AI in Mind: Can Digital Therapeutics Reshape Mental Healthcare’s Future?
Have you ever battled anxiety or depression and wished that help could be instantly at hand, available any hour in any place? If you have followed recent advances in AI and wondered whether technology can make that possible, you are…
When ECT Doesn’t Work: Next Steps for Treatment-Resistant Depression
Electroconvulsive therapy (ECT) remains one of the most effective interventions for treatment-resistant depression (TRD), with response rates often exceeding 70%. For many patients who have not found relief through psychotherapy or multiple medication trials, ECT can offer life-changing improvement. However,…
From Brexanolone to Psychedelics: The New Frontier in Pharmacologic Psychiatry
After decades of modest advances in psychopharmacology, psychiatry is finally entering a new era—one marked not by incremental adjustments to serotonin pathways, but by bold forays into previously uncharted neurobiological terrain. Novel agents like brexanolone, the first FDA-approved treatment specifically…
The Hidden Delay in ECT for Catatonia Patients
Catatonia is a severe neuropsychiatric syndrome that can leave patients trapped in states of profound motor immobility, mutism, or agitation. It’s a psychiatric emergency—yet far too often, patients with catatonia are caught in therapeutic limbo, receiving escalating doses of benzodiazepines…
The Assessment Framework Behind Treatment-Resistant Depression Specialized Consultation Clinics
In the second installment of their landmark series, the National Network of Depression Centers (NNDC) Task Group deepens the conversation on developing effective care for treatment-resistant depression (TRD) with Part II: Assessment, published in the Journal of Clinical Psychiatry. Following…
Calming and Grounding Techniques
Written By: Amy K. Garcia, PhD, NCSP, LP and Daniela Sosa-Castillo, LMSW Stress According to the World Health Organization (WHO), stress is defined as “a state of worry or mental tension caused by a difficult situation” (WHO, 2023). Humans all…
A Roadmap for Treatment-Resistant Depression Programs
As rates of depression continue to climb worldwide, a new consensus paper offers much-needed guidance for health centers seeking to launch specialized consultation programs for treatment-resistant depression (TRD). Published by a task group from the National Network of Depression Centers…
Accelerated vs. Standard rTMS for Depression
A new systematic review sheds light on how accelerated repetitive transcranial magnetic stimulation (aTMS) protocols compare to standard or sham rTMS in treating major depressive disorder (MDD) and treatment-resistant depression (TRD). Published in Neuroscience and Biobehavioral Reviews (2025) and led…
Vaporized DMT Shows Promise for Rapid and Sustained Relief in Treatment-Resistant Depression
A new phase 2a clinical trial brings hope to patients struggling with treatment-resistant depression (TRD) through an innovative approach: inhaled N,N-dimethyltryptamine (DMT). In a landmark study published in Neuropsychopharmacology (2025), researchers led by Marcelo Falchi-Carvalho, Fernanda Palhano-Fontes, and colleagues from…
Great Minds Don’t Think Alike: Great Minds Think Differently
This April, in honor of Autism Acceptance Month, we’re challenging the familiar saying, Great Minds Think Alike. Instead, we want to celebrate a more powerful truth: Great Minds Think Differently. Fifteen years ago, Temple Grandin, PhD, delivered a TED Talk…