Multicenter Molecular Diagnosis and Host Response of Respiratory Viral Infections in Pediatric Transplant Recipients (VIPER)

Overview

The VIPER Study (Viral Infections in Pediatric Transplant Recipients) is a multicenter prospective cohort study. The study aims at establishing a comprehensive predictive model for respiratory viral infections (RVI) in children undergoing transplantation.

Population of the study: Individuals < 18 years old undergoing hematopoietic stem cell transplant (HCT) or solid organ transplant (SOT)

Intervention: Blood samples are collected pre transplant, at day 100 post transplant, and at the time of the first RVI during the first year post transplant. Respiratory samples are collected at pre transplant and at the time of the first RVI during the first year post transplant. Basic clinical information is collected as well including demographics, transplant type, immunosuppressive therapy, and laboratory results.

Outcome: The study monitors for the development of RVIs during the first year post transplant and correlates it to baseline viral colonization as well as immunological factors at baseline and during the first year post transplant.

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Trial Information

Target Enrollment: Global target enrollment 1000: 500 SOT and 500 HC
Sponsor: National Institutes of Health R01 Grant
Duration of Study: 5 years

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UTHealth Houston Principal Investigator

 

 

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