Rodrigo Machado-Vieira, MD, PhD, MSc is a Professor at the Faillace Department of Psychiatry and Behavioral Sciences, Director of Bipolar Disorder Program, Director of the UTHealth Experimental Therapeutics and Molecular Pathophysiology Program, and Visiting Professor, Institute of Psychiatry, King’s College London.

After a master in biochemistry, residency, and PhD, Machado-Vieira completed a Fellowship in Experimental Therapeutics at the National Institute of Mental Health (NIMH) until 2009. At the Intramural NIMH, Machado-Vieira was later the Director of the Translational Research Clinic in Mood Disorders from 2012 to 2017 in the Experimental Therapeutics and Pathophysiology Branch.

In 2017, joined the Faillace Department of Psychiatry and Behavioral Sciences. Machado-Vieira’s current research focuses on the identification of novel biomarkers and improved therapeutics for mood disorders. Dr. Machado-Vieira’s work focuses on proof of concept clinical trials evaluating new or repurposed medications. His research also utilizes translational technologies such as brain imaging, biochemical, molecular, and genetic approaches to identify biological signatures of antidepressant responses to new agents in human and preclinical studies. A multidisciplinary translational research team conducts the research and also involves residents, fellows, and trainees.

Machado-Vieira has more than 200 peer-review publications, which have been cited more than 13,000 times (H index 60). His achievements and awards include the National Institutes of Health Fellows Award for Research Excellence, the Brazilian Psychiatric Association Award, the Sao Paulo Young Investigator Research Award, Stanley Medical Research Institute Research Award, and the Gerald Klerman Young Investigator Award, Depression and Bipolar Support Alliance (DBSA).


Medical Degree
PUC-RS, Brazil
Psychiatry, Federal University of Health Sciences of Porto Alegre, Brazil
Mood Disorders, National Institute of Mental Health, National Institute of Mental Health, NIH, Bethesda, MD
Doctoral Degree
Psychiatry, University of Sao Paulo, Brazil
Master's Degree in Biochemistry
Federal University of Rio Grande Do Sul, Brazil

Areas of Interest

Clinical Interests

  • Bipolar Disorder
  • Depression

Research Interests

  • Mood Disorders
  • Neuroimaging
  • Psychopharmacology