Accelerated vs. Standard rTMS for Depression
A new systematic review sheds light on how accelerated repetitive transcranial magnetic stimulation (aTMS) protocols compare to standard or sham rTMS in treating major depressive disorder (MDD) and treatment-resistant depression (TRD). Published in Neuroscience and Biobehavioral Reviews (2025) and led…
Vaporized DMT Shows Promise for Rapid and Sustained Relief in Treatment-Resistant Depression
A new phase 2a clinical trial brings hope to patients struggling with treatment-resistant depression (TRD) through an innovative approach: inhaled N,N-dimethyltryptamine (DMT). In a landmark study published in Neuropsychopharmacology (2025), researchers led by Marcelo Falchi-Carvalho, Fernanda Palhano-Fontes, and colleagues from…
Great Minds Don’t Think Alike: Great Minds Think Differently
This April, in honor of Autism Acceptance Month, we’re challenging the familiar saying, Great Minds Think Alike. Instead, we want to celebrate a more powerful truth: Great Minds Think Differently. Fifteen years ago, Temple Grandin, PhD, delivered a TED Talk…
Pharmacogenomic Testing Brings Real-World Benefits for Depression Treatment
Major depressive disorder (MDD) affects one in five Americans during their lifetime, and while medication is the most common treatment, only about 40% of patients find relief with the first antidepressant they try. The journey to recovery often involves a…
Celebrating the 10th Anniversary of the UTHealth Houston Treatment-Resistant Depression Program
Written by Joao L. de Quevedo, MD, PhD On April 22, 2025, UTHealth Houston marks a significant milestone—the 10th anniversary of its pioneering Treatment-Resistant Depression (TRD) Program. Launched in 2015 within the Louis A. Faillace, MD, Department of Psychiatry and Behavioral…
A New Consensus on Transcranial Magnetic Stimulation (TMS)
Written by Joao L. de Quevedo, MD, PhD A newly published expert review is shedding light on how Transcranial Magnetic Stimulation (TMS) is changing the way we treat depression. This update, backed by leading medical groups like the National Network of…
Long-Term Success with Deep Brain Stimulation for Treatment-Resistant Depression
Written by Joao L. de Quevedo, MD, PhD Depression is relentless. For many, it’s a shadow that refuses to lift—even with medication, therapy, or even electroconvulsive therapy. However, a pioneering study from the UTHealth Houston Center for Interventional Psychiatry has been…
Raising Awareness, Breaking Stigma, and Spreading Hope in the World Bipolar Day
Written by Joao L. de Quevedo, MD, PhD Every year on March 30, people around the globe recognize World Bipolar Day, a powerful moment to educate, advocate, and amplify the voices of those living with bipolar disorder. The date was chosen…
Pragmatic Accelerated Theta-Burst Stimulation Shows Promise for Treatment-Resistant Depression
Written by Joao L. de Quevedo, MD, PhD Introduction Major depressive disorder (MDD) affects millions worldwide, and for nearly half of these individuals, standard treatments such as medication and psychotherapy are insufficient. This condition, known as treatment-resistant depression (TRD), has prompted…
rTMS vs. Antidepressants: A New Path for Treatment-Resistant Depression
Written by Joao L. de Quevedo, MD, PhD Introduction For individuals with treatment-resistant depression (TRD)—those who have not found relief with traditional antidepressants—the search for effective treatment options can be frustrating and exhausting. A recent randomized controlled trial by Dalhuisen et…