Selected Publications

An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype

Posey, KL, Veerisetty, AC, Liu, P, Wang, HR, Poindexter, BJ, Bick, R, Alcorn, JL, Hecht, JT: An inducible COMP mouse model recapitulates human PSACH phenotype. Am J Pathol 175(4):1555-63, 2009.

RNAi Reduces Expression and Intracellular Retention of Mutant Cartilage Oligomeric Matrix Protein

Posey, KL, Liu, P, Wang, HR, Veerisetty, AC, Alcorn, JL, Hecht, JT: RNAi Reduces Expression and Intracellular Retention of Mutant Cartilage Oligomeric Matrix Protein (COMP). Plos One 5(4):e10302, 2010.

Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia

Posey KL, Coustry F, Veerisetty AC, Liu P, Alcorn JL, Hecht JT: Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia. Am J Pathol 180(2):727-37, 2012.

D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis

Coustry F, Posey KL, Liu P, Alcorn JL, Hecht JT: D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis. Am J Pathol 180(2):738-48, 2012.

Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia

Posey KL, Coustry F, Veerisetty AC, Hossain M, Alcorn JL, Hecht JT: Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia. Hum Mol Genet. 15;24(14):3918-28. 2015.

Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies

Posey KL, Coustry F, Veerisetty AC, Hossain MG, Gambello MJ, Hecht JT: Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies. Am J Pathol. 2019 Jan;189(1):132-146.

Mutant COMP shapes growth and development of skull and facial structures in mice and humans

Burger A. Roosenboom J, Hossain M, Weinberg SM, Hecht JT, Posey KL: Mutant COMP shapes growth and development of skull and facial structures in mice and humans. Mol Genet Genomic Med. 2020 Jul;8(7):e1251.

Resveratrol Reduces COMPopathy in Mice Through Activation of Autophagy

Hecht JT, Coustry F, Veerisetty AC, Hossain MG, Posey KL: Resveratrol reduces COMPopathy in mice through activation of autophagy, J of Bone and Mineral Res. In press