The Genomics of Electroconvulsive Therapy (ECT)

Overview:

This study is being carried out to investigate the genetic factors that contribute to mood disorders, specifically major depressive disorder (MDD) and bipolar disorder. This study is also being conducted to investigate how genetic factors can contribute to patient response to Electroconvulsive Therapy (ECT). The goal of this study is to learn whether we can, very early on in treatment, or even at first presentation, identify people who will likely respond well to ECT versus people who will likely respond poorly or have adverse effects from ECT.

Inclusion Criteria:

1. Subject is over age 18 at time of consent, has a primary lifetime diagnosis of MDD or BPD, and:
2. a) is currently receiving ECT; or
3. b) has received ECT in the past; or
4. c) is/was a candidate for ECT but declined or opted for another non-first line treatment, such as repetitive transcranial magnetic stimulation or IV/IN ketamine;
5. d) or is/was admitted and treated in the hospital for a severe major depressive episode.

Contact:

BSC Research Department: BSC.ResearchDepartment@uth.tmc.edu