Selected publications

  • Pritzkow S, Morales R, Moda F, Telling GC, Hoover E, and Soto, C. (2015) Grass plants bind, retain, uptake, and transport infectious prions. Cell Rep. 2015 May26:11(8):1168-75.                              http://www.ncbi.nlm.nih.gov/pubmed/25981035
  • Morales, R., Bravo-Alegria, J., Duran-Aniotz, C. and Soto, C. (2015) Titration of biologically active amyloid–β seeds in a transgenic mouse model of Alzheimer’s disease. Scientific Reports 5:9349.
    http://www.ncbi.nlm.nih.gov/pubmed/25879692
  • Moda, F., Gambetti, P., Notari, S., Concha-Marambio, L., Catania, M., Park, K.W., Maderna, E., Suardi, S., Haïk, S., Brandel, J.P., Ironside, J., Knight, R., Tagliavini, F., Soto, C. (2014) Prions in the urine of patients with variant Creutzfeldt-Jakob disease. N Engl J Med. 371(6):530-9.
    http://www.ncbi.nlm.nih.gov/pubmed/25099577
  • Salvadores, N., Shahnawaz, M., Scarpini, E., Tagliavini, F., Soto, C. (2014) Detection of misfolded Aβ oligomers for sensitive biochemical diagnosis of Alzheimer’s disease. Cell Rep. 7(1):261-8.
    http://www.ncbi.nlm.nih.gov/pubmed/24656814 
  • Moreno-Gonzalez, I., Estrada, L.D., Sanchez-Mejias, E. and Soto, C. (2013) Smoking exacerbates amyloid pathology in a mouse model of Alzheimer’s disease. Nature Communications 4: 1495.
    http://www.ncbi.nlm.nih.gov/pubmed/23422663
  • Morales, R., Duran-Aniotz C, Castilla, J., Estrada, L.D., and Soto, C. (2012) De novo induction of amyloid-B deposition in vivo. Mol. Psych. 17(12):1347-53.
    http://www.ncbi.nlm.nih.gov/pubmed/21968933
  • Soto, C. (2012) Transmissible proteins: expanding the prion heresy. Cell. 149(5):968-77.
    http://www.ncbi.nlm.nih.gov/pubmed/22632966
  • Soto, C. (2011) Prion Hypothesis: The End of the Controversy? Trends Biochem. Sci. 36: 151-158.
    http://www.ncbi.nlm.nih.gov/pubmed/21130657
  • Chen, B., Morales, R., Barria, M.A. and Soto, C. (2010) Estimating prion concentration in fluids and tissues by quantitative PMCA. Nature methods 7: 519-521.
    http://www.ncbi.nlm.nih.gov/pubmed/20512142
  • Castilla, J., Gonzalez, D., Saa, P., Morales, R., De Castro, J. and Soto, C. (2008) Crossing the species barrier by PrP(Sc) replication in vitro generates unique infectious prions.  Cell. 134:757-768, 2008.
    http://www.ncbi.nlm.nih.gov/pubmed/18775309
  • Saa, P., Castilla, J. and Soto, C. (2006) Presymptomatic detection of prions in blood. Science. 313(5783):92-94.
    http://www.ncbi.nlm.nih.gov/pubmed/16825570
  • Castilla, J., Saa, P. and Soto, C.: Detection of prions in blood. Nature medicine. 11(9):982-985, 2005.
    http://www.ncbi.nlm.nih.gov/pubmed/16127436
  • Castilla, J., Saa, P., Hetz, C. and Soto, C. (2005)  In vitro generation of infectious scrapie prions. Cell. 121:195-206.
    http://www.ncbi.nlm.nih.gov/pubmed/15851027
  • Soto, C. and Castilla, J. (2004) The controversial protein-only hypothesis of prion propagation. Nature medicine 10: S63-S67.
    http://www.ncbi.nlm.nih.gov/pubmed/15272271
  • Soto, C. (2003) Unfolding the role of Protein Misfolding in Neurodegenerative Diseases. Nature Rev. Neurosci. 4: 49-60
    http://www.ncbi.nlm.nih.gov/pubmed/12511861
  • Saborio, G.P., Permanne, B. and Soto, C. (2001) Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding. Nature. 411:810-813.
    http://www.ncbi.nlm.nih.gov/pubmed/11459061
  • Soto, C., Kascsak, R.J., Saborio, G., Aucouturier, P., Wisniewski, T., Prelli, F., R. Kascsak, Mendez, E., Harris, D.A., Ironside, J., Tagliavini, F., Carp, R.I. & Frangione, B. (2000) Reversion of prion protein conformational changes by synthetic ß-sheet breaker peptides. The Lancet. 355:192-197.
    http://www.ncbi.nlm.nih.gov/pubmed/10675119
  • Soto, C., Sigursson, E., Morelli, L., Kumar, R.A., Castaño, E.M. and Frangione, B. (1998)  ß-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer’s therapy. Nature Med. 4(7):822-826.
    http://www.ncbi.nlm.nih.gov/pubmed/9662374