Pathway Comparison

Description of the problem:

Number of classes: 2
Column of the Experiment Descriptors sheet that defines class variable: Group

Number of genes used for random variance estimation: 8541
Number of genes that passed filtering criteria: 8541
Number of investigated pathways: 426 Broad/MIT

Random variance model was used

Pathways which have more genes differentially expressed among the phenotype classes than expected by chance

Table – The first 21 Pathway are significant at the nominal 0.005 level of the LS permutation test or KS permutation test (sorted by p-values of the LS permutation test).

Order Broad Pathway Pathway description Number of genes LS Permutation p-value KS Permutation p-value
1 h_egfPathway The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. 11 0.0001781 0.0007173
2 h_at1rPathway Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. 19 0.0004368 0.0095861
3 h_igf1Pathway BioCarta 9 0.0006275 0.0004011
4 h_ghPathway BioCarta 11 0.0010702 0.0324908
5 h_pyk2Pathway BioCarta 17 0.0011765 0.0104516
6 h_spryPathway BioCarta 7 0.0012316 0.0038862
7 MAPK_Cascade_h GO 10 0.0012932 0.0167688
8 h_radiation_sensitivity BioCarta 20 0.0013331 0.0149414
9 h_insulinPathway BioCarta 9 0.0014628 0.0090869
10 h_cellcyclePathway Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. 17 0.0016052 0.004197
11 HOXA9_DOWN_h Dorsam_et_al_2004 25 0.0016679 0.0428986
12 h_gata3Pathway BioCarta 8 0.0022081 0.0692661
13 h_ctla4Pathway T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. 11 0.0027336 0.0673271
14 cell_cycle_checkpointII_h GO 7 0.0031081 0.0028034
15 h_g1Pathway BioCarta 17 0.0042274 0.0077604
16 EMT_UP_h Jechlinger_et_al_2003 32 0.0042758 0.0361
17 h_tumor_supressor BioCarta 15 0.0044661 0.0847671
18 h_drug_resistance_and_metabolism BioCarta 62 0.0045301 0.0571057
19 h_pmlPathway BioCarta 10 0.0048356 0.0997659
20 h_EGF_receptor_signaling_pathway BioCarta 9 0.0071864 0.0032054
21 GPCRs_Class_A_Rhodopsin-like_h GO 58 0.0716031 0.0022145

The significant genes can be found by clicking the link here.

Pathways which discriminate among classes by running the Hotelling T-square test for testing the hypothesis that for each pathway no genes in the set are differentially expressed between classes:

The number of principal components: 3

Table – The first 109 pathways are significant at the nominal 0.005 level of the Hotelling T-square test (sorted by p-values).

Order Broad Pathway Pathway description Number of genes Hotelling test p-value
1 h_spryPathway BioCarta 7 1.1e-06
2 h_ST_p38_MAPK_Pathway Signalling Transduction KE 20 6.9e-06
3 EMT_UP_h Jechlinger_et_al_2003 32 1.34e-05
4 h_egfPathway The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. 11 1.92e-05
5 h_insulinPathway BioCarta 9 3.63e-05
6 h_igf1Pathway BioCarta 9 3.67e-05
7 h_il6Pathway BioCarta 10 5.91e-05
8 GLUCOSE_DOWN_h Peng_et_al_2002 89 6.99e-05
9 h_ghPathway BioCarta 11 9.38e-05
10 h_il2rbPathway BioCarta 22 9.39e-05
11 ST_T_Cell_Signal_Transduction_h Signalling Transduction KE 24 9.47e-05
12 h_pdgfPathway BioCarta 12 0.0001013
13 h_igf1rPathway BioCarta 8 0.0001044
14 MAPK_Cascade_h GO 10 0.0001361
15 FRASOR_ER_DOWN_h Frasor_et_al_2004 37 0.0001462
16 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES_h Signalling Alliance 13 0.0001492
17 h_mapkPathway BioCarta 54 0.0001557
18 MAP00010_Glycolysis_Gluconeogenesis_h GenMAPP 23 0.0001634
19 h_pyk2Pathway BioCarta 17 0.0001722
20 h_mta3Pathway BioCarta 5 0.0001966
21 h_gata3Pathway BioCarta 8 0.0002448
22 h_fcer1Pathway In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. 19 0.0002452
23 h_metPathway BioCarta 16 0.0002699
24 cell_motility_h Any process involved in the controlled movement of a cell. 58 0.0002877
25 ca_nf_at_signalling_h GEArray 58 0.0002992
26 h_nfatPathway BioCarta 29 0.0003129
27 h_il3Pathway BioCarta 8 0.0003487
28 FETAL_LIVER_HS_ENRICHED_TF_JP_h Manually Curated 46 0.0004007
29 h_epoPathway Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. 8 0.0004264
30 h_nthiPathway BioCarta 15 0.0004378
31 HOXA9_DOWN_h Dorsam_et_al_2004 25 0.0004546
32 fmlppathway_h The fMLP receptor is a G-protein coupled receptor in neutrophiles that recognizes formylated bacterial peptides and activates NADPH oxidase. 20 0.0004828
33 h_at1rPathway Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. 19 0.000559
34 h_tumor_supressor BioCarta 15 0.0005798
35 NFKB_INDUCED_h Hinata_et_al_2003 60 0.000606
36 DNA_DAMAGE_SIGNALLING_h GO 66 0.0006144
37 GPCRs_Class_A_Rhodopsin-like_h GO 58 0.0007054
38 MAP00230_Purine_metabolism_h GenMAPP 50 0.0007068
39 h_raccycdPathway BioCarta 15 0.0007662
40 h_stressPathway BioCarta 15 0.0008401
41 MAP00190_Oxidative_phosphorylation_h GenMAPP 20 0.0009015
42 h_atrbrcaPathway BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. 12 0.0009417
43 EMT_DOWN_h Jechlinger_et_al_2003 21 0.0009966
44 h_ngfPathway BioCarta 8 0.0010117
45 CR_TRANSCRIPTION_FACTORS_h PNAS_2013 46 0.0011226
46 h_erkPathway Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. 17 0.0011573
47 h_ST_G_alpha_i_Pathway_ Signalling Transduction KE 20 0.0011874
48 h_tpoPathway BioCarta 8 0.0012393
49 h_gleevecPathway BioCarta 12 0.0012794
50 h_il2Pathway BioCarta 13 0.0013664
51 h_pparaPathway BioCarta 34 0.0014403
52 GNF_FEMALE_GENES_h na 50 0.0016619
53 MAP00510_N_Glycans_biosynthesis_h GenMAPP 11 0.0016653
54 CR_PROTEIN_MOD_h PNAS_2010 96 0.0017479
55 h_p27Pathway BioCarta 10 0.0017628
56 SA_PTEN_PATHWAY_h SigmaAldrich 10 0.0018065
57 CR_TRANSPORT_OF_VESICLES_h PNAS_2015 18 0.002019
58 h_il1rPathway BioCarta 15 0.002075
59 h_tollPathway BioCarta 19 0.0022275
60 MAP00240_Pyrimidine_metabolism_h GenMAPP 29 0.0023595
61 h_g2Pathway BioCarta 18 0.002402
62 h_gabaPathway BioCarta 5 0.002409
63 h_keratinocytePathway BioCarta 26 0.0024116
64 h_lairPathway BioCarta 9 0.0024136
65 MAP00030_Pentose_phosphate_pathway_h GenMAPP 11 0.0024356
66 ANDROGEN_UP_GENES_h na 32 0.0025209
67 h_SIG_InsulinReceptorPathwayInCardiacMyocytes Signalling Alliance 29 0.0025548
68 h_crebPathway CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. 14 0.0027324
69 h_ST_JNK_MAPK_Pathway Signalling Transduction KE 24 0.0027719
70 h_radiation_sensitivity BioCarta 20 0.0027867
71 h_mtorPathway BioCarta 14 0.0028072
72 h_glycolysisPathway BioCarta 5 0.0029056
73 shh_lisa_h Manually Curated 13 0.0030194
74 h_ST_G_alpha_5_Pathway Signalling Transduction KE 7 0.0030305
75 h_ptdinsPathway BioCarta 16 0.0030497
76 h_insulin_signalling BioCarta 58 0.0030521
77 h_biopeptidesPathway Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. 19 0.0030677
78 h_ST_Ga13_Pathway Signalling Transduction KE 25 0.0031494
79 h_ST_Dictyostelium_discoideum_cAMP_Chemotaxis_Pathway Signalling Transduction KE 22 0.0031671
80 cell_adhesion_h The attachment of a cell, either to another cell or to the extracellular matrix, via cell adhesion molecules. 97 0.0032822
81 h_ceramidePathway Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. 16 0.0033054
82 h_eea1Pathway The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. 7 0.0033393
83 ST_B_Cell_Antigen_Receptor_h Signalling Transduction KE 24 0.0033761
84 h_tidPathway BioCarta 9 0.0033789
85 DOWNREG_BY_HOXA9_h Manually Curated 22 0.0034111
86 ST_GRANULE_CELL_SURVIVAL_PATHWAY_h Signalling Transduction KE 19 0.0035205
87 h_bcrPathway B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. 17 0.0035561
88 h_egfr_smrtePathway EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. 6 0.0035752
89 HEMO_TF_LIST_JP_h Manually Curated 45 0.0036197
90 h_hcmvPathway BioCarta 11 0.0036815
91 MAP00051_Fructose_and_mannose_metabolism_h GenMAPP 12 0.003728
92 MAP_kinase_kinase_activity_h GenMAPP 5 0.0038348
93 LEU_UP_h Peng_et_al_2002 77 0.0038565
94 h_p53Pathway BioCarta 11 0.0038582
95 h_ppargPathway BioCarta 6 0.0038969
96 h_ST_ERK1_ERK2_MAPK_Pathway Signalling Transduction KE 20 0.0039951
97 MAP00710_Carbon_fixation_h GenMAPP 8 0.004022
98 h_drug_resistance_and_metabolism BioCarta 62 0.0040238
99 h_il10Pathway BioCarta 7 0.0041077
100 h_rbPathway BioCarta 9 0.0041223
101 h_mprPathway BioCarta 14 0.0041417
102 h_S1P_Signaling BioCarta 17 0.0042391
103 MAP00600_Sphingoglycolipid_metabolism_h GenMAPP 8 0.0043908
104 h_ST_Differentiation_Pathway_in_PC12_Cells Signalling Transduction KE 24 0.0044761
105 h_integrinPathway BioCarta 24 0.0046608
106 h_longevityPathway BioCarta 5 0.0047172
107 h_p53_signalling BioCarta 58 0.0048118
108 ST_ADRENERGIC_h Signalling Transduction KE 24 0.0048368
109 h_ptenPathway BioCarta 9 0.004882

The significant genes can be found by clicking the link here.

Table – Significant pathway which have more genes differentially expressed among the phenotype classes than expected by chance consist of the following genes (sorted by p-values).

Order Broad Pathway Pathway description Unique id Annotations Description Clone GB acc UG cluster Gene symbol Defined gene lists Parametric p-value Geometric mean of ratios (class Disease /class Normal )
1 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H002040_01 Info Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) H002040_01 X00588 77432 EGFR Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc 0.0004362 0.669
2 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H002186_01 Info Serum response factor (c-fos serum response element-binding transcription factor) H002186_01 J03161 155321 SRF EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription 0.0017465 0.722
3 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
4 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
5 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H003611_01 Info Mitogen-activated protein kinase kinase 4 H003611_01 L36870 75217 MAP2K4 Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system 0.012502 0.753
6 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H001365_01 Info Protein kinase C, beta 1 H001365_01 X07109 77202 PRKCB1 Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction 0.0304335 1.379
7 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
8 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H001600_01 Info RAS p21 protein activator (GTPase activating protein) 1 H001600_01 M23379 758 RASA1 EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction 0.1015906 0.844
9 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H003158_01 Info Mitogen-activated protein kinase 8 H003158_01 L26318 190913 MAPK8 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … 0.1287835 1.166
10 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H001349_01 Info Janus kinase 1 (a protein tyrosine kinase) H001349_01 M64174 50651 JAK1 EGF Signaling Pathway, IFN alpha signaling pathway, IFN gamma signaling pathway , IL 2 signaling pathway, IL 4 signaling pathway, IL-10 Anti-inflammatory Signaling Pathway, IL-2 Receptor Beta Chain in T cell Activation, IL-7 Signal Transduction, PDGF Signaling Pathway, cell_cycle, cell_signaling, immunology, signal_transduction 0.2754104 1.129
11 egfPathway_h The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
12 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002040_01 Info Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) H002040_01 X00588 77432 EGFR Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc 0.0004362 0.669
13 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
14 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
15 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H003006_01 Info Serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 8 H003006_01 K02215 3697 SERPINA8 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Angiotensin-converting enzyme 2 regulates heart function, Bioactive Peptide Induced Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, immunology 0.0063778 1.296
16 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002573_01 Info Protein tyrosine kinase 2 beta H002573_01 U43522 20313 PTK2B Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CXCR4 Signaling Pathway, IL-7 Signal Transduction, Ion Channel and Phorbol Esters Signaling Pathway, Links between Pyk2 and Map Kinases, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of nicotinic acetylcholine receptors in the regulation of apoptosis, Signaling of Hepatocyte Growth Factor Receptor, Thrombin signaling and protease-activated receptors, angiogenesis, immunology, signal_transduction 0.0091935 1.367
17 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H003611_01 Info Mitogen-activated protein kinase kinase 4 H003611_01 L36870 75217 MAP2K4 Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system 0.012502 0.753
18 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H003493_01 Info MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B) H003493_01 X63380 78881 MEF2B 0.0145042 1.328
19 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H001992_01 Info Activating transcription factor 2 H001992_01 X15875 198166 ATF2 ALK in cardiac myocytes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , The 4-1BB-dependent immune response, The information-processing pathway at the IFN-beta enhancer 0.0178377 0.749
20 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H001365_01 Info Protein kinase C, beta 1 H001365_01 X07109 77202 PRKCB1 Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction 0.0304335 1.379
21 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
22 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002287_01 Info P21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) H002287_01 U24152 62402 PAK1 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, FAS signaling pathway ( CD95 ), fMLP induced chemokine gene expression in HMC-1 cells, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Rac 1 cell motility signaling pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, TNFR1 Signaling Pathway 0.1104284 0.815
23 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H003158_01 Info Mitogen-activated protein kinase 8 H003158_01 L26318 190913 MAPK8 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … 0.1287835 1.166
24 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002501_01 Info Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) H002501_01 D25274 173737 RAC1 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, fMLP induced chemokine gene expression in HMC-1 cells, How does salmonella hijack a cell, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , Phosphoinositides and their downstream targets., Phospholipids as signalling intermediaries, Rac 1 cell motility signaling pathway, Ras Signaling Pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of MAL in Rho-Mediated Activation of SRF, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, T Cell Receptor Signaling Pathway, Transcription factor CREB and its extracellular signals, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, uCalpain and friends in Cell spread, Y branching of actin filaments 0.1980127 1.118
25 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002112_01 Info PTK2 protein tyrosine kinase 2 H002112_01 L13616 740 PTK2 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Apoptotic Signaling in Response to DNA Damage, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, CCR3 signaling in Eosinophils, Cell to Cell Adhesion Signaling, CXCR4 Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, HIV-I Nef: negative effector of Fas and TNF, Integrin Signaling Pathway, mCalpain and friends in Cell motility, Phospholipids as signalling intermediaries, PTEN dependent cell cycle arrest and apoptosis, Role of nicotinic acetylcholine receptors in the regulation of apoptosis, Signaling of Hepatocyte Growth Factor Receptor, Trefoil Factors Initiate Mucosal Healing, uCalpain and friends in Cell spread, VEGF, Hypoxia, and Angiogenesis, angiogenesis, signal_transduction 0.2346929 0.896
26 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002405_01 Info Mitogen-activated protein kinase kinase 2 H002405_01 L11285 72241 MAP2K2 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Bioactive Peptide Induced Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, fMLP induced chemokine gene expression in HMC-1 cells, Human Cytomegalovirus and Map Kinase Pathways, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway, Role of MAL in Rho-Mediated Activation of SRF, Role of �-arrestins in the activation and targeting of MAP kinases, Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling, Signaling of Hepatocyte Growth Factor Receptor 0.3118803 1.093
27 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H011336_01 Info Guanine nucleotide binding protein (G protein), q polypeptide H011336_01 U43083 296261 GNAQ Activation of PKC through G protein coupled receptor, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CCR3 signaling in Eosinophils, CXCR4 Signaling Pathway, Effects of calcineurin in Keratinocyte Differentiation, G-Protein Signaling Through Tubby Proteins, Links between Pyk2 and Map Kinases, Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, Signaling Pathway from G-Protein Families, Thrombin signaling and protease-activated receptors, immunology 0.3713616 0.89
28 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
29 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H002404_01 Info Synaptotagmin I H002404_01 M55047 154679 SYT1 0.8170962 0.971
30 at1rPathway_h Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. H000579_01 Info Calmodulin 2 (phosphorylase kinase, delta) H000579_01 D45887 182278 CALM2 0.9689776 1.004
31 igf1Pathway_h BioCarta H000732_01 Info Insulin receptor substrate 1 H000732_01 S62539 96063 IRS1 Perou’s – Intrinsic- Breast-Cancer-Genes, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 4 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Insulin Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of eIF4e and p70 S6 Kinase, immunology 0.0013348 0.643
32 igf1Pathway_h BioCarta H002186_01 Info Serum response factor (c-fos serum response element-binding transcription factor) H002186_01 J03161 155321 SRF EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription 0.0017465 0.722
33 igf1Pathway_h BioCarta H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
34 igf1Pathway_h BioCarta H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
35 igf1Pathway_h BioCarta H002473_01 Info Insulin-like growth factor 1 receptor H002473_01 NM_000875 239176 IGF1R Perou’s – Intrinsic- Breast-Cancer-Genes, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Erk1/Erk2 Mapk Signaling pathway, IGF-1 Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Telomeres, Telomerase, Cellular Aging, and Immortality, The IGF-1 Receptor and Longevity, immunology 0.079692 1.158
36 igf1Pathway_h BioCarta H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
37 igf1Pathway_h BioCarta H001600_01 Info RAS p21 protein activator (GTPase activating protein) 1 H001600_01 M23379 758 RASA1 EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction 0.1015906 0.844
38 igf1Pathway_h BioCarta H003158_01 Info Mitogen-activated protein kinase 8 H003158_01 L26318 190913 MAPK8 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … 0.1287835 1.166
39 igf1Pathway_h BioCarta H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
40 ghPathway_h BioCarta H000732_01 Info Insulin receptor substrate 1 H000732_01 S62539 96063 IRS1 Perou’s – Intrinsic- Breast-Cancer-Genes, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 4 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Insulin Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of eIF4e and p70 S6 Kinase, immunology 0.0013348 0.643
41 ghPathway_h BioCarta H002186_01 Info Serum response factor (c-fos serum response element-binding transcription factor) H002186_01 J03161 155321 SRF EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription 0.0017465 0.722
42 ghPathway_h BioCarta H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
43 ghPathway_h BioCarta H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
44 ghPathway_h BioCarta H002890_01 Info Ribosomal protein S6 kinase, 90kD, polypeptide 1 H002890_01 L07597 149957 RPS6KA1 Cell Cycle: G2/M Checkpoint, Erk1/Erk2 Mapk Signaling pathway, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, MAP Kinase Signaling Pathway, Melanocyte Development and Pigmentation Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Role of Erk5 in Neuronal Survival, Transcription factor CREB and its extracellular signals, Phosphatidylinositol signaling system 0.0138896 1.42
45 ghPathway_h BioCarta H001365_01 Info Protein kinase C, beta 1 H001365_01 X07109 77202 PRKCB1 Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction 0.0304335 1.379
46 ghPathway_h BioCarta H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
47 ghPathway_h BioCarta H002624_01 Info Insulin receptor H002624_01 X02160 89695 INSR Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Growth Hormone Signaling Pathway, Insulin Signaling Pathway, immunology 0.433218 0.919
48 ghPathway_h BioCarta H002261_01 Info Signal transducer and activator of transcription 5B H002261_01 U47686 244613 STAT5B 0.441402 1.071
49 ghPathway_h BioCarta H009068_01 Info Homo sapiens mRNA; cDNA DKFZp586N1323 (from clone DKFZp586N1323) H009068_01 AL080218 24064 0.509279 1.056
50 ghPathway_h BioCarta H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
51 pyk2Pathway_h BioCarta H003200_01 Info Mitogen-activated protein kinase kinase 3 H003200_01 D87116 180533 MAP2K3 fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, Signal transduction through IL1R, TNF/Stress Related Signaling, Toll-Like Receptor Pathway 0.0009666 1.561
52 pyk2Pathway_h BioCarta H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
53 pyk2Pathway_h BioCarta H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
54 pyk2Pathway_h BioCarta H002895_01 Info Mitogen-activated protein kinase 14 H002895_01 L35263 79107 MAPK14 BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, Map Kinase Inactivation of SMRT Corepressor, MAP Kinase Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), NFkB activation by Nontypeable Hemophilus influenzae, Oxidative Stress Induced Gene Expression Via Nrf2, p38 MAPK Signaling Pathway , Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Regulation of eIF4e and p70 S6 Kinase, Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, SARS Coronavirus Protease, Signal transduction through IL1R, TACI and BCMA stimulation of B cell imm … 0.0086925 1.429
55 pyk2Pathway_h BioCarta H002573_01 Info Protein tyrosine kinase 2 beta H002573_01 U43522 20313 PTK2B Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CXCR4 Signaling Pathway, IL-7 Signal Transduction, Ion Channel and Phorbol Esters Signaling Pathway, Links between Pyk2 and Map Kinases, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of nicotinic acetylcholine receptors in the regulation of apoptosis, Signaling of Hepatocyte Growth Factor Receptor, Thrombin signaling and protease-activated receptors, angiogenesis, immunology, signal_transduction 0.0091935 1.367
56 pyk2Pathway_h BioCarta H003611_01 Info Mitogen-activated protein kinase kinase 4 H003611_01 L36870 75217 MAP2K4 Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system 0.012502 0.753
57 pyk2Pathway_h BioCarta H003332_01 Info V-crk avian sarcoma virus CT10 oncogene homolog-like H003332_01 X59656 37078 CRKL IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, Signaling of Hepatocyte Growth Factor Receptor, tsonc 0.0164206 0.675
58 pyk2Pathway_h BioCarta H001365_01 Info Protein kinase C, beta 1 H001365_01 X07109 77202 PRKCB1 Bioactive Peptide Induced Signaling Pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Ion Channel and Phorbol Esters Signaling Pathway, T Cell Receptor Signaling Pathway, Phosphatidylinositol signaling system, angiogenesis, cell_cycle, cell_signaling, signal_transduction 0.0304335 1.379
59 pyk2Pathway_h BioCarta H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
60 pyk2Pathway_h BioCarta H002287_01 Info P21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related) H002287_01 U24152 62402 PAK1 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, FAS signaling pathway ( CD95 ), fMLP induced chemokine gene expression in HMC-1 cells, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Rac 1 cell motility signaling pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, TNFR1 Signaling Pathway 0.1104284 0.815
61 pyk2Pathway_h BioCarta H003158_01 Info Mitogen-activated protein kinase 8 H003158_01 L26318 190913 MAPK8 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … 0.1287835 1.166
62 pyk2Pathway_h BioCarta H002501_01 Info Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) H002501_01 D25274 173737 RAC1 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, fMLP induced chemokine gene expression in HMC-1 cells, How does salmonella hijack a cell, Influence of Ras and Rho proteins on G1 to S Transition, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , Phosphoinositides and their downstream targets., Phospholipids as signalling intermediaries, Rac 1 cell motility signaling pathway, Ras Signaling Pathway, Ras-Independent pathway in NK cell-mediated cytotoxicity, Role of MAL in Rho-Mediated Activation of SRF, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, T Cell Receptor Signaling Pathway, Transcription factor CREB and its extracellular signals, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, uCalpain and friends in Cell spread, Y branching of actin filaments 0.1980127 1.118
63 pyk2Pathway_h BioCarta H002405_01 Info Mitogen-activated protein kinase kinase 2 H002405_01 L11285 72241 MAP2K2 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Bioactive Peptide Induced Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, fMLP induced chemokine gene expression in HMC-1 cells, Human Cytomegalovirus and Map Kinase Pathways, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway, Role of MAL in Rho-Mediated Activation of SRF, Role of �-arrestins in the activation and targeting of MAP kinases, Roles of �-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling, Signaling of Hepatocyte Growth Factor Receptor 0.3118803 1.093
64 pyk2Pathway_h BioCarta H011336_01 Info Guanine nucleotide binding protein (G protein), q polypeptide H011336_01 U43083 296261 GNAQ Activation of PKC through G protein coupled receptor, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CCR3 signaling in Eosinophils, CXCR4 Signaling Pathway, Effects of calcineurin in Keratinocyte Differentiation, G-Protein Signaling Through Tubby Proteins, Links between Pyk2 and Map Kinases, Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase, Signaling Pathway from G-Protein Families, Thrombin signaling and protease-activated receptors, immunology 0.3713616 0.89
65 pyk2Pathway_h BioCarta H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
66 pyk2Pathway_h BioCarta H002404_01 Info Synaptotagmin I H002404_01 M55047 154679 SYT1 0.8170962 0.971
67 pyk2Pathway_h BioCarta H000579_01 Info Calmodulin 2 (phosphorylase kinase, delta) H000579_01 D45887 182278 CALM2 0.9689776 1.004
68 spryPathway_h BioCarta H002040_01 Info Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) H002040_01 X00588 77432 EGFR Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc 0.0004362 0.669
69 spryPathway_h BioCarta H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
70 spryPathway_h BioCarta H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
71 spryPathway_h BioCarta H002847_01 Info Protein tyrosine phosphatase, receptor type, B H002847_01 X54131 123641 PTPRB Sprouty regulation of tyrosine kinase signals, cell_cycle, cell_signaling 0.0110757 1.299
72 spryPathway_h BioCarta H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
73 spryPathway_h BioCarta H001600_01 Info RAS p21 protein activator (GTPase activating protein) 1 H001600_01 M23379 758 RASA1 EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction 0.1015906 0.844
74 spryPathway_h BioCarta H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
75 MAPK_Cascade_h GO H003200_01 Info Mitogen-activated protein kinase kinase 3 H003200_01 D87116 180533 MAP2K3 fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, Signal transduction through IL1R, TNF/Stress Related Signaling, Toll-Like Receptor Pathway 0.0009666 1.561
76 MAPK_Cascade_h GO H001648_01 Info Myelin basic protein H001648_01 M13577 69547 MBP 0.0014651 0.667
77 MAPK_Cascade_h GO H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
78 MAPK_Cascade_h GO H002895_01 Info Mitogen-activated protein kinase 14 H002895_01 L35263 79107 MAPK14 BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, Map Kinase Inactivation of SMRT Corepressor, MAP Kinase Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), NFkB activation by Nontypeable Hemophilus influenzae, Oxidative Stress Induced Gene Expression Via Nrf2, p38 MAPK Signaling Pathway , Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Regulation of eIF4e and p70 S6 Kinase, Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, SARS Coronavirus Protease, Signal transduction through IL1R, TACI and BCMA stimulation of B cell imm … 0.0086925 1.429
79 MAPK_Cascade_h GO H003611_01 Info Mitogen-activated protein kinase kinase 4 H003611_01 L36870 75217 MAP2K4 Perou’s – Intrinsic- Breast-Cancer-Genes, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Ceramide Signaling Pathway, EGF Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, Inhibition of Cellular Proliferation by Gleevec, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , PDGF Signaling Pathway, T Cell Receptor Signaling Pathway, TNF/Stress Related Signaling, TNFR1 Signaling Pathway, Toll-Like Receptor Pathway, Phosphatidylinositol signaling system 0.012502 0.753
80 MAPK_Cascade_h GO H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
81 MAPK_Cascade_h GO H000029_01 Info Mitogen-activated protein kinase kinase kinase 3 H000029_01 U78876 29282 MAP3K3 MAP Kinase Signaling Pathway, Phosphatidylinositol signaling system 0.2027051 1.138
82 MAPK_Cascade_h GO H002943_01 Info V-raf murine sarcoma viral oncogene homolog B1 H002943_01 M95712 622 BRAF MAP Kinase Signaling Pathway, cell_cycle, cell_signaling, immunology, signal_transduction, tsonc 0.2376595 0.895
83 MAPK_Cascade_h GO H003309_01 Info Mitogen-activated protein kinase kinase 7 H003309_01 AF013589 110299 MAP2K7 Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Keratinocyte Differentiation, MAP Kinase Signaling Pathway 0.3044184 1.088
84 MAPK_Cascade_h GO H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
85 radiation_sensitivity_h BioCarta H001935_01 Info Glyceraldehyde-3-phosphate dehydrogenase H001935_01 U34995 169476 GAPD 0.0001082 1.485
86 radiation_sensitivity_h BioCarta H002040_01 Info Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) H002040_01 X00588 77432 EGFR Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc 0.0004362 0.669
87 radiation_sensitivity_h BioCarta H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
88 radiation_sensitivity_h BioCarta H002681_01 Info Cyclin D3 H002681_01 M92287 83173 CCND3 Cyclins and Cell Cycle Regulation, cell_cycle 0.0084801 1.28
89 radiation_sensitivity_h BioCarta H002092_01 Info Ataxia telangiectasia and Rad3 related H002092_01 U49844 77613 ATR Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Regulation of cell cycle progression by Plk3, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Phosphatidylinositol signaling system, DNA_replication, immunology 0.0105491 0.753
90 radiation_sensitivity_h BioCarta H003739_01 Info Cell division cycle 2, G1 to S and G2 to M H003739_01 X05360 184572 CDC2 Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, cdc25 and chk1 Regulatory Pathway in response to DNA damage, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Protein Kinase A at the Centrosome, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of Splicing through Sam68, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, Phosphatidylinositol signaling system, cell_cycle 0.0222229 0.733
91 radiation_sensitivity_h BioCarta H002789_01 Info Tumor protein p53 (Li-Fraumeni syndrome) H002789_01 NM_000546 1846 TP53 Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc 0.0273242 1.207
92 radiation_sensitivity_h BioCarta H002149_01 Info Cyclin-dependent kinase inhibitor 1A (p21, Cip1) H002149_01 U03106 179665 CDKN1A ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc 0.0349766 1.236
93 radiation_sensitivity_h BioCarta H002473_01 Info Insulin-like growth factor 1 receptor H002473_01 NM_000875 239176 IGF1R Perou’s – Intrinsic- Breast-Cancer-Genes, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Erk1/Erk2 Mapk Signaling pathway, IGF-1 Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Telomeres, Telomerase, Cellular Aging, and Immortality, The IGF-1 Receptor and Longevity, immunology 0.079692 1.158
94 radiation_sensitivity_h BioCarta H002987_01 Info Cyclin B2 H002987_01 AK001404 194698 CCNB2 Estrogen-responsive protein Efp controls cell cycle and breast tumors growth 0.0829851 0.84
95 radiation_sensitivity_h BioCarta H002323_01 Info Cyclin E1 H002323_01 M74093 9700 CCNE1 Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle 0.1107382 0.884
96 radiation_sensitivity_h BioCarta H002760_01 Info RAD51 (S. cerevisiae) homolog (E coli RecA homolog) H002760_01 D14134 23044 RAD51 ATM Signaling Pathway, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, DNA_replication 0.1212274 1.154
97 radiation_sensitivity_h BioCarta H003605_01 Info BCL2-associated X protein H003605_01 L22474 159428 BAX Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology 0.253339 0.907
98 radiation_sensitivity_h BioCarta H003644_01 Info Tumor necrosis factor receptor superfamily, member 6 H003644_01 X63717 82359 TNFRSF6 apoptosis, immunology 0.4621499 0.927
99 radiation_sensitivity_h BioCarta H003538_01 Info Actin, beta H003538_01 NM_001101 288061 ACTB Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes 0.6253266 0.956
100 radiation_sensitivity_h BioCarta H003542_01 Info V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene H003542_01 M11730 323910 ERBB2 Perou’s – Intrinsic- Breast-Cancer-Genes, Role of ERBB2 in Signal Transduction and Oncology, Trefoil Factors Initiate Mucosal Healing, immunology, signal_transduction, tsonc 0.7160857 1.031
101 radiation_sensitivity_h BioCarta H006841_01 Info Homo sapiens mRNA; cDNA DKFZp564P073 (from clone DKFZp564P073) H006841_01 AL049301 278577 Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology 0.7810094 0.98
102 radiation_sensitivity_h BioCarta H003766_01 Info Mouse double minute 2, human homolog of; p53-binding protein H003766_01 M92424 170027 MDM2 ATM Signaling Pathway, Cell Cycle: G2/M Checkpoint, CTCF: First Multivalent Nuclear Factor, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Sumoylation by RanBP2 Regulates Transcriptional Repression, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, gene_regulation, transcription, tsonc 0.8018001 0.978
103 radiation_sensitivity_h BioCarta H003816_01 Info Caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase) H003816_01 M87507 2490 CASP1 Caspase Cascade in Apoptosis, D4-GDI Signaling Pathway, IL 18 Signaling Pathway, apoptosis, immunology 0.9157209 1.011
104 radiation_sensitivity_h BioCarta H003027_01 Info Cyclin D2 H003027_01 D13639 75586 CCND2 Cyclins and Cell Cycle Regulation, cell_cycle 0.9682473 0.996
105 insulinPathway_h BioCarta H000732_01 Info Insulin receptor substrate 1 H000732_01 S62539 96063 IRS1 Perou’s – Intrinsic- Breast-Cancer-Genes, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 4 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Insulin Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of eIF4e and p70 S6 Kinase, immunology 0.0013348 0.643
106 insulinPathway_h BioCarta H002186_01 Info Serum response factor (c-fos serum response element-binding transcription factor) H002186_01 J03161 155321 SRF EGF Signaling Pathway, Growth Hormone Signaling Pathway, Hop Pathway in Cardiac Development, IGF-1 Signaling Pathway, IL 6 signaling pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Role of MAL in Rho-Mediated Activation of SRF, cell_cycle, cell_signaling, development, gene_regulation, transcription 0.0017465 0.722
107 insulinPathway_h BioCarta H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
108 insulinPathway_h BioCarta H002893_01 Info V-raf-1 murine leukemia viral oncogene homolog 1 H002893_01 X03484 85181 RAF1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho proteins on G1 to S Transition, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links betw … 0.0062484 1.596
109 insulinPathway_h BioCarta H003178_01 Info Mitogen-activated protein kinase 3 H003178_01 X60188 861 MAPK3 Perou’s – Intrinsic- Breast-Cancer-Genes, Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, How Progesterone Initiates the Oocyte Maturation, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Influence of Ras and Rho … 0.0986041 1.184
110 insulinPathway_h BioCarta H001600_01 Info RAS p21 protein activator (GTPase activating protein) 1 H001600_01 M23379 758 RASA1 EGF Signaling Pathway, HIV-I Nef: negative effector of Fas and TNF, IGF-1 Signaling Pathway, Insulin Signaling Pathway, PDGF Signaling Pathway, Regulation of Splicing through Sam68, Signaling of Hepatocyte Growth Factor Receptor, Sprouty regulation of tyrosine kinase signals, T Cell Receptor Signaling Pathway, TPO Signaling Pathway, cell_signaling, signal_transduction 0.1015906 0.844
111 insulinPathway_h BioCarta H003158_01 Info Mitogen-activated protein kinase 8 H003158_01 L26318 190913 MAPK8 Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, ATM Signaling Pathway, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Bone Remodelling, Ceramide Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, FAS signaling pathway ( CD95 ), Fc Epsilon Receptor I Signaling in Mast Cells, HIV-I Nef: negative effector of Fas and TNF, Hypoxia and p53 in the Cardiovascular system, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Nerve growth factor pathway (NGF), NFAT and Hypertrophy of the heart (Transcription in the broken heart), Oxidative Stress Induced Gene Expression Via Nrf2, PDGF Signaling Pathway, Pertussis toxin-insensitive CCR5 Sig … 0.1287835 1.166
112 insulinPathway_h BioCarta H002624_01 Info Insulin receptor H002624_01 X02160 89695 INSR Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Growth Hormone Signaling Pathway, Insulin Signaling Pathway, immunology 0.433218 0.919
113 insulinPathway_h BioCarta H002722_01 Info Mitogen-activated protein kinase kinase 1 H002722_01 L11284 3446 MAP2K1 Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, Anthrax Toxin Mechanism of Action, Aspirin Blocks Signaling Pathway Involved in Platelet Activation, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Cadmium induces DNA synthesis and proliferation in macrophages, CCR3 signaling in Eosinophils, Ceramide Signaling Pathway, CXCR4 Signaling Pathway, EGF Signaling Pathway, EPO Signaling Pathway, Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, Growth Hormone Signaling Pathway, Human Cytomegalovirus and Map Kinase Pathways, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 6 signaling pathway, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Keratinocyte Differentiation, Links between Pyk2 and Map Kinas … 0.7377933 0.973
114 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
115 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H002412_01 Info Cyclin-dependent kinase 2 H002412_01 M68520 19192 CDK2 CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, immunology, signal_transduction 0.0040171 0.711
116 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H002681_01 Info Cyclin D3 H002681_01 M92287 83173 CCND3 Cyclins and Cell Cycle Regulation, cell_cycle 0.0084801 1.28
117 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H000136_01 Info Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) H000136_01 AF041248 4854 CDKN2C Cyclins and Cell Cycle Regulation, immunology 0.0088074 0.705
118 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H005436_01 Info Homo sapiens cDNA FLJ20653 fis, clone KAT01739 H005436_01 AK000660 180059 Perou’s – Intrinsic- Breast-Cancer-Genes, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Influence of Ras and Rho proteins on G1 to S Transition, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction 0.0126769 0.793
119 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003739_01 Info Cell division cycle 2, G1 to S and G2 to M H003739_01 X05360 184572 CDC2 Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, cdc25 and chk1 Regulatory Pathway in response to DNA damage, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Protein Kinase A at the Centrosome, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of Splicing through Sam68, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, Phosphatidylinositol signaling system, cell_cycle 0.0222229 0.733
120 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003410_01 Info Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) H003410_01 U26727 1174 CDKN2A Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0245577 0.782
121 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003759_01 Info Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) H003759_01 U40343 29656 CDKN2D Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation 0.0311312 1.253
122 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H002149_01 Info Cyclin-dependent kinase inhibitor 1A (p21, Cip1) H002149_01 U03106 179665 CDKN1A ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc 0.0349766 1.236
123 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H002371_01 Info Cyclin B1 H002371_01 M25753 23960 CCNB1 Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, cell_cycle 0.037756 0.797
124 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H002323_01 Info Cyclin E1 H002323_01 M74093 9700 CCNE1 Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle 0.1107382 0.884
125 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H001999_01 Info Cyclin D1 (PRAD1: parathyroid adenomatosis 1) H001999_01 X59798 82932 CCND1 Perou’s – Intrinsic- Breast-Cancer-Genes, BTG family proteins and cell cycle regulation, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, WNT Signaling Pathway, cell_cycle, tsonc 0.3215316 0.898
126 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003750_01 Info Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) H003750_01 AF004819 72901 CDKN2B Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, cell_cycle, cell_signaling, signal_transduction, tsonc 0.3235256 0.886
127 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H000126_01 Info Retinoblastoma-like 1 (p107) H000126_01 L14812 87 RBL1 Cyclins and Cell Cycle Regulation, METS affect on Macrophage Differentiation, cell_cycle 0.4736162 1.053
128 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003162_01 Info Transcription factor Dp-1 H003162_01 L23959 279576 TFDP1 Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, Regulation of p27 Phosphorylation during Cell Cycle Progression 0.6646128 0.958
129 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H002606_01 Info Cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase) H002606_01 L20320 184298 CDK7 Perou’s – Intrinsic- Breast-Cancer-Genes, Cyclins and Cell Cycle Regulation, Degradation of the RAR and RXR by the proteasome, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction 0.9364784 0.991
130 cellcyclePathway_h Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. H003027_01 Info Cyclin D2 H003027_01 D13639 75586 CCND2 Cyclins and Cell Cycle Regulation, cell_cycle 0.9682473 0.996
131 HOXA9_DOWN_h Dorsam_et_al_2004 H003124_01 Info Fc fragment of IgG, receptor, transporter, alpha H003124_01 U12255 111903 FCGRT 2.86e-05 1.917
132 HOXA9_DOWN_h Dorsam_et_al_2004 H000825_01 Info S100 calcium-binding protein A8 (calgranulin A) H000825_01 X06234 100000 S100A8 immunology 0.0001788 2.746
133 HOXA9_DOWN_h Dorsam_et_al_2004 H002406_01 Info Jun B proto-oncogene H002406_01 X51345 198951 JUNB GATA3 participate in activating the Th2 cytokine genes expression, tsonc 0.0021761 1.408
134 HOXA9_DOWN_h Dorsam_et_al_2004 H002878_01 Info V-yes-1 Yamaguchi sarcoma viral related oncogene homolog H002878_01 M16038 80887 LYN BCR Signaling Pathway, Eph Kinases and ephrins support platelet aggregation, Fc Epsilon Receptor I Signaling in Mast Cells, Phosphoinositides and their downstream targets., immunology, signal_transduction, tsonc 0.0068841 1.545
135 HOXA9_DOWN_h Dorsam_et_al_2004 H000316_01 Info Delta sleep inducing peptide, immunoreactor H000316_01 AL110191 75450 DSIPI 0.0102545 1.531
136 HOXA9_DOWN_h Dorsam_et_al_2004 H006355_01 Info KIAA1451 protein H006355_01 AL049923 109694 KIAA1451 0.0105169 1.369
137 HOXA9_DOWN_h Dorsam_et_al_2004 H000199_01 Info Translocated promoter region (to activated MET oncogene) H000199_01 X66397 169750 TPR tsonc 0.036441 0.801
138 HOXA9_DOWN_h Dorsam_et_al_2004 H001971_01 Info Retinoblastoma-binding protein 6 H001971_01 X85133 85273 RBBP6 0.0366619 0.747
139 HOXA9_DOWN_h Dorsam_et_al_2004 H006255_01 Info Syndecan binding protein (syntenin) H006255_01 AF000652 8180 SDCBP 0.0567867 1.234
140 HOXA9_DOWN_h Dorsam_et_al_2004 H002168_01 Info GATA-binding protein 2 H002168_01 M68891 760 GATA2 gene_regulation, misc, transcription 0.0841754 0.806
141 HOXA9_DOWN_h Dorsam_et_al_2004 H004936_01 Info DKFZP564A122 protein H004936_01 AL110269 187991 DKFZP564A122 0.0852946 1.175
142 HOXA9_DOWN_h Dorsam_et_al_2004 H007504_01 Info Hemoglobin, epsilon 1 H007504_01 NM_005330 117848 HBE1 0.118007 0.749
143 HOXA9_DOWN_h Dorsam_et_al_2004 H002091_01 Info V-myc avian myelocytomatosis viral oncogene homolog H002091_01 K02276 79070 MYC Cadmium induces DNA synthesis and proliferation in macrophages, CTCF: First Multivalent Nuclear Factor, Erk1/Erk2 Mapk Signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, MAP Kinase Signaling Pathway, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Overview of telomerase protein component gene hTert Transcriptional Regulation , p38 MAPK Signaling Pathway , Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, WNT Signaling Pathway, gene_regulation, immunology, transcription, tsonc 0.1797519 0.824
144 HOXA9_DOWN_h Dorsam_et_al_2004 H001023_01 Info Mannosidase, alpha, class 2A, member 2 H001023_01 L28821 295605 MAN2A2 ER associated degradation (ERAD) Pathway, Steps in the Glycosylation of Mammalian N-linked Oligosaccharides, N-Glycan biosynthesis 0.2111813 1.139
145 HOXA9_DOWN_h Dorsam_et_al_2004 H003255_01 Info CDC37 (cell division cycle 37, S. cerevisiae, homolog) H003255_01 U43077 160958 CDC37 0.2178008 0.878
146 HOXA9_DOWN_h Dorsam_et_al_2004 H000068_01 Info Signal recognition particle 72kD H000068_01 AF069765 237825 SRP72 Perou’s – Intrinsic- Breast-Cancer-Genes 0.2609516 0.897
147 HOXA9_DOWN_h Dorsam_et_al_2004 H012741_01 Info Glutaredoxin (thioltransferase) H012741_01 AF069668 28988 GLRX pharmacology 0.2704585 1.145
148 HOXA9_DOWN_h Dorsam_et_al_2004 H006807_01 Info Cytokine inducible SH2-containing protein H006807_01 AF132297 8257 CISH Growth Hormone Signaling Pathway, IL-2 Receptor Beta Chain in T cell Activation, immunology 0.3746206 0.888
149 HOXA9_DOWN_h Dorsam_et_al_2004 H004864_01 Info Ubiquitin specific protease 1 H004864_01 AF117386 35086 USP1 0.3871195 0.908
150 HOXA9_DOWN_h Dorsam_et_al_2004 H006584_01 Info Splicing factor, arginine/serine-rich 11 H006584_01 M74002 11482 SFRS11 0.4576641 1.062
151 HOXA9_DOWN_h Dorsam_et_al_2004 H010826_01 Info Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide H010826_01 AB024334 25001 YWHAG 0.6175419 1.047
152 HOXA9_DOWN_h Dorsam_et_al_2004 H016588_01 Info Hypothetical protein DKFZp761B2423 H016588_01 AK026954 91065 DKFZp761B2423 0.6339659 1.046
153 HOXA9_DOWN_h Dorsam_et_al_2004 H010792_01 Info Dynein, cytoplasmic, light intermediate polypeptide 2 H010792_01 AF035812 194625 DNCLI2 0.6511108 1.058
154 HOXA9_DOWN_h Dorsam_et_al_2004 H002850_01 Info Murine leukemia viral (bmi-1) oncogene homolog H002850_01 L13689 431 BMI1 Perou’s – Intrinsic- Breast-Cancer-Genes, The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails, immunology, tsonc 0.7846354 0.976
155 HOXA9_DOWN_h Dorsam_et_al_2004 H003618_01 Info Dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) H003618_01 D17547 301865 DCT Tyrosine metabolism 0.9648525 0.996
156 gata3Pathway_h BioCarta H003200_01 Info Mitogen-activated protein kinase kinase 3 H003200_01 D87116 180533 MAP2K3 fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, Signal transduction through IL1R, TNF/Stress Related Signaling, Toll-Like Receptor Pathway 0.0009666 1.561
157 gata3Pathway_h BioCarta H002406_01 Info Jun B proto-oncogene H002406_01 X51345 198951 JUNB GATA3 participate in activating the Th2 cytokine genes expression, tsonc 0.0021761 1.408
158 gata3Pathway_h BioCarta H003415_01 Info Protein kinase, cAMP-dependent, catalytic, beta H003415_01 M34181 87773 PRKACB Perou’s – Intrinsic- Breast-Cancer-Genes, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction 0.0048904 0.647
159 gata3Pathway_h BioCarta H002895_01 Info Mitogen-activated protein kinase 14 H002895_01 L35263 79107 MAPK14 BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Human Cytomegalovirus and Map Kinase Pathways, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, Keratinocyte Differentiation, Links between Pyk2 and Map Kinases, Map Kinase Inactivation of SMRT Corepressor, MAP Kinase Signaling Pathway, NFAT and Hypertrophy of the heart (Transcription in the broken heart), NFkB activation by Nontypeable Hemophilus influenzae, Oxidative Stress Induced Gene Expression Via Nrf2, p38 MAPK Signaling Pathway , Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Regulation of eIF4e and p70 S6 Kinase, Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases, SARS Coronavirus Protease, Signal transduction through IL1R, TACI and BCMA stimulation of B cell imm … 0.0086925 1.429
160 gata3Pathway_h BioCarta H006601_01 Info V-maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog H006601_01 AF055376 30250 MAF GATA3 participate in activating the Th2 cytokine genes expression, tsonc 0.079493 0.812
161 gata3Pathway_h BioCarta H001698_01 Info Protein kinase, cAMP-dependent, regulatory, type II, alpha H001698_01 X14968 289075 PRKAR2A AKAP95 role in mitosis and chromosome dynamics, Protein Kinase A at the Centrosome, Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation 0.2569617 1.125
162 gata3Pathway_h BioCarta H000645_01 Info Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) H000645_01 M33336 183037 PRKAR1A Activation of cAMP-dependent protein kinase, PKA, cell_cycle, cell_signaling, signal_transduction 0.4305614 0.935
163 gata3Pathway_h BioCarta H002045_01 Info Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 H002045_01 U80917 96149 NFATC1 BCR Signaling Pathway, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Effects of calcineurin in Keratinocyte Differentiation, Fc Epsilon Receptor I Signaling in Mast Cells, fMLP induced chemokine gene expression in HMC-1 cells, GATA3 participate in activating the Th2 cytokine genes expression, Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, NFAT and Hypertrophy of the heart (Transcription in the broken heart), Role of MEF2D in T-cell Apoptosis, Signaling Pathway from G-Protein Families, T Cell Receptor Signaling Pathway, immunology 0.623508 1.051
164 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H001032_01 Info Cytotoxic T-lymphocyte-associated protein 4 H001032_01 L15006 247824 CTLA4 The Co-Stimulatory Signal During T-cell Activation, immunology 0.0001134 0.56
165 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
166 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H001210_01 Info Major histocompatibility complex, class II, DR beta 3 H001210_01 V00522 279930 HLA-DRB3 Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology 0.0031398 1.8
167 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H003054_01 Info Major histocompatibility complex, class II, DR alpha H003054_01 J00194 76807 HLA-DRA Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology 0.0045394 1.755
168 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H002284_01 Info Major histocompatibility complex, class II, DR beta 5 H002284_01 M20430 308026 HLA-DRB5 Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology 0.0670054 1.503
169 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H015660_01 Info Major histocompatibility complex, class II, DR beta 4 H015660_01 NM_021983 293934 HLA-DRB4 Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology 0.2187912 0.885
170 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H003820_01 Info Lymphocyte-specific protein tyrosine kinase H003820_01 X05027 1765 LCK Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, IL 2 signaling pathway, IL-7 Signal Transduction, Lck and Fyn tyrosine kinases in initiation of TCR Activation, T Cell Receptor Signaling Pathway, The Co-Stimulatory Signal During T-cell Activation, immunology, signal_transduction, tsonc 0.2266863 0.873
171 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H000858_01 Info Homo sapiens, clone MGC:12387, mRNA, complete CDS H000858_01 M16942 318720 Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor, Antigen Dependent B Cell Activation, Antigen Processing and Presentation, B Lymphocyte Cell Surface Molecules, Bystander B Cell Activation, Cytokines and Inflammatory Response, IL 5 Signaling Pathway, Lck and Fyn tyrosine kinases in initiation of TCR Activation, Th1/Th2 Differentiation, The Co-Stimulatory Signal During T-cell Activation, The Role of Eosinophils in the Chemokine Network of Allergy, immunology 0.2327988 1.274
172 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H001197_01 Info T cell receptor beta locus H001197_01 X00437 303157 TRB@ 0.4180662 0.913
173 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H002570_01 Info Interleukin 2 H002570_01 S82692 89679 IL2 Antigen Dependent B Cell Activation, Cytokine Network, Cytokines and Inflammatory Response, IL 18 Signaling Pathway, IL 2 signaling pathway, OX40 Signaling Pathway, Regulation of hematopoiesis by cytokines, Role of Tob in T-cell activation, Selective expression of chemokine receptors during T-cell polarization, Th1/Th2 Differentiation, The 4-1BB-dependent immune response, The Co-Stimulatory Signal During T-cell Activation, immunology 0.6483346 1.043
174 ctla4Pathway_h T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APCs CD80 or 86. H001267_01 Info CD3Z antigen, zeta polypeptide (TiT3 complex) H001267_01 NM_000734 97087 CD3Z immunology 0.8300402 1.024
175 cell_cycle_checkpointII_h GO H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
176 cell_cycle_checkpointII_h GO H001983_01 Info Fanconi anemia, complementation group G H001983_01 AJ007669 8047 FANCG BRCA1-dependent Ub-ligase activity, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, immunology 0.0098981 0.692
177 cell_cycle_checkpointII_h GO H002092_01 Info Ataxia telangiectasia and Rad3 related H002092_01 U49844 77613 ATR Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Regulation of cell cycle progression by Plk3, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Phosphatidylinositol signaling system, DNA_replication, immunology 0.0105491 0.753
178 cell_cycle_checkpointII_h GO H003410_01 Info Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) H003410_01 U26727 1174 CDKN2A Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0245577 0.782
179 cell_cycle_checkpointII_h GO H002789_01 Info Tumor protein p53 (Li-Fraumeni syndrome) H002789_01 NM_000546 1846 TP53 Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc 0.0273242 1.207
180 cell_cycle_checkpointII_h GO H001967_01 Info Cyclin E2 H001967_01 AF091433 30464 CCNE2 cell_cycle 0.0814824 0.826
181 cell_cycle_checkpointII_h GO H002232_01 Info Cell division cycle 34 H002232_01 L22005 76932 CDC34 Cell Cycle: G2/M Checkpoint, Cyclin E Destruction Pathway, E2F1 Destruction Pathway, Ubiquitin mediated proteolysis 0.8799021 0.983
182 g1Pathway_h BioCarta H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
183 g1Pathway_h BioCarta H002412_01 Info Cyclin-dependent kinase 2 H002412_01 M68520 19192 CDK2 CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, immunology, signal_transduction 0.0040171 0.711
184 g1Pathway_h BioCarta H002092_01 Info Ataxia telangiectasia and Rad3 related H002092_01 U49844 77613 ATR Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Regulation of cell cycle progression by Plk3, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Phosphatidylinositol signaling system, DNA_replication, immunology 0.0105491 0.753
185 g1Pathway_h BioCarta H005436_01 Info Homo sapiens cDNA FLJ20653 fis, clone KAT01739 H005436_01 AK000660 180059 Perou’s – Intrinsic- Breast-Cancer-Genes, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Influence of Ras and Rho proteins on G1 to S Transition, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, signal_transduction 0.0126769 0.793
186 g1Pathway_h BioCarta H003739_01 Info Cell division cycle 2, G1 to S and G2 to M H003739_01 X05360 184572 CDC2 Activation of Src by Protein-tyrosine phosphatase alpha, AKAP95 role in mitosis and chromosome dynamics, cdc25 and chk1 Regulatory Pathway in response to DNA damage, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, How Progesterone Initiates the Oocyte Maturation, Protein Kinase A at the Centrosome, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of Splicing through Sam68, Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle, Stathmin and breast cancer resistance to antimicrotubule agents, Phosphatidylinositol signaling system, cell_cycle 0.0222229 0.733
187 g1Pathway_h BioCarta H003410_01 Info Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) H003410_01 U26727 1174 CDKN2A Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0245577 0.782
188 g1Pathway_h BioCarta H002789_01 Info Tumor protein p53 (Li-Fraumeni syndrome) H002789_01 NM_000546 1846 TP53 Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc 0.0273242 1.207
189 g1Pathway_h BioCarta H002149_01 Info Cyclin-dependent kinase inhibitor 1A (p21, Cip1) H002149_01 U03106 179665 CDKN1A ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc 0.0349766 1.236
190 g1Pathway_h BioCarta H002323_01 Info Cyclin E1 H002323_01 M74093 9700 CCNE1 Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle 0.1107382 0.884
191 g1Pathway_h BioCarta H003207_01 Info V-abl Abelson murine leukemia viral oncogene homolog 1 H003207_01 NM_005157 146355 ABL1 cell_signaling, signal_transduction, tsonc 0.1292454 0.826
192 g1Pathway_h BioCarta H003023_01 Info Dihydrofolate reductase H003023_01 NM_000791 83765 DHFR Cell Cycle: G1/S Check Point , Folate biosynthesis, One carbon pool by folate, immunology, pharmacology 0.1336155 0.862
193 g1Pathway_h BioCarta H001999_01 Info Cyclin D1 (PRAD1: parathyroid adenomatosis 1) H001999_01 X59798 82932 CCND1 Perou’s – Intrinsic- Breast-Cancer-Genes, BTG family proteins and cell cycle regulation, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, WNT Signaling Pathway, cell_cycle, tsonc 0.3215316 0.898
194 g1Pathway_h BioCarta H003750_01 Info Cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) H003750_01 AF004819 72901 CDKN2B Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, cell_cycle, cell_signaling, signal_transduction, tsonc 0.3235256 0.886
195 g1Pathway_h BioCarta H009086_01 Info S-phase kinase-associated protein 2 (p45) H009086_01 U33761 23348 SKP2 Cell Cycle: G1/S Check Point , E2F1 Destruction Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression 0.330649 1.089
196 g1Pathway_h BioCarta H000650_01 Info Glycogen synthase kinase 3 beta H000650_01 L33801 78802 GSK3B ALK in cardiac myocytes, Cell Cycle: G1/S Check Point , Deregulation of CDK5 in Alzheimer’s Disease, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Multi-step Regulation of Transcription by Pitx2, NFAT and Hypertrophy of the heart (Transcription in the broken heart), Phosphoinositides and their downstream targets., Presenilin action in Notch and Wnt signaling, Regulation of eIF2, Segmentation Clock, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Sonic Hedgehog (Shh) Pathway, WNT Signaling Pathway, Phosphatidylinositol signaling system 0.353328 1.118
197 g1Pathway_h BioCarta H003162_01 Info Transcription factor Dp-1 H003162_01 L23959 279576 TFDP1 Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, Regulation of p27 Phosphorylation during Cell Cycle Progression 0.6646128 0.958
198 g1Pathway_h BioCarta H000578_01 Info Histone deacetylase 1 H000578_01 D50405 88556 HDAC1 immunology 0.8155423 1.017
199 EMT_UP_h Jechlinger_et_al_2003 H003225_01 Info Interferon regulatory factor 7 H003225_01 AF076494 166120 IRF7 gene_regulation, transcription 6.44e-05 1.728
200 EMT_UP_h Jechlinger_et_al_2003 H000825_01 Info S100 calcium-binding protein A8 (calgranulin A) H000825_01 X06234 100000 S100A8 immunology 0.0001788 2.746
201 EMT_UP_h Jechlinger_et_al_2003 H001850_01 Info Interferon-stimulated protein, 15 kDa H001850_01 M13755 833 ISG15 0.0003862 1.943
202 EMT_UP_h Jechlinger_et_al_2003 H000473_01 Info Uridine phosphorylase H000473_01 X90858 77573 UP Pyrimidine metabolism 0.0005102 1.339
203 EMT_UP_h Jechlinger_et_al_2003 H002726_01 Info B-cell CLL/lymphoma 3 H002726_01 M31732 31210 BCL3 tsonc 0.0147426 1.351
204 EMT_UP_h Jechlinger_et_al_2003 H003466_01 Info CD68 antigen H003466_01 S57235 246381 CD68 angiogenesis, immunology, metastasis 0.0179458 1.335
205 EMT_UP_h Jechlinger_et_al_2003 H003299_01 Info Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) H003299_01 M59979 88474 PTGS1 Aspirin Blocks Signaling Pathway Involved in Platelet Activation, Eicosanoid Metabolism, Mechanism of Acetaminophen Activity and Toxicity, Prostaglandin and leukotriene metabolism, immunology 0.023304 0.813
206 EMT_UP_h Jechlinger_et_al_2003 H003029_01 Info Disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) H003029_01 U53446 81988 DAB2 0.0291633 0.78
207 EMT_UP_h Jechlinger_et_al_2003 H003752_01 Info Platelet-derived growth factor receptor, beta polypeptide H003752_01 J03278 76144 PDGFRB cell_cycle, cell_signaling, immunology, misc, signal_transduction 0.0333891 0.832
208 EMT_UP_h Jechlinger_et_al_2003 H006885_01 Info Ribonuclease 6 precursor H006885_01 NM_003730 8297 RNASE6PL 0.0955467 1.208
209 EMT_UP_h Jechlinger_et_al_2003 H000998_01 Info Solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 H000998_01 AB018010 79748 SLC3A2 Perou’s – Intrinsic- Breast-Cancer-Genes 0.1156436 0.843
210 EMT_UP_h Jechlinger_et_al_2003 H001908_01 Info Discoidin domain receptor family, member 2 H001908_01 X74764 71891 DDR2 0.1167676 0.839
211 EMT_UP_h Jechlinger_et_al_2003 H001001_01 Info Procollagen C-endopeptidase enhancer H001001_01 NM_002593 202097 PCOLCE 0.1228497 0.868
212 EMT_UP_h Jechlinger_et_al_2003 H000774_01 Info Collagen, type VI, alpha 1 H000774_01 X15880 108885 COL6A1 0.1448402 0.841
213 EMT_UP_h Jechlinger_et_al_2003 H002775_01 Info Platelet-derived growth factor receptor, alpha polypeptide H002775_01 M21574 74615 PDGFRA Perou’s – Intrinsic- Breast-Cancer-Genes, CBL mediated ligand-induced downregulation of EGF receptors, Erk1/Erk2 Mapk Signaling pathway, PDGF Signaling Pathway, Phospholipids as signalling intermediaries, Rac 1 cell motility signaling pathway, Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration, immunology, signal_transduction 0.1636921 1.107
214 EMT_UP_h Jechlinger_et_al_2003 H010646_01 Info Ribonuclease 6 precursor H010646_01 AK001769 8297 RNASE6PL 0.1872503 1.127
215 EMT_UP_h Jechlinger_et_al_2003 H002295_01 Info Adenosine deaminase H002295_01 X02994 1217 ADA Purine metabolism, gene_regulation, immunology, transcription 0.1882263 0.871
216 EMT_UP_h Jechlinger_et_al_2003 H012626_01 Info Beta-2-microglobulin H012626_01 AB021288 75415 B2M Antigen Processing and Presentation, CTL mediated immune response against target cells , Ras-Independent pathway in NK cell-mediated cytotoxicity, immunology 0.1923361 1.156
217 EMT_UP_h Jechlinger_et_al_2003 H003645_01 Info Interleukin 11 H003645_01 X58377 1721 IL11 Cytokines and Inflammatory Response, Erythrocyte Differentiation Pathway, Regulation of hematopoiesis by cytokines, immunology 0.2074062 1.116
218 EMT_UP_h Jechlinger_et_al_2003 H003593_01 Info Collagen, type VI, alpha 2 H003593_01 AL096746 159263 COL6A2 0.300891 1.098
219 EMT_UP_h Jechlinger_et_al_2003 H001198_01 Info Homo sapiens, alpha-1 (VI) collagen H001198_01 M20776 25459 0.3632512 1.1
220 EMT_UP_h Jechlinger_et_al_2003 H002451_01 Info Flavin containing monooxygenase 1 H002451_01 M64082 1424 FMO1 immunology, misc 0.3681883 0.911
221 EMT_UP_h Jechlinger_et_al_2003 H000592_01 Info Interferon-induced protein with tetratricopeptide repeats 1 H000592_01 X03557 20315 IFIT1 0.4335751 1.121
222 EMT_UP_h Jechlinger_et_al_2003 H002713_01 Info Phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) H002713_01 U24577 93304 PLA2G7 Glycerophospholipid metabolism 0.4631812 0.89
223 EMT_UP_h Jechlinger_et_al_2003 H010497_01 Info Interferon induced transmembrane protein 3 (1-8U) H010497_01 X57352 182241 IFITM3 0.5875785 1.062
224 EMT_UP_h Jechlinger_et_al_2003 H003695_01 Info Secreted protein, acidic, cysteine-rich (osteonectin) H003695_01 J03040 111779 SPARC misc 0.6414286 1.051
225 EMT_UP_h Jechlinger_et_al_2003 H002330_01 Info Cadherin 15, M-cadherin (myotubule) H002330_01 D83542 148090 CDH15 0.7996949 0.974
226 EMT_UP_h Jechlinger_et_al_2003 H002397_01 Info Methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase H002397_01 X16396 154672 MTHFD2 Glyoxylate and dicarboxylate metabolism, One carbon pool by folate 0.8081788 0.975
227 EMT_UP_h Jechlinger_et_al_2003 H002672_01 Info G protein-coupled receptor H002672_01 U67784 23016 RDC1 0.8527585 0.967
228 EMT_UP_h Jechlinger_et_al_2003 H002490_01 Info Hexabrachion (tenascin C, cytotactin) H002490_01 X78565 289114 HXB Perou’s – Intrinsic- Breast-Cancer-Genes 0.856155 0.983
229 EMT_UP_h Jechlinger_et_al_2003 H002283_01 Info Secretory leukocyte protease inhibitor (antileukoproteinase) H002283_01 X04470 251754 SLPI Perou’s – Intrinsic- Breast-Cancer-Genes, Proepithelin Conversion to Epithelin and Wound Repair Control, immunology 0.9075348 1.012
230 EMT_UP_h Jechlinger_et_al_2003 H004245_01 Info Snail 1 (drosophila homolog), zinc finger protein H004245_01 AF125377 48029 SNAI1 Downregulated of MTA-3 in ER-negative Breast Tumors 0.9743253 1.003
231 tumor_supressor_h BioCarta H001935_01 Info Glyceraldehyde-3-phosphate dehydrogenase H001935_01 U34995 169476 GAPD 0.0001082 1.485
232 tumor_supressor_h BioCarta H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
233 tumor_supressor_h BioCarta H002387_01 Info MutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) H002387_01 NM_000251 78934 MSH2 DNA_damage, tsonc 0.004273 0.694
234 tumor_supressor_h BioCarta H000570_01 Info CREB binding protein (Rubinstein-Taybi syndrome) H000570_01 U47741 23598 CREBBP gene_regulation, transcription 0.0048718 1.469
235 tumor_supressor_h BioCarta H000208_01 Info Breast cancer 1, early onset H000208_01 NM_007295 194143 BRCA1 ATM Signaling Pathway, BRCA1-dependent Ub-ligase activity, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G2/M Checkpoint, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, immunology, tsonc 0.009032 0.746
236 tumor_supressor_h BioCarta H002789_01 Info Tumor protein p53 (Li-Fraumeni syndrome) H002789_01 NM_000546 1846 TP53 Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc 0.0273242 1.207
237 tumor_supressor_h BioCarta H003759_01 Info Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) H003759_01 U40343 29656 CDKN2D Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation 0.0311312 1.253
238 tumor_supressor_h BioCarta H002114_01 Info Neurofibromin 2 (bilateral acoustic neuroma) H002114_01 L11353 902 NF2 immunology, tsonc 0.2904249 0.837
239 tumor_supressor_h BioCarta H002700_01 Info Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD) H002700_01 L11695 220 TGFBR1 ALK in cardiac myocytes, Function of SLRP in Bone: An Integrated View, MAP Kinase Signaling Pathway, NFkB activation by Nontypeable Hemophilus influenzae, p38 MAPK Signaling Pathway , TGF beta signaling pathway, Phosphatidylinositol signaling system, angiogenesis, development 0.3279632 0.903
240 tumor_supressor_h BioCarta H002611_01 Info Interferon regulatory factor 1 H002611_01 X14454 80645 IRF1 gene_regulation, transcription 0.3284273 0.915
241 tumor_supressor_h BioCarta H006635_01 Info Homo sapiens clone 23607 mRNA sequence H006635_01 AF038181 167825 ALK in cardiac myocytes, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Multi-step Regulation of Transcription by Pitx2, Presenilin action in Notch and Wnt signaling, TGF beta signaling pathway, WNT Signaling Pathway, development, immunology, tsonc 0.6181322 1.041
242 tumor_supressor_h BioCarta H003538_01 Info Actin, beta H003538_01 NM_001101 288061 ACTB Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes 0.6253266 0.956
243 tumor_supressor_h BioCarta H007492_01 Info Cofilin 1 (non-muscle) H007492_01 X95404 180370 CFL1 CCR3 signaling in Eosinophils, Rac 1 cell motility signaling pathway, Rho cell motility signaling pathway 0.685636 1.038
244 tumor_supressor_h BioCarta H003594_01 Info Cyclin-dependent kinase inhibitor 1C (p57, Kip2) H003594_01 U22398 106070 CDKN1C cell_cycle, immunology, tsonc 0.7532847 0.968
245 tumor_supressor_h BioCarta H003151_01 Info E1A binding protein p300 H003151_01 U01877 25272 EP300 Acetylation and Deacetylation of RelA in The Nucleus, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G2/M Checkpoint, Control of Gene Expression by Vitamin D Receptor, Hypoxia and p53 in the Cardiovascular system, Hypoxia-Inducible Factor in the Cardiovascular System, IL-7 Signal Transduction, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Melanocyte Development and Pigmentation Pathway, Multi-step Regulation of Transcription by Pitx2, NFkB activation by Nontypeable Hemophilus influenzae, Pelp1 Modulation of Estrogen Receptor Activity, Role of ERBB2 in Signal Transduction and Oncology, Role of MEF2D in T-cell Apoptosis, Role of PPAR-gamma Coactivators in Obesity and Thermogenesis, TGF beta signaling pathway, Transcription Regulation by Methyltransferase of CARM1, gene_regulation, transcription 0.9607239 1.004
246 drug_resistance_and_metabolism_h BioCarta H001935_01 Info Glyceraldehyde-3-phosphate dehydrogenase H001935_01 U34995 169476 GAPD 0.0001082 1.485
247 drug_resistance_and_metabolism_h BioCarta H002040_01 Info Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) H002040_01 X00588 77432 EGFR Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc 0.0004362 0.669
248 drug_resistance_and_metabolism_h BioCarta H003596_01 Info O-6-methylguanine-DNA methyltransferase H003596_01 M29971 1384 MGMT DNA_adducts, DNA_damage 0.0006291 0.667
249 drug_resistance_and_metabolism_h BioCarta H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
250 drug_resistance_and_metabolism_h BioCarta H002412_01 Info Cyclin-dependent kinase 2 H002412_01 M68520 19192 CDK2 CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Phosphatidylinositol signaling system, cell_cycle, cell_signaling, immunology, signal_transduction 0.0040171 0.711
251 drug_resistance_and_metabolism_h BioCarta H000872_01 Info ATP-binding cassette, sub-family C (CFTR/MRP), member 5 H000872_01 AF104942 108660 ABCC5 0.00423 0.773
252 drug_resistance_and_metabolism_h BioCarta H002387_01 Info MutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1) H002387_01 NM_000251 78934 MSH2 DNA_damage, tsonc 0.004273 0.694
253 drug_resistance_and_metabolism_h BioCarta H000208_01 Info Breast cancer 1, early onset H000208_01 NM_007295 194143 BRCA1 ATM Signaling Pathway, BRCA1-dependent Ub-ligase activity, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G2/M Checkpoint, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, DNA_damage, immunology, tsonc 0.009032 0.746
254 drug_resistance_and_metabolism_h BioCarta H003606_01 Info Retinoid X receptor, alpha H003606_01 U66306 20084 RXRA Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, Control of Gene Expression by Vitamin D Receptor, Degradation of the RAR and RXR by the proteasome, FXR and LXR Regulation of Cholesterol Metabolism, Map Kinase Inactivation of SMRT Corepressor, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, Role of PPAR-gamma Coactivators in Obesity and Thermogenesis, Transcription Regulation by Methyltransferase of CARM1, Visceral Fat Deposits and the Metabolic Syndrome, development, gene_regulation, transcription 0.0142664 1.308
255 drug_resistance_and_metabolism_h BioCarta H001848_01 Info Glutathione S-transferase M1 H001848_01 J03817 324730 GSTM1 Glutathione metabolism, immunology, pharmacology 0.018415 0.773
256 drug_resistance_and_metabolism_h BioCarta H003283_01 Info Topoisomerase (DNA) II alpha (170kD) H003283_01 J04088 156346 TOP2A Apoptotic DNA fragmentation and tissue homeostasis, DNA_adducts, DNA_damage, DNA_replication 0.0203748 0.733
257 drug_resistance_and_metabolism_h BioCarta H002533_01 Info ATP-binding cassette, sub-family C (CFTR/MRP), member 6 H002533_01 AF076622 274260 ABCC6 0.0229826 1.478
258 drug_resistance_and_metabolism_h BioCarta H003410_01 Info Cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) H003410_01 U26727 1174 CDKN2A Cell Cycle: G1/S Check Point , CTCF: First Multivalent Nuclear Factor, Cyclins and Cell Cycle Regulation, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0245577 0.782
259 drug_resistance_and_metabolism_h BioCarta H002789_01 Info Tumor protein p53 (Li-Fraumeni syndrome) H002789_01 NM_000546 1846 TP53 Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc 0.0273242 1.207
260 drug_resistance_and_metabolism_h BioCarta H003759_01 Info Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) H003759_01 U40343 29656 CDKN2D Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation 0.0311312 1.253
261 drug_resistance_and_metabolism_h BioCarta H002149_01 Info Cyclin-dependent kinase inhibitor 1A (p21, Cip1) H002149_01 U03106 179665 CDKN1A ATM Signaling Pathway, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Cyclins and Cell Cycle Regulation, Effects of calcineurin in Keratinocyte Differentiation, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia and p53 in the Cardiovascular system, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, immunology, tsonc 0.0349766 1.236
262 drug_resistance_and_metabolism_h BioCarta H002424_01 Info Bleomycin hydrolase H002424_01 X92106 78943 BLMH immunology, pharmacology 0.0414602 0.81
263 drug_resistance_and_metabolism_h BioCarta H007820_01 Info Retinoic acid receptor-beta associated open reading frame H007820_01 S82362 1938 LOC51036 Control of Gene Expression by Vitamin D Receptor, DNA_adducts, DNA_damage, gene_regulation, transcription 0.0421365 0.794
264 drug_resistance_and_metabolism_h BioCarta H003156_01 Info V-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide H003156_01 M83221 858 RELB tsonc 0.0527226 1.209
265 drug_resistance_and_metabolism_h BioCarta H007892_01 Info Cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19 H007892_01 M61854 198501 CYP2C19 Fatty acid metabolism, gamma-Hexachlorocyclohexane degradation, Tryptophan metabolism, pharmacology 0.0560255 0.801
266 drug_resistance_and_metabolism_h BioCarta H003713_01 Info Topoisomerase (DNA) II beta (180kD) H003713_01 X68060 75248 TOP2B Control of Gene Expression by Vitamin D Receptor, DNA_adducts, DNA_damage, gene_regulation, transcription 0.075384 0.83
267 drug_resistance_and_metabolism_h BioCarta H002473_01 Info Insulin-like growth factor 1 receptor H002473_01 NM_000875 239176 IGF1R Perou’s – Intrinsic- Breast-Cancer-Genes, Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK), Erk1/Erk2 Mapk Signaling pathway, IGF-1 Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Regulation of BAD phosphorylation, Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway, Telomeres, Telomerase, Cellular Aging, and Immortality, The IGF-1 Receptor and Longevity, immunology 0.079692 1.158
268 drug_resistance_and_metabolism_h BioCarta H003600_01 Info Epoxide hydrolase 2, cytoplasmic H003600_01 L05779 113 EPHX2 Tetrachloroethene degradation, immunology, metabolism, pharmacology 0.092835 0.858
269 drug_resistance_and_metabolism_h BioCarta H002323_01 Info Cyclin E1 H002323_01 M74093 9700 CCNE1 Perou’s – Intrinsic- Breast-Cancer-Genes, CDK Regulation of DNA Replication, Cell Cycle: G1/S Check Point , Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, Regulation of p27 Phosphorylation during Cell Cycle Progression, cell_cycle 0.1107382 0.884
270 drug_resistance_and_metabolism_h BioCarta H003376_01 Info Aryl hydrocarbon receptor nuclear translocator H003376_01 M69238 166172 ARNT Ahr Signal Transduction Pathway, Erythropoietin mediated neuroprotection through NF-kB, Hypoxia-Inducible Factor in the Cardiovascular System, VEGF, Hypoxia, and Angiogenesis, angiogenesis, immunology 0.1249479 1.133
271 drug_resistance_and_metabolism_h BioCarta H014546_01 Info Peptidylprolyl isomerase A (cyclophilin A) H014546_01 NM_021130 182937 PPIA IL-2 Receptor Beta Chain in T cell Activation 0.129858 1.176
272 drug_resistance_and_metabolism_h BioCarta H003023_01 Info Dihydrofolate reductase H003023_01 NM_000791 83765 DHFR Cell Cycle: G1/S Check Point , Folate biosynthesis, One carbon pool by folate, immunology, pharmacology 0.1336155 0.862
273 drug_resistance_and_metabolism_h BioCarta H003550_01 Info Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) H003550_01 S76638 73090 NFKB2 gene_regulation, immunology, transcription, tsonc 0.1593331 1.165
274 drug_resistance_and_metabolism_h BioCarta H001986_01 Info Aryl hydrocarbon receptor H001986_01 NM_001621 170087 AHR Ahr Signal Transduction Pathway, gene_regulation, immunology, transcription 0.1792938 1.117
275 drug_resistance_and_metabolism_h BioCarta H002091_01 Info V-myc avian myelocytomatosis viral oncogene homolog H002091_01 K02276 79070 MYC Cadmium induces DNA synthesis and proliferation in macrophages, CTCF: First Multivalent Nuclear Factor, Erk1/Erk2 Mapk Signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, MAP Kinase Signaling Pathway, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells, Overview of telomerase protein component gene hTert Transcriptional Regulation , p38 MAPK Signaling Pathway , Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, WNT Signaling Pathway, gene_regulation, immunology, transcription, tsonc 0.1797519 0.824
276 drug_resistance_and_metabolism_h BioCarta H003810_01 Info Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (adult)) H003810_01 X02317 75428 SOD1 Cardiac Protection Against ROS , Free Radical Induced Apoptosis, immunology, pharmacology 0.1871555 1.13
277 drug_resistance_and_metabolism_h BioCarta H003242_01 Info Excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pig H003242_01 M31899 77929 ERCC3 CARM1 and Regulation of the Estrogen Receptor, Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes, Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, DNA_damage, DNA_replication, immunology 0.2157492 0.873
278 drug_resistance_and_metabolism_h BioCarta H003042_01 Info BCL2-like 1 H003042_01 Z23115 305890 BCL2L1 Apoptotic Signaling in Response to DNA Damage, IL-2 Receptor Beta Chain in T cell Activation, Opposing roles of AIF in Apoptosis and Cell Survival, Ras Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, immunology 0.2336065 1.143
279 drug_resistance_and_metabolism_h BioCarta H003605_01 Info BCL2-associated X protein H003605_01 L22474 159428 BAX Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology 0.253339 0.907
280 drug_resistance_and_metabolism_h BioCarta H003514_01 Info Cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2 H003514_01 M55053 1361 CYP1A2 Mechanism of Acetaminophen Activity and Toxicity, Nuclear Receptors in Lipid Metabolism and Toxicity, Fatty acid metabolism, gamma-Hexachlorocyclohexane degradation, Tryptophan metabolism, immunology, pharmacology 0.2704204 1.089
281 drug_resistance_and_metabolism_h BioCarta H011468_01 Info ATP-binding cassette, sub-family G (WHITE), member 2 H011468_01 AF103796 194720 ABCG2 0.2713892 0.876
282 drug_resistance_and_metabolism_h BioCarta H002577_01 Info MutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2) H002577_01 U07418 57301 MLH1 DNA_damage, DNA_replication, tsonc 0.2947975 0.894
283 drug_resistance_and_metabolism_h BioCarta H003016_01 Info Insulin-like growth factor 2 receptor H003016_01 Y00285 76473 IGF2R immunology 0.3174469 1.143
284 drug_resistance_and_metabolism_h BioCarta H001999_01 Info Cyclin D1 (PRAD1: parathyroid adenomatosis 1) H001999_01 X59798 82932 CCND1 Perou’s – Intrinsic- Breast-Cancer-Genes, BTG family proteins and cell cycle regulation, CARM1 and Regulation of the Estrogen Receptor, Cell Cycle: G1/S Check Point , Cyclins and Cell Cycle Regulation, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Influence of Ras and Rho proteins on G1 to S Transition, p53 Signaling Pathway, WNT Signaling Pathway, cell_cycle, tsonc 0.3215316 0.898
285 drug_resistance_and_metabolism_h BioCarta H002702_01 Info Retinoic acid receptor, gamma H002702_01 M38258 1497 RARG Nuclear Receptors in Lipid Metabolism and Toxicity, development, gene_regulation, transcription 0.4297075 1.087
286 drug_resistance_and_metabolism_h BioCarta H002294_01 Info ATP-binding cassette, sub-family C (CFTR/MRP), member 1 H002294_01 X78338 89433 ABCC1 Multi-Drug Resistance Factors 0.4691659 0.928
287 drug_resistance_and_metabolism_h BioCarta H002907_01 Info Retinoic acid receptor, alpha H002907_01 X06614 250505 RARA Degradation of the RAR and RXR by the proteasome, Map Kinase Inactivation of SMRT Corepressor, Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, Nuclear Receptors in Lipid Metabolism and Toxicity, Regulation of transcriptional activity by PML, Transcription Regulation by Methyltransferase of CARM1, development 0.4825926 1.084
288 drug_resistance_and_metabolism_h BioCarta H000149_01 Info Epoxide hydrolase 1, microsomal (xenobiotic) H000149_01 NM_000120 89649 EPHX1 Eicosanoid Metabolism, Tetrachloroethene degradation, immunology, metabolism, pharmacology 0.512274 0.938
289 drug_resistance_and_metabolism_h BioCarta H001952_01 Info Ribosomal protein L13a H001952_01 X56932 119122 RPL13A 0.565051 1.059
290 drug_resistance_and_metabolism_h BioCarta H006635_01 Info Homo sapiens clone 23607 mRNA sequence H006635_01 AF038181 167825 ALK in cardiac myocytes, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Multi-step Regulation of Transcription by Pitx2, Presenilin action in Notch and Wnt signaling, TGF beta signaling pathway, WNT Signaling Pathway, development, immunology, tsonc 0.6181322 1.041
291 drug_resistance_and_metabolism_h BioCarta H002777_01 Info Cytochrome P450, subfamily IIE (ethanol-inducible) H002777_01 J02625 75183 CYP2E Mechanism of Acetaminophen Activity and Toxicity, Nuclear Receptors in Lipid Metabolism and Toxicity, Fatty acid metabolism, gamma-Hexachlorocyclohexane degradation, Tryptophan metabolism 0.6229802 0.953
292 drug_resistance_and_metabolism_h BioCarta H003538_01 Info Actin, beta H003538_01 NM_001101 288061 ACTB Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes 0.6253266 0.956
293 drug_resistance_and_metabolism_h BioCarta H013267_01 Info Homo sapiens clone R2 ErbB-3 R2 (c-erbB-3) mRNA, partial CDS H013267_01 U88358 306251 Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of ERBB2 in Signal Transduction and Oncology, cell_cycle, cell_signaling, signal_transduction, tsonc 0.6380266 1.054
294 drug_resistance_and_metabolism_h BioCarta H001853_01 Info Cellular retinoic acid-binding protein 1 H001853_01 S74445 7678 CRABP1 Perou’s – Intrinsic- Breast-Cancer-Genes 0.6817674 0.954
295 drug_resistance_and_metabolism_h BioCarta H002094_01 Info Thymidylate synthetase H002094_01 X02308 82962 TYMS One carbon pool by folate, Pyrimidine metabolism, metabolism, pharmacology 0.6945693 1.041
296 drug_resistance_and_metabolism_h BioCarta H002029_01 Info V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 H002029_01 M34309 199067 ERBB3 Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of ERBB2 in Signal Transduction and Oncology, cell_cycle, cell_signaling, signal_transduction, tsonc 0.7019431 1.035
297 drug_resistance_and_metabolism_h BioCarta H003542_01 Info V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene H003542_01 M11730 323910 ERBB2 Perou’s – Intrinsic- Breast-Cancer-Genes, Role of ERBB2 in Signal Transduction and Oncology, Trefoil Factors Initiate Mucosal Healing, immunology, signal_transduction, tsonc 0.7160857 1.031
298 drug_resistance_and_metabolism_h BioCarta H003482_01 Info Catechol-O-methyltransferase H003482_01 NM_000754 240013 COMT Tyrosine metabolism, behavior, immunology 0.777803 1.026
299 drug_resistance_and_metabolism_h BioCarta H006841_01 Info Homo sapiens mRNA; cDNA DKFZp564P073 (from clone DKFZp564P073) H006841_01 AL049301 278577 Apoptotic Signaling in Response to DNA Damage, Ceramide Signaling Pathway, Hypoxia and p53 in the Cardiovascular system, p53 Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, development, immunology 0.7810094 0.98
300 drug_resistance_and_metabolism_h BioCarta H000245_01 Info Peroxisome proliferative activated receptor, gamma H000245_01 L40904 100724 PPARG Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, Nuclear Receptors in Lipid Metabolism and Toxicity, Role of PPAR-gamma Coactivators in Obesity and Thermogenesis, Visceral Fat Deposits and the Metabolic Syndrome 0.7837641 0.944
301 drug_resistance_and_metabolism_h BioCarta H003772_01 Info Xeroderma pigmentosum, complementation group C H003772_01 D21089 320 XPC DNA_damage, immunology 0.7950726 0.977
302 drug_resistance_and_metabolism_h BioCarta H003355_01 Info Retinoid X receptor, gamma H003355_01 U38480 26550 RXRG development 0.8348881 1.017
303 drug_resistance_and_metabolism_h BioCarta H001977_01 Info ATP-binding cassette, sub-family C (CFTR/MRP), member 3 H001977_01 AF085692 90786 ABCC3 Multi-Drug Resistance Factors, Nuclear Receptors in Lipid Metabolism and Toxicity 0.8363263 1.021
304 drug_resistance_and_metabolism_h BioCarta H002350_01 Info Peroxisome proliferative activated receptor, alpha H002350_01 L02932 998 PPARA Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Nuclear Receptors in Lipid Metabolism and Toxicity, Regulation of PGC-1a, �-arrestins in GPCR Desensitization, Toll-Like Receptor Pathway 0.8655149 1.015
305 drug_resistance_and_metabolism_h BioCarta H003711_01 Info Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) H003711_01 M58603 83428 NFKB1 Acetylation and Deacetylation of RelA in The Nucleus, Activation of PKC through G protein coupled receptor, AKT Signaling Pathway, ATM Signaling Pathway, Bone Remodelling, Cadmium induces DNA synthesis and proliferation in macrophages, CD40L Signaling Pathway, Ceramide Signaling Pathway, Chaperones modulate interferon Signaling Pathway, Corticosteroids and cardioprotection, CXCR4 Signaling Pathway, Double Stranded RNA Induced Gene Expression, Erythropoietin mediated neuroprotection through NF-kB, fMLP induced chemokine gene expression in HMC-1 cells, Free Radical Induced Apoptosis, HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages, Induction of apoptosis through DR3 and DR4/5 Death Receptors , Influence of Ras and Rho proteins on G1 to S Transition, Keratinocyte Differentiation, MAP Kinase Signaling Pathway, Neuropeptides VIP and PACAP inhibit the apoptosis of a … 0.8665095 1.017
306 drug_resistance_and_metabolism_h BioCarta H002373_01 Info MutS (E. coli) homolog 3 H002373_01 U61981 42674 MSH3 DNA_damage, immunology 0.8910817 0.986
307 drug_resistance_and_metabolism_h BioCarta H015889_01 Info BCL2-like 1 H015889_01 NM_001191 305890 BCL2L1 Apoptotic Signaling in Response to DNA Damage, IL-2 Receptor Beta Chain in T cell Activation, Opposing roles of AIF in Apoptosis and Cell Survival, Ras Signaling Pathway, Regulation of BAD phosphorylation, Role of Mitochondria in Apoptotic Signaling, apoptosis, immunology 0.996743 1.001
308 pmlPathway_h BioCarta H002420_01 Info Promyelocytic leukemia H002420_01 M79462 89633 PML Regulation of transcriptional activity by PML, gene_regulation, immunology, transcription 0.0004143 0.71
309 pmlPathway_h BioCarta H003112_01 Info Retinoblastoma 1 (including osteosarcoma) H003112_01 L41870 75770 RB1 BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Chaperones modulate interferon Signaling Pathway, Cyclin E Destruction Pathway, Cyclins and Cell Cycle Regulation, E2F1 Destruction Pathway, FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Human Cytomegalovirus and Map Kinase Pathways, Influence of Ras and Rho proteins on G1 to S Transition, Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha), Overview of telomerase RNA component gene hTerc Transcriptional Regulation, p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of p27 Phosphorylation during Cell Cycle Progression, Regulation of transcriptional activity by PML, Telomeres, Telomerase, Cellular Aging, and Immortality, TNFR1 Signaling Pathway, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, immunology, tsonc 0.0008596 0.674
310 pmlPathway_h BioCarta H000570_01 Info CREB binding protein (Rubinstein-Taybi syndrome) H000570_01 U47741 23598 CREBBP gene_regulation, transcription 0.0048718 1.469
311 pmlPathway_h BioCarta H002789_01 Info Tumor protein p53 (Li-Fraumeni syndrome) H002789_01 NM_000546 1846 TP53 Apoptotic Signaling in Response to DNA Damage, ATM Signaling Pathway, BTG family proteins and cell cycle regulation, Cell Cycle: G1/S Check Point , Cell Cycle: G2/M Checkpoint, Chaperones modulate interferon Signaling Pathway, CTCF: First Multivalent Nuclear Factor, Double Stranded RNA Induced Gene Expression, Estrogen-responsive protein Efp controls cell cycle and breast tumors growth, Hypoxia and p53 in the Cardiovascular system, Overview of telomerase protein component gene hTert Transcriptional Regulation , p53 Signaling Pathway, RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage, Regulation of cell cycle progression by Plk3, Regulation of transcriptional activity by PML, Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility, Telomeres, Telomerase, Cellular Aging, and Immortality, Tumor Suppressor Arf Inhibits Ribosomal Biogenesis, DNA_damage, gene_regulation, immunology, transcription, tsonc 0.0273242 1.207
312 pmlPathway_h BioCarta H002049_01 Info Death-associated protein 6 H002049_01 AB015051 180224 DAXX FAS signaling pathway ( CD95 ), HIV-I Nef: negative effector of Fas and TNF, Keratinocyte Differentiation, MAP Kinase Signaling Pathway, p38 MAPK Signaling Pathway , Regulation of transcriptional activity by PML, Stress Induction of HSP Regulation, apoptosis 0.0788021 1.159
313 pmlPathway_h BioCarta H002506_01 Info Tumor necrosis factor receptor superfamily, member 1B H002506_01 M32315 256278 TNFRSF1B TNFR2 Signaling Pathway, immunology 0.1166754 1.17
314 pmlPathway_h BioCarta H007835_01 Info Sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1 H007835_01 NM_012238 31176 SIRT1 Regulation of transcriptional activity by PML 0.2402857 0.874
315 pmlPathway_h BioCarta H003644_01 Info Tumor necrosis factor receptor superfamily, member 6 H003644_01 X63717 82359 TNFRSF6 apoptosis, immunology 0.4621499 0.927
316 pmlPathway_h BioCarta H002907_01 Info Retinoic acid receptor, alpha H002907_01 X06614 250505 RARA Degradation of the RAR and RXR by the proteasome, Map Kinase Inactivation of SMRT Corepressor, Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells, Nuclear Receptors in Lipid Metabolism and Toxicity, Regulation of transcriptional activity by PML, Transcription Regulation by Methyltransferase of CARM1, development 0.4825926 1.084
317 pmlPathway_h BioCarta H000554_01 Info Nuclear antigen Sp100 H000554_01 AF056322 77617 SP100 Regulation of transcriptional activity by PML, gene_regulation, transcription 0.8369981 0.979
318 EGF_receptor_signaling_pathway_h BioCarta H002040_01 Info Epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) H002040_01 X00588 77432 EGFR Agrin in Postsynaptic Differentiation, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Keratinocyte Differentiation, Map Kinase Inactivation of SMRT Corepressor, mCalpain and friends in Cell motility, Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling, Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy, Role of ERBB2 in Signal Transduction and Oncology, Sprouty regulation of tyrosine kinase signals, Telomeres, Telomerase, Cellular Aging, and Immortality, The role of FYVE-finger proteins in vesicle transport, Trefoil Factors Initiate Mucosal Healing, angiogenesis, signal_transduction, tsonc 0.0004362 0.669
319 EGF_receptor_signaling_pathway_h BioCarta H002055_01 Info Growth factor receptor-bound protein 2 H002055_01 M96995 296381 GRB2 Activation of Src by Protein-tyrosine phosphatase alpha, Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling, BCR Signaling Pathway, Bioactive Peptide Induced Signaling Pathway, Calcium Signaling by HBx of Hepatitis B virus, CBL mediated ligand-induced downregulation of EGF receptors, EGF Signaling Pathway, EPO Signaling Pathway, Erk1/Erk2 Mapk Signaling pathway, Fc Epsilon Receptor I Signaling in Mast Cells, Growth Hormone Signaling Pathway, IGF-1 Signaling Pathway, IL 2 signaling pathway, IL 3 signaling pathway, IL 4 signaling pathway, IL 6 signaling pathway, IL-2 Receptor Beta Chain in T cell Activation, Inhibition of Cellular Proliferation by Gleevec, Insulin Signaling Pathway, Integrin Signaling Pathway, Links between Pyk2 and Map Kinases, MAP Kinase Signaling Pathway, Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation, Nerve growth factor pathway (NGF), p38 MAPK Signaling Pathway , PDGF Signaling Pathway, PTEN dependent cel … 0.0022348 1.459
320 EGF_receptor_signaling_pathway_h BioCarta H011186_01 Info Growth factor receptor-bound protein 7 H011186_01 D43772 86859 GRB7 Perou’s – Intrinsic- Breast-Cancer-Genes 0.0262471 0.742
321 EGF_receptor_signaling_pathway_h BioCarta H000928_01 Info Epiregulin H000928_01 D30783 115263 EREG 0.1139333 0.813
322 EGF_receptor_signaling_pathway_h BioCarta H010696_01 Info NCK adaptor protein 2 H010696_01 AF047487 101695 NCK2 0.1245534 1.19
323 EGF_receptor_signaling_pathway_h BioCarta H006546_01 Info Neuronal Shc H006546_01 D84361 151123 SHC3 0.1304854 1.158
324 EGF_receptor_signaling_pathway_h BioCarta H002156_01 Info Epidermal growth factor receptor pathway substrate 15 H002156_01 Z29064 79095 EPS15 Endocytotic role of NDK, Phosphins and Dynamin, immunology, misc 0.1357021 0.865
325 EGF_receptor_signaling_pathway_h BioCarta H002376_01 Info Epidermal growth factor receptor pathway substrate 8 H002376_01 U12535 2132 EPS8 misc 0.231316 0.841
326 EGF_receptor_signaling_pathway_h BioCarta H002632_01 Info GRB2-associated binding protein 1 H002632_01 U43885 239706 GAB1 Signaling of Hepatocyte Growth Factor Receptor 0.3021702 1.095
327 GPCRs_Class_A_Rhodopsin-like_h GO H002088_01 Info Prostaglandin E receptor 4 (subtype EP4) H002088_01 L25124 199248 PTGER4 Eicosanoid Metabolism 0.0029063 0.734
328 GPCRs_Class_A_Rhodopsin-like_h GO H004080_01 Info Histamine receptor H3 H004080_01 NM_007232 251399 HRH3 0.0035969 0.66
329 GPCRs_Class_A_Rhodopsin-like_h GO H003668_01 Info Histamine receptor H1 H003668_01 Z34897 1570 HRH1 0.0076811 0.709
330 GPCRs_Class_A_Rhodopsin-like_h GO H002813_01 Info 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled) H002813_01 U68488 73739 HTR7 immunology 0.0089719 1.292
331 GPCRs_Class_A_Rhodopsin-like_h GO H002667_01 Info Prostaglandin E receptor 1 (subtype EP1), 42kD H002667_01 L22647 159360 PTGER1 Eicosanoid Metabolism, Phospholipase C-epsilon pathway 0.0102067 1.228
332 GPCRs_Class_A_Rhodopsin-like_h GO H003590_01 Info Retinal G protein coupled receptor H003590_01 U14910 1544 RGR 0.0153777 1.301
333 GPCRs_Class_A_Rhodopsin-like_h GO H002494_01 Info Adrenergic, alpha-1B-, receptor H002494_01 U03865 123055 ADRA1B Phospholipase C d1 in phospholipid associated cell signaling 0.0200341 1.572
334 GPCRs_Class_A_Rhodopsin-like_h GO H002167_01 Info Chemokine binding protein 2 H002167_01 U94888 117572 CCBP2 0.0225142 0.731
335 GPCRs_Class_A_Rhodopsin-like_h GO H002027_01 Info Prostaglandin I2 (prostacyclin) receptor (IP) H002027_01 D25418 393 PTGIR Eicosanoid Metabolism, immunology 0.0236242 0.789
336 GPCRs_Class_A_Rhodopsin-like_h GO H003343_01 Info Galanin receptor 1 H003343_01 NM_001480 272191 GALR1 0.0260438 0.759
337 GPCRs_Class_A_Rhodopsin-like_h GO H002347_01 Info Leukotriene b4 receptor (chemokine receptor-like 1) H002347_01 D89078 28408 LTB4R immunology 0.0284508 1.35
338 GPCRs_Class_A_Rhodopsin-like_h GO H003130_01 Info Interleukin 8 receptor, beta H003130_01 L19593 846 IL8RB immunology 0.0345675 1.307
339 GPCRs_Class_A_Rhodopsin-like_h GO H002464_01 Info G protein-coupled receptor 2 H002464_01 AF215981 278446 GPR2 immunology 0.0493902 0.772
340 GPCRs_Class_A_Rhodopsin-like_h GO H006487_01 Info Neuropeptide Y receptor Y6 (pseudogene) H006487_01 D86519 73086 NPY6R 0.0535714 1.212
341 GPCRs_Class_A_Rhodopsin-like_h GO H003428_01 Info 5-hydroxytryptamine (serotonin) receptor 2A H003428_01 X57830 298623 HTR2A immunology 0.0558704 1.169
342 GPCRs_Class_A_Rhodopsin-like_h GO H002592_01 Info Opioid receptor, mu 1 H002592_01 L25119 2353 OPRM1 behavior, immunology 0.0609704 0.812
343 GPCRs_Class_A_Rhodopsin-like_h GO H003745_01 Info Neuropeptide Y receptor Y1 H003745_01 NM_000909 169266 NPY1R Perou’s – Intrinsic- Breast-Cancer-Genes, immunology 0.0754043 1.285
344 GPCRs_Class_A_Rhodopsin-like_h GO H002332_01 Info Bradykinin receptor B2 H002332_01 NM_000623 250882 BDKRB2 Actions of Nitric Oxide in the Heart, angiogenesis, immunology 0.0806551 0.852
345 GPCRs_Class_A_Rhodopsin-like_h GO H003670_01 Info Adrenergic, beta-1-, receptor H003670_01 J03019 99913 ADRB1 behavior, immunology 0.0878218 1.205
346 GPCRs_Class_A_Rhodopsin-like_h GO H002366_01 Info Chemokine (C-C motif) receptor 9 H002366_01 NM_006641 225946 CCR9 0.0908646 1.196
347 GPCRs_Class_A_Rhodopsin-like_h GO H002585_01 Info G protein-coupled receptor 17 H002585_01 Z94155 46453 GPR17 0.1077387 1.234
348 GPCRs_Class_A_Rhodopsin-like_h GO H002758_01 Info Chemokine-like receptor 1 H002758_01 U79526 159553 CMKLR1 immunology 0.1103372 1.187
349 GPCRs_Class_A_Rhodopsin-like_h GO H003899_01 Info Chemokine (C-C motif) receptor 1 H003899_01 D10925 301921 CCR1 Selective expression of chemokine receptors during T-cell polarization, immunology 0.1258208 1.15
350 GPCRs_Class_A_Rhodopsin-like_h GO H002321_01 Info G protein-coupled receptor 30 H002321_01 AF015257 113207 GPR30 immunology 0.1344665 1.164
351 GPCRs_Class_A_Rhodopsin-like_h GO H015702_01 Info G protein-coupled receptor 44 H015702_01 NM_004778 299567 GPR44 0.1450231 1.171
352 GPCRs_Class_A_Rhodopsin-like_h GO H002567_01 Info Thyroid stimulating hormone receptor H002567_01 M31774 123078 TSHR immunology 0.1458901 0.876
353 GPCRs_Class_A_Rhodopsin-like_h GO H002097_01 Info Dopamine receptor D2 H002097_01 X51362 73893 DRD2 behavior, immunology 0.1531006 0.865
354 GPCRs_Class_A_Rhodopsin-like_h GO H002110_01 Info Coagulation factor II (thrombin) receptor H002110_01 NM_001992 128087 F2R Perou’s – Intrinsic- Breast-Cancer-Genes, Acute Myocardial Infarction, Extrinsic Prothrombin Activation Pathway, Fibrinolysis Pathway, Intrinsic Prothrombin Activation Pathway, immunology 0.1560498 0.883
355 GPCRs_Class_A_Rhodopsin-like_h GO H002476_01 Info Chemokine (C-C motif) receptor 5 H002476_01 NM_000579 54443 CCR5 HIV Induced T Cell Apoptosis, IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, NO2-dependent IL 12 Pathway in NK cells, Pertussis toxin-insensitive CCR5 Signaling in Macrophage, Selective expression of chemokine receptors during T-cell polarization, immunology 0.1574808 0.842
356 GPCRs_Class_A_Rhodopsin-like_h GO H015524_01 Info AD026 protein H015524_01 NM_020683 28847 AD026 0.1577677 1.184
357 GPCRs_Class_A_Rhodopsin-like_h GO H002454_01 Info Follicle stimulating hormone receptor H002454_01 M65085 1428 FSHR Regulation of Spermatogenesis by CREM 0.1580303 1.111
358 GPCRs_Class_A_Rhodopsin-like_h GO H002487_01 Info Complement component 5 receptor 1 (C5a ligand) H002487_01 M62505 2161 C5R1 immunology 0.1622511 1.213
359 GPCRs_Class_A_Rhodopsin-like_h GO H000667_01 Info Purinergic receptor (family A group 5) H000667_01 AF000546 189999 P2Y5 0.1930389 0.884
360 GPCRs_Class_A_Rhodopsin-like_h GO H009013_01 Info Dopamine receptor D2 H009013_01 AF176812 73893 DRD2 behavior, immunology 0.2238033 1.119
361 GPCRs_Class_A_Rhodopsin-like_h GO H003535_01 Info Galanin receptor 3 H003535_01 AF073799 158353 GALR3 0.227577 1.12
362 GPCRs_Class_A_Rhodopsin-like_h GO H003381_01 Info Melatonin receptor 1A H003381_01 U14108 248147 MTNR1A 0.3138134 1.113
363 GPCRs_Class_A_Rhodopsin-like_h GO H015755_01 Info Chemokine (C-C motif) receptor 1 H015755_01 NM_001295 301921 CCR1 Selective expression of chemokine receptors during T-cell polarization, immunology 0.3366567 1.129
364 GPCRs_Class_A_Rhodopsin-like_h GO H006918_01 Info Neuropeptide G protein-coupled receptor; neuropeptide FF 2 H006918_01 NM_004885 99231 NPGPR 0.4203767 0.905
365 GPCRs_Class_A_Rhodopsin-like_h GO H002976_01 Info G protein-coupled receptor 9 H002976_01 X95876 198252 GPR9 IL12 and Stat4 Dependent Signaling Pathway in Th1 Development, mCalpain and friends in Cell motility, NO2-dependent IL 12 Pathway in NK cells, Selective expression of chemokine receptors during T-cell polarization 0.4390046 0.918
366 GPCRs_Class_A_Rhodopsin-like_h GO H002698_01 Info Adrenergic, beta-3-, receptor H002698_01 NM_000025 2549 ADRB3 behavior, immunology 0.4399337 0.93
367 GPCRs_Class_A_Rhodopsin-like_h GO H010325_01 Info Chemokine (C-C motif) receptor-like 2 H010325_01 AF015525 302043 CCRL2 0.4610352 0.915
368 GPCRs_Class_A_Rhodopsin-like_h GO H002378_01 Info Adrenergic, alpha-2C-, receptor H002378_01 J03853 123022 ADRA2C behavior, immunology 0.4753686 1.073
369 GPCRs_Class_A_Rhodopsin-like_h GO H003577_01 Info Adrenergic, alpha-1A-, receptor H003577_01 D32202 52931 ADRA1A behavior 0.5296756 1.062
370 GPCRs_Class_A_Rhodopsin-like_h GO H003424_01 Info Chemokine (C-C motif) receptor 3 H003424_01 U28694 158324 CCR3 CCR3 signaling in Eosinophils, IL 5 Signaling Pathway, Selective expression of chemokine receptors during T-cell polarization, The Role of Eosinophils in the Chemokine Network of Allergy, immunology 0.5671442 1.138
371 GPCRs_Class_A_Rhodopsin-like_h GO H007948_01 Info F-box and WD-40 domain protein 2 H007948_01 NM_012164 13755 FBXW2 0.5814024 1.048
372 GPCRs_Class_A_Rhodopsin-like_h GO H003584_01 Info Platelet-activating factor receptor H003584_01 D10202 46 PTAFR angiogenesis, immunology 0.5977382 1.05
373 GPCRs_Class_A_Rhodopsin-like_h GO H003654_01 Info Coagulation factor II (thrombin) receptor-like 2 H003654_01 U92971 194351 F2RL2 immunology 0.6746058 0.966
374 GPCRs_Class_A_Rhodopsin-like_h GO H002380_01 Info Chemokine (C-C motif) receptor 8 H002380_01 D49919 113222 CCR8 immunology 0.6915296 1.035
375 GPCRs_Class_A_Rhodopsin-like_h GO H002317_01 Info Chemokine (C-X3-C) receptor 1 H002317_01 U20350 78913 CX3CR1 immunology 0.7275779 1.038
376 GPCRs_Class_A_Rhodopsin-like_h GO H016261_01 Info Putative G protein-coupled receptor 92 H016261_01 NM_020400 330563 GPR92 0.7713793 0.962
377 GPCRs_Class_A_Rhodopsin-like_h GO H012371_01 Info Thyroid stimulating hormone receptor H012371_01 S82807 123078 TSHR immunology 0.7783963 1.03
378 GPCRs_Class_A_Rhodopsin-like_h GO H003426_01 Info Prostaglandin D2 receptor (DP) H003426_01 U31099 158326 PTGDR 0.800069 0.971
379 GPCRs_Class_A_Rhodopsin-like_h GO H003721_01 Info Dopamine receptor D4 H003721_01 L12398 99922 DRD4 behavior, immunology 0.8251335 1.023
380 GPCRs_Class_A_Rhodopsin-like_h GO H002672_01 Info G protein-coupled receptor H002672_01 U67784 23016 RDC1 0.8527585 0.967
381 GPCRs_Class_A_Rhodopsin-like_h GO H003854_01 Info Burkitt lymphoma receptor 1, GTP-binding protein H003854_01 X68149 113916 BLR1 0.882872 0.982
382 GPCRs_Class_A_Rhodopsin-like_h GO H002271_01 Info Neuropeptide Y receptor Y2 H002271_01 NM_000910 37125 NPY2R 0.9438408 0.993
383 GPCRs_Class_A_Rhodopsin-like_h GO H002797_01 Info Adenosine A3 receptor H002797_01 NM_000677 258 ADORA3 0.9481775 0.993
384 GPCRs_Class_A_Rhodopsin-like_h GO H002327_01 Info Adenosine A1 receptor H002327_01 L22214 77867 ADORA1 immunology 0.9613941 1.005

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