Selected Publications

• Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
  Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T.
  Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4017-25.
  PMCID: PMC4522808
• Structure of the F-actin-tropomyosin complex
  von der Ecken J¹, Müller M², Lehman W³, Manstein DJ², Penczek PA⁴, Raunser S¹.
  Nature. 2015 Mar 5;519(7541):114-7
  PMCID: PMC4477711
• A primer to single-particle cryo-electron microscopy
  Cheng Y¹, Grigorieff N², Penczek PA³, Walz T⁴
  Cell. 2015 Apr 23;161(3):438-49
  PMCID: PMC4409659
• Structural snapshots of actively translating human ribosomes
  Behrmann E¹, Loerke J¹, Budkevich TV¹, Yamamoto K¹, Schmidt A², Penczek PA³, Vos MR⁴, Bürger J¹, Mielke T⁵, Scheerer P², Spahn CM⁶
  Cell. 2015 May 7;161(4):845-57
  PMCID: PMC4432480
• Visualization of arrestin recruitment by a G-protein-coupled receptor
  Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ.
  Nature. 2014 Aug 14;512(7513):218-22
  PMCID: PMC4134437
• CTER-rapid estimation of CTF parameters with error assessment
  Penczek PA, Fang J, Li X, Cheng Y, Loerke J, Spahn CM
  Ultramicroscopy. 2014 May;140:9-19. doi: 10.1016/j.ultramic.2014.01.009. Epub 2014 Feb 7.
  PMCID: PMC4016771
• Molecular Imprinting as a Signal-Activation Mechanism of the Viral RNA Sensor RIG-I
  Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.
  Mol Cell. 2014 Aug 21;55(4):511-23. doi: 10.1016/j.molcel.2014.06.010. Epub 2014 Jul 10.
  PMCID: PMC4142144
• Visualization of arrestin recruitment by a G-protein-coupled receptor
  Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, Chen X, Hanna R, Choi M, Yao XJ, Klink BU, Kahsai AW, Sidhu SS, Koide S, Penczek PA, Kossiakoff AA, Woods VL Jr, Kobilka BK, Skiniotis G, Lefkowitz RJ.
  Nature. 2014 Aug 14;512(7513):218-22. doi: 10.1038/nature13430. Epub 2014 Jun 22.
  PMCID: PMC4134437
• Structure of the rigor actin-tropomyosin-myosin complex.
  Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S.
  Cell. 2012 Jul 20;150(2):327-38. doi: 10.1016/j.cell.2012.05.037.
  PMID: 22817895
• Interaction of the mediator head module with RNA polymerase II.
  Cai G, Chaban YL, Imasaki T, Kovacs JA, Calero G, Penczek PA, Takagi Y, Asturias FJ.
  Structure. 2012 May 9;20(5):899-910. doi: 10.1016/j.str.2012.02.023.
  PMID: 22579255
• Iterative stable alignment and clustering of 2D transmission electron microscope images.
  Yang Z, Fang J, Chittuluru J, Asturias FJ, Penczek PA.
  Structure. 2012 Feb 8;20(2):237-47. doi: 10.1016/j.str.2011.12.007.
  PMID: 22325773
• Real-space processing of helical filaments in SPARX.
  Behrmann E, Tao G, Stokes DL, Egelman EH, Raunser S, Penczek PA.
  J Struct Biol. 2012 Feb;177(2):302-13. doi: 10.1016/j.jsb.2011.12.020. Epub 2012 Jan 11.
  PMID: 22248449
• Identifying conformational states of macromolecules by eigen-analysis of resampled cryo-EM images.
  Penczek PA, Kimmel M, Spahn CM.
  Structure. 2011 Nov 9;19(11):1582-90. doi: 10.1016/j.str.2011.10.003.
  PMID: 22078558
• Head swivel on the ribosome facilitates translocation by means of intra-subunit tRNA hybrid sites.
  Ratje AH, Loerke J, Mikolajka A, Brünner M, Hildebrand PW, Starosta AL, Dönhöfer A, Connell SR, Fucini P, Mielke T, Whitford PC, Onuchic JN, Yu Y, Sanbonmatsu KY, Hartmann RK, Penczek PA, Wilson DN, Spahn CM.
  Nature. 2010 Dec 2;468(7324):713-6. doi: 10.1038/nature09547.
  PMID: 21124459
• Resolution measures in molecular electron microscopy.
  Penczek PA.
  Methods Enzymol. 2010;482:73-100. doi: 10.1016/S0076-6879(10)82003-8.
  PMID: 20888958
• Image restoration in cryo-electron microscopy.
  Penczek PA.
  Methods Enzymol. 2010;482:35-72. doi: 10.1016/S0076-6879(10)82002-6.
  PMID: 20888957
• Fundamentals of three-dimensional reconstruction from projections.
  Penczek PA.
  Methods Enzymol. 2010;482:1-33. doi: 10.1016/S0076-6879(10)82001-4. Review.
  PMID: 20888956
• GTPase activation of elongation factor EF-Tu by the ribosome during decoding.
  Schuette JC, Murphy FV 4th, Kelley AC, Weir JR, Giesebrecht J, Connell SR, Loerke J, Mielke T, Zhang W, Penczek PA, Ramakrishnan V, Spahn CM.
  EMBO J. 2009 Mar 18;28(6):755-65. doi: 10.1038/emboj.2009.26. Epub 2009 Feb 19.
  PMID: 19229291
• Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex.
  Fu, TM, Li Y, Lu A, Li Z, Vajjhaia PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H.
  Mol Cel.  64:236-250