Biography

Dr. Mackenzie’s Ph.D. research was on the light-harvesting antenna complexes of photosynthetic bacteria. This work was jointly supervised by Drs. Richard Cogdell and Kim Kaiser in the UK. After a short postdoctoral fellowship, which involved isolating genes involved in Drosophila behavior, he moved to the US and returned to working with photosynthetic bacteria. This work was carried out in the lab of Dr. Samuel Kaplan in this department. Their work was among the early genome projects and focused on sequencing Rhodobacter sphaeroides 2.4.1 and using bioinformatics to examine novel regulatory pathways in this organism.

His current research focuses on the possible link between Streptococcus gallolyticus and colon cancer, a project he shares with his spouse, Dr. Yi Xu at Texas A&M’s Institute of Biosciences and Technology.

Education

Postdoctoral Fellow
University of Texas Health Science Center, Houston, 2005
Ph.D.
The University of Glasgow, UK, 1990

Research Information

My current research interests lie with the possible connection between Streptococcus gallolyticus and colon cancer and how bioinformatic methods may be used to guide experimental approaches in the lab.

In terms of teaching; I am the course director for the courses Medical Microbiology and Clinical Applications both of which are taught to first year medical students. I am also a facilitator for Problem Based Learning (PBL) for second year students.

Publications

Publication Information

Kumar, R., J. L. Herold, D. Schady, J. Davis, S. Kopetz, M. Martinez-Moczygemba, B. E. Murray, F. Han, Y. Li, E. Callaway, R. S. Chapkin, W. M. Dashwood, R. H. Dashwood, T. Berry, C. Mackenzie and Y. Xu (2017). “Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.” PLoS Pathog 13(7): e1006440.

Barbu E.M., Mackenzie, C., Foster, T.J., and Höök, M. SdrC induces staphylococcal biofilm formation through a homophilic interaction. Molecular Microbiology. Oct;94(1):172-85. (2014).

Barbu E.M., Vannakambadi, K.G., Shivasankarappa, G., Mackenzie, C., Foster, T.J., Sudhof, T.C. and Hook, M. β-Neurexin is a ligand for the Staphylococcus aureus MSCRAMM SdrC. PLoS Pathogens. 6(1):e1000726. (2010).

Mackenzie, C., Eraso, J. M., Choudhary, M., Roh, J. H., Zeng, X., Bruscella, P., Puskas, A., Kaplan, S. Postgenomic adventures with Rhodobacter sphaeroides Annu. Rev. Microbiol. 61: 283-307. (2007).

Goldman BS, Nierman WC, Kaiser D, Slater SC, Durkin AS, Eisen JA, Ronning CM, Barbazuk WB, Blanchard M, Field C, Halling C, Hinkle G, Iartchuk O, Kim HS, Mackenzie C, Madupu R, Miller N, Shvartsbeyn A, Sullivan SA, Vaudin M, Wiegand R, Kaplan HB. Evolution of sensory complexity recorded in a myxobacterial genome. Proc. Natl. Acad. Sci. USA. 103: 15200-5 (2006).

Mao L., Mackenzie C., Roh JH., Eraso J.M., Kaplan S. and Resat H. Combining microarray and genomic data to predict DNA binding motifs. Microbiology. 151: 3197-213. (2005).

Pappas C.T., Sram J., Moskvin O.V., Ivanov P.S., Mackenzie R.C., Choudhary M., Land M.L., Larimer F.W., Kaplan S., Gomelsky M. Construction and validation of the Rhodobacter sphaeroides 2.4.1 DNA microarray: transcriptome flexibility at diverse growth modes. J. Bacteriol. 186: 4748-58. (2004).