Research
Research will happen through investigator-initiated and pharmaceutical or device industry-sponsored clinical trials. Translational research will be pursued under foundation, donor and NIH-sponsored studies.
VENTURA-7 Research Study for Adults with MDD and Anhedonia
This study, led by Johnson and Johnson, aims to evaluate a new oral medication taken once daily as an adjunctive therapy for participants currently being treated for major depressive disorder (MDD) with moderate to severe anhedonia.
Neumora KOASTAL-2 Research Study for Adults with MDD
This study, led by Neumora, aims to evaluate the effects of NMRA-335140 (formerly BTRX-335140) on symptoms of depression in participants with Major Depressive Disorder (MDD).
The primary objective of this study is to comprehensively evaluate the effectiveness of active VNS Therapy compared to a no-stimulation control group in achieving a significant reduction in baseline depressive symptom severity.
The Genomics of Electroconvulsive Therapy (ECT)
This study is being carried out to investigate the genetic factors that contribute to mood disorders, specifically major depressive disorder (MDD) and bipolar disorder.
This study will compare the effectiveness of ketamine compared to electroconvulsive therapy for the treatment of acute suicidal depression.
Magnetic Seizure Therapy in Bipolar Depression and Treatment Resistant Depression
The purpose of this study is to obtain a preliminary comparison of the feasibility, safety, and efficacy of Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT).
UTHealth Houston Treatment-Resistant Psychiatric Disorders Cohort
This comprehensive longitudinal study is designed to collect critical data that will identify key clinical, neural, and biological factors contributing to poor outcomes in patients with treatment-resistant depression.
Deep Brain Stimulation Therapy for Treatment-resistant MDD
The purpose of this study is to examine the safety and efficacy of using deep brain stimulation to regulate symptoms of treatment-resistant depression.