Rachel K. Miller, Ph.D.
- Assistant Professor
- Ph.D., Genetics and Molecular Biology
- Emory University, Atlanta, Georgia, 2007
- Postdoctoral and Odyssey Fellow, Developmental and Cell Biology
- The University of Texas MD Anderson Cancer Center, Houston, Texas, 2007-2012; Instructor 2012-2013
Areas of Interests
Our studies focus on how Wnt signaling modulates cell shape and organization to facilitate the formation of tubules. We utilize frog Xenopus embryonic kidneys and mammalian cultured cells as models. Cells perceive their orientation within a tissue through a specific Wnt signaling pathway called planar cell polarity (PCP). Our studies focus on how PCP components with cytoskeletal roles regulate tubulogenesis.
Cystic kidneys are the most common feature of a group of genetic diseases known as ciliopathies. They result from defects in the primary cilia projecting into nephron lumens. Primary cilia act as cellular antennae, orchestrating cellular signaling and orienting cells through PCP. We are interested in the role of PCP and primary cilia in shaping nephric tubules.
Blackburn A, Bekheirnia N, Uma VC, Rosenfeld JA, Bainbridge MN, Yang Y, Liu P, Madan-Khetarpal S, Delgado MR, Hudgins L, Krantz I, Rodriguez-Buritica D, Wheeler PG, Al Gazali L, Al Shamsi A, Gomez-Ospina N, Chao H, Mirzaa GM, Scheuerle AE, Kukolich MK, Scaglia F, Eng C, Braun MC, Lamb DJ, Miller RK, Bekheirnia M.
bioRxiv [Preprint]. 2019 January 10.
Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK.
bioRxiv [Preprint]. 2019 January 04.
DeLay BD, Baldwin TA, Miller RK.
bioRxiv [Preprint]. 2018 September 11. Front. Physiol., 26 February 2019.
Corkins ME, Hanania HL, Krneta-Stankic V, DeLay BD, Pearl EJ, Lee M, Ji H, Davidson AJ, Horb ME, Miller RK.
Genes. 2018; 9(4).
DeLay BD, Corkins ME, Hanania HL, Salanga M, Deng JM, Sudou N, Taira M, Horb ME, Miller RK.
Genetics. 2018; 208(2):673-686.
Krneta-Stankic V, DeLay BD, Miller RK.
Pediatric nephrology (Berlin, Germany). 2017; 32(4):547-555. NIHMSID: NIHMS780787
Miller RK (Volume Editor)
Results and problems in cell differentiation. 2017, Springer Nature
Series Editors: Kubiak, Jacek Z., Kloc, Malgorzata.
DeLay BD, Krneta-Stankic V, Miller RK.
Journal of visualized experiments : JoVE. 2016; (111). NIHMSID: NIHMS786565
Miller RK, Lee M, McCrea PD.
1st ed. Kloc M, Kubiak JZ, editors. Oxford: John Wiley & Sons; 2014. Chapter 12, The Xenopus Pronephros: A Kidney Model Making Leaps toward Understanding Tubule Development; p.215-238. 424p.
Miller RK, Hong JY, Muñoz WA, McCrea PD.
Progress in molecular biology and translational science. 2013; 116:387-407. NIHMSID: NIHMS493599
Miller RK, Canny SG, Jang CW, Cho K, Ji H, Wagner DS, Jones EA, Habas R, McCrea PD.
Journal of the American Society of Nephrology : JASN. 2011; 22(9):1654-64.
Miller RK, McCrea PD.
Developmental dynamics : an official publication of the American Association of Anatomists. 2010; 239(1):77-93. NIHMSID: NIHMS351761
Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.
Mechanisms of development. 2009; 126(3-4):142-59. NIHMSID: NIHMS88829