Moruno Lab

---

Jose Felix Moruno, PhD – Assistant Professor

Education & Training
PhD Biotechnology, Polytechnic University of Valencia – Spain

Areas of Interest
Research interests: Neurodegeneration and cerebrovascular aging

Research & Experience
Dr. Moruno’s research focuses on two main aspects of the aged brain biology. On one hand, the aged brain losses its capacity to remove damaged organelles and toxic compounds from cells by autophagy downregulation. On the other hand, in the aged brain cells that constitute the cerebral vasculature (endothelial cells) might enter in an irreversible proliferative-arrest state (senescence), which negatively affects cerebral blood flow and cerebrovascular architecture. Both reduced autophagy and senescence cells accumulation in the aged brain are associated to brain dysfunction and dementia. Identifying targets involved in these mechanisms will help to develop new therapeutic approaches to prevent, or at least mitigate, dementia.

---