Basic Science
Chronic rhinosinusitis describes an inflammation of the lining of the nasal and sinus cavities causing symptoms of nasal congestion, facial pain and pressure, and nasal drainage which can significantly affect a patients quality of life. Disturbances in smell and taste and sleep are two of the most common issues and translates into more than $6 billion spent on direct health care cost annually.
Our lab is focused on various environmental triggers including a fungi which is commonly found in the environment, especially in the southern US. We have identified disruptions in the immune response leading to types of chronic rhinosinusitis. Focused on the molecular pathways leading to the chronic inflammation associated with chronic rhinosinusitis, our goal is to identify novel therapeutic targets.
Recent Key Publications
Sun H, Knight JM, Li YD, Ashoori F, Citardi MJ, Yao WC, Corry DB, Luong AU. Allergic fungal rhinosinusitis linked to other hyper-IgE syndromes through defective TH17 responses. J Allergy Clin Immunol. 2024 Nov;154(5):1169-1179.
Vance D, Cho S, Luong AU, Ledford DK. Management of Chronic Rhinosinusitis with or Without Nasal Polyposis. Immunol Allergy Clin North Am. 2026 Feb;46(1):145-160.
Roland LT, Damask C, Luong AU, Azar A, Ebert CS Jr, Edwards T, Cahill KN, Cho DY, Corry D, Croston TL, Freeman AF, Javer A, Khoury P, Kim J, Koval M, McCoul ED, Mims JW, Peters A, Piccirillo JF, Ramonell RP, Samarasinghe A, Schleimer RP, Smith-Davidson P, Spec A, Wechsler ME, Wise SK, Levy JM. Allergic Fungal Rhinosinusitis Diagnosis, Management, Associated Conditions, Pathophysiology, and Future Directions: Summary of a Multidisciplinary Workshop. Int Forum Allergy Rhinol. 2025 Jun;15(6):626-641.