UTMOVE Clinical Research
UTMOVE offers leading-edge observational and interventional studies. We hope to understand more about the underlying mechanisms of disease and develop novel disease-modifying therapies for movement disorders through research.
Some of our current trials include Parkinson’s Disease and Huntington’s Disease.
| Study | Principal Investigator | Description | Status |
|---|---|---|---|
| PSR: Post-Market Registry of the effectiveness of Medtronic market-released products | Mya Schiess, MD | Worldwide database with performance and safety information on Deep Brain Stimulation. | Recruiting |
| Open-Label Phase 4 Study of CREXONT® (Carbidopa and Levodopa) Extended-Release Capsules in Parkinson’s Disease Patients | Mya Schiess, MD | Phase IV open-label study recruiting patients with Parkinson's Disease who experience "Off" periods to evaluate the efficacy and safety of CREXONT® in a real-world setting, focusing on improving the duration of "On" time. | Recruiting |
| Bemdaneprocel (human embryonic stem cell [hESC]-derived midbrain dopaminergic [mDA] neuronal cells) for the treatment of patients with Parkinson’s Disease | Mya Schiess, MD | Phase III clinical trial to evaluate the efficacy and safety of Bemdaneprocel, a therapy using midbrain dopaminergic neurons derived from human embryonic stem cells, for treating Parkinson’s Disease (PD) | Site activation |
| An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy (PRISMS) Manifestations in Persons with REM Sleep Behavior Disorder (RBD) | Mya Schiess, MD | To assess the ability of adalimumab as compared to placebo to reduce or prevent progression of synuclein-related neurodegeneration in persons with idiopathic REM Sleep Behavior Disorder (RBD) | Site activation |
| Allogeneic Mesenchymal Stem Cells a disease-modifying therapy for idiopathic Parkinson’s Disease Phase III | Mya Schiess, MD | A randomized, double-blind, placebo-controlled trial Phase III of allogeneic bone marrow-derived Mesenchymal Stem Cells as a disease-modifying therapy for idiopathic Parkinson’s disease. | Planning Phase |
| Fecal Microbiota Transplantation as a disease-modifying therapy for idiopathic Parkinson's disease | Herbert Dupont, MD Mya Schiess, MD | A randomized, double-blind, placebo-controlled trial of Fecal Microbiota Transplantation as a disease-modifying therapy for idiopathic Parkinson's disease. | Planning Phase |
| A Natural History Analysis of Rapid Eye Movement Sleep Behavior Disorder as Prognostic for Parkinson’s Disease | Mya Schiess, MD | Prospective longitudinal biomarker study is looking at different alpha-synucleinopathies including REM Sleep Behavior Disorder (RBD) as a prodromal condition for patients with Multiple system atrophy (MSA), Lewy Body dementia (LBD) and Parkinson’s Disease. | Ongoing, not recruiting |
| UCB-PD-0055 | Mya Schiess, MD | A double-blind, placebo-controlled, randomized, Phase 2a study with oral UCB0599 in participants with early Parkinson’s. | Ongoing, not recruiting |
| TOPAZ | Mya Schiess, MD Elsa Rodarte, MD | This home-based study is a randomized, placebo-controlled trial of a single infusion of zoledronic acid for the prevention of fractures in subjects with Parkinson's disease and parkinsonism. | Ongoing, not recruiting |
For more information about these trials, |
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| Study | Principal Investigator | Description | Status |
| TEMPO-001 | Raja Mehanna, MD | A Phase 3, double-blind, randomized, placebo-controlled, parallel-group, 27-week trial to evaluate the efficacy, safety, and tolerability of two fixed doses of Tavapadon | Ongoing, not recruiting |
| TEMPO-004 | Raja Mehanna, MD | Open-label PD trial for TEMPO-001 | Ongoing, not recruiting |
For more information about these trials, |
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| Study | Principal Investigator | Description | Status |
| Change-HD | Erin Furr Stimming, MD | Observational study to evaluate brain development in individuals with a family history of HD. Participants are ages 6-30 that have a parent or grandparent who has tested positive or diagnosed with Huntington's Disease qualify. Participants do not need to know their gene status. | Recruiting |
| HD-Clarity | Erin Furr Stimming, MD | Study to generate a high-quality cerebrospinal fluid (CSF) sample collection for evaluation of biomarkers that will enable the development of novel treatments for Huntington's disease. | Recruiting |
| BLAAC-PD | Erin Furr Stimming, MD Shivika Chandra, MD | Black and African American Connections to Parkinson's Disease (BLAAC PD) is part of the Global Parkinson's Genetics Program (GP2). The study aims to learn more about gene changes that may cause Parkinson's in Black and African American people. | Recruiting |
| uniQure | Erin Furr Stimming, MD | To demonstrate safety and tolerability of AMT-130 when delivered directly to the brain by evaluating changes in safety parameters out to 5 years post AMT-130 treatment in genetically confirmed, early manifest HD patients. | Recruiting |
| DIMENSION study (Sage 718-CIH-201) | Erin Furr Stimming, MD | A study to evaluate the effect of SAGE-718 on cognitive function in Huntington's Disease (HD). Study is 9x in-person visits, approximately 4 months in duration | Recruiting |
| SURVEYOR study (Sage 718-CIH-202) | Erin Furr Stimming, MD | A 28-day study to evaluate the effect of SAGE-718 on cognitive performance and functioning capacity (including the use of a driving simulator) in participants with early Huntington's disease (HD). Study is 6x in-person visits, 2.5 months in duration. | Recruiting |
| IDCS for HD | Erin Furr Stimming, MD | An open-label clinical trial to assess feasibility, acceptability, and safety of home-based transcranial direct current stimulation (tDCS) for patients in the early to middle stages in Huntington's disease (HD). The study period is 8 weeks. | Recruiting |
| KINECT-HD2 | Erin Furr Stimming, MD | Open-label rollover study for continuing valbenazine administration for the treatment of chorea associated with Huntington's Disease. New patients who did not complete the KINECT-HD study can also participate, after a screening visit. | Recruiting |
| Enroll-HD | Erin Furr Stimming, MD | Worldwide observational study for Huntington's disease families. It monitors how the disease creates changes over time. | Recruiting |
For more information about these trials, |
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Research Coordinators:
Juan Martinez Lemus M.D.
Robert Ritter, III, MA
Jamie Sims, BS, CCRP
Brittany J. Duncan, BS