CMS NTAP and APC Designation for SAINT® TMS: A Turning Point for Access in Interventional Psychiatry


By Joao L. de Quevedo, MD, PhD, Director, Center for Interventional Psychiatry UTHealth Houston
April 6, 2026

A Major Milestone for Interventional Psychiatry

The recent Centers for Medicare & Medicaid Services (CMS) decisions to grant both New Technology Add-on Payment (NTAP) and New Technology Ambulatory Payment Classification (APC) designations for SAINT® (Stanford Accelerated Intelligent Neuromodulation Therapy) represent a transformative moment in the field of interventional psychiatry.

These designations go beyond reimbursement—they signal recognition of clinical innovation, validation of therapeutic impact, and a pathway toward broader patient access.

What Is SAINT® TMS?

SAINT® is an advanced form of accelerated, high-dose, precision-targeted transcranial magnetic stimulation (TMS) designed for patients with treatment-resistant depression (TRD).

Unlike conventional TMS protocols, SAINT delivers:

  • Multiple sessions per day
  • Individualized targeting using functional connectivity
  • Rapid antidepressant effects—often within days

Clinical trials have demonstrated remarkably high remission rates, with many patients improving within 2–3 days.

Understanding NTAP: Supporting Innovation in the Inpatient Setting

CMS developed the New Technology Add-on Payment (NTAP) program to ensure that hospitals can adopt new, high-cost, high-impact medical technologies without financial loss.

To qualify for NTAP, a technology must demonstrate:

  • Newness
  • Cost beyond standard reimbursement
  • Substantial clinical improvement

SAINT® met these criteria and became:

The first interventional psychiatry treatment to receive the NTAP designation

This allows hospitals to receive additional reimbursement (up to $12,675 per case) in addition to standard inpatient payments.

Understanding APC: Expanding Access in the Outpatient Setting

CMS also assigned SAINT® to New Technology APC categories under the Hospital Outpatient Prospective Payment System (OPPS).

APCs are the mechanism through which CMS reimburses outpatient procedures, grouping services based on:

  • Clinical similarity
  • Resource utilization

For SAINT®, CMS established:

  • ~$3,750 per treatment day
  • ~$19,700 total reimbursement for a full treatment course

This is a critical step, as it enables hospitals to deliver SAINT® in an outpatient setting, where most psychiatric care occurs.

Why This Matters for Patients

Historically, one of the greatest barriers to innovation in psychiatry has been reimbursement.

Even highly effective treatments often face delays in adoption because:

  • Costs are not covered
  • Infrastructure is expensive
  • Payment models lag behind innovation

The NTAP + APC designations address these barriers directly:

1️. Improved Access

More hospitals can now offer SAINT®, expanding availability for patients with severe depression.

2️. Faster Adoption

Reimbursement reduces financial risk for health systems, accelerating implementation.

3️. Equity in Care

Medicare beneficiaries—often among the most vulnerable—gain access to cutting-edge treatment.

Why This Matters for Health Systems

For hospital systems and academic centers, these CMS decisions are equally significant:

  • Provide financial sustainability for offering SAINT®
  • Support program development in interventional psychiatry
  • Enable integration into hospital outpatient departments (HOPDs)

Importantly, CMS has maintained payment stability into 2026, ensuring continued access and program viability.

A Signal of Broader Change in Psychiatry

The dual designation of NTAP and APC for SAINT® reflects a broader shift:

Psychiatry is entering an era where device-based, circuit-targeted treatments are being recognized at a systems level

This includes:

  • FDA Breakthrough Device designations
  • CMS innovation funding pathways
  • New CPT coding structures

Together, these developments are moving psychiatry toward a model similar to other medical specialties—where innovation, reimbursement, and clinical practice evolve in parallel.

Implications for the Future of Interventional Psychiatry

At the Center for Interventional Psychiatry at UTHealth Houston, these developments reinforce a strategic direction:

  • Expansion of accelerated neuromodulation therapies
  • Integration of precision psychiatry approaches
  • Development of comprehensive treatment pathways for TRD and DTD

SAINT® represents not only a new treatment, but a new paradigm:

  • Rapid symptom relief
  • Personalized targeting
  • Scalable delivery within healthcare systems

Final Thoughts

The CMS NTAP and APC designations for SAINT® TMS mark a critical inflection point:

  • From innovation → to implementation
  • From research → to real-world access
  • From experimental therapy → to standard of care pathway

For patients with treatment-resistant depression, this means something profoundly important:

Access to faster, more effective treatment is becoming a reality—not just a possibility

References

  1. Centers for Medicare & Medicaid Services (CMS). Hospital Outpatient Prospective Payment System (OPPS) and APC overview.
  2. CMS NTAP Program Overview.
  3. Magnus Medical. CMS NTAP approval for SAINT® neuromodulation therapy.
  4. Magnus Medical. CMS OPPS Final Rule and APC payment rates for SAINT®.
  5. Magnus Medical. 2026 OPPS Final Rule payment stability.

Contact

Request for Second Opinion Form – https://Go.uth.edu/CIPIntake

Phone – (713) 486-2621

Fax – (713) 500-2728

E-mail – [email protected]

Website: https://go.uth.edu/CIP

Disclaimer

This article was created with the assistance of artificial intelligence (AI) to help organize and refine the presentation of scientific information. All medical and scientific content has been reviewed and approved by Joao L. de Quevedo, MD, PhD, Executive Director of the Center for Interventional Psychiatry at the John S. Dunn Behavioral Sciences Center at UTHealth Houston. The content is intended for educational and informational purposes only and does not substitute for professional medical advice.