Depression in Adults

Psilocybin for Treatment-Resistant Depression 

Center of Excellence on Mood Disorders is taking part in a worldwide multi-center study investigating the effects of psilocybin in treatment-resistant depression. The study is sponsored by COMPASS Pathways and listed on clinicaltrials.gov.


Study of Alto-100 In Adults With Major Depressive Disorder

This study has been designed for people with depression who have not received the kind of relief from their current medication they hoped.


Neurodegenerative Changes in Post-Stroke Depression

The Post-stroke depression (PSD) is a terrible complication of stroke. The purpose of this study is to better understand what is happening in the brain that can predispose to depression.


Transcranial Electric Stimulation in Anhedonia Treatment of Bipolar Depression

The purpose of this study is to investigate whether transcranial direct current stimulation (tDCS) therapy will reduce symptoms of depression and anhedonia (lack of pleasure) in people with bipolar disorder.


Magnetic Seizure Therapy in Bipolar Depression and Treatment Resistant Depression

The purpose of this study is to obtain a preliminary comparison of the feasibility, safety, and efficacy of Magnetic Seizure Therapy (MST) and Electroconvulsive Therapy (ECT).


Rapid Reversal of Suicidal Depression: Comparative Effectiveness of Electroconvulsive Therapy vs. Ketamine

This study will compare the effectiveness of ketamine compared to electroconvulsive therapy for the treatment of acute suicidal depression.