General Research
Collaborative Projects
Impact of Circadian-Microbiome Interaction on the Gut-Pancreas Axis in Aging (U01)
This research aims to understand the modality and contributing factors of healthy aging. In this study, we aim to examine the role of abnormal eating time (a common lifestyle factor that affects circadian rhythm) in accelerating aging by modulating intestinal barrier damage, microbiota dysbiosis, gut leakiness, and pancreatic damage.
Microbial signaling networks and their interaction with host biological rhythms as targetable mechanisms involved in aging will be studied. Findings from these experiments will identify intervenable mechanisms to prevent organ damage by age.
Two enrollment sites:
- UTHealth Houston
- PI: Faraz Bishehsari, MD, PhD
- Co-investigator: Mahboobeh ‘Maha’ Mahdavinia, MD, PhD
- Brownsville
- Co-investigators: