Stroke Research
- Prevention Clinical Trials
- Recovery Trials
- Acute Ischemic Stroke Trials
- Acute Brain Hemorrhage Trials
- Subarachnoid Hemorrhage Trials
Arteriovenous Malformation (AVM)
bAVM
Purpose: Human Brain Arteriovenous Malformation (bAVM) Molecular Analysis; EndMT as a Target to Treat Human Brain Arteriovenous Malformations.
Principal Investigator: Ping R Chen, MD
Lead CRC: Eddie Aguilar
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Stroke Prevention Trials
Librexia
Purpose: A Phase 3, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, for Stroke Prevention after an Acute Ischemic Stroke or High-Risk Transient Ischemic Attack.
Principal Investigator: Robert J Brown, MD
Lead CRC: Kaitlin Simmons
NCT#: 05702034
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SATURN: StATins Use in intRacerebral hemorrhage patieNts
Investigator: Chen, Jared
Lead CRC: Kristina Ramirez
Purpose: determine the effects of continuation vs. discontinuation of statins on the risk of ICH recurrence
Key Inclusion Criteria: Patients presenting with a spontaneous lobar lCH while taking a statin drug
Enrollment Status: Actively enrolling
NCT#: 03936361
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START – Optimal Delay Time to Initiate Anticoagulation after Ischemic Stroke in Atrial Fibrillation
Investigator: Abdelhamid, Noureldin
Lead CR: Cooksey, Gabretta
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SLEEP-SMART – Sleep for Stroke Management and Recovery Trial
Investigator: Sudha Tallavajhula, MD and Anjail Sharrief, MD
Lead CR: Cohen, Audrey S
Sleep apnea in TIA/AIS.
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STOP STROKE – Stroke Telemedicine Outpatient Prevention Program for Blood Pressure Reduction
Investigator: Sharrief, Anjail
Lead CR: Cooksey, Gabretta
Ischemic and hemorrhagic stroke.
Enrollment Status: Actively enrolling
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AXIOMATIC – A Study on BMS-986177 for the Prevention of a Stroke in Patients Receiving Aspirin and Clopidogrel
Investigator: Sharrief, Anjail
Lead CR: Cohen, Audrey S
Factor XIa inhibitor in non-lacunar AIS or TIA.
Enrollment Status: Enrollment beginning in the near future.
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WVACHII obs – Registry for Women’s Vascular and Cardiac Health Interdisciplinary Initiative
Investigator: Gonzales, Nicole R
Lead CR: Tulod, Kathleen B
Enrollment Status: Actively enrolling
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Recovery Trials
MicroRNAs, Mitochondria and the Blood-Brain Barrier – Therapeutic Targets for Stroke
Investigator: Xuefang Ren, MD, PhD
Purpose: The objective of this proposal is to investigate if endothelial specific miR-34a affects stroke outcomes in the aged brain. We hypothesize that endothelial miR-34a regulates BBB permeability, ischemic damage, hemorrhagic transformation, and stroke-induced deficits by inhibiting translation of LETM1 and LETMD1 leading to impaired mitochondrial bioenergetics in CECs.
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PREDICT – ICH obs – Predicting Upper Extremity Motor Recovery in Subcortical Hemorrhagic Stroke Using DTI and TMS
Investigator: Sean Savitz, MD (Zafer/Shayan/Aronowski)
Lead CRC: Dorothea Parker
Diagnostics TMS in ICH
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LAPHI obs – Lesion size and Brain Atrophy changes in Patients with Hemorrhagic and Ischemic Stroke (LAPHI)
Investigator: Muhammad Haque, MD
Lead CRC: George, Sarah
Summary Assessment of MRI after stroke
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TRANSPORT-2 – TRANScranial direct current stimulation for Post-stroke motor Recovery – a phase II study
Investigator: Gerard Francisco, MD
Lead CRC: Parker, Dorothea M
Purpose: Upper extremity recovery after ischemic stroke
Key Inclusion Criteria: 1st ever, unilateral ischemic stroke; at least 10 degrees of wrist extension
tDCS+CIMT for with 6 months of 1st ever, unihemispheric AIS.
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PISCES – A Randomized, Placebo-Controlled Study of the Efficacy and Safety of Intracerebral Stem Cells (CTX0E03 DP) in subjects with Disability Following an Ischemic Stroke
Investigator: Savitz, Sean I
Lead CRC: Dorothea Parker
Purpose: Motor recovery
Key Inclusion Criteria: ischemic stroke, wrist extension and shoulder shrug present
Enrollment Status: Actively enrolling
Summary IV Stem cell therapy for chronic IS
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iACQUIRE – Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation
Investigator: Nivedita Thakur, MD
Lead CRC: Dorothea Parker
Purpose: Recovery of upper extremity weakness in neonatal stroke
Key Inclusion Criteria: 8-36 months with unilateral upper extremity deficit
In-home CIMT in chronic pediatric AIS.
Enrollment Status: Actively enrolling
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Study Name VAST-rehab (Obs) – Virtually Assisted home rehabilitation after Acute Stroke
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Summary Home-based telerehab after acute stroke (AIS / ICH)
Enrollment Status: On hold
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COPOR Obs Clinical Outcome and Patient Factors in Patient’s outcomes admitted to inpatient rehabilitation facility
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Purpose: Evaluating the effect of IPR on stroke recovery
Key Inclusion Criteria: admitted to IPR facility within MH system
Retrospective analysis of inpatient rehab and recovery data
Enrollment Status: Actively enrolling
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NCS-01
Investigator: Anjail Sharrief, MD
Lead CRC: Dorothea Parker
Purpose: Recovery
Key Inclusion Criteria: Ischemic stroke; NIHSS 6-18 w/ or w/o TPA/IAT (maintains score after intervention); pre-stroke mRS <3; LSN < 32 hours from planned infusion
Assesses regional patterns of care for ICH
Enrollment Status: Actively enrolling
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BIONICS
Investigator: Sean Savitz, MD
Lead CRC: Dorothea Parker
Purpose: Machine learning
Key Inclusion Criteria: Cleared to participate in rehab activity
Enrollment Status: Actively enrolling
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Acute Ischemic Stroke (AIS)
Millipede AspiRation for Revascularization in Stroke (MARRS) Study
Purpose: The objectives of the study are to examine the performance and safety characteristics of the Millipede System when used for revascularization of patients with acute ischemic stroke due to Large Vessel Occlusions (LVOs) and to record associated clinical outcomes.
Investigator: Michael Nahhas, MD
Lead CRC: Joseph Samaha
Enrollment Status: Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator: HuiMahn Alex Choi, MD
Lead CRC: Glenda L Torres
IS, ICH, SAH
Enrollment Status: Actively Enrolling
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Stroke (AIS) Bio-Repository
Investigator: Aronowski, J
Lead CRC: Satani, Nikunj
Biorepository of specimens including blood, CSF and brain tissue
Enrollment Status: Actively Enrolling
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SPLENDID
Purpose: Safety, Performance and Lesion Evaluation of Neurothrombectomy using CEREGLIDE 92 Intermediate Catheter: A Prospective Multi-Center Single-Arm IDE Trial
Principal Investigator: Ping R Chen, MD
Lead CRC: Eddie Aguilar
Enrollment status: Upcoming
NCT#: 06386289
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Acute Brain Hemorrhage Trials
Andexanet-Alpha
Purpose: Early administration and treatment of factor Xa related intracranial hemorrhage on a Mobile Stroke Unit: A prospective pilot feasibility study.
Principal Investigator: Ritvij Bowry, MD
Lead CRC: Glenda Torres.
BEACH
Purpose: Biomarker and Edema Attenuation in IntraCerebral Hemorrhage.
Principal Investigator: Tiffany Chang, MD
Lead CRC: Glenda Torres
NCT#: 05020535
FASTEST (start up pending) – Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial
Investigator: James Grotta
Lead CR: Bratina, Patti L
Enrollment Status: Actively Enrolling
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Novartis
Investigator: HuiMahn Alex Choi, MD
Lead CRC: Glenda Torres
Enrollment Status: Actively Enrolling
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Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator: HuiMahn Alex Choi, MD
Lead CRC: Torres, Glenda L
AIS, ICH, SAH
Enrollment Status: Actively Enrolling
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CAA-ICH – Developing a Biochemical Test to Differentiate Cerebral Amyloid Angiopathy-Intracerebral Hemorrhage from Hypertensive Hemorrhage (obs)
Investigator: Gonzales, Nicole R
Lead CRC: Kathleen Tulod
Enrollment Status: Actively Enrolling
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Hemostasis obs
Investigator: Chang, Tiffany R
Lead CRC: Torres, Glenda L
Enrollment Status: Actively Enrolling
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Subarachnoid Hemorrhage Trials
Intrepid – Impact of Fever Prevention in Brain Injured Patients
Investigator: HuiMahn Alex Choi
Lead CR: Glenda L Torres
Enrollment Status: Actively Enrolling
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Mani bio-Repository
Investigators: Huimahn Alex Choi/Tiffany Chang
Lead CR: Glenda L Torres
Enrollment Status: Actively Enrolling
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Clinical Trials
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