Magnetic Seizure Therapy (MST)

Magnetic Seizure Therapy (MST) is an investigational neuromodulation treatment being studied for individuals with severe and treatment-resistant depression and other refractory psychiatric conditions. MST combines elements of transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT) by using focused magnetic fields to induce a therapeutic seizure under controlled medical conditions.

The goal of MST is to achieve antidepressant efficacy comparable to ECT while potentially reducing cognitive side effects, particularly memory impairment. MST remains under active clinical investigation and is offered in specialized academic settings as part of research or advanced clinical programs.

At the UTHealth Houston Center for Interventional Psychiatry, MST reflects the Center’s commitment to innovation, research, and the development of next-generation interventional treatments.

Who May Be Appropriate for MST

MST may be considered for selected patients who:

  • Have severe or treatment-resistant depression
  • Have not responded adequately to standard treatments, including medications and psychotherapy
  • May benefit from a seizure-based therapy, but are concerned about cognitive side effects associated with ECT
  • Are appropriate candidates for investigational or research-based interventions

Eligibility for MST is determined through a comprehensive psychiatric and medical evaluation, and participation may be limited to specific clinical protocols or research studies.

Treatment Process

MST is delivered in a controlled medical setting under general anesthesia, similar to ECT. Key elements of the treatment process include:

  • Application of high-intensity magnetic pulses to targeted brain regions
  • Induction of a brief, controlled seizure
  • Use of muscle relaxation and continuous physiologic monitoring
  • Post-treatment recovery and observation

Treatment schedules and the number of sessions vary depending on the clinical protocol and individual response.

Safety and Cognitive Considerations

Because MST uses focal magnetic stimulation, it is designed to limit electrical spread to deeper brain structures that may contribute to cognitive side effects. Early research suggests that MST may be associated with less post-treatment confusion and memory impairment compared with ECT. However, ongoing studies are required to establish safety, efficacy, and long-term outcomes fully.

As with other seizure-based therapies, potential risks, benefits, and alternatives are reviewed carefully with patients before participation.

Integration With Academic and Clinical Care

MST is not offered as a standalone clinical service and is integrated with:

  • Comprehensive psychiatric evaluation and longitudinal care
  • Ongoing medication management and psychotherapy
  • Research oversight and outcome monitoring

Through MST and other advanced neuromodulation approaches, the Center aims to contribute to the advancement of interventional psychiatry and expand future treatment options for patients with severe and treatment-resistant psychiatric illness.