Biography

A native of Florida, Dr. Regenhardt received his Bachelor of Science with Honors in the combined early acceptance BS-MD program at the University of Florida. As part of the also combined MD-PhD program, he earned his PhD in physiology and neuroscience, followed by his MD with Honors from the College of Medicine, where he was inducted into the Alpha Omega Alpha medical honor society. He completed residency training in neurology at Harvard Medical School’s Massachusetts General Hospital and Brigham and Women’s Hospital. Following residency, he completed a clinical fellowship in vascular neurology and an NIH-funded postdoctoral research fellowship in translational stroke at Harvard’s Massachusetts General Hospital and Brigham and Women’s Hospital. He then completed a clinical fellowship in neuroendovascular surgery at Harvard’s Massachusetts General Hospital, mentored by leaders in the field with backgrounds in neurosurgery, neuroradiology, and neurology. Following fellowship training he joined the faculty staff of Harvard’s Massachusetts General Hospital, before being recruited to UTHealth Houston. Dr. Regenhardt serves on several journal editorial boards, including Stroke: Vascular and Interventional Neurology, Journal of Neuroimaging, Frontiers in Neurology, and The Neurohospitalist. He also serves as an ad hoc peer reviewer for numerous journals, including The BMJ, JAMA Neurology, Neurology, Annals of Neurology, Journal of Neurology, Neurosurgery, and Psychiatry, Clinical Neurology and Neurosurgery, Neurosurgical Review, World Neurosurgery, Stroke, Translational Stroke Research, Journal of Stroke, Journal of the American Heart Association, Journal of NeuroInterventional Surgery, Interventional Neuroradiology, American Journal of Neuroradiology, Radiology, among many others. Dr. Regenhardt is active member of many professional societies, including the Society of Vascular and Interventional Neurology (SVIN), where he serves as vice chair for abstracts, and on the annual meeting, research, and digital strategy committees, Society of NeuroInterventional Surgery (SNIS), American Society of Neuroimaging (ASN), where he serves on the communications committee, American Heart/Stroke Association (AHA/ASA), and American Academy of Neurology (AAN). He has been recognized with a long list of awards, including the Distinguished Service Award, Science for Life Award for mentorship, Global and Humanitarian Health Certificate, Science and Clinical Investigation Certificate, McKinney Award and subsequently Qureshi Award from the American Society of Neuroimaging, Editor’s Choice Award and Top Cited Article Award for several years by the Journal of NeuroInterventional Surgery and Journal of Neuroimaging, among many others.

Education

MD/PhD (Medical and Doctorate Degree)
University of Florida, College of Medicine - Gainesville, FL
Residency
Neurology, Harvard Medical School, Mass General Brigham Health Care System - Boston, MA
Fellowship
Vascular Neurology, Harvard Medical School, Mass General Brigham Health Care System - Boston, MA
Fellowship
Neuroendovascular Surgery, Harvard Medical School, Massachusetts General Hospital - Boston, MA

Areas of Interest

Clinical Interests

Dr. Regenhardt has expertise in the management of intracerebral hemorrhage, subarachnoid hemorrhage (SAH), subdural hematoma (SDH), cerebral aneurysms, dural arteriovenous fistulas (DAVF), carotid cavernous fistulas (CCF), arteriovenous malformations (AVM), ischemic stroke, acute large vessel occlusion, intracranial stenosis and atherosclerosis (ICAD), carotid artery stenosis, idiopathic intracranial hypertension (IIH, pseudotumor cerebri), epistaxis, and oropharyngeal hemorrhage. He performs the full spectrum of endovascular procedures, involving the brain, head, neck, and spine, for hemorrhagic and ischemic diseases. These procedures include aneurysm embolization, coil embolization, stent-assisted coil embolization, flow diversion treatment (e.g., Pipeline), intrasaccular embolization (e.g., Woven EndoBridge), intracranial embolization, embolization with liquid embolics (e.g., Onyx) for DAVF and AVM, middle meningeal artery (MMA) embolization for SDH, mechanical thrombectomy, intra-arterial infusions (e.g. spasmolysis), intracranial stenting, carotid artery stenting, transverse sinus stenting, extracranial head and neck embolization, diagnostic cerebral angiography, and diagnostic spinal angiography.

Research Interests

Dr. Regenhardt’s research interests span the spectrum of translation for cerebrovascular diseases, and he has served as principal investigator on numerous research projects. Funded by an NIH T32 award, his PhD dissertation focus was examining the effects of a neuroprotective peptide. He showed this peptide had anti-inflammatory properties in a preclinical model of ischemic stroke and had neuroprotective potential in preclinical models of intracerebral hemorrhage. As a resident, he was selected for a NIH R25 award that supported his research during residency and subsequent postdoctoral research fellowship at the Kistler Stroke Research Center at Harvard Medical School. Dr. Regenhardt’s other research support included funding from the Harvard Center of Expertise Global and Humanitarian Health Grant, Massachusetts General Hospital Global Health Award, Society of Vascular and Interventional Neurology Pilot Grant, and Heitman Young Investigator Career Development Award. While he started residency intending to maintain focus in the preclinical science of stroke, he was grateful for opportunities to explore clinical and translational research. Through these experiences took advantage of his unique background and pursued work at the intersection of these fields. Thus far, he has demonstrated relationships between final infarct topography and long-term outcomes after mechanical thrombectomy, including that greater white matter infarct volume independently reduced the odds of a good outcome. Furthermore, he has shown there is infarct growth despite thrombectomy, and that it is related to long-term outcomes. Using advanced neuroimaging techniques, his current research focus is to better understand infarct growth despite thrombectomy and reperfusion injury and hemorrhagic transformation after thrombectomy. He also studies thrombus samples retrieved from thrombectomy to better understand how their biology is related to procedural success and clinical outcomes. Dr. Regenhardt has also served as site PI for several large industry-sponsored studies, including those evaluating the Thunderbolt aspiration system for thrombectomy, and FRED and WEB devices for complex aneurysm treatment. Recently, he has also been involved in many investigator-led national and international multi-site studies for various cerebrovascular diseases including distal medium vessel occlusion stroke, large vessel occlusion stroke requiring rescue stenting, and novel cerebral aneurysm treatments.

Publications

Visit the PubMed profile page

As of 2024, Dr. Regenhardt’s work in translational cerebrovascular research has resulted in over 180 publications in many premier journals, including Stroke, Journal of Stroke, Stroke: Vascular and Interventional Neurology, Journal of NeuroInterventional Surgery, Interventional Neuroradiology, JAMA Neurology, Neurology, Journal of Neurology, Neurosurgery, and Psychiatry, Neurosurgery, Journal of Neurosurgery, Radiology, Journal of Neuroimaging, Neuroradiology, American Journal of Neuroradiology, among many others.