For the study, the researchers conducted several experiments on the intestines of mice. They used various imaging techniques, including flow cytometry and immunofluorescence microscopy, and performed mRNA sequencing on tissue cultures from the colon.
In the end, they found that immune cells in the intestines can detect microbes. These immune cells then relay signals to induce an inflammatory protein called interleukin-1 (IL-1), which increases levels of another protein called IL-22, known to promote cellular proliferation, resistance to cell death, and wound healing.
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