Ph.D., Genetics and Molecular Biology
Emory University, Atlanta, Georgia, 2007
Postdoctoral and Odyssey Fellow, Developmental and Cell Biology
The University of Texas MD Anderson Cancer Center, Houston, Texas, 2007-2012; Instructor 2012-2013

Areas of Interests

Research Interests

Our studies focus on how Wnt signaling modulates cell shape and organization to facilitate the formation of tubules. We utilize frog Xenopus embryonic kidneys and mammalian cultured cells as models. Cells perceive their orientation within a tissue through a specific Wnt signaling pathway called planar cell polarity (PCP). Our studies focus on how PCP components with cytoskeletal roles regulate tubulogenesis.

Cystic kidneys are the most common feature of a group of genetic diseases known as ciliopathies. They result from defects in the primary cilia projecting into nephron lumens. Primary cilia act as cellular antennae, orchestrating cellular signaling and orienting cells through PCP. We are interested in the role of PCP and primary cilia in shaping nephric tubules.


Publication Information


DYRK1A-related intellectual disability: a syndrome associated with congenital anomalies of the kidney and urinary tract

Blackburn A, Bekheirnia N, Uma VC, Rosenfeld JA, Bainbridge MN, Yang Y, Liu P, Madan-Khetarpal S, Delgado MR, Hudgins L, Krantz I, Rodriguez-Buritica D, Wheeler PG, Al Gazali L, Al Shamsi A, Gomez-Ospina N, Chao H, Mirzaa GM, Scheuerle AE, Kukolich MK, Scaglia F, Eng C, Braun MC, Lamb DJ, Miller RK, Bekheirnia M.

bioRxiv [Preprint]. 2019 January 10.


The Role of the Wnt/PCP Formin Daam1 in Renal Ciliogenesis

Corkins ME, Krneta-Stankic V, Kloc M, McCrea PD, Gladden AB, Miller RK.

bioRxiv [Preprint]. 2019 January 04.


Dynamin binding protein is required for Xenopus laevis kidney development

DeLay BD, Baldwin TA, Miller RK.

bioRxiv [Preprint]. 2018 September 11. Front. Physiol., 26 February 2019.


Transgenic Xenopus laevis Line for In Vivo Labeling of Nephrons within the Kidney.

Corkins ME, Hanania HL, Krneta-Stankic V, DeLay BD, Pearl EJ, Lee M, Ji H, Davidson AJ, Horb ME, Miller RK.

Genes. 2018; 9(4).


Tissue-Specific Gene Inactivation in Xenopus laevis: Knockout of lhx1 in the Kidney with CRISPR/Cas9.

DeLay BD, Corkins ME, Hanania HL, Salanga M, Deng JM, Sudou N, Taira M, Horb ME, Miller RK.

Genetics. 2018; 208(2):673-686.


Xenopus: leaping forward in kidney organogenesis.

Krneta-Stankic V, DeLay BD, Miller RK.

Pediatric nephrology (Berlin, Germany). 2017; 32(4):547-555. NIHMSID: NIHMS780787


Kidney Development and Disease

Miller RK (Volume Editor)

Results and problems in cell differentiation. 2017, Springer Nature

Series Editors: Kubiak, Jacek Z., Kloc, Malgorzata.


Technique to Target Microinjection to the Developing Xenopus Kidney.

DeLay BD, Krneta-Stankic V, Miller RK.

Journal of visualized experiments : JoVE. 2016; (111). NIHMSID: NIHMS786565


Xenopus Development

Miller RK, Lee M, McCrea PD.

1st ed. Kloc M, Kubiak JZ, editors. Oxford: John Wiley & Sons; 2014. Chapter 12, The Xenopus Pronephros: A Kidney Model Making Leaps toward Understanding Tubule Development; p.215-238. 424p.


Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling.

Miller RK, Hong JY, Muñoz WA, McCrea PD.

Progress in molecular biology and translational science. 2013; 116:387-407. NIHMSID: NIHMS493599


Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling.

Miller RK, Canny SG, Jang CW, Cho K, Ji H, Wagner DS, Jones EA, Habas R, McCrea PD.

Journal of the American Society of Nephrology : JASN. 2011; 22(9):1654-64.


Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis.

Miller RK, McCrea PD.

Developmental dynamics : an official publication of the American Association of Anatomists. 2010; 239(1):77-93. NIHMSID: NIHMS351761


Requirement of Wnt/beta-catenin signaling in pronephric kidney development.

Lyons JP, Miller RK, Zhou X, Weidinger G, Deroo T, Denayer T, Park JI, Ji H, Hong JY, Li A, Moon RT, Jones EA, Vleminckx K, Vize PD, McCrea PD.

Mechanisms of development. 2009; 126(3-4):142-59. NIHMSID: NIHMS88829