Publications

Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases. (external link)
Faisal M, Tran L, Gutierrez Y, Bi J, Yamaguchi H, Komatsu Y.
Results Probl Cell Differ (Book Chapter in Springer). 2026;78:275-317. doi: 10.1007/978-3-032-19509-8_12.

Enhanced BMP signaling in cranial neural crest cells induces aberrant chondrogenesis by upregulating Tbx20 expression during craniofacial development. (external link)
Yamaguchi H, Tran LT, Bi J, Urayama A, Yutzey KE, Mishina Y, Komatsu Y.
Biochem Biophys Res Commun. 2025 Jun 8;765:151834. doi: 10.1016/j.bbrc.2025.151834.
 
The primary cilia: Orchestrating cranial neural crest cell development. (external link)
Yamaguchi H, Meyer MD, Barrell WB, Faisal M, Berdeaux R, Liu KJ, Komatsu Y.
Differentiation. 2025 Mar-Apr;142:100818. doi: 10.1016/j.diff.2024.100818.
 
Disruption of distal appendage protein CEP164 causes skeletal malformation in mice. (external link)
Yamaguchi H, Kitami M, Li M, Swaminathan S, Darabi R, Takemaru KI, Komatsu Y.
Biochem Biophys Res Commun. 2024 Dec 31;741:151063. doi: 10.1016/j.bbrc.2024.151063.
 
Ciliary and non-ciliary functions of Rab34 during craniofacial bone development. (external link)
Yamaguchi H, Barrell WB, Faisal M, Liu KJ, Komatsu Y.
Biochem Biophys Res Commun. 2024 Sep 10;724:150174. doi: 10.1016/j.bbrc.2024.150174.
 
Enhanced BMP signaling in Cathepsin K-positive tendon progenitors induces heterotopic ossification. (external link)
Yamaguchi H, Li M, Kitami M, Swaminathan S, Mishina Y, Komatsu Y.
Biochem Biophys Res Commun. 2023 Dec 25;688:149147. doi: 10.1016/j.bbrc.2023.149147. 
 
Enhanced BMP signaling leads to enlarged nasal cartilage formation in mice. (external link)
Yamaguchi H, Swaminathan S, Mishina Y, Komatsu Y.
Biochem Biophys Res Commun. 2023 Oct 20;678:173-178. doi: 10.1016/j.bbrc.2023.08.053.
 
Enhanced BMP signaling through ALK2 attenuates keratinocyte differentiation.  (external link)
Yamaguchi H, Shen J, Little DR, Li M, Sozen S, Suzuki K, Mishina Y, Komatsu Y.

Biochem Biophys Res Commun. 2022 Nov 12;629:101-105. doi: 10.1016/j.bbrc.2022.09.014.

 
Disruption of Trip11 in cranial neural crest cells is associated with increased ER and Golgi stress contributing to skull defects in mice. (external link)
Yamaguchi H, Meyer MD, He L, Komatsu Y.
Dev Dyn. 2022 Jul;251(7):1209-1222. doi: 10.1002/dvdy.461.

 
Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. (external link)
Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y.

Dev Biol. 2022 Feb;482:91-100. doi: 10.1016/j.ydbio.2021.12.004.
 
The molecular complex of ciliary and golgin protein is crucial for skull development. (external link)
Yamaguchi H, Meyer MD, He L, Senavirathna L, Pan S, Komatsu Y.

Development. 2021 Jul 1;148(13):dev199559. doi: 10.1242/dev.199559.

 
Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation. (external link)
Yang J, Kitami M, Pan H, Nakamura MT, Zhang H, Liu F, Zhu L, Komatsu Y#, Mishina Y#.

Sci Signal. 2021 Jan 12;14(665):eaaz9368. doi: 10.1126/scisignal.aaz9368. #Co-corresponding authors.

 
Alteration of DNA Damage Response Causes Cleft Palate. (external link)
Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y.

Front Physiol. 2021 Mar 29;12:649492. doi: 10.3389/fphys.2021.649492.

 
IFT20 is critical for collagen biosynthesis in craniofacial bone formation. (external link)
Yamaguchi H, Terajima M, Kitami M, Wang J, He L, Saeki M, Yamauchi M, Komatsu Y.

Biochem Biophys Res Commun. 2020 Dec 17;533(4):739-744. doi: 10.1016/j.bbrc.2020.09.033.

 
IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage. (external link)
Kitami M, Yamaguchi H, Ebina M, Kaku M, Chen D, Komatsu Y.

Biochem Biophys Res Commun. 2019 Jan 29;509(1):222-226. doi: 10.1016/j.bbrc.2018.12.107.

 
BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. (external link)
Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y.

PLoS Genet. 2018 May 2;14(5):e1007340. doi: 10.1371/journal.pgen.1007340. This paper has been recommended by the Faculty of 1000.

 
Abro1 maintains genome stability and limits replication stress by protecting replication fork stability. (external link)
Xu S, Wu X, Wu L, Castillo A, Liu J, Atkinson E, Paul A, Su D, Schlacher K, Komatsu Y, You MJ, Wang B.

Genes Dev. 2017 Jul 15;31(14):1469-1482. doi: 10.1101/gad.299172.117.

 
Functional Diversity of Ciliary Proteins in Bone Development and Disease. (external link)
Kaku M, Komatsu Y.
Curr Osteoporosis Rep. 2017 Apr;15(2):96-102. doi: 10.1007/s11914-017-0351-6.
 
An epistatic explanation. (external link)
Komatsu Y, Mishina Y.
Elife. 2016 Sep 30;5:e21162. doi: 10.7554/eLife.21162.
 
Canonical and noncanonical intraflagellar transport regulates craniofacial skeletal development. (external link)
Noda K, Kitami M, Kitami K, Kaku M, Komatsu Y.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2589-97. doi: 10.1073/pnas.1519458113.

 
Constitutively active mutation of ACVR1 in oral epithelium causes submucous cleft palate in mice. (external link)
Noda K, Mishina Y, Komatsu Y.
Dev Biol. 2016 Jul 15;415(2):306-313. doi: 10.1016/j.ydbio.2015.06.014.
 
Fibulin-5 deficiency causes developmental defect of premaxillary bone in mice. (external link)
Noda K, Nakamura T, Komatsu Y.

Biochem Biophys Res Commun. 2015 Oct 23;466(3):585-91. doi: 10.1016/j.bbrc.2015.09.089.

 
SHP2-Deficiency in Chondrocytes Deforms Orofacial Cartilage and Ciliogenesis in Mice. (external link)
Kamiya N, Shen J, Noda K, Kitami M, Feng GS, Chen D, Komatsu Y.

J Bone Miner Res. 2015 Nov;30(11):2028-32. doi: 10.1002/jbmr.2541.

 
Selected from previous publications

Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis. (external link)
Hayano S, Komatsu Y, Pan H, Mishina Y.
Development. 2015 Apr 1;142(7):1357-67. doi: 10.1242/dev.118802. 
 
In situ hybridization methods for mouse whole mounts and tissue sections with and without additional β-galactosidase staining. (external link)
Komatsu Y, Kishigami S, Mishina Y.
Methods Mol Biol. 2014;1092:1-15. doi: 10.1007/978-1-60327-292-6_1.
 
Establishment of left-right asymmetry in vertebrate development: the node in mouse embryos. (external link)
Komatsu Y, Mishina Y.
Cell Mol Life Sci. 2013 Dec;70(24):4659-66. doi: 10.1007/s00018-013-1399-9.
 
Augmentation of Smad-dependent BMP signaling in neural crest cells causes craniosynostosis in mice. (external link)
Komatsu Y, Yu PB, Kamiya N, Pan H, Fukuda T, Scott GJ, Ray MK, Yamamura K, Mishina Y.
J Bone Miner Res. 2013 Jun;28(6):1422-33. doi: 10.1002/jbmr.1857.
 
The phosphatase Dullard negatively regulates BMP signaling and is essential for nephron maintenance after birth. (external link)
Sakaguchi M, Sharmin S, Taguchi A, Ohmori T, Fujimura S, Abe T, Kiyonari H, Komatsu Y, Mishina Y, Asashima M, Araki E, Nishinakamura R.
Nat Commun. 2013;4:1398. doi: 10.1038/ncomms2408.
 
TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. (external link)
Morioka S, Inagaki M, Komatsu Y, Mishina Y, Matsumoto K, Ninomiya-Tsuji J.
Blood. 2012 Nov 1;120(18):3846-57. doi: 10.1182/blood-2012-03-416198. 
 
Neural crest contribution to lingual mesenchyme, epithelium and developing taste papillae and taste buds. (external link)
Liu HX, Komatsu Y, Mishina Y, Mistretta CM.
Dev Biol. 2012 Aug 15;368(2):294-303. doi: 10.1016/j.ydbio.2012.05.028. 
 
Cell cycle arrest in node cells governs ciliogenesis at the node to break left-right symmetry. (external link)
Komatsu Y, Kaartinen V, Mishina Y.
Development. 2011 Sep;138(18):3915-20. doi: 10.1242/dev.068833. This paper has been highlighted in the “node” in Development.

 
TAK1-binding protein 1, TAB1, mediates osmotic stress-induced TAK1 activation but is dispensable for TAK1-mediated cytokine signaling. (external link)
Inagaki M, Omori E, Kim JY, Komatsu Y, Scott G, Ray MK, Yamada G, Matsumoto K, Mishina Y, Ninomiya-Tsuji J.
J Biol Chem. 2008 Nov 28;283(48):33080-6. doi: 10.1074/jbc.M807574200.
 
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. (external link)
Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y, Archer TK.
Mol Cell Biol. 2008 Oct;28(20):6426-38. doi: 10.1128/MCB.00359-08.
 
BMP type I receptor ALK2 is essential for proper patterning at late gastrulation during mouse embryogenesis. (external link)
Komatsu Y, Scott G, Nagy A, Kaartinen V, Mishina Y.
Dev Dyn. 2007 Feb;236(2):512-7. doi: 10.1002/dvdy.21021.
 
Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. (external link)
Komatsu Y, Shibuya H, Takeda N, Ninomiya-Tsuji J, Yasui T, Miyado K, Sekimoto T, Ueno N, Matsumoto K, Yamada G.
Mech Dev. 2002 Dec;119(2):239-49. doi: 10.1016/s0925-4773(02)00391-x.