Biography

Hope Northrup, MD, is a board-certified clinical and biochemical and molecular geneticist and pediatrician whose career has been defined by her pioneering work in neurogenetics. She received her medical degree from the Medical University of South Carolina in 1983, followed by a residency in Pediatrics at Children’s Medical Center, Southwestern Medical School in Dallas, Texas. She completed her fellowship in Medical Genetics at Baylor College of Medicine’s Institute for Molecular Genetics (now the Department of Molecular and Human Genetics) in 1989.

Dr. Northrup holds permanent certification from the American Board of Pediatrics and the American Board of Medical Genetics in clinical, biochemical, and molecular genetics. She remains an active participant in maintenance of certification (MOC) for both clinical medical genetics and medical biochemical genetics.

Her clinical and research interests center on the genetic and molecular underpinnings of neurogenetic disorders, with a particular emphasis on tuberous sclerosis complex (TSC) and spina bifida. She is internationally recognized for her contributions to the field, having authored or co-authored over 200 peer-reviewed publications. Her research has been supported by the National Institutes of Health, private foundations, and industry collaborations. In 2003, she was honored with the Manuel R. Gomez Professional Recognition Award by the TSC Alliance for her outstanding research and clinical contributions.

Dr. Northrup is also an award-winning educator. In 2016, she received the Regents’ Outstanding Teaching Award from the University of Texas System, a distinction granted to faculty members who demonstrate exceptional commitment to student success across one of the nation’s largest public university systems. Her clinical excellence has been recognized consistently through her inclusion in Best Doctors in America, America’s Top Doctors, and Texas Super Doctors.

Education

Graduate School
Medical University of South Carolina, Charleston, South Carolina, 1983
Residency
Children’s Medical Center Southwestern Medical School, Dallas, Texas, 1983-1986
Fellowship
Institute for Molecular Genetics (now Department of Molecular and Human Genetics) Baylor College of Medicine, Houston, Texas, 1986-1989

Areas of Interest

Clinical Interests

Neurogenetic disorders, particularly tuberous sclerosis complex (TSC) and spina bifida

Publications

Visit the PubMed profile page

  1. Peron A, Northrup H. Tuberous sclerosis complex. Am J Med Genet C Semin Med Genet. 2018 Sept; 178(3):274-277. Doi: 10.1002/ajmg.c.31657. Epub 2018 Oct. PMID: 30325570.
  2. Peron A, Au KS, Northrup H. Genetics, genomics, and genotype-phenotype correlations of TSC: Insights for clinical practice. Am J Med Genet C Semin Med Genet. 2018 Sep;178(3):281-290. doi: 10.1002/ajmg.c.31651. Epub 2018 Sep 26. Review. PMID: 30255984.
  3. Slopis JM, Arevalo O, Bell CS, Hebert AA, Northrup H, Riascos RF, Samuels JA, Smith KC, Tate P, Koenig MK. Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis-1 with Everolimus: A Phase II, Open_label, Single-Arm Trial. Drugs R D. 2018 Oct 3. doi: 10.1007/s40268-018-0248-6. [Epub ahead of print]  PMID: 30284154
  4. Hussain SA, Schmid E, Peters JM, Goyal M, Bebin EM, Northrup H, Sahin M, Krueger DA, Wu JY; Tuberous Sclerosis Complex Autism Center of Excellence Network. High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. Epilepsy Res. 2018 Dec;148:1-7. doi: 10.1016/j.eplepsyres.2018.09.016. Epub 2018 Oct 2. PMID: 30296632.
  5. Longo N, Dimmock D, Levy H, Viau K, Bausell H, BilderDA, Burton B, Gross C, Northrup H, Rohr F, Sacharow S, Sanchez-Valle A, Stuy M, Thomas J, Vockley J, Zori R, Harding CO.  Evidence- and consensus-based recommendations for the use of pegvaliase in adults with phenylketonuria.  Genet Med. 2018 Dec 14. doi: 10.1038/s41436-018-0403-z. [Epub ahead of print] PMID: 30546086