo. may contribute to the less invasive phenotypes of lepidic growth tumor cells. in mast cells, may mediate attachment to and promote communication with nerves. cadm1, together with mitf, is essential for development and survival of mast cells in vivo. may act as a synaptic cell adhesion molecule that drives synapse assembly. may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to sertoli cells and for their normal differentiation into mature spermatozoa.	SP Local: cell membrane; single-pass type i membrane protein. note=associates with perinuclear and plasma membranes in vivo. localized to the basolateral plasma membrane of epithelial cells in gall bladder.	Gene Ontology: molecular function: PDZ domain binding molecular function: protein C-terminus binding molecular function: protein homodimerization activity molecular function: receptor binding molecular function: receptor binding biological process: T cell mediated cytotoxicity biological process: activated T cell proliferation biological process: adherens junction organization biological process: apoptosis biological process: calcium-independent cell-cell adhesion biological process: cell adhesion biological process: cell differentiation biological process: cell junction assembly biological process: cell recognition biological process: cell recognition biological process: cell-cell junction organization biological process: detection of stimulus biological process: detection of stimulus biological process: heterophilic cell-cell adhesion biological process: homophilic cell adhesion biological process: liver development biological process: multicellular organismal development biological process: positive regulation of cytokine secretion biological process: positive regulation of natural killer cell mediated cytotoxicity biological process: positive regulation of natural killer cell mediated cytotoxicity biological process: spermatogenesis biological process: susceptibility to natural killer cell mediated cytotoxicity biological process: susceptibility to natural killer cell mediated cytotoxicity biological process: synapse assembly cellular component: axon cellular component: basolateral plasma membrane cellular component: cell-cell junction cellular component: dendrite cellular component: integral to membrane cellular component: plasma membrane cellular component: plasma membrane cellular component: plasma membrane cellular component: synapse cellular component: synaptic vesicle cellular component: synaptosome	BioCarta Pathways:	KEGG Pathways: 1: Cell adhesion molecules (CAMs) (external link)
Unique ID: 161478 Name: aquaporin 9 UniGene: Hs.104624 Symbol: AQP9 (external link) Entrez ID: 366 (external link) Chromosome: 15 Cytoband: 15q DrugBank: Query Gene Symbol:AQP9	Sum Func:	SP Function: forms a channel with a broad specificity. mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, na(+), k(+), cl(-), and deprotonated monocarboxylates are excluded. also permeable to urea and glycerol.	SP Local: membrane; multi-pass membrane protein.	Gene Ontology: molecular function: amine transmembrane transporter activity molecular function: carboxylic acid transmembrane transporter activity molecular function: glycerol channel activity molecular function: polyol transmembrane transporter activity molecular function: porin activity molecular function: purine base transmembrane transporter activity molecular function: pyrimidine base transmembrane transporter activity molecular function: transporter activity molecular function: water channel activity molecular function: water transmembrane transporter activity biological process: amine transport biological process: amine transport biological process: canalicular bile acid transport biological process: carboxylic acid transport biological process: cellular response to cAMP biological process: excretion biological process: glycerol transport biological process: immune response biological process: metabolic process biological process: polyol transport biological process: purine base transport biological process: pyrimidine base transport biological process: response to mercury ion biological process: response to organic substance biological process: response to osmotic stress biological process: transmembrane transport biological process: transport biological process: water homeostasis biological process: water transport biological process: water transport cellular component: basolateral plasma membrane cellular component: integral to membrane cellular component: integral to plasma membrane cellular component: intracellular membrane-bounded organelle cellular component: microsome cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 165324 Name: peroxisomal membrane protein 2, 22kDa UniGene: Hs.430299 Symbol: PXMP2 (external link) Entrez ID: 5827 (external link) Chromosome: 12 Cytoband: 12q24.33 DrugBank: Query Gene Symbol:PXMP2	Sum Func:	SP Function: seems to be involved in pore-forming activity and may contribute to the unspecific permeability of the peroxisomal membrane.	SP Local: peroxisome membrane; multi-pass membrane protein.	Gene Ontology: molecular function: protein binding cellular component: integral to membrane cellular component: membrane cellular component: peroxisomal membrane cellular component: peroxisome	BioCarta Pathways:	KEGG Pathways:
Unique ID: 168366 Name: sterol carrier protein 2 UniGene: Hs.476365 Symbol: SCP2 (external link) Entrez ID: 6342 (external link) Chromosome: 1 Cytoband: 1p32 DrugBank: Query Gene Symbol:SCP2	Sum Func:	SP Function: mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. may play a role in regulating steroidogenesis.	SP Local: isoform scp2: mitochondrion (probable).	Gene Ontology: molecular function: lipid binding molecular function: propanoyl-CoA C-acyltransferase activity molecular function: propionyl-CoA C2-trimethyltridecanoyltransferase activity molecular function: protein binding molecular function: sterol binding molecular function: transferase activity biological process: bile acid biosynthetic process biological process: bile acid metabolic process biological process: cellular lipid metabolic process biological process: fatty acid beta-oxidation using acyl-CoA oxidase biological process: lipid transport biological process: peroxisome organization biological process: steroid biosynthetic process biological process: transport cellular component: cytoplasm cellular component: intracellular membrane-bounded organelle cellular component: mitochondrion cellular component: nucleolus cellular component: nucleus cellular component: peroxisomal matrix cellular component: peroxisome	BioCarta Pathways:	KEGG Pathways: 1: PPAR signaling pathway (external link)
Unique ID: 166095 Name: carbamoyl-phosphate synthase 1, mitochondrial UniGene: Hs.149252 Symbol: CPS1 (external link) Entrez ID: 1373 Chromosome: 2 Cytoband: 2q35 DrugBank: Query Gene Symbol:CPS1	Sum Func:	SP Function: involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.	SP Local: mitochondrion.	Gene Ontology: molecular function: ATP binding molecular function: calcium ion binding molecular function: carbamoyl-phosphate synthase (ammonia) activity molecular function: carbamoyl-phosphate synthase (ammonia) activity molecular function: carbamoyl-phosphate synthase activity molecular function: endopeptidase activity molecular function: glutamate binding molecular function: ligase activity molecular function: nucleotide binding molecular function: phospholipid binding molecular function: protein binding molecular function: protein complex binding biological process: anion homeostasis biological process: carbamoyl phosphate biosynthetic process biological process: cellular nitrogen compound metabolic process biological process: cellular response to cAMP biological process: cellular response to fibroblast growth factor stimulus biological process: cellular response to glucagon stimulus biological process: cellular response to oleic acid biological process: citrulline biosynthetic process biological process: glutamine metabolic process biological process: glycogen catabolic process biological process: hepatocyte differentiation biological process: midgut development biological process: nitric oxide metabolic process biological process: positive regulation of vasodilation biological process: response to amino acid stimulus biological process: response to dexamethasone stimulus biological process: response to drug biological process: response to food biological process: response to growth hormone stimulus biological process: response to lipopolysaccharide biological process: response to starvation biological process: response to steroid hormone stimulus biological process: response to toxin biological process: response to zinc ion biological process: triglyceride catabolic process biological process: urea cycle biological process: urea cycle cellular component: cytoplasm cellular component: mitochondrial inner membrane cellular component: mitochondrial matrix cellular component: mitochondrial nucleoid cellular component: mitochondrion cellular component: protein complex	BioCarta Pathways:	KEGG Pathways: 1: Arginine and proline metabolism (external link) 2: Nitrogen metabolism (external link) 3: Urea cycle and metabolism of amino groups (external link) 4: Glutamate metabolism (external link)
Unique ID: 165233 Name: glycine-N-acyltransferase UniGene: Hs.145384 Symbol: GLYAT (external link) Entrez ID: 10249 (external link) Chromosome: 11 Cytoband: 11q12.1 DrugBank: Query Gene Symbol:GLYAT	Sum Func:	SP Function: mitochondrial acyltransferase which transfers the acyl group to the n-terminus of glycine. can conjugate a multitude of substrates to form a variety of n-acylglycines.	SP Local: mitochondrion (by similarity).	Gene Ontology: molecular function: acyltransferase activity molecular function: glycine N-acyltransferase activity molecular function: glycine N-benzoyltransferase activity molecular function: transferase activity biological process: acyl-CoA metabolic process biological process: response to toxin biological process: xenobiotic metabolic process cellular component: mitochondrial matrix cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways:
Unique ID: 165777 Name: guanine nucleotide binding protein (G protein), beta polypeptide 2 UniGene: Hs.185172 Symbol: GNB2 (external link) Entrez ID: 2783 (external link) Chromosome: 7 Cytoband: 7q21.3-q22.1 DrugBank: Query Gene Symbol:GNB2	Sum Func:	SP Function: guanine nucleotide-binding proteins (g proteins) are involved as a modulator or transducer in various transmembrane signaling systems. the beta and gamma chains are required for the gtpase activity, for replacement of gdp by gtp, and for g protein- effector interaction.	SP Local: cytoplasm, perinuclear region.	Gene Ontology: molecular function: GTPase activity molecular function: calcium channel regulator activity molecular function: protein binding molecular function: signal transducer activity biological process: G-protein coupled receptor protein signaling pathway biological process: GTP catabolic process biological process: cellular response to glucagon stimulus biological process: energy reserve metabolic process biological process: synaptic transmission cellular component: cytoplasm cellular component: perinuclear region of cytoplasm cellular component: plasma membrane cellular component: plasma membrane cellular component: protein complex	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161491 Name: ligase IV, DNA, ATP-dependent UniGene: Hs.166091 Symbol: LIG4 (external link) Entrez ID: 3981 (external link) Chromosome: 13 Cytoband: 13q33-q34 DrugBank: Query Gene Symbol:LIG4	Sum Func:	SP Function: efficiently joins single-strand breaks in a double- stranded polydeoxynucleotide in an atp-dependent reaction. involved in dna non-homologous end joining (nhej) required for double-strand break repair and v(d)j recombination. the lig4-xrcc4 complex is responsible for the nhej ligation step, and xrcc4 enhances the joining activity of lig4. binding of the lig4-xrcc4 complex to dna ends is dependent on the assembly of the dna-dependent protein kinase complex dna-pk to these dna ends.	SP Local: nucleus.	Gene Ontology: molecular function: ATP binding molecular function: DNA binding molecular function: DNA ligase (ATP) activity molecular function: DNA ligase activity molecular function: DNA ligase activity molecular function: ligase activity molecular function: metal ion binding molecular function: nucleotide binding molecular function: protein C-terminus binding molecular function: protein binding biological process: DNA ligation biological process: DNA ligation involved in DNA recombination biological process: DNA ligation involved in DNA repair biological process: DNA ligation involved in DNA repair biological process: DNA repair biological process: DNA replication biological process: T cell differentiation in thymus biological process: T cell receptor V(D)J recombination biological process: V(D)J recombination biological process: cell cycle biological process: cell division biological process: cell proliferation biological process: central nervous system development biological process: chromosome organization biological process: double-strand break repair biological process: double-strand break repair biological process: double-strand break repair biological process: double-strand break repair via nonhomologous end joining biological process: double-strand break repair via nonhomologous end joining biological process: double-strand break repair via nonhomologous end joining biological process: immunoglobulin V(D)J recombination biological process: in utero embryonic development biological process: initiation of viral infection biological process: isotype switching biological process: negative regulation of neuron apoptosis biological process: neuron apoptosis biological process: nucleotide-excision repair, DNA gap filling biological process: positive regulation of fibroblast proliferation biological process: positive regulation of neurogenesis biological process: pro-B cell differentiation biological process: provirus integration biological process: response to X-ray biological process: response to gamma radiation biological process: single strand break repair biological process: somatic stem cell maintenance biological process: viral reproduction cellular component: DNA ligase IV complex cellular component: DNA-dependent protein kinase-DNA ligase 4 complex cellular component: DNA-dependent protein kinase-DNA ligase 4 complex cellular component: condensed chromosome cellular component: cytoplasm cellular component: focal adhesion cellular component: intracellular cellular component: nonhomologous end joining complex cellular component: nucleolus cellular component: nucleoplasm cellular component: nucleus cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 166778 Name: phosphoenolpyruvate carboxykinase 2 (mitochondrial) UniGene: Hs.75812 Symbol: PCK2 (external link) Entrez ID: 5106 Chromosome: 14 Cytoband: 14q11.2 DrugBank: Query Gene Symbol:PCK2	Sum Func:	SP Function: catalyzes the conversion of oxaloacetate (oaa) to phosphoenolpyruvate (pep), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (by similarity).	SP Local: mitochondrion.	Gene Ontology: molecular function: GTP binding molecular function: lyase activity molecular function: metal ion binding molecular function: phosphoenolpyruvate carboxykinase (GTP) activity molecular function: phosphoenolpyruvate carboxykinase activity molecular function: purine nucleotide binding biological process: carbohydrate metabolic process biological process: gluconeogenesis biological process: glucose metabolic process biological process: oxaloacetate metabolic process biological process: response to glucocorticoid stimulus cellular component: mitochondrial matrix cellular component: mitochondrion cellular component: soluble fraction	BioCarta Pathways:	KEGG Pathways: 1: PPAR signaling pathway (external link) 2: Adipocytokine signaling pathway (external link) 3: Insulin signaling pathway (external link) 4: Pyruvate metabolism (external link) 5: Citrate cycle (TCA cycle) (external link)
Unique ID: 162315 Name: calcium channel, voltage-dependent, beta 3 subunit UniGene: Hs.250712 Symbol: CACNB3 (external link) Entrez ID: 784 Chromosome: 12 Cytoband: 12q13 DrugBank: Query Gene Symbol:CACNB3	Sum Func:	SP Function: the beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.	SP Local:	Gene Ontology: molecular function: protein binding molecular function: voltage-gated calcium channel activity molecular function: voltage-gated ion channel activity biological process: T cell receptor signaling pathway biological process: axon guidance biological process: calcium ion transport biological process: ion transport biological process: membrane depolarization biological process: regulation of calcium ion transport via voltage-gated calcium channel activity biological process: regulation of calcium ion transport via voltage-gated calcium channel activity biological process: synaptic transmission biological process: transport cellular component: apical plasma membrane cellular component: cytosol cellular component: membrane cellular component: voltage-gated calcium channel complex	BioCarta Pathways:	KEGG Pathways: 1: MAPK signaling pathway (external link)
Unique ID: 166910 Name: acireductone dioxygenase 1 UniGene: Hs.502773 Symbol: ADI1 (external link) Entrez ID: 55256 Chromosome: 2 Cytoband: 2p25.3 DrugBank: Query Gene Symbol:ADI1	Sum Func:	SP Function: has aci-reductone dioxygenase (ard) activity and can function in the 5-methylthioadenosine (mta) methionine salvage pathway. down-regulates cell migration mediated by mmp14. necessary for hepatitis c virus replication in an otherwise non- permissive cell line.	SP Local: cell membrane; peripheral membrane protein; cytoplasmic side. nucleus.	Gene Ontology: molecular function: acireductone dioxygenase (Ni2+-requiring) activity molecular function: metal ion binding molecular function: oxidoreductase activity molecular function: protein binding biological process: L-methionine salvage from methylthioadenosine biological process: cellular amino acid biosynthetic process biological process: methionine biosynthetic process biological process: oxidation-reduction process cellular component: cytoplasm cellular component: nucleus cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 167281 Name: cyclin-dependent kinase 13 UniGene: Hs.233552 Symbol: CDK13 (external link) Entrez ID: 8621 Chromosome: 7 Cytoband: 7p13 DrugBank: Query Gene Symbol:CDK13	Sum Func:	SP Function: cyclin-dependent kinase which displays ctd kinase activity and is required for rna splicing. has ctd kinase activity by hyperphosphorylating the c-terminal heptapeptide repeat domain (ctd) of the largest rna polymerase ii subunit rpb1, thereby acting as a key regulator of transcription elongation. required for rna splicing, probably by phosphorylating srsf1/sf2. required during hematopoiesis. in case of infection by hiv-1 virus, interacts with hiv-1 tat protein acetylated at 'lys-50' and 'lys- 51', thereby increasing hiv-1 mrna splicing and promoting the production of the doubly spliced hiv-1 protein nef.	SP Local: nucleus speckle.	Gene Ontology: molecular function: ATP binding molecular function: RNA polymerase II carboxy-terminal domain kinase activity molecular function: cyclin-dependent protein kinase activity molecular function: nucleotide binding molecular function: protein binding molecular function: protein kinase activity molecular function: transferase activity biological process: alternative nuclear mRNA splicing, via spliceosome biological process: alternative nuclear mRNA splicing, via spliceosome biological process: hemopoiesis biological process: multicellular organismal development biological process: phosphorylation of RNA polymerase II C-terminal domain biological process: positive regulation of cell proliferation biological process: regulation of mitosis cellular component: nuclear cyclin-dependent protein kinase holoenzyme complex cellular component: nuclear speck	BioCarta Pathways:	KEGG Pathways:
Unique ID: 164136 Name: acyl-CoA dehydrogenase, long chain UniGene: Hs.471277 Symbol: ACADL (external link) Entrez ID: 33 Chromosome: 2 Cytoband: 2q34-q35 DrugBank: Query Gene Symbol:ACADL	Sum Func:	SP Function:	SP Local: mitochondrion matrix.	Gene Ontology: molecular function: acyl-CoA dehydrogenase activity molecular function: fatty-acyl-CoA binding molecular function: flavin adenine dinucleotide binding molecular function: long-chain-acyl-CoA dehydrogenase activity molecular function: palmitoyl-CoA oxidase activity biological process: carnitine catabolic process biological process: carnitine metabolic process, CoA-linked biological process: cellular lipid catabolic process biological process: cellular lipid metabolic process biological process: fatty acid beta-oxidation biological process: fatty acid beta-oxidation using acyl-CoA dehydrogenase biological process: fatty acid metabolic process biological process: long-chain fatty acid catabolic process biological process: negative regulation of fatty acid biosynthetic process biological process: negative regulation of fatty acid oxidation biological process: oxidation-reduction process biological process: protein homotetramerization biological process: regulation of cholesterol metabolic process biological process: temperature homeostasis cellular component: cytoplasm cellular component: mitochondrial matrix cellular component: mitochondrial membrane cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways: 1: Propanoate metabolism (external link) 2: Fatty acid metabolism (external link) 3: beta-Alanine metabolism (external link) 4: Valine, leucine and isoleucine degradation (external link) 5: PPAR signaling pathway (external link)
Unique ID: 160425 Name: cystathionase (cystathionine gamma-lyase) UniGene: Hs.19904 Symbol: CTH (external link) Entrez ID: 1491 Chromosome: 1 Cytoband: 1p31.1 DrugBank: Query Gene Symbol:CTH	Sum Func:	SP Function: catalyzes the last step in the transsulfuration pathway from methionine to cysteine. has broad substrate specificity. converts cystathionine to cysteine, ammonia and 2-oxobutanoate. converts two cysteine molecules to lanthionine and hydrogen sulfide. can also accept homocysteine as substrate. specificity depends on the levels of the endogenous substrates. generates the endogenous signaling molecule hydrogen sulfide (h2s), and so contributes to the regulation of blood pressure.	SP Local: cytoplasm.	Gene Ontology: molecular function: L-cysteine desulfhydrase activity molecular function: cystathionine beta-lyase activity molecular function: cystathionine gamma-lyase activity molecular function: lyase activity molecular function: pyridoxal phosphate binding biological process: cellular amino acid biosynthetic process biological process: cysteine biosynthetic process biological process: cysteine metabolic process biological process: glutathione metabolic process biological process: homocysteine metabolic process biological process: hydrogen sulfide biosynthetic process biological process: negative regulation of cell growth biological process: negative regulation of cell proliferation biological process: protein homotetramerization biological process: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine cellular component: cytoplasm cellular component: nucleus	BioCarta Pathways:	KEGG Pathways: 1: Cysteine metabolism (external link) 2: Nitrogen metabolism (external link) 3: Glycine, serine and threonine metabolism (external link) 4: Selenoamino acid metabolism (external link) 5: Methionine metabolism (external link)
Unique ID: 165825 UniGene: In multiple Geneids Symbol: SDS (external link) DrugBank: Query Gene Symbol:SDS	Sum Func:	SP Function:	SP Local:	Gene Ontology:	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161296 Name: haptoglobin UniGene: Hs.513711 Symbol: HP (external link) Entrez ID: 3240 Chromosome: 16 Cytoband: 16q22.1 DrugBank: Query Gene Symbol:HP	Sum Func:	SP Function: haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes.	SP Local: secreted.	Gene Ontology: molecular function: catalytic activity molecular function: hemoglobin binding molecular function: serine-type endopeptidase activity biological process: cellular iron ion homeostasis biological process: defense response biological process: negative regulation of hydrogen peroxide catabolic process biological process: negative regulation of oxidoreductase activity biological process: positive regulation of cell death biological process: proteolysis biological process: response to hydrogen peroxide cellular component: extracellular region cellular component: haptoglobin-hemoglobin complex	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161511 Name: ATPase, Na+/K+ transporting, alpha 3 polypeptide UniGene: Hs.515427 Symbol: ATP1A3 (external link) Entrez ID: 478 Chromosome: 19 Cytoband: 19q13.31 DrugBank: Query Gene Symbol:ATP1A3	Sum Func:	SP Function: this is the catalytic component of the active enzyme, which catalyzes the hydrolysis of atp coupled with the exchange of sodium and potassium ions across the plasma membrane. this action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.	SP Local: cell membrane; multi-pass membrane protein.	Gene Ontology: molecular function: ATP binding molecular function: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism molecular function: hydrolase activity molecular function: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances molecular function: metal ion binding molecular function: monovalent inorganic cation transmembrane transporter activity molecular function: nucleotide binding molecular function: sodium:potassium-exchanging ATPase activity biological process: ATP biosynthetic process biological process: adult locomotory behavior biological process: ion transmembrane transport biological process: ion transmembrane transport biological process: ionotropic glutamate receptor signaling pathway biological process: memory biological process: potassium ion transport biological process: response to drug biological process: sodium ion transport biological process: transmembrane transport biological process: visual learning cellular component: Golgi apparatus cellular component: cytoplasm cellular component: endoplasmic reticulum cellular component: integral to membrane cellular component: nucleus cellular component: plasma membrane cellular component: plasma membrane cellular component: sodium:potassium-exchanging ATPase complex	BioCarta Pathways:	KEGG Pathways:
Unique ID: 166057 Name: POU class 1 homeobox 1 UniGene: Hs.591654 Symbol: POU1F1 (external link) Entrez ID: 5449 Chromosome: 3 Cytoband: 3p11 DrugBank: Query Gene Symbol:POU1F1	Sum Func:	SP Function: transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. activates growth hormone and prolactin genes. specifically binds to the consensus sequence 5'- taaat-3'.	SP Local: nucleus.	Gene Ontology: molecular function: sequence-specific DNA binding molecular function: sequence-specific DNA binding transcription factor activity molecular function: transcription regulator activity biological process: cell fate specification biological process: negative regulation of cell proliferation biological process: positive regulation of gene-specific transcription biological process: regulation of transcription, DNA-dependent biological process: transcription from RNA polymerase II promoter biological process: transcription, DNA-dependent cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 164992 Name: D-amino-acid oxidase UniGene: Hs.113227 Symbol: DAO (external link) Entrez ID: 1610 Chromosome: 12 Cytoband: 12q24 DrugBank: Query Gene Symbol:DAO	Sum Func:	SP Function: regulates the level of the neuromodulator d-serine in the brain. has high activity towards d-dopa and contributes to dopamine synthesis. could act as a detoxifying agent which removes d-amino acids accumulated during aging. acts on a variety of d- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. does not act on acidic amino acids.	SP Local: peroxisome.	Gene Ontology: molecular function: D-amino-acid oxidase activity molecular function: binding molecular function: oxidoreductase activity biological process: cellular nitrogen compound metabolic process biological process: glyoxylate metabolic process biological process: leucine metabolic process biological process: oxidation-reduction process cellular component: peroxisomal matrix cellular component: peroxisome	BioCarta Pathways:	KEGG Pathways: 1: Arginine and proline metabolism (external link) 2: Glycine, serine and threonine metabolism (external link) 3: D-Arginine and D-ornithine metabolism (external link)
Unique ID: 169679	Sum Func:	SP Function:	SP Local:	Gene Ontology:	BioCarta Pathways:	KEGG Pathways:
Unique ID: 163485 Name: desmoglein 1 UniGene: Hs.2633 Symbol: DSG1 (external link) Entrez ID: 1828 Chromosome: 18 Cytoband: 18q12.1 DrugBank: Query Gene Symbol:DSG1	Sum Func:	SP Function: component of intercellular desmosome junctions. involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.	SP Local: cell membrane; single-pass type i membrane protein (by similarity). cell junction, desmosome.	Gene Ontology: molecular function: calcium ion binding molecular function: gamma-catenin binding molecular function: protein binding molecular function: toxin binding biological process: apoptosis biological process: calcium-dependent cell-cell adhesion biological process: cell-cell adhesion biological process: cell-cell junction assembly biological process: cellular component disassembly involved in apoptosis biological process: homophilic cell adhesion biological process: protein stabilization cellular component: cell-cell junction cellular component: cytosol cellular component: desmosome cellular component: integral to membrane cellular component: internal side of plasma membrane cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways: 1: Cell Communication (external link)
Unique ID: 160233 Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 UniGene: Hs.164267 Symbol: DYRK3 (external link) Entrez ID: 8444 Chromosome: 1 Cytoband: 1q32.1 DrugBank: Query Gene Symbol:DYRK3	Sum Func:	SP Function: negative regulator of epo-dependent erythropoiesis, may place an upper limit on red cell production during stress erythropoiesis. inhibits cell death due to cytokine withdrawal in hematopoietic progenitor cells. may act by regulating creb/cre signaling.	SP Local: nucleus.	Gene Ontology: molecular function: ATP binding molecular function: magnesium ion binding molecular function: nucleotide binding molecular function: protein binding molecular function: protein kinase activity molecular function: protein serine/threonine kinase activity molecular function: protein tyrosine kinase activity molecular function: transferase activity biological process: erythrocyte differentiation biological process: protein phosphorylation cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 166974 Name: growth arrest and DNA-damage-inducible, alpha UniGene: Hs.80409 Symbol: GADD45A (external link) Entrez ID: 1647 Chromosome: 1 Cytoband: 1p31.2 DrugBank: Query Gene Symbol:GADD45A	Sum Func:	SP Function: binds to proliferating cell nuclear antigen. might affect pcna interaction with some cdk (cell division protein kinase) complexes; stimulates dna excision repair in vitro and inhibits entry of cells into s phase.	SP Local:	Gene Ontology: molecular function: protein binding biological process: DNA repair biological process: G2/M transition of mitotic cell cycle biological process: apoptosis biological process: cell cycle arrest biological process: cellular response to ionizing radiation biological process: cellular response to mechanical stimulus biological process: centrosome cycle biological process: negative regulation of protein kinase activity biological process: regulation of cyclin-dependent protein kinase activity biological process: signal transduction in response to DNA damage cellular component: nucleus	BioCarta Pathways: 1: Cell Cycle: G2/M Checkpoint 2: ATM Signaling Pathway 3: p53 Signaling Pathway 4: Hypoxia and p53 in the Cardiovascular system	KEGG Pathways: 1: MAPK signaling pathway (external link) 2: Cell cycle (external link)
Unique ID: 167196 Name: 3-hydroxybutyrate dehydrogenase, type 1 UniGene: Hs.274539 Symbol: BDH1 (external link) Entrez ID: 622 Chromosome: 3 Cytoband: 3q29 DrugBank: Query Gene Symbol:BDH1	Sum Func:	SP Function:	SP Local: mitochondrion matrix.	Gene Ontology: molecular function: 3-hydroxybutyrate dehydrogenase activity molecular function: 3-hydroxybutyrate dehydrogenase activity molecular function: binding molecular function: oxidoreductase activity molecular function: phospholipid binding biological process: adipose tissue development biological process: brain development biological process: cellular ketone body metabolic process biological process: cellular lipid metabolic process biological process: ketone body biosynthetic process biological process: ketone body catabolic process biological process: liver development biological process: metabolic process biological process: oxidation-reduction process biological process: response to cadmium ion biological process: response to corticosterone stimulus biological process: response to drug biological process: response to estradiol stimulus biological process: response to ethanol biological process: response to growth hormone stimulus biological process: response to hormone stimulus biological process: response to insulin stimulus biological process: response to nutrient biological process: response to starvation biological process: response to toxin cellular component: mitochondrial inner membrane cellular component: mitochondrial matrix cellular component: mitochondrial matrix cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways: 1: Butanoate metabolism (external link) 2: Synthesis and degradation of ketone bodies (external link)
Unique ID: 163580 Name: adrenergic, beta-2-, receptor, surface UniGene: Hs.2551 Symbol: ADRB2 (external link) Entrez ID: 154 Chromosome: 5 Cytoband: 5q31-q32 DrugBank: Query Gene Symbol:ADRB2	Sum Func:	SP Function: beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of g proteins. the beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.	SP Local: cell membrane; multi-pass membrane protein.	Gene Ontology: molecular function: G-protein coupled receptor activity molecular function: adenylate cyclase binding molecular function: adrenergic receptor activity molecular function: beta2-adrenergic receptor activity molecular function: dopamine binding molecular function: drug binding molecular function: epinephrine binding molecular function: ionotropic glutamate receptor binding molecular function: norepinephrine binding molecular function: potassium channel regulator activity molecular function: protein binding molecular function: protein homodimerization activity molecular function: receptor activity biological process: G-protein signaling, coupled to cAMP nucleotide second messenger biological process: activation of adenylate cyclase activity biological process: activation of adenylate cyclase activity by G-protein signaling pathway biological process: activation of transmembrane receptor protein tyrosine kinase activity biological process: bone resorption biological process: brown fat cell differentiation biological process: cell surface receptor linked signaling pathway biological process: desensitization of G-protein coupled receptor protein signaling pathway by arrestin biological process: diaphragm contraction biological process: diet induced thermogenesis biological process: endosome to lysosome transport biological process: heat generation biological process: negative regulation of calcium ion transport via voltage-gated calcium channel activity biological process: negative regulation of inflammatory response biological process: negative regulation of multicellular organism growth biological process: negative regulation of ossification biological process: negative regulation of smooth muscle contraction biological process: positive regulation of MAPKKK cascade biological process: positive regulation of apoptosis biological process: positive regulation of bone mineralization biological process: positive regulation of cell proliferation biological process: positive regulation of heart contraction biological process: positive regulation of potassium ion transport biological process: positive regulation of skeletal muscle tissue growth biological process: positive regulation of sodium ion transport biological process: positive regulation of transcription from RNA polymerase II promoter biological process: positive regulation of vasodilation biological process: receptor-mediated endocytosis biological process: regulation of sensory perception of pain biological process: response to cold biological process: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure cellular component: apical plasma membrane cellular component: axon cellular component: caveola cellular component: dendritic spine cellular component: endosome cellular component: integral to plasma membrane cellular component: intracellular part cellular component: lysosome cellular component: membrane fraction cellular component: microsome cellular component: neuronal cell body membrane cellular component: nucleus cellular component: plasma membrane cellular component: plasma membrane cellular component: plasma membrane cellular component: receptor complex cellular component: sarcolemma	BioCarta Pathways: 1: Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway 2: Phospholipase C-epsilon pathway 3: Corticosteroids and cardioprotection	KEGG Pathways: 1: Neuroactive ligand-receptor interaction (external link) 2: Calcium signaling pathway (external link)
Unique ID: 160471 Name: heat-responsive protein 12 UniGene: Hs.18426 Symbol: HRSP12 (external link) Entrez ID: 10247 Chromosome: 8 Cytoband: 8q22 DrugBank: Query Gene Symbol:HRSP12	Sum Func:	SP Function: endoribonuclease responsible for the inhibition of the translation by cleaving mrna inhibits cell-free protein synthesis. cleaves phosphodiester bonds only in single-stranded rna (by similarity).	SP Local: cytoplasm. nucleus. note=mostly cytoplasmic but, in less differentiated cells occasionally nuclear.	Gene Ontology: molecular function: endonuclease activity molecular function: hydrolase activity biological process: regulation of translational termination cellular component: cytoplasm cellular component: mitochondrion cellular component: nucleolus cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 169589 Name: homogentisate 1,2-dioxygenase UniGene: Hs.368254 Symbol: HGD (external link) Entrez ID: 3081 Chromosome: 3 Cytoband: 3q13.33 DrugBank: Query Gene Symbol:HGD	Sum Func:	SP Function:	SP Local:	Gene Ontology: molecular function: homogentisate 1,2-dioxygenase activity molecular function: metal ion binding molecular function: oxidoreductase activity biological process: L-phenylalanine catabolic process biological process: cellular nitrogen compound metabolic process biological process: oxidation-reduction process biological process: tyrosine catabolic process cellular component: cytosol	BioCarta Pathways:	KEGG Pathways: 1: Tyrosine metabolism (external link) 2: Styrene degradation (external link)
Unique ID: 159780 Name: multiple PDZ domain protein UniGene: Hs.169378 Symbol: MPDZ (external link) Entrez ID: 8777 Chromosome: 9 Cytoband: 9p23 DrugBank: Query Gene Symbol:MPDZ	Sum Func:	SP Function: interacts with htr2c and provokes its clustering at the cell surface (by similarity). member of the nmdar signaling complex that may play a role in control of ampar potentiation and synaptic plasticity in excitatory synapses.	SP Local: cell membrane; peripheral membrane protein; cytoplasmic side. apical cell membrane; peripheral membrane protein; cytoplasmic side. cell junction, synapse, postsynaptic cell membrane, postsynaptic density. cell projection, dendrite. cell junction, synapse. cell junction, tight junction. cell junction, synapse. cell junction, synapse, synaptosome. note=associated with membranes. colocalizes with htr2c on the apical membrane of epithelial choroid plexus cells. highly enriched in postsynaptic densities (psd). localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker dlg4. localized mainly in the schmidt-lanterman incisures of myelinating schwann cells (by similarity). in the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. enriched at the tight junctions of epithelial cells. association to the tight junctions depends on cxadr.	Gene Ontology: molecular function: protein C-terminus binding molecular function: protein binding biological process: interspecies interaction between organisms cellular component: apical plasma membrane cellular component: cell junction cellular component: cell projection cellular component: dendrite cellular component: plasma membrane cellular component: postsynaptic density cellular component: postsynaptic membrane cellular component: synapse cellular component: synaptosome cellular component: tight junction	BioCarta Pathways:	KEGG Pathways: 1: Tight junction (external link)
Unique ID: 161003 Name: alcohol dehydrogenase 1B (class I), beta polypeptide UniGene: Hs.4 Symbol: ADH1B (external link) Entrez ID: 125 Chromosome: 4 Cytoband: 4q23 DrugBank: Query Gene Symbol:ADH1B	Sum Func:	SP Function:	SP Local: cytoplasm.	Gene Ontology: molecular function: alcohol dehydrogenase activity, zinc-dependent molecular function: binding molecular function: metal ion binding molecular function: oxidoreductase activity molecular function: zinc ion binding biological process: ethanol oxidation biological process: ethanol oxidation biological process: xenobiotic metabolic process cellular component: cytoplasm cellular component: cytosol	BioCarta Pathways:	KEGG Pathways: 1: Fatty acid metabolism (external link) 2: Tyrosine metabolism (external link) 3: Bile acid biosynthesis (external link) 4: Glycerolipid metabolism (external link) 5: Glycolysis / Gluconeogenesis (external link) 6: Metabolism of xenobiotics by cytochrome P450 (external link) 7: 1- and 2-Methylnaphthalene degradation (external link)
Unique ID: 164412 UniGene: In multiple Geneids Symbol: CES2 (external link) DrugBank: Query Gene Symbol:CES2	Sum Func:	SP Function:	SP Local:	Gene Ontology:	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161259 Name: solute carrier family 22 (organic cation transporter), member 1 UniGene: Hs.117367 Symbol: SLC22A1 (external link) Entrez ID: 6580 Chromosome: 6 Cytoband: 6q26 DrugBank: Query Gene Symbol:SLC22A1	Sum Func:	SP Function: translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (mpp), tetraethylammonium (tea), n-1-methylnicotinamide (nmn), 4-(4-(dimethylamino)styryl)- n-methylpyridinium (asp), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. the transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (tma), cocaine, lidocaine, nmda receptor antagonists, atropine, prazosin, cimetidine, tea and nmn, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. translocates organic cations in an electrogenic and ph-independent manner. translocates organic cations across the plasma membrane in both directions. transports the polyamines spermine and spermidine. transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. the choline transport is activated by mmts. regulated by various intracellular signaling pathways including inhibition by protein kinase a activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase ii and lck tyrosine kinase.	SP Local: basolateral cell membrane; multi-pass membrane protein.	Gene Ontology: molecular function: ion transmembrane transporter activity molecular function: organic cation transmembrane transporter activity molecular function: protein binding molecular function: transporter activity biological process: organic cation transport biological process: transmembrane transport cellular component: basolateral plasma membrane cellular component: integral to plasma membrane cellular component: membrane fraction cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 160174 Name: complement component 6 UniGene: Hs.481992 Symbol: C6 (external link) Entrez ID: 729 Chromosome: 5 Cytoband: 5p13 DrugBank: Query Gene Symbol:C6	Sum Func:	SP Function: constituent of the membrane attack complex (mac) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.	SP Local: secreted.	Gene Ontology: molecular function: protein binding biological process: activation of caspase activity biological process: complement activation biological process: complement activation, classical pathway biological process: cytolysis biological process: in utero embryonic development biological process: induction of apoptosis biological process: innate immune response biological process: positive regulation of activation of membrane attack complex biological process: positive regulation of angiogenesis cellular component: extracellular region cellular component: extracellular region cellular component: extracellular space cellular component: membrane attack complex	BioCarta Pathways: 1: Classical Complement Pathway 2: Complement Pathway 3: Cells and Molecules involved in local acute inflammatory response 4: Alternative Complement Pathway 5: Lectin Induced Complement Pathway	KEGG Pathways: 1: Complement and coagulation cascades (external link)
Unique ID: 161323 Name: semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) UniGene: Hs.24640 Symbol: SEMA7A (external link) Entrez ID: 8482 Chromosome: 15 Cytoband: 15q22.3-q23 DrugBank: Query Gene Symbol:SEMA7A	Sum Func:	SP Function: plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. promotes formation of focal adhesion complexes, activation of the protein kinase ptk2/fak1 and subsequent phosphorylation of mapk1 and mapk3. promotes production of proinflammatory cytokines by monocytes and macrophages. plays an important role in modulating inflammation and t cell-mediated immune responses. promotes axon growth in the embryonic olfactory bulb. promotes attachment, spreading and dendrite outgrowth in melanocytes.	SP Local: cell membrane; lipid-anchor, gpi-anchor; extracellular side. note=detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.	Gene Ontology: molecular function: protein binding molecular function: receptor activity biological process: axon guidance biological process: cell differentiation biological process: immune response biological process: integrin-mediated signaling pathway biological process: multicellular organismal development biological process: nervous system development biological process: positive regulation of ERK1 and ERK2 cascade biological process: positive regulation of axon extension biological process: positive regulation of macrophage cytokine production biological process: regulation of inflammatory response cellular component: anchored to membrane cellular component: external side of plasma membrane cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways: 1: Axon guidance (external link)
Unique ID: 163533 Name: enoyl CoA hydratase domain containing 2 UniGene: Hs.476319 Symbol: ECHDC2 (external link) Entrez ID: 55268 Chromosome: 1 Cytoband: 1p32.3 DrugBank: Query Gene Symbol:ECHDC2	Sum Func:	SP Function:	SP Local: mitochondrion (potential).	Gene Ontology: molecular function: lyase activity biological process: fatty acid metabolic process biological process: lipid metabolic process cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162878 Name: transmembrane protein 56 UniGene: Hs.483512 Symbol: TMEM56 (external link) Entrez ID: 148534 Chromosome: 1 Cytoband: 1p21.3 DrugBank: Query Gene Symbol:TMEM56	Sum Func:	SP Function:	SP Local: membrane; multi-pass membrane protein (potential).	Gene Ontology: molecular function: molecular_function biological process: biological_process cellular component: cellular_component cellular component: integral to membrane cellular component: membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 163887 Name: prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) UniGene: Hs.201978 Symbol: PTGS1 (external link) Entrez ID: 5742 Chromosome: 9 Cytoband: 9q32-q33.3 DrugBank: Query Gene Symbol:PTGS1	Sum Func:	SP Function: may play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.	SP Local: microsome membrane; peripheral membrane protein. endoplasmic reticulum membrane; peripheral membrane protein.	Gene Ontology: molecular function: heme binding molecular function: lipid binding molecular function: metal ion binding molecular function: oxidoreductase activity molecular function: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen molecular function: peroxidase activity molecular function: prostaglandin-endoperoxide synthase activity biological process: aging biological process: cyclooxygenase pathway biological process: fatty acid biosynthetic process biological process: hormone biosynthetic process biological process: lipid metabolic process biological process: negative regulation of epinephrine secretion biological process: negative regulation of norepinephrine secretion biological process: oxidation-reduction process biological process: positive regulation of smooth muscle contraction biological process: positive regulation of vasoconstriction biological process: prostaglandin biosynthetic process biological process: prostanoid metabolic process biological process: regulation of blood pressure biological process: regulation of cell proliferation biological process: response to corticosterone stimulus biological process: response to organic nitrogen biological process: response to oxidative stress biological process: xenobiotic metabolic process cellular component: Golgi apparatus cellular component: cytoplasm cellular component: cytoplasmic part cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: intracellular membrane-bounded organelle cellular component: microsome cellular component: nuclear envelope cellular component: nucleus cellular component: plasma membrane	BioCarta Pathways: 1: Aspirin Blocks Signaling Pathway Involved in Platelet Activation 2: Mechanism of Acetaminophen Activity and Toxicity 3: Eicosanoid Metabolism	KEGG Pathways: 1: Arachidonic acid metabolism (external link)
Unique ID: 159969 Name: complement component 1, r subcomponent UniGene: Hs.524224 Symbol: C1R (external link) Entrez ID: 715 Chromosome: 12 Cytoband: 12p13 DrugBank: Query Gene Symbol:C1R	Sum Func:	SP Function: c1r b chain is a serine protease that combines with c1q and c1s to form c1, the first component of the classical pathway of the complement system.	SP Local:	Gene Ontology: molecular function: calcium ion binding molecular function: peptidase activity molecular function: serine-type endopeptidase activity molecular function: serine-type peptidase activity biological process: complement activation biological process: complement activation, classical pathway biological process: immune response biological process: innate immune response biological process: proteolysis cellular component: extracellular region cellular component: extracellular region cellular component: extracellular region	BioCarta Pathways: 1: Classical Complement Pathway 2: Complement Pathway	KEGG Pathways: 1: Complement and coagulation cascades (external link)
Unique ID: 161484 Name: cytochrome P450, family 4, subfamily F, polypeptide 3 UniGene: Hs.106242 Symbol: CYP4F3 (external link) Entrez ID: 4051 Chromosome: 19 Cytoband: 19p13.2 DrugBank: Query Gene Symbol:CYP4F3	Sum Func:	SP Function: cytochromes p450 are a group of heme-thiolate monooxygenases. this enzyme requires molecular oxygen and NADph for the omega-hydroxylation of ltb4, a potent chemoattractant for polymorphonuclear leukocytes.	SP Local: endoplasmic reticulum membrane; single-pass membrane protein (by similarity). microsome membrane; single-pass membrane protein (by similarity).	Gene Ontology: molecular function: electron carrier activity molecular function: heme binding molecular function: leukotriene-B4 20-monooxygenase activity molecular function: metal ion binding molecular function: monooxygenase activity molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular function: oxygen binding biological process: leukotriene metabolic process biological process: oxidation-reduction process biological process: xenobiotic metabolic process cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: integral to membrane cellular component: membrane cellular component: microsome	BioCarta Pathways:	KEGG Pathways: 1: Arachidonic acid metabolism (external link)
Unique ID: 165274 Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1 UniGene: Hs.443874 Symbol: SLC6A1 (external link) Entrez ID: 6529 Chromosome: 3 Cytoband: 3p25-p24 DrugBank: Query Gene Symbol:SLC6A1	Sum Func:	SP Function: terminates the action of gaba by its high affinity sodium-dependent reuptake into presynaptic terminals.	SP Local: cell membrane; multi-pass membrane protein. membrane; multi-pass membrane protein. note=localized at the plasma membrane and in a subset of intracellular vesicles. localized at the presynaptic terminals of interneurons (by similarity).	Gene Ontology: molecular function: gamma-aminobutyric acid:sodium symporter activity molecular function: neurotransmitter:sodium symporter activity molecular function: symporter activity biological process: gamma-aminobutyric acid import biological process: learning biological process: negative regulation of synaptic transmission, GABAergic biological process: neurotransmitter secretion biological process: protein homooligomerization biological process: response to calcium ion biological process: response to cocaine biological process: response to estradiol stimulus biological process: response to lead ion biological process: response to organic nitrogen biological process: response to purine-containing compound biological process: response to sucrose stimulus biological process: response to toxin biological process: synaptic transmission biological process: transmembrane transport biological process: transport cellular component: integral to membrane cellular component: integral to plasma membrane cellular component: membrane fraction cellular component: plasma membrane cellular component: synaptosome	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162599 Name: haptoglobin-related protein UniGene: Hs.655361 Symbol: HPR (external link) Entrez ID: 3250 Chromosome: 16 Cytoband: 16q22.1 DrugBank: Query Gene Symbol:HPR	Sum Func:	SP Function:	SP Local: secreted (potential).	Gene Ontology: molecular function: catalytic activity molecular function: hemoglobin binding molecular function: serine-type endopeptidase activity biological process: proteolysis cellular component: extracellular region cellular component: spherical high-density lipoprotein particle	BioCarta Pathways:	KEGG Pathways:
Unique ID: 164597 Name: chromosome 8 open reading frame 40 UniGene: Hs.655320 Symbol: C8orf40 (external link) Entrez ID: 114926 Chromosome: 8 Cytoband: 8p11.21 DrugBank: Query Gene Symbol:C8orf40	Sum Func:	SP Function:	SP Local: membrane; single-pass membrane protein (potential).	Gene Ontology: cellular component: cytoplasm cellular component: integral to membrane cellular component: membrane cellular component: nucleolus cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 169027 Name: apolipoprotein C-IV UniGene: Hs.655423 Symbol: APOC4 (external link) Entrez ID: 346 Chromosome: 19 Cytoband: 19q13.2 DrugBank: Query Gene Symbol:APOC4	Sum Func:	SP Function: may participate in lipoprotein metabolism.	SP Local: secreted.	Gene Ontology: molecular function: lipid transporter activity biological process: lipid metabolic process biological process: lipid transport biological process: positive regulation of sequestering of triglyceride biological process: transport biological process: triglyceride homeostasis cellular component: extracellular region cellular component: high-density lipoprotein particle cellular component: very-low-density lipoprotein particle cellular component: very-low-density lipoprotein particle	BioCarta Pathways:	KEGG Pathways:
Unique ID: 160100 Name: aldehyde dehydrogenase 7 family, member A1 UniGene: Hs.483239 Symbol: ALDH7A1 (external link) Entrez ID: 501 Chromosome: 5 Cytoband: 5q31 DrugBank: Query Gene Symbol:ALDH7A1	Sum Func:	SP Function: multifunctional enzyme mediating important protective effects. metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. involved in lysine catabolism.	SP Local: isoform 2: cytoplasm, cytosol.	Gene Ontology: molecular function: L-aminoadipate-semialdehyde dehydrogenase activity molecular function: aldehyde dehydrogenase (NAD) activity molecular function: betaine-aldehyde dehydrogenase activity molecular function: oxidoreductase activity biological process: cellular aldehyde metabolic process biological process: cellular nitrogen compound metabolic process biological process: lysine catabolic process biological process: oxidation-reduction process biological process: sensory perception of sound cellular component: cellular_component cellular component: cytoplasm cellular component: cytosol cellular component: mitochondrial matrix cellular component: mitochondrion cellular component: nucleus	BioCarta Pathways:	KEGG Pathways: 1: Lysine degradation (external link) 2: Limonene and pinene degradation (external link) 3: Propanoate metabolism (external link) 4: Fatty acid metabolism (external link) 5: Glycolysis / Gluconeogenesis (external link) 6: Arginine and proline metabolism (external link) 7: Ascorbate and aldarate metabolism (external link) 8: Glycerolipid metabolism (external link) 9: Tryptophan metabolism (external link) 10: Histidine metabolism (external link) 11: Butanoate metabolism (external link) 12: Pyruvate metabolism (external link) 13: beta-Alanine metabolism (external link) 14: Valine, leucine and isoleucine degradation (external link) 15: Bile acid biosynthesis (external link)
Unique ID: 164495 Name: acetyl-CoA carboxylase beta UniGene: Hs.234898 Symbol: ACACB (external link) Entrez ID: 32 Chromosome: 12 Cytoband: 12q24.11 DrugBank: Query Gene Symbol:ACACB	Sum Func:	SP Function: acc-beta may be involved in the provision of malonyl-coa or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.	SP Local: endomembrane system. note=may associate with membranes.	Gene Ontology: molecular function: ATP binding molecular function: acetyl-CoA carboxylase activity molecular function: acetyl-CoA carboxylase activity molecular function: biotin carboxylase activity molecular function: ligase activity molecular function: metal ion binding molecular function: nucleotide binding molecular function: protein binding biological process: acetyl-CoA metabolic process biological process: carnitine shuttle biological process: cellular lipid metabolic process biological process: energy reserve metabolic process biological process: fatty acid biosynthetic process biological process: positive regulation of cellular metabolic process biological process: protein homotetramerization biological process: regulation of fatty acid oxidation cellular component: Golgi apparatus cellular component: cytoplasm cellular component: cytosol cellular component: cytosol cellular component: endomembrane system cellular component: membrane	BioCarta Pathways:	KEGG Pathways: 1: Propanoate metabolism (external link) 2: Pyruvate metabolism (external link) 3: Adipocytokine signaling pathway (external link) 4: Fatty acid biosynthesis (external link) 5: Insulin signaling pathway (external link)
Unique ID: 165554 Name: aminolevulinate, delta-, synthase 1 UniGene: Hs.476308 Symbol: ALAS1 (external link) Entrez ID: 211 Chromosome: 3 Cytoband: 3p21.1 DrugBank: Query Gene Symbol:ALAS1	Sum Func:	SP Function:	SP Local: mitochondrion matrix.	Gene Ontology: molecular function: 5-aminolevulinate synthase activity molecular function: acyltransferase activity molecular function: pyridoxal phosphate binding molecular function: transferase activity, transferring nitrogenous groups biological process: biosynthetic process biological process: heme biosynthetic process biological process: porphyrin metabolic process biological process: tetrapyrrole biosynthetic process cellular component: mitochondrial matrix cellular component: mitochondrion	BioCarta Pathways: 1: Hemoglobin's Chaperone	KEGG Pathways: 1: Glycine, serine and threonine metabolism (external link)
Unique ID: 164296 Name: apolipoprotein C-III UniGene: Hs.73849 Symbol: APOC3 (external link) Entrez ID: 345 Chromosome: 11 Cytoband: 11q23.1-q23.2 DrugBank: Query Gene Symbol:APOC3	Sum Func:	SP Function: inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. this suggests that it delays the catabolism of triglyceride-rich particles.	SP Local: secreted.	Gene Ontology: molecular function: cholesterol binding molecular function: enzyme regulator activity molecular function: high-density lipoprotein particle receptor binding molecular function: lipase inhibitor activity molecular function: phospholipid binding biological process: Cdc42 protein signal transduction biological process: G-protein coupled receptor protein signaling pathway biological process: cholesterol efflux biological process: cholesterol homeostasis biological process: cholesterol metabolic process biological process: chylomicron remnant clearance biological process: high-density lipoprotein particle remodeling biological process: lipid metabolic process biological process: lipid transport biological process: lipoprotein metabolic process biological process: negative regulation of cholesterol import biological process: negative regulation of fatty acid biosynthetic process biological process: negative regulation of high-density lipoprotein particle clearance biological process: negative regulation of lipid catabolic process biological process: negative regulation of lipid metabolic process biological process: negative regulation of lipoprotein lipase activity biological process: negative regulation of low-density lipoprotein particle clearance biological process: negative regulation of receptor-mediated endocytosis biological process: negative regulation of triglyceride catabolic process biological process: negative regulation of very-low-density lipoprotein particle clearance biological process: negative regulation of very-low-density lipoprotein particle remodeling biological process: negative regulation of very-low-density lipoprotein particle remodeling biological process: phospholipid efflux biological process: reverse cholesterol transport biological process: transport biological process: triglyceride catabolic process biological process: triglyceride homeostasis biological process: triglyceride metabolic process biological process: triglyceride mobilization biological process: very-low-density lipoprotein particle assembly cellular component: chylomicron cellular component: extracellular region cellular component: extracellular region cellular component: extracellular space cellular component: intermediate-density lipoprotein particle cellular component: spherical high-density lipoprotein particle cellular component: very-low-density lipoprotein particle	BioCarta Pathways:	KEGG Pathways: 1: PPAR signaling pathway (external link)
Unique ID: 166966 Name: hydroxysteroid (17-beta) dehydrogenase 10 UniGene: Hs.171280 Symbol: HSD17B10 (external link) Entrez ID: 3028 Chromosome: X Cytoband: Xp11.2 DrugBank: Query Gene Symbol:HSD17B10	Sum Func:	SP Function: functions in mitochondrial trna maturation. part of mitochondrial ribonuclease p, an enzyme composed of mrpp1/rg9mtd1, mrpp2/hsd17b10 and mrpp3/kiaa0391, which cleaves trna molecules in their 5'-ends. by interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with alzheimer disease (ad).	SP Local: mitochondrion.	Gene Ontology: molecular function: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity molecular function: 3-hydroxyacyl-CoA dehydrogenase activity molecular function: NAD binding molecular function: acetoacetyl-CoA reductase activity molecular function: beta-amyloid binding molecular function: cholate 7-alpha-dehydrogenase activity molecular function: estradiol 17-beta-dehydrogenase activity molecular function: identical protein binding molecular function: oxidoreductase activity molecular function: protein binding molecular function: steroid binding biological process: Leydig cell differentiation biological process: branched chain family amino acid catabolic process biological process: cell aging biological process: cellular nitrogen compound metabolic process biological process: lipid metabolic process biological process: oxidation-reduction process biological process: protein homotetramerization biological process: tRNA processing cellular component: cytoplasm cellular component: endoplasmic reticulum cellular component: mitochondrial inner membrane cellular component: mitochondrial matrix cellular component: mitochondrion cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways: 1: Tryptophan metabolism (external link) 2: Valine, leucine and isoleucine degradation (external link) 3: Fatty acid elongation in mitochondria (external link) 4: Butanoate metabolism (external link) 5: Fatty acid metabolism (external link) 6: Caprolactam degradation (external link) 7: Lysine degradation (external link)
Unique ID: 169282	Sum Func:	SP Function:	SP Local:	Gene Ontology:	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162415 Name: betaine–homocysteine S-methyltransferase UniGene: Hs.80756 Symbol: BHMT (external link) Entrez ID: 635 Chromosome: 5 Cytoband: 5q13.1-q15 DrugBank: Query Gene Symbol:BHMT	Sum Func:	SP Function: involved in the regulation of homocysteine metabolism. converts betaine and homocysteine to dimethylglycine and methionine, respectively. this reaction is also required for the irreversible oxidation of choline.	SP Local: cytoplasm.	Gene Ontology: molecular function: betaine-homocysteine S-methyltransferase activity molecular function: homocysteine S-methyltransferase activity molecular function: metal ion binding molecular function: methyltransferase activity molecular function: protein complex binding molecular function: transferase activity molecular function: zinc ion binding biological process: methionine biosynthetic process biological process: protein methylation biological process: regulation of homocysteine metabolic process cellular component: cytoplasm cellular component: protein complex	BioCarta Pathways:	KEGG Pathways: 1: Methionine metabolism (external link) 2: Glycine, serine and threonine metabolism (external link)
Unique ID: 168483 Name: family with sequence similarity 134, member B UniGene: Hs.720770 Symbol: FAM134B (external link) Entrez ID: 54463 Chromosome: 5 Cytoband: 5p15.1 DrugBank: Query Gene Symbol:FAM134B	Sum Func:	SP Function: required for long-term survival of nociceptive and autonomic ganglion neurons.	SP Local: golgi apparatus, cis-golgi network membrane; multi-pass membrane protein (by similarity).	Gene Ontology: biological process: sensory perception of pain cellular component: Golgi apparatus cellular component: cis-Golgi network cellular component: endoplasmic reticulum cellular component: integral to membrane cellular component: membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 167750 Name: adenosine kinase UniGene: Hs.656586 Symbol: ADK (external link) Entrez ID: 132 Chromosome: 10 Cytoband: 10q22 DrugBank: Query Gene Symbol:ADK	Sum Func:	SP Function: atp dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.	SP Local:	Gene Ontology: molecular function: ATP binding molecular function: adenosine kinase activity molecular function: kinase activity molecular function: metal ion binding molecular function: nucleotide binding molecular function: phosphotransferase activity, alcohol group as acceptor molecular function: transferase activity biological process: adenosine metabolic process biological process: dATP biosynthetic process biological process: nucleobase, nucleoside and nucleotide metabolic process biological process: positive regulation of T cell proliferation biological process: purine base metabolic process biological process: purine ribonucleoside salvage biological process: purine-containing compound salvage biological process: ribonucleoside monophosphate biosynthetic process cellular component: cytosol cellular component: nucleus	BioCarta Pathways:	KEGG Pathways: 1: Purine metabolism (external link)
Unique ID: 165041 Name: hypothetical protein LOC727993 UniGene: Hs.551466 Symbol: LOC727993 (external link) Entrez ID: 727993 Chromosome: 20 Cytoband: 20p13 DrugBank: Query Gene Symbol:LOC727993	Sum Func:	SP Function:	SP Local:	Gene Ontology:	BioCarta Pathways:	KEGG Pathways:
Unique ID: 160017 Name: matrix metallopeptidase 15 (membrane-inserted) UniGene: Hs.80343 Symbol: MMP15 (external link) Entrez ID: 4324 Chromosome: 16 Cytoband: 16q13 DrugBank: Query Gene Symbol:MMP15	Sum Func:	SP Function: endopeptidase that degrades various components of the extracellular matrix. may activate progelatinase a.	SP Local: membrane; single-pass type i membrane protein; extracellular side (potential).	Gene Ontology: molecular function: calcium ion binding molecular function: enzyme activator activity molecular function: metalloendopeptidase activity molecular function: peptidase activity molecular function: protein binding molecular function: zinc ion binding biological process: metabolic process biological process: protein modification process biological process: proteolysis cellular component: extracellular matrix cellular component: integral to plasma membrane cellular component: membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161416 Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 UniGene: Hs.444304 Symbol: PFKFB1 (external link) Entrez ID: 5207 Chromosome: X Cytoband: Xp11.21 DrugBank: Query Gene Symbol:PFKFB1	Sum Func:	SP Function: synthesis and degradation of fructose 2,6-bisphosphate.	SP Local:	Gene Ontology: molecular function: 6-phosphofructo-2-kinase activity molecular function: ATP binding molecular function: fructose-2,6-bisphosphate 2-phosphatase activity molecular function: fructose-2,6-bisphosphate 2-phosphatase activity molecular function: fructose-6-phosphate binding molecular function: hydrolase activity molecular function: identical protein binding molecular function: kinase activity molecular function: kinase binding molecular function: nucleotide binding molecular function: protein binding molecular function: transferase activity biological process: carbohydrate metabolic process biological process: carbohydrate phosphorylation biological process: energy reserve metabolic process biological process: fructose 2,6-bisphosphate metabolic process biological process: gluconeogenesis biological process: glucose metabolic process biological process: glycolysis biological process: intracellular protein kinase cascade biological process: organ regeneration biological process: positive regulation of glucokinase activity biological process: response to cAMP biological process: response to glucagon stimulus biological process: response to glucocorticoid stimulus biological process: response to insulin stimulus biological process: response to starvation cellular component: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex cellular component: cytosol cellular component: cytosol	BioCarta Pathways:	KEGG Pathways: 1: Fructose and mannose metabolism (external link)
Unique ID: 162311 Name: serpin peptidase inhibitor, clade C (antithrombin), member 1 UniGene: Hs.75599 Symbol: SERPINC1 (external link) Entrez ID: 462 Chromosome: 1 Cytoband: 1q23-q25.1 DrugBank: Query Gene Symbol:SERPINC1	Sum Func:	SP Function: most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. at-iii inhibits thrombin as well as factors ixa, xa and xia. its inhibitory activity is greatly enhanced in the presence of heparin.	SP Local: secreted, extracellular space.	Gene Ontology: molecular function: heparin binding molecular function: peptidase inhibitor activity molecular function: protease binding molecular function: protein binding molecular function: serine-type endopeptidase inhibitor activity molecular function: serine-type endopeptidase inhibitor activity biological process: blood coagulation biological process: negative regulation of endopeptidase activity biological process: negative regulation of inflammatory response biological process: regulation of proteolysis biological process: response to nutrient cellular component: extracellular region cellular component: extracellular region cellular component: extracellular space cellular component: plasma membrane	BioCarta Pathways: 1: Extrinsic Prothrombin Activation Pathway 2: Acute Myocardial Infarction 3: Intrinsic Prothrombin Activation Pathway	KEGG Pathways: 1: Complement and coagulation cascades (external link)
Unique ID: 164943 Name: cytochrome P450, family 2, subfamily C, polypeptide 8 UniGene: Hs.709188 Symbol: CYP2C8 (external link) Entrez ID: 1558 Chromosome: 10 Cytoband: 10q23.33 DrugBank: Query Gene Symbol:CYP2C8	Sum Func:	SP Function: cytochromes p450 are a group of heme-thiolate monooxygenases. in liver microsomes, this enzyme is involved in an NADph-dependent electron transport pathway. it oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. in the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. it is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol).	SP Local: endoplasmic reticulum membrane; peripheral membrane protein. microsome membrane; peripheral membrane protein.	Gene Ontology: molecular function: aromatase activity molecular function: caffeine oxidase activity molecular function: electron carrier activity molecular function: heme binding molecular function: metal ion binding molecular function: monooxygenase activity molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen molecular function: oxygen binding biological process: drug metabolic process biological process: exogenous drug catabolic process biological process: organic acid metabolic process biological process: oxidation-reduction process biological process: oxidative demethylation biological process: xenobiotic metabolic process cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: membrane cellular component: microsome	BioCarta Pathways:	KEGG Pathways: 1: Arachidonic acid metabolism (external link) 2: Linoleic acid metabolism (external link) 3: Metabolism of xenobiotics by cytochrome P450 (external link)
Unique ID: 161326 Name: retinol dehydrogenase 16 (all-trans) UniGene: Hs.134958 Symbol: RDH16 (external link) Entrez ID: 8608 Chromosome: 12 Cytoband: 12q13.3 DrugBank: Query Gene Symbol:RDH16	Sum Func:	SP Function: oxidoreductase with a preference for NAD. oxidizes all- trans-retinol and 13-cis-retinol to the corresponding aldehydes. has higher activity towards crbp-bound retinol than with free retinol. oxidizes 3-alpha-hydroxysteroids. oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. can also catalyze the reverse reaction.	SP Local: microsome membrane; single-pass type iv membrane protein. endoplasmic reticulum membrane; single-pass type iv membrane protein (potential).	Gene Ontology: molecular function: binding molecular function: electron carrier activity molecular function: oxidoreductase activity molecular function: retinol dehydrogenase activity biological process: lipid metabolic process biological process: oxidation-reduction process cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: integral to membrane cellular component: membrane cellular component: microsome	BioCarta Pathways:	KEGG Pathways:
Unique ID: 163931 Name: alcohol dehydrogenase 1C (class I), gamma polypeptide UniGene: Hs.654537 Symbol: ADH1C (external link) Entrez ID: 126 Chromosome: 4 Cytoband: 4q23 DrugBank: Query Gene Symbol:ADH1C	Sum Func:	SP Function:	SP Local: cytoplasm.	Gene Ontology: molecular function: alcohol dehydrogenase (NAD) activity molecular function: binding molecular function: metal ion binding molecular function: oxidoreductase activity molecular function: zinc ion binding biological process: ethanol oxidation biological process: ethanol oxidation biological process: xenobiotic metabolic process cellular component: cytoplasm cellular component: cytosol	BioCarta Pathways:	KEGG Pathways: 1: 1- and 2-Methylnaphthalene degradation (external link) 2: Tyrosine metabolism (external link) 3: Glycerolipid metabolism (external link) 4: Metabolism of xenobiotics by cytochrome P450 (external link) 5: Fatty acid metabolism (external link) 6: Glycolysis / Gluconeogenesis (external link) 7: Bile acid biosynthesis (external link)
Unique ID: 162099 Name: betaine–homocysteine S-methyltransferase UniGene: Hs.80756 Symbol: BHMT (external link) Entrez ID: 635 Chromosome: 5 Cytoband: 5q13.1-q15 DrugBank: Query Gene Symbol:BHMT	Sum Func:	SP Function: involved in the regulation of homocysteine metabolism. converts betaine and homocysteine to dimethylglycine and methionine, respectively. this reaction is also required for the irreversible oxidation of choline.	SP Local: cytoplasm.	Gene Ontology: molecular function: betaine-homocysteine S-methyltransferase activity molecular function: homocysteine S-methyltransferase activity molecular function: metal ion binding molecular function: methyltransferase activity molecular function: protein complex binding molecular function: transferase activity molecular function: zinc ion binding biological process: methionine biosynthetic process biological process: protein methylation biological process: regulation of homocysteine metabolic process cellular component: cytoplasm cellular component: protein complex	BioCarta Pathways:	KEGG Pathways: 1: Methionine metabolism (external link) 2: Glycine, serine and threonine metabolism (external link)
Unique ID: 160366 Name: ubiquitin specific peptidase 10 UniGene: Hs.136778 Symbol: USP10 (external link) Entrez ID: 9100 Chromosome: 16 Cytoband: 16q24.1 DrugBank: Query Gene Symbol:USP10	Sum Func:	SP Function: hydrolase that can remove conjugated ubiquitin from target proteins such as p53/tp53, snx3 and cftr. acts as an essential regulator of p53/tp53 stability: in unstressed cells, specifically deubiquitinates p53/tp53 in the cytoplasm, leading to counteract mdm2 action and stabilize p53/tp53. following dna damage, translocates to the nucleus and deubiquitinates p53/tp53, leading to regulate the p53/tp53-dependent dna damage response. does not deubiquitinate mdm2. deubiquitinates cftr in early endosomes, enhancing its endocytic recycling.	SP Local: cytoplasm. nucleus. early endosome. note=cytoplasmic in normal conditions. after dna damage, translocates to the nucleus following phosphorylation by atm.	Gene Ontology: molecular function: cysteine-type peptidase activity molecular function: cystic fibrosis transmembrane conductance regulator binding molecular function: p53 binding molecular function: peptidase activity molecular function: protein binding molecular function: ubiquitin thiolesterase activity molecular function: ubiquitin-specific protease activity molecular function: ubiquitin-specific protease activity biological process: DNA damage response, signal transduction by p53 class mediator biological process: DNA repair biological process: protein deubiquitination biological process: protein deubiquitination biological process: ubiquitin-dependent protein catabolic process cellular component: cytoplasm cellular component: early endosome cellular component: intermediate filament cytoskeleton cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 169315 Name: selenium binding protein 1 UniGene: Hs.632460 Symbol: SELENBP1 (external link) Entrez ID: 8991 Chromosome: 1 Cytoband: 1q21.3 DrugBank: Query Gene Symbol:SELENBP1	Sum Func:	SP Function: selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. may be involved in intra-golgi protein transport (by similarity).	SP Local: nucleus. cytoplasm, cytosol. membrane; peripheral membrane protein (by similarity). note=may associate with golgi membrane. may associate with the membrane of autophagosomes (by similarity).	Gene Ontology: molecular function: protein binding molecular function: selenium binding biological process: protein transport cellular component: cytoplasm cellular component: cytosol cellular component: membrane cellular component: nucleolus cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 169441 Name: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa UniGene: Hs.534168 Symbol: NDUFA1 (external link) Entrez ID: 4694 Chromosome: X Cytoband: Xq24 DrugBank: Query Gene Symbol:NDUFA1	Sum Func:	SP Function: accessory subunit of the mitochondrial membrane respiratory chain NADh dehydrogenase (complex i), that is believed not to be involved in catalysis. complex i functions in the transfer of electrons from NADh to the respiratory chain. the immediate electron acceptor for the enzyme is believed to be ubiquinone.	SP Local: mitochondrion inner membrane; single-pass membrane protein; matrix side.	Gene Ontology: molecular function: NADH dehydrogenase (ubiquinone) activity biological process: mitochondrial electron transport, NADH to ubiquinone biological process: respiratory electron transport chain biological process: transport cellular component: integral to membrane cellular component: membrane cellular component: mitochondrial inner membrane cellular component: mitochondrial membrane cellular component: mitochondrial respiratory chain complex I cellular component: mitochondrial respiratory chain complex I cellular component: mitochondrion cellular component: respiratory chain	BioCarta Pathways: 1: Electron Transport Reaction in Mitochondria	KEGG Pathways: 1: Oxidative phosphorylation (external link)
Unique ID: 169675 Name: galactokinase 1 UniGene: Hs.407966 Symbol: GALK1 (external link) Entrez ID: 2584 Chromosome: 17 Cytoband: 17q24 DrugBank: Query Gene Symbol:GALK1	Sum Func:	SP Function: major enzyme for galactose metabolism.	SP Local:	Gene Ontology: molecular function: ATP binding molecular function: galactokinase activity molecular function: galactokinase activity molecular function: galactose binding molecular function: kinase activity molecular function: nucleotide binding molecular function: transferase activity biological process: carbohydrate metabolic process biological process: carbohydrate phosphorylation biological process: galactose catabolic process biological process: galactose metabolic process biological process: metabolic process cellular component: cytoplasm cellular component: cytosol cellular component: membrane fraction	BioCarta Pathways: 1: Leloir pathway of galactose metabolism	KEGG Pathways: 1: Galactose metabolism (external link)
Unique ID: 165440 Name: phenazine biosynthesis-like protein domain containing UniGene: Hs.198158 Symbol: PBLD (external link) Entrez ID: 64081 Chromosome: 10 Cytoband: 10pter-q25.3 DrugBank: Query Gene Symbol:PBLD	Sum Func:	SP Function:	SP Local:	Gene Ontology: molecular function: isomerase activity molecular function: molecular_function biological process: biological_process biological process: biosynthetic process cellular component: cellular_component	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162162 Name: complement component 8, alpha polypeptide UniGene: Hs.93210 Symbol: C8A (external link) Entrez ID: 731 Chromosome: 1 Cytoband: 1p32 DrugBank: Query Gene Symbol:C8A	Sum Func:	SP Function: constituent of the membrane attack complex (mac) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. c8a inserts into the target membrane, but does not form pores by itself.	SP Local: secreted. cell membrane; multi-pass membrane protein. note=secreted as soluble protein. inserts into the cell membrane of target cells.	Gene Ontology: biological process: complement activation biological process: complement activation, alternative pathway biological process: complement activation, classical pathway biological process: cytolysis biological process: immune response biological process: innate immune response cellular component: extracellular region cellular component: extracellular region cellular component: extracellular space cellular component: integral to membrane cellular component: membrane cellular component: membrane attack complex cellular component: plasma membrane	BioCarta Pathways: 1: Lectin Induced Complement Pathway 2: Alternative Complement Pathway 3: Classical Complement Pathway 4: Complement Pathway	KEGG Pathways: 1: Complement and coagulation cascades (external link)
Unique ID: 160741 Name: aldehyde dehydrogenase 8 family, member A1 UniGene: Hs.486520 Symbol: ALDH8A1 (external link) Entrez ID: 64577 Chromosome: 6 Cytoband: 6q23.2 DrugBank: Query Gene Symbol:ALDH8A1	Sum Func:	SP Function: converts 9-cis-retinal to 9-cis-retinoic acid. has lower activity towards 13-cis-retinal. has much lower activity towards all-trans-retinal. has highest activity with benzaldehyde and decanal (in vitro). has a preference for NAD, but shows considerable activity with NADp (in vitro).	SP Local: cytoplasm (by similarity).	Gene Ontology: molecular function: oxidoreductase activity molecular function: retinal dehydrogenase activity biological process: 9-cis-retinoic acid biosynthetic process biological process: oxidation-reduction process biological process: retinal metabolic process biological process: retinoic acid metabolic process cellular component: cytoplasm cellular component: intracellular	BioCarta Pathways:	KEGG Pathways:
Unique ID: 163597 Name: syntabulin (syntaxin-interacting) UniGene: Hs.390738 Symbol: SYBU (external link) Entrez ID: 55638 Chromosome: 8 Cytoband: 8q23.2 DrugBank: Query Gene Symbol:SYBU	Sum Func:	SP Function: part of a kinesin motor-adapter complex that is critical for the anterograde axonal transport of active zone components and contributes to activity-dependent presynaptic assembly during neuronal development (by similarity).	SP Local: isoform 5: golgi apparatus membrane; single- pass membrane protein.	Gene Ontology: cellular component: Golgi apparatus cellular component: Golgi membrane cellular component: cytoplasm cellular component: cytoplasmic membrane-bounded vesicle cellular component: cytoskeleton cellular component: integral to membrane cellular component: membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 167287 Name: cytochrome b5 type A (microsomal) UniGene: Hs.465413 Symbol: CYB5A (external link) Entrez ID: 1528 Chromosome: 18 Cytoband: 18q23 DrugBank: Query Gene Symbol:CYB5A	Sum Func:	SP Function: cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases.	SP Local: isoform 2: cytoplasm.	Gene Ontology: molecular function: aldo-keto reductase activity molecular function: cytochrome-c oxidase activity molecular function: enzyme binding molecular function: heme binding molecular function: metal ion binding biological process: electron transport chain biological process: transport biological process: vitamin metabolic process biological process: water-soluble vitamin metabolic process cellular component: cytoplasm cellular component: endoplasmic reticulum cellular component: endoplasmic reticulum membrane cellular component: integral to membrane cellular component: membrane cellular component: microsome cellular component: mitochondrial outer membrane cellular component: mitochondrial outer membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162192 Name: acyl-CoA dehydrogenase, C-4 to C-12 straight chain UniGene: Hs.445040 Symbol: ACADM (external link) Entrez ID: 34 Chromosome: 1 Cytoband: 1p31 DrugBank: Query Gene Symbol:ACADM	Sum Func:	SP Function: this enzyme is specific for acyl chain lengths of 4 to 16.	SP Local: mitochondrion matrix.	Gene Ontology: molecular function: acyl-CoA dehydrogenase activity molecular function: acyl-CoA dehydrogenase activity molecular function: acyl-CoA dehydrogenase activity molecular function: flavin adenine dinucleotide binding molecular function: identical protein binding molecular function: medium-chain-acyl-CoA dehydrogenase activity biological process: carnitine biosynthetic process biological process: carnitine metabolic process, CoA-linked biological process: cellular lipid metabolic process biological process: fatty acid beta-oxidation biological process: fatty acid beta-oxidation biological process: fatty acid beta-oxidation using acyl-CoA dehydrogenase biological process: fatty acid beta-oxidation using acyl-CoA dehydrogenase biological process: medium-chain fatty acid catabolic process biological process: medium-chain fatty acid metabolic process biological process: oxidation-reduction process cellular component: mitochondrial matrix cellular component: mitochondrion	BioCarta Pathways:	KEGG Pathways: 1: Fatty acid metabolism (external link) 2: PPAR signaling pathway (external link) 3: Propanoate metabolism (external link) 4: beta-Alanine metabolism (external link) 5: Valine, leucine and isoleucine degradation (external link)
Unique ID: 168791 Name: eukaryotic translation initiation factor 4 gamma, 1 UniGene: Hs.433750 Symbol: EIF4G1 (external link) Entrez ID: 1981 Chromosome: 3 Cytoband: 3q27-qter DrugBank: Query Gene Symbol:EIF4G1	Sum Func:	SP Function: component of the protein complex eif4f, which is involved in the recognition of the mrna cap, atp-dependent unwinding of 5'-terminal secondary structure and recruitment of mrna to the ribosome.	SP Local:	Gene Ontology: molecular function: protein binding molecular function: translation factor activity, nucleic acid binding molecular function: translation initiation factor activity biological process: RNA metabolic process biological process: cellular protein metabolic process biological process: gene expression biological process: insulin receptor signaling pathway biological process: interspecies interaction between organisms biological process: mRNA metabolic process biological process: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay biological process: nuclear-transcribed mRNA poly(A) tail shortening biological process: regulation of translational initiation biological process: regulation of translational initiation biological process: translation biological process: translational initiation cellular component: cytoplasm cellular component: cytosol cellular component: cytosol cellular component: eukaryotic translation initiation factor 4F complex	BioCarta Pathways: 1: mTOR Signaling Pathway 2: Internal Ribosome entry pathway 3: Regulation of eIF4e and p70 S6 Kinase 4: Eukaryotic protein translation	KEGG Pathways:
Unique ID: 166785 Name: solute carrier family 38, member 4 UniGene: Hs.446077 Symbol: SLC38A4 (external link) Entrez ID: 55089 Chromosome: 12 Cytoband: 12q13 DrugBank: Query Gene Symbol:SLC38A4	Sum Func:	SP Function: sodium-dependent amino acid transporter. mediates electrogenic symport of neutral amino acids and sodium ions. has a broad specificity, with a preference for ala, followed by his, cys, asn, ser, gly, val, thr, gln and met. may mediate sodium- independent transport of cationic amino acids, such as arg and lys. amino acid uptake is ph-dependent, with low transport activities at ph 6.5, intermediate at ph 7.0 and highest between ph 7.5 and 8.5.	SP Local: cell membrane; multi-pass membrane protein.	Gene Ontology: molecular function: amino acid transmembrane transporter activity molecular function: symporter activity biological process: amino acid transmembrane transport biological process: amino acid transport biological process: cellular nitrogen compound metabolic process biological process: ion transport biological process: sodium ion transport biological process: transmembrane transport cellular component: integral to membrane cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 167390 Name: nuclear paraspeckle assembly transcript 1 (non-protein coding) UniGene: Hs.523789 Symbol: NEAT1 (external link) Entrez ID: 283131 Chromosome: 11 Cytoband: 11q13.1 DrugBank: Query Gene Symbol:NEAT1	Sum Func:	SP Function:	SP Local:	Gene Ontology:	BioCarta Pathways:	KEGG Pathways:
Unique ID: 165127 Name: alpha-fetoprotein UniGene: Hs.518808 Symbol: AFP (external link) Entrez ID: 174 Chromosome: 4 Cytoband: 4q11-q13 DrugBank: Query Gene Symbol:AFP	Sum Func:	SP Function: binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. only a small percentage (less than 2%) of the human afp shows estrogen-binding properties.	SP Local: secreted.	Gene Ontology: molecular function: metal ion binding biological process: SMAD protein signal transduction biological process: liver development biological process: organ regeneration biological process: ovulation from ovarian follicle biological process: pancreas development biological process: progesterone metabolic process biological process: response to organic substance biological process: sexual reproduction biological process: transport cellular component: cytoplasm cellular component: extracellular region cellular component: extracellular space	BioCarta Pathways:	KEGG Pathways:
Unique ID: 167243 Name: small nuclear ribonucleoprotein polypeptide N UniGene: Hs.555970 Symbol: SNRPN (external link) Entrez ID: 6638 Chromosome: 15 Cytoband: 15q11.2 DrugBank: Query Gene Symbol:SNRPN	Sum Func:	SP Function: may be involved in tissue-specific alternative rna processing events.	SP Local: nucleus.	Gene Ontology: molecular function: RNA binding molecular function: identical protein binding molecular function: protein binding biological process: RNA splicing cellular component: nucleus cellular component: small nuclear ribonucleoprotein complex cellular component: spliceosomal complex	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162373 Name: glypican 3 UniGene: Hs.644108 Symbol: GPC3 (external link) Entrez ID: 2719 Chromosome: X Cytoband: Xq26.1 DrugBank: Query Gene Symbol:GPC3	Sum Func:	SP Function: cell surface proteoglycan that bears heparan sulfate. inhibits the dipeptidyl peptidase activity of dpp4. may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. may play a role in the modulation of igf2 interactions with its receptor and thereby modulate its function. may regulate growth and tumor predisposition.	SP Local: secreted glypican-3: secreted, extracellular space (by similarity).	Gene Ontology: molecular function: heparan sulfate proteoglycan binding molecular function: peptidyl-dipeptidase inhibitor activity molecular function: protein binding biological process: anatomical structure morphogenesis biological process: body morphogenesis biological process: branching involved in ureteric bud morphogenesis biological process: cell proliferation involved in kidney development biological process: mesonephric duct morphogenesis biological process: negative regulation of cell proliferation biological process: negative regulation of growth biological process: negative regulation of smoothened signaling pathway biological process: organ morphogenesis biological process: positive regulation of BMP signaling pathway biological process: positive regulation of endocytosis biological process: positive regulation of protein catabolic process cellular component: anchored to plasma membrane cellular component: extracellular region cellular component: extracellular space cellular component: integral to plasma membrane cellular component: lysosome cellular component: plasma membrane cellular component: proteinaceous extracellular matrix	BioCarta Pathways:	KEGG Pathways:
Unique ID: 161147 Name: serine/threonine kinase 17a UniGene: Hs.709489 Symbol: STK17A (external link) Entrez ID: 9263 Chromosome: 7 Cytoband: 7p13 DrugBank: Query Gene Symbol:STK17A	Sum Func:	SP Function: acts as a positive regulator of apoptosis.	SP Local: nucleus.	Gene Ontology: molecular function: ATP binding molecular function: nucleotide binding molecular function: protein serine/threonine kinase activity biological process: apoptosis biological process: induction of apoptosis biological process: intracellular protein kinase cascade biological process: protein phosphorylation cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 163304 Name: insulin-like growth factor 2 mRNA binding protein 3 UniGene: Hs.700696 Symbol: IGF2BP3 (external link) Entrez ID: 10643 Chromosome: 7 Cytoband: 7p11 DrugBank: Query Gene Symbol:IGF2BP3	Sum Func:	SP Function: rna-binding protein that act as a regulator of mrna translation and stability. binds to the 5'-utr of the insulin-like growth factor 2 (igf2) mrnas binds to sequences in the 3'-utr of cd44 mrna	SP Local: nucleus. cytoplasm. note=found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. the subcytoplasmic localization is cell specific and regulated by cell contact and growth. localized at the connecting piece and the tail of the spermatozoa. colocalized with cd44 mrna in rnp granules.	Gene Ontology: molecular function: RNA binding molecular function: mRNA 3'-UTR binding molecular function: mRNA 5'-UTR binding molecular function: nucleotide binding molecular function: protein binding molecular function: translation regulator activity biological process: anatomical structure morphogenesis biological process: negative regulation of translation biological process: regulation of cytokine biosynthetic process biological process: translation cellular component: cytoplasm cellular component: cytosol cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 166900 Name: STEAP family member 4 UniGene: Hs.521008 Symbol: STEAP4 (external link) Entrez ID: 79689 Chromosome: 7 Cytoband: 7q21.12 DrugBank: Query Gene Symbol:STEAP4	Sum Func:	SP Function: metalloreductase that has the ability to reduce both fe(3+) to fe(2+) and cu(2+) to cu(1+). uses NAD(+) as acceptor. play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (by similarity). associated with obesity and insulin-resistance. involved in inflammatory arthritis, through the regulation of inflammatory cytokines. inhibits anchorage-independent cell proliferation.	SP Local: cell membrane. golgi apparatus membrane; multi-pass membrane protein.	Gene Ontology: molecular function: binding molecular function: electron carrier activity molecular function: flavin adenine dinucleotide binding molecular function: iron ion binding molecular function: metal ion binding molecular function: oxidoreductase activity biological process: fat cell differentiation biological process: ion transport biological process: iron ion transport biological process: oxidation-reduction process cellular component: Golgi apparatus cellular component: Golgi membrane cellular component: integral to membrane cellular component: plasma membrane	BioCarta Pathways:	KEGG Pathways:
Unique ID: 162399 Name: S100 calcium binding protein P UniGene: Hs.2962 Symbol: S100P (external link) Entrez ID: 6286 Chromosome: 4 Cytoband: 4p16 DrugBank: Query Gene Symbol:S100P	Sum Func:	SP Function:	SP Local: nucleus. cytoplasm. note=colocalizes with s100pbp in the nucleus.	Gene Ontology: molecular function: calcium ion binding molecular function: calcium-dependent protein binding molecular function: magnesium ion binding molecular function: protein binding biological process: endothelial cell migration cellular component: cytoplasm cellular component: cytoplasm cellular component: nucleus	BioCarta Pathways:	KEGG Pathways:
Unique ID: 160418 Name: dual specificity phosphatase 6 UniGene: Hs.298654 Symbol: DUSP6 (external link) Entrez ID: 1848 Chromosome: 12 Cytoband: 12q22-q23 DrugBank: Query Gene Symbol:DUSP6	Sum Func:	SP Function: inactivates map kinases. has a specificity for the erk family.	SP Local: cytoplasm.	Gene Ontology: molecular function: MAP kinase tyrosine/serine/threonine phosphatase activity molecular function: hydrolase activity molecular function: protein tyrosine phosphatase activity biological process: MyD88-dependent toll-like receptor signaling pathway biological process: MyD88-dependent toll-like receptor signaling pathway biological process: MyD88-independent toll-like receptor signaling pathway biological process: MyD88-independent toll-like receptor signaling pathway biological process: Toll signaling pathway biological process: cell differentiation biological process: dorsal/ventral pattern formation biological process: inactivation of MAPK activity biological process: innate immune response biological process: negative regulation of ERK1 and ERK2 cascade biological process: negative regulation of protein phosphorylation biological process: nerve growth factor receptor signaling pathway biological process: peptidyl-tyrosine dephosphorylation biological process: positive regulation of apoptosis biological process: regulation of endodermal cell fate specification biological process: regulation of fibroblast growth factor receptor signaling pathway biological process: regulation of heart growth biological process: response to drug biological process: response to growth factor stimulus biological process: response to nitrosative stress biological process: response to organic cyclic compound biological process: stress-activated MAPK cascade biological process: toll-like receptor 1 signaling pathway biological process: toll-like receptor 2 signaling pathway biological process: toll-like receptor 3 signaling pathway biological process: toll-like receptor 4 signaling pathway biological process: toll-like receptor signaling pathway cellular component: cytoplasm cellular component: cytosol cellular component: nucleoplasm	BioCarta Pathways: 1: Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases	KEGG Pathways: 1: MAPK signaling pathway (external link)