Biography

Devika S. Manickam received her Ph.D. in Pharmaceutical Sciences from Wayne State University (Detroit, MI). Her laboratory is developing extracellular vesicles (EVs) for the delivery of mitochondria as a platform technology for treating a wide range of diseases associated with mitochondrial dysfunction. Her laboratory has championed the idea of harnessing the innate EV mitochondrial load as a therapeutic cargo, in addition to engineering EVs for the delivery of exogenous therapeutic proteins. Prof. Manickam has published 50 papers in leading drug delivery journals. She is one of the recipients of the 2022 Young Innovator award in Cellular and Molecular Bioengineering and also received the 2023 Young Investigator award in Bioengineering from the Controlled Release Society. She has presented 50 invited talks in various national and international meetings. Her research is currently supported by the National Institutes of Health and the Department of Defense.

Education

Bachelor's Degree (BTech)
University of Madras, Chennai, India
Master's Degree (MS)
Wayne State University, Detroit, Michigan
Doctorate Degree (PhD)
Wayne State University, Detroit, Michigan

Areas of Interest

Research Interests

1. Development of engineered extracellular vesicles (EVs) for the delivery of mitochondria and therapeutic proteins

2. Cellular engineering to increase quality and quantity of mitochondria in secreted EVs

3. Re-engineering of lipid nanoparticles using ionic liquids for drug delivery to extra-hepatic targets

Publications

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1. Dave KM, Venna VR, Rao KS, Stolz DB, Brady B, Quaicoe VA, Maniskas ME, Hildebrand EE, Green D, Chen M, Milosevic J, Zheng S-y, Shiva SS, McCullough LD, Manickam DS. “Mitochondria-containing extracellular vesicles from mouse vs. human brain endothelial cells for ischemic stroke therapy.” Journal of Controlled Release, 2024. 373, 803-822, PMID: 38293207 PMCID: PMC10827130.

2. Dave KM, Stolz DB, Venna VR, Quaicoe VA, Maniskas ME, Reynolds MJ, Babidhan R, Dobbins DX, Farinelli MF, Sullivan A, Bhatia TN, Yankello H, Reddy R, Bae Y, Leak RK, Shiva SS, McCullough LD, Manickam DS. “Mitochondria-containing Extracellular Vesicles (EV) Reduce Mouse Brain Infarct Sizes and EV/HSP27 Protect Ischemic Brain Endothelial Cultures.” Journal of Controlled Release, 2023 Vol. 354 Pages 368-393. PMID: 36642252 PMCID: PMC9974867.

3. Dave KM, Dobbins DX, Farinelli MN, Sullivan A, Milosevic J, Stolz DB, Kim J, Zheng S and Manickam DS. Engineering Extracellular Vesicles to Modulate Their Innate Mitochondrial Load. Cellular and Molecular Bioengineering, 2022. October 2022, Vol. 15, issue 5 (The 2022 Young Innovators of Cellular and Molecular Bioengineering) PMID: 36444353, PMCID: PMC9700543.

4. D’Souza A, Burch A, Dave KM, Sreeram A, Reynolds MJ, Dobbins DX, Kamte YS, Zhao W, Sabatelle C, Joy G, Soman V, Chandran UR, Shiva SS, Quillinan N, Herson PS and Manickam DS. Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells. Journal of Controlled Release 2021 Vol. 338 Pages 505-526. PMID: 34450196 PMCID: PMC8526414

5. Khare, Edgecomb SX, Hamadani CM, Conway JF, Tanner EEL and Manickam DS. “Ionic liquid-coated lipid nanoparticles increase siRNA uptake into CNS targets”. Nanoscale Advances, 2024, 6, 1853–1873. *highlighted as outside front cover art and listed as a “Popular Advance”