Depression is characterized by low mood, loss or reduced interest and motivation, poor concentration, low energy, marked changes in appetite and body weight and significant decline in functioning. It is one of the most common psychiatric illnesses and is associated with increased risk of self -harm and suicide, affects families and society and causes substantial loss in productivity.

Directed by Sudhakar Selvaraj, M.D., Ph.D., the Depression Research Lab, part of the Center of Excellence on Mood Disorders, is primarily focused on understanding the biological mechanisms underlying the depression, stress and suicidal behavior. The team is currently investigating novel treatment strategies, biomarkers of treatment response and functional recovery using simple clinical and neuropsychological, psychopharmacological and brain neurophysiological imaging techniques.

Current projects include:

  • Clinical and brain based biomarkers of treatment response to antidepressant treatment, transcranial magnetic stimulation (TMS) and ketamine in mood disorders.
  • Novel treatment strategies in postpartum depression and in young adults with anxiety and depression.
  • Effects of stress and inflammation on brain processing of emotion and reward.
  • Neurophysiological correlates of ketamine response in Treatment Resistant Depression


Selvaraj, Sudhakar







Sudhakar Selvaraj, M.D., Ph.D.
Assistant Professor
Director, UTHealth Student Counseling Center

Contact Us

Phone: 713-486-2627

Behavioral and Biomedical Sciences Building (BBSB)
1941 East Road
Houston, TX 77054