Biography

Xiaoyang Hua, MD, PhD, FACS, is a physician, researcher, and Associate Professor in the Department of Otorhinolaryngology at UTHealth. He began his academic journey at Tongji Medical University in China, where he obtained both his MD and PhD degrees and completed a residency in Otolaryngology-Head and Neck Surgery. His tenure at Tongji also saw him excel as a faculty member with specialized clinical and research interests in rhinology and the anterior skull base.

Dr. Hua’s thirst for knowledge and innovation led him to a research fellowship at the University of North Carolina at Chapel Hill. He immersed himself in the intricacies of respiratory cell biopsy, airway physiology, and immunology, resulting in numerous journal publications. After leaving UNC, Dr. Hua pursued advanced clinical and research training at the University of Iowa Hospitals and Clinics. He completed a surgical internship, research fellowship, and an additional Otolaryngology residency.

In his subsequent roles as a faculty member at Duke University and the University of Iowa, Xiaoyang Hua continued to distinguish himself as a leader in his field. He was one of three surgeons involved in a groundbreaking clinical trial for robotic insertion of cochlear implantation and holds patents pending for multiple medical devices for sinus and skull base surgery.

He is author or co-author of numerous abstracts, articles, and presentations and has been invited to give lectures nationally and internationally. He has served in editorial roles for journals including the Laryngoscope, the International Forum of Allergy and Rhinology, the Clinical Reviews in Allergy & Immunology, the Annals of Otology, Rhinology and Laryngology, Acta Oto-Laryngologica, and Scientific Reports. He is a grant reviewer for the National Institutes of Health (Lung Respiratory, Cardiac, and Circulatory Sciences Review Branch).

Dr. Hua is board-certified by the American Board of Otolaryngology-Head and Neck Surgery, a member of the American Rhinologic Society and the American Academy of Otolaryngology-Head and Neck Surgery, and a fellow of the American College of Surgeons.

As a principal investigator, Dr. Hua has secured grants from esteemed institutions, including the NIH (R01, R21, K12), Duke University, and the University of Iowa, to propel his research forward. Additionally, the Hua lab investigates the immune mechanisms driving the persistence of chronic inflammatory diseases in the head and neck area.

Education

Medical School
Tongji Medical University, 1996
Residency
Tongji Hospital, 2001
Research Scholar
University of North Carolina at Chapel Hill, 2009
Internship
University of Iowa Hospitals and Clinics, 2013
Research Fellowship
University of Iowa Hospitals and Clinics, 2015
Residency
University of Iowa Hospitals and Clinics, 2019

Areas of Interest

Clinical Interests

In his clinical practice, Dr. Hua specializes in treating patients with disorders affecting the ear, nose, throat, voice box, head, and neck, with particular clinical interests in diseases and surgeries of the nose and ears, including sinusitis, allergies, septal deviation, skull base issues, nasal obstruction, chronic ear infections and drainage, cholesteatoma, ear drum perforation, and hearing problems.

Research Interests

His primary research interest lies in airway mucosal immunology and inflammation, particularly focusing on how activation of the nasal mucosal immune system regulates both innate and adaptive immunity in the airway and contributes to the pathogenesis of diseases affecting the upper and lower airways.

Publications

Abstracts

  • MMI Annual Meeting, MMI, Philadelphia, Activation of Gs-coupled adenosine receptors chronically but differentially inhibits antigen induced mast cell activation.5/2007.
  • American Thoracic Society Annual Conference, American Thoracic Society, San Francisco, California. Adenosine Induces Airway Hyperresponsiveness through an A1-independent, A3-dependent, Mast Cell­ dependent Mechanism. 5/2007
  • American Thoracic Society Annual Conference, American Thoracic Society, San Francisco, California. Adenosine Stimulates Chloride Secretion through Activation of the A2b Adenosine Receptor in respiratory epithelial cell. 5/2007
  • American Thoracic Society Annual Conference, American Thoracic Society, San Francisco, Inhibition of Mast Cell Degranulation via Activation of the A2b Adenosine Receptor. 5/2007
  • American Thoracic Society Annual Conference, American Thoracic Society, San Francisco, Role of A2a and A2b Adenosine Receptors in Antigen-induced Mast Cell Degranulation. 5/2007
  • Th2 Milieu Amplifies the Response of Human Mast Cells to American Thoracic Society Annual Conference, Denver, Colorado. 5/2007
  • Nasal priming of lung innate ARS annual meeting/MO-EXPO meeting, MO-HNSF, Orlando, Florida.
  • Topical adenosine inhibits inflammatory response and mucus prod1,1ction in a mouse model of viral acute rhinosinusitis. Annual Conference of the Association for Clinical and Translational Sciences. Washington, DC

Referred Original Articles in Journals

  • Hua X*, Cui CT characteristics of non-Hodgkin’s lymphoma in nasal cavity and paranasal sinuses., Chinese Clinical Journal of Otolaryngology-Head and Neck Surgery. 2000;14(2) :62-64.
  • Hua X*, Gao Malignant fibrous histiocytoma of maxillary sinuses (case report and literature review)., Chinese journal of Otolaryngology and Skull Base Surgery. 2001 January;7(4):223-225.
  • Chu H, Hua X, Gao Q, Cui Y. Analysis of the reason that patients with chronic sinusitis having a negative CT manifestation, Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology. 2001 January 1;15(5):195-196.                                                                                                                                                                            s
  • Zhang S, Liu Q, Liu Z, Hua X. Expression of extracellular matrix glycoprotein tenascin in the laryngeal cancer. Journal of clinical otorhinolaryngology. 2002 January 1;16(12):643-645.
  • Zhen H, Gao Q, Cui Y, Hua X, Li H, Feng J. The use of oxymetazoline in nasal endoscopic sinus surgery. Journal of clinical otorhinolaryngology. 2003 January 1;17(5):281-282.
  • McCaskill JG, Chason KO, Hua X, Neuringer IP, Ghio AJ, Funkhouser WK, Tilley SL. Pulmonary immune responses to Propionibacterium acnes in C57BL/6 and BALB/c mice, American Journal of Respiratory Cell and Molecular Biology. 2006 September 1;35(3):347-356.
  • Hua X, Kovarova M, Chason KO, Nguyen MT, Koller BH, Tilley SL. Enhanced mast cell activation in mice deficient in the A2b adenosine receptor, Journal of Experimental Medicine. 2007 January 22;204(1):117-128.
  • Tilley SL, Jaradat M, Stapleton C, Dixon D, Hua X, Erikson CJ, McCaskill JG, Chason KO, Liao G, Jania L, Koller BH, Jetten Retinoid-related orphan receptor y controls immunoglobulin production and Th1/Th2 cytokine balance in the adaptive immune response to allergen, Journal of Immunology. 2007 March 1;178(5):3208-3218.
  • Hua X, Erikson CJ, Chason KO, Rosebrock CN, Deshpande DA, Penn RB, Tilley Involvement of A1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice, American Journal of Physiology – Lung Cellular and Molecular Physiology. 2007 July 1;293{1).
  • Hua X, Chason KO, Fredholm BB, Deshpande DA, Penn RB, Tilley SL. Adenosine induces airway hyperresponsiveness through activation of A3 receptors on mast cells, Journal of Allergy and Clinical Immunology. 2008 January 1;122(1).
  • Coffman LG, Brown JC, Johnson DA, Parthasarathy N, D’Agostino RB, Lively MO, Hua X, Tilley SL, Muller-Esterl W, Willingham MC, Torti FM, Torti SV. Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin, American Journal of Physiology – Lung Cellular and Molecular Physiology. 2008 March 1;294(3).
  • Addi AB, Lefort A, Hua X, Libert F, Communi D, Ledent C, Macours P, Tilley SL, Boeynaems JM, Robaye B. Modulation of murine dendritic cell function by adenine nucleotides and adenosine: Involvement of the A2B receptor, European Journal of 2008 June 1;38(6):1610-1620.
  • Xu G, Xia J, Hua X, Zhou H, Yu C, Liu Z, Cai K, Shi J, Li H. Activated mammalian target of rapamycin is associated with T regulatory cell insufficiency in nasal polyps, Respiratory Research. 2009 February 27;10.
  • Jaspers I, Sheridan PA, Zhang W, Brighton LE, Chason KD, Hua X, Tilley Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection, Particle and Fibre Toxicology. 2009 August 14;6.
  • Hua X*, Zeman KL, Zhou B, Hua Q, Senior BA, Tilley SL, Bennett WD. Noninvasive real-time measurement of nasal mucociliary clearance in mice by pinhole gamma scintigraphy, Journal of Applied Physiology. 2010 January 1;108(1):189-196.
  • Cao P, Hua X, Liu Z, Chu H, Cui [Mast cell and its relation to eosinophilic inflammation in CRSsNP]., Journal of clinical otorhinolaryngology, head and neck surgery. 2010 October 1;24(20):921-923.
  • Liu Y, Lu X, Yu HJ, Hua X, Cui YH, Huang SK, Liu The expression of osteopontin and its association with Clara cell 10 kDa protein in allergic rhinitis, Clinical and Experimental Allergy. 2010 November 1;40(11):1632-1641.
  • Huang Xw, Zhou W, Chen J, Chu Hq, Xiao Cw, Hua X, Zhang P, Li Hq, Cui Yh. [A pilot investigation on serum protein fingerprinting of nasopharyngeal Chinese journal of otorhinolaryngology head and neck surgery. 2011 January 1;46(6):509-512.
  • Yang X, Walton W, Cook DN, Hua X, Tilley S, Haskell CA, Horuk R, Blackstock AW, Kirby The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation-induced pulmonary fibrosis, American Journal of Respiratory Cell and Molecular Biology. 2011 July 1;45{1):127-135.
  • Hua X, Chason KO, Patel JY, Naselsky WC, Tilley IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors, PLoS ONE. 2011 September 26;6(9).
  • Allen IC, Jania CM, Wilson JE, Tekeppe EM, Hua X, Brickey WJ, Kwan M, Koller BH, Tilley SL, Ting JPY. Analysis of NLRP3 in the development of allergic airway disease in mice, Journal of 2012 March 15;188(6):2884-2893.
  • Brickey WJ, Neuringer IP, Walton W, Hua X, Wang EY, Jha S, Sempowski GD, Yang X, Kirby SL, Tilley SL, Ting JPY. MyD88 provides a protective role in long-term radiation-induced lung injury, International Journal of Radiation Biology. 2012 April 1;88(4):335-347.
  • Hua X*, Naselsky WC, Bennett WD, Ledent C, Senior BA, Tilley SL. Adenosine increases nasal mucociliary clearance rate in mice through A2A and A2B adenosine receptors, 2013 February 1;123(2):306-310. *Corresponding author.
  • Hua X, Chason KD, Jania C, Acosta T, Ledent C, Tilley SL. Gs-Coupled adenosine receptors differentially limit antigen-induced mast cell activation, Journal of Pharmacology and Experimental Therapeutics. 2013 February 1;344(2):426-435.
  • Li M, Wetzel-Strong SE, Hua X, Tilley SL, Oswald E, Krummel MF, Caron Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice, PLoS ONE. 2014 July 10;9(7).
  • Vijay R, Hua X, Meyerholz DK, Miki Y, Yamamoto K, Gelb M, Murakami M, Perlman S. Critical role of phospholipase A2 group 11D in age-related susceptibility to severe acute respiratory syndrome – CoV infection, Journal of Experimental Medicine. 2015 October 19;212(11):1851-1868.
  • Hua X, Naselsky WC, Jania CM, Chason KD, Huang JJ, Doerschuk CM, Graham SM, Senior BA, Tilley SL. Mast cell deficiency limits the development of chronic rhinosinusitis in mice, Annals of Otology, Rhinology and Laryngology. 2016 April 1;125(4):290-296.
  • Hua X, Diggelmann H, Jalukar V, Turek JW, Pagedar Successful Prediction of a Left Nonrecurrent Laryngeal Nerve in a Patient with Right-Sided Aorta and Aberrant Left Subclavian Artery, Annals of Otology, Rhinology and Laryngology. 2018 February 1;127(2):124-127.
  • Hua X, Vijay R, Channappanavar R, Athmer J, Meyerholz DK, Pagedar N, Tilley S, Perlman Nasal priming by a murine coronavirus provides protective immunity against lethal heterologous virus pneumonia, JCI insight. 2018 June 7;3(11).
  • Teitelbaum JI, Grasse C, Quan D, Abi Hachem R, Goldstein BJ, Hua X, Jang OW. General Complications after Endoscopic Sinus Surgery in Smokers: A 2005-2016 NSQIP Analysis, Ann Otol Rhinol Laryngol.;2020 Aug 20;3489420952481. PMID:
  • Kong X, Bennett W, Jania C, Chason K, Hua X, Tilley S. Identification of an ATP-P2X7-mast cell pathway mediating ozone-induced bronchial , JCI Insight. 2021 Sep 21:e140207. doi: 10.1172/jci.insight.140207. Online ahead of print.
  • Gantz J, Gantz B, Kaufmann C, Henslee A, Dunn C, Hua X, Hansen M. A Steadier Hand: The First Human Clinical Trial of a Single-use Surgical Robot for Cochlear Implant Electrode Otology and Neurotology. November 14, 2022 – Volume – Issue – 10.1097/MA0.0000000000003749
  • Waldstein K, Ganama M, Varga S, Tilley S, Hua X*. Topical adenosine inhibits inflammatory response and mucus production in a mouse model of viral acute Laryngoscope. 2022 Dec 28. doi: 10.1002/lary.30541. *Corresponding author.

Curriculum Vitae

Academic and Administrative Appointments:

  • Research Assistant Professor, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States. 2009-2012
  • Assistant Professor of Surgery, Department of Head and Neck Surgery, Duke University Medical Center, Durham, North Carolina, United States. 2019-2020
  • Assistant Professor, Department of Otolaryngology – Head & Neck Surgery, University of Iowa, Iowa City, Iowa, United States. 2020-2024

Hospital Appointments:

  • Staff Surgeon (Otolaryngology/Rhinology and Skull Base Surgery). Department of Otolaryngology­ Head and Neck Surgery, Tongji Medical 1/2002-2/2005
  • Staff Surgeon, Department of Head and Neck Surgery, Duke University Medical Center, Durham, North Carolina, United States. 8/2019-8/2020
  • Staff Surgeon, Durham VA Medical Center, Durham, North Carolina, United 03/2020-08/2020
  • Staff Surgeon, Department of Otolaryngology – Head & Neck Surgery, University of Iowa, Iowa City, Iowa, United States. 8/2020-4/2024
  • Staff Surgeon, Durham VA Medical Center, Durham, North Carolina, United 8/2020-04/2024

Licensure:

  • Iowa Medical License, Iowa. 2019-present (active)
  • Texas Medical License, Texas, 2023 (active)
  • Missouri Medical License, Missouri, 2023 (active)
  • North Carolina Medical License, North Carolina, 2019-2020
  • Nebraska Medical License, Nebraska, 2019-2020

Certification:

  • BLS (active)
  • ATLS (active)
  • ACLS (inactive)
  • DEA Certificate (Active)
  • Board Certificate: Certified by the American Board of Otolaryngology-Head and Neck Surgery

Professional Organizations and Committees

  • Member, The Resident Research Committee of the Department of Otolaryngology-Head and Neck Surgery, University of Iowa (Local, 2020-present)
  • The Iowa Academy of Otolaryngology (Regional, 2012 to present)
  • Member, American Rhinologic Society (National, 2022 to present)
  • Member, American Academy of Otolaryngology-Head and Neck Surgery (National, 2012-present)
  • Fellow, American College of Surgeons (National, 2022-present)

Honors and Awards:

  • The Postdoctoral Award for Research Excellence – University of North Carolina at Chapel
  • The MO-HNS/F Resident Leadership Grant Award – American Academy of Otolaryngology-Head and Surgery
  • First Place Award in the Temporal Bone Dissection Competition – Department of Otolaryngology-Head and Neck Surgery, University of Iowa
  • Best Research Project, the Resident Research Day- Department of Otolaryngology, University of Iowa
  • Best edits, Iowa Head and Neck Protocols – Department of Otolaryngology – Head and Neck Surgery, University of Iowa
  • KL-2 Scholar, the University of Iowa Institute for Translational and Clinical
  • Making a Difference for Clinical Excellence

Editorial Positions:

  • Editorial Board Member for Scientific Reports (a Nature Portfolio Journal)
  • Annals of Otology, Rhinology and Laryngology
  • Laryngoscope
  • Acta Oto-laryngologica
  • International forum of allergy and rhinology

Sponsorship of Candidates for Postgraduate Degree

  • Medical school admission committee, University of Iowa Carver College of Medicine

Sponsorship of Postdoctoral Fellows:

  • Lina Fu, PhD. Postdoctoral fellow, Department of Head and Neck Surgery, Duke University,
  • Kody Waldstein, PhD, Postdoctoral fellow, Department of Otolaryngology-Head and Neck Surgery, University of Iowa.
  • Arman lssimov, PhD, Postdoctoral fellow, Department of Otolaryngology-Head and Neck Surgery, University of Iowa.
  • Maria Ganama, MD, Department of Otolaryngology-Head and Neck Surgery, University of 2023
  • Valerie Jinge, Department of Otolaryngology-Head and Neck Surgery, University of Iowa. 2024

Current Teaching Responsibilities:

  • Core faculty member of the residency program, Department of Otolaryngology-Head and Neck Surgery, University of Texas McGovern Medical School

Mentoring Activities:

  • Core faculty member of the residency program, Department of Head and Neck Surgery, Duke University. 08/2019-04/2020.
  • Clinical Mentor for, Priya Dukes, MD, Resident, Department of Head and Neck Surgery, Duke University. 2020
  • Clinical Mentor for, Andrew Liu, MD, PhD, Resident, Department of Otolaryngology-Head and Neck Surgery, University of Iowa. 2020-2022 (graduated in 2022)
  • Clinical Mentor for, Alexandria McMillan, MD, PhD, Resident, Department of Otolaryngology-Head and Neck Surgery, University of Iowa (2020 to present)
  • Core faculty member of the residency program, Department of Otolaryngology-Head and Neck Surgery, University of Iowa. 08/2020-04/2024
  • Member, The Resident Research Committee of the Department of Otolaryngology-Head and Neck Surgery, University of
  • Physician advisor, MSTP – Summer Undergraduate MSTP Research (SUMR) University of Iowa
  • Clinical Mentor for, Zach Heinzman, Medical Student, University of Iowa. 2020
  • Clinical Mentor for, Colin Clark, MSTP Student (MD & PhD Candidate), University of Iowa. 2021

Current Clinical Service Responsibilities:

  • Staff Physician/Surgeon, Department of Otolaryngology-Head and Neck Surgery, University of Texas McGovern Medical School
  • Staff Physician/Surgeon, Harris health/LBJ, 5656 Kelley St. Houston, TX, USA

Current Grant Support:

  • The nose lung cross-talk in upper respiratory virus infection induced asthma 1R01 Al173313-A1, NIH/NHBLI, R01. Role: Principal investigator. $3,288,144
  • Cellular and molecular mechanism underlying nasal viral priming induced innate immunity in the lungs, Carver Covid-19 Pilot Individual (renewal). 3/1/2023, to 2/29 2024. $50000
  • Understanding the Nasal Complex as a Fundamental Portal to Human Health Jumpstarting Grant, University of Iowa. 01/01/2022 to 12/30/2022. $150,000 Role: Team leader (Co-Pl). Team Pl: Sarah Vigmostad, PhD

Post Grant Support:

  • NIH/NCATS, N5KL2TR002536-04. Dec 1, 2021, to June 30, 2023. $360,000.
    The Mechanisms underlying upper respiratory virus infection induced asthma exacerbation.
    Role: Principal Investigator, Co-Pl: Alexander Bassuk, MD, PhD
  • University of Iowa Venture (GAP Funding). 04/01/2021 to 05/30/2023. $60000 Intra-operative irrigation-suction for Endoscopic sine-nasal and skull base surgery
    Role: Principal Investigator
  • Carver Covid-19 Pilot Individual. 11/1/2020, to 12/30/2021. $50000
    Cellular and molecular mechanism underlying nasal viral priming induced innate immunity in the lungs.
    Role: Principal Investigator
  • Duke/UNC CTSA Consortium Collaborative Translational Research DUR62006. March 2020 – March 2021. $50000
    Role of adenosine in Intubation associated laryngotracheal stenosis: a pilot study
    Role: Principal Investigator.
  • Nasal priming of lung innate Cook Medical/MO-HNSF CORE Research Grant, 314113, July 1, 2014-June 30, 2016. $10000
    Role: Principal Investigator
  • NIH/NIAID, 1R21AI096139-01A1, February 1, 2012-January 31, 2015. $270000
    Adenosine Receptors as Therapeutic Targets for Chronic Rhinosinusitis
    Role: Principal Investigator (Contact), Tilley, Stephen (Co-Pl)
  • Role of Mast Cells in Chronic North Carolina Translational and Clinical Sciences Institute Large Pilot Grant, 50KR20926. January 1, 2010 – January 31, 2011. $50000
    Role: Principal Investigator
  • Role of Adenosine in chronic Rhinosinusitis, MOA/MO-HNSF CORE Research Grant 92997, July 1, 2008-June 30,2009.$10000
    Role: Principal Investigator