Pioglitazone with Cognitive-Behavioral Therapy for Cocaine Relapse Prevention

Center for Neurobehavioral Research on Addictions (CNRA)

Principal Investigator: Joy Schmitz, PhD

Study Contact

Name: Joy Schmitz

Phone Number: 713-486-2800

This study is currently looking for people who:

• Are 18 to 60 years old
• Currently using cocaine
• Willing to participate in a 5-day inpatient detox program and 12-week outpatient program

Study Description:

The purpose of this study is to see how well pioglitazone improves the chances of recovery in people who have recently stopped using cocaine when combined with a type of talk therapy called cognitive behavioral therapy (CBT). During the study, you will be asked questions about mental health, medical conditions, medications, and current or past drug use. We will also collect a blood sample.

Pioglitazone is a drug originally used in the management of type 2 diabetes. Recent studies have also shown benefits of this medication in treating substance use disorders; they have demonstrated that patients receiving pioglitazone has a higher likelihood of reduced cocaine craving and improved brain integrity.

All participants will be compensated for their time.