Infectious Diseases Education
Faculty members in the infectious diseases division provide medical students, internal medicine house staff and ID fellows with the opportunity to obtain information on basic microbiology, diagnostic bacteriology and virology, appropriate use of antimicrobial agents, host factors important to pathogenesis of infection, clinical diagnosis and management of infectious illness, including HIV, infection control procedures in the prevention of nosocomial infections and antibiotic stewardship. Regular student/house staff/fellow conferences are conducted to provide the medical students, internal medicine residents and ID fellows the opportunity to acquire the principles of diagnosis and management of infectious diseases.
A busy consultative service has been established at Memorial Hermann Hospital-Texas Medical Center where a fellow in infectious diseases, two medical residents, and two fourth-year medical students make up a team under the direction of one of the faculty members. Faculty are also active in teaching at LBJ hospital, Thomas Street Health Center (HIV care), UT Professional Building (outpatient ID) and the West Loop Clinic (travel medicine). Our colleagues at M.D. Anderson Cancer Center have four consultative teaching services: Hematology, Solid Tumors, ICU, and Leukemia.
Division of Infectious Diseases faculty have frequently been awarded the Dean’s Teaching Award for teaching excellence.
Faculty of the Division of Infectious Diseases conduct a wide range of well funded research. The Division also has strong collaborative relationships with colleagues in other schools and departments that bring together multi-disciplinary research teams to investigate the problems of infectious diseases. One of the cross collaborative efforts is the Center for the Study of Emerging and Re-emerging Pathogens which includes faculty in the Department of Micro and Molecular Genetics, Department of Pathology, and the Department of Pediatrics. Another collaborative effort brings together faculty of both UT and Baylor Medical Schools and the UT School of Public Health. Basic and clinical research in the division includes studies of the mechanisms and molecular epidemiology of antimicrobial resistance, fungal diseases, bacterial pathogenesis, diarrheal diseases including cryptosporidium, pharmacokinetics, and HIV/AIDS. Funding sources for this research include NIH, pharmaceutical companies and other grants. Colleagues at MD Anderson Cancer Center are likewise well funded and productive in research.
Infectious Diseases Fellows are encouraged to pick a research mentor early in their fellowship. Fellows are expected to complete a project during their first year in time to submit an abstract to either the annual meeting of the Infectious Disease Society of America or the Interscience Conference on Antimicrobial Agents and Chemotherapy. Fellows’ abstracts are frequently accepted for presentation and travel grants are commonly awarded.
Publications of Infectious Disease fellows, who graduated in 2010 or later
Comparing quantitative culture of a blood sample obtained through the catheter with differential time to positivity in establishing a diagnosis of catheter-related bloodstream infection.
Al Wohoush I, Cairo J, Rangaraj G, Granwehr B, Hachem R, Raad I.
Infect Control Hosp Epidemiol. 2010 Oct;31(10):1089-91. doi: 10.1086/656381.
A woman with HIV infection, brain abscesses, and eosinophilia.
Campo M, Phung MK, Ahmed R, Cantey P, Bishop H, Bell TK, Gardiner C, Arias CA.
Clin Infect Dis. 2010 Jan 15;50(2):239-40, 276-7. doi: 10.1086/649538.
Palatal mucormycosis in patients with hematologic malignancy and stem cell transplantation.
Al Akhrass F, Debiane L, Abdallah L, Best L, Mulanovich V, Rolston K, Kontoyiannis DP.
Med Mycol. 2011 May;49(4):400-5. doi: 10.3109/13693786.2010.533391. Epub 2010 Nov 15. Review
Central venous catheter-associated Nocardia bacteremia in cancer patients.
Al Akhrass F, Hachem R, Mohamed JA, Tarrand J, Kontoyiannis DP, Chandra J, Ghannoum M, Haydoura S, Chaftari AM, Raad I.
Emerg Infect Dis. 2011 Sep;17(9):1651-8. doi: 10.3201/eid1709.101810
Multicentric hepatic EBV-associated smooth muscle tumors in an AIDS patient: a case report, investigation of mTOR activation and review of the literature.
Shen Q, Feng W, Long MS, Duan X, Jaijakul S, Arias CA, Brown RE, Zhao B.
Int J Clin Exp Pathol. 2011 Apr;4(4):421-9. Epub 2011 Apr 23. Review.
Rare opportunistic (non-Candida, non-Cryptococcus) yeast bloodstream infections in patients with cancer.
Chitasombat MN, Kofteridis DP, Jiang Y, Tarrand J, Lewis RE, Kontoyiannis DP.
J Infect. 2012 Jan;64(1):68-75. doi: 10.1016/j.jinf.2011.11.002. Epub 2011 Nov 11
Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complications.
Rodriguez GH, Ahmed SI, Al-akhrass F, Rallapalli V, Safdar A.
Leuk Lymphoma. 2012 Aug;53(8):1530-5. doi: 10.3109/10428194.2012.656626. Epub 2012 Feb 21
Rhodococcus bacteremia in cancer patients is mostly catheter related and associated with biofilm formation.
Al Akhrass F, Al Wohoush I, Chaftari AM, Reitzel R, Jiang Y, Ghannoum M, Tarrand J, Hachem R, Raad I.
PLoS One. 2012;7(3):e32945. doi: 10.1371/journal.pone.0032945. Epub 2012 Mar 13.
Comparison of posaconazole versus weekly amphotericin B lipid complex for the prevention of invasive fungal infections in hematopoietic stem-cell transplantation.
Chaftari AM, Hachem RY, Ramos E, Kassis C, Campo M, Jiang Y, Prince RA, Wang W, Raad II.
Transplantation. 2012 Aug 15;94(3):302-8. doi: 10.1097/TP.0b013e3182577485
Screening for Neurocognitive Impairment in HIV Individuals: The Utility of the Montreal Cognitive Assessment Test.
Hasbun R, Eraso J, Ramireddy S, Wainwright DA, Salazar L, Grimes R, York M, Strutt A.
J AIDS Clin Res. 2012 Dec;3(10):186.
Toscana meningoencephalitis: a comparison to other viral central nervous system infections.
Jaijakul S, Arias CA, Hossain M, Arduino RC, Wootton SH, Hasbun R.
J Clin Virol. 2012 Nov;55(3):204-8. doi: 10.1016/j.jcv.2012.07.007. Epub 2012 Aug 4.
(1,3)-β-D-glucan as a prognostic marker of treatment response in invasive candidiasis.
Jaijakul S, Vazquez JA, Swanson RN, Ostrosky-Zeichner L.
Clin Infect Dis. 2012 Aug;55(4):521-6. doi: 10.1093/cid/cis456. Epub 2012 May 9
Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis.
Sims CR, Jaijakul S, Mohr J, Rodriguez J, Finkelman M, Ostrosky-Zeichner L.
J Clin Microbiol. 2012 Jun;50(6):2104-6. doi: 10.1128/JCM.00773-12. Epub 2012 Mar 29.
Native valve endocarditis caused by Corynebacterium striatum with heterogeneous high-level daptomycin resistance: collateral damage from daptomycin therapy?
Tran TT, Jaijakul S, Lewis CT, Diaz L, Panesso D, Kaplan HB, Murray BE, Wanger A, Arias CA.
Antimicrob Agents Chemother. 2012 Jun;56(6):3461-4. doi: 10.1128/AAC.00046-12. Epub 2012 Mar 26.
Cutaneous phaeohyphomycosis caused by Paraconiothyrium cyclothyrioides.
Gordon RA, Sutton DA, Thompson EH, Shrikanth V, Verkley GJ, Stielow JB, Mays R, Oleske D, Morrison LK, Lapolla WJ, Galfione S, Tyring S, Samathanam CA, Fu J, Wickes BL, Mulanovich V, Wanger A, Arias CA.
J Clin Microbiol. 2012 Nov;50(11):3795-8. doi: 10.1128/JCM.01943-12. Epub 2012 Aug 22
Enterococcal endocarditis: can we win the war?
Munita JM, Arias CA, Murray BE.
Curr Infect Dis Rep. 2012 Aug;14(4):339-49. doi: 10.1007/s11908-012-0270-8
Granulocyte macrophage colony-stimulating factor in 66 patients with myeloid or lymphoid neoplasms and recipients of hematopoietic stem cell transplantation with invasive fungal disease.
Safdar A, Rodriguez G, Zuniga J, Al Akhrass F, Georgescu G, Pande A.
Acta Haematol. 2013;129(1):26-34. doi: 10.1159/000342121. Epub 2012 Oct 2.
Tacrolimus enhances the potency of posaconazole against Rhizopus oryzae in vitro and in an experimental model of mucormycosis.
Lewis RE, Ben-Ami R, Best L, Albert N, Walsh TJ, Kontoyiannis DP.
J Infect Dis. 2013 Mar 1;207(5):834-41. doi: 10.1093/infdis/jis767. Epub 2012 Dec 13
Pro-adrenomedullin as a novel biomarker for predicting infections and response to antimicrobials in febrile patients with hematologic malignancies.
Al Shuaibi M, Bahu RR, Chaftari AM, Al Wohoush I, Shomali W, Jiang Y, Debiane L, Raad S, Jabbour J, Al Akhrass F, Hachem RY, Raad I.
Clin Infect Dis. 2013 Apr;56(7):943-50. doi: 10.1093/cid/cis1029. Epub 2013 Jan 3
Reply to “Why should we monitor (1-3)-β-D-glucan levels during invasive candidiasis? Just ask your ophthalmologist!”.
Jaijakul S, Ostrosky-Zeichner L.
J Clin Microbiol. 2013 May;51(5):1647. doi: 10.1128/JCM.03258-12.
Reply to Chow and Hurley.
Jaijakul S, Ostrosky-Zeichner L.
Clin Infect Dis. 2013 Feb;56(3):466-7. doi: 10.1093/cid/cis906. Epub 2012 Oct 22.
Rapidly growing mycobacterial bloodstream infections.
El Helou G, Viola GM, Hachem R, Han XY, Raad II.
Lancet Infect Dis. 2013 Feb;13(2):166-74. doi: 10.1016/S1473-3099(12)70316-X. Review
Management of rapidly growing mycobacterial bacteremia in cancer patients.
El Helou G, Hachem R, Viola GM, El Zakhem A, Chaftari AM, Jiang Y, Tarrand J, Raad II.
Clin Infect Dis. 2013 Mar;56(6):843-6. doi: 10.1093/cid/cis1032. Epub 2012 Dec 19.
Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids.
Tran TT, Panesso D, Mishra NN, Mileykovskaya E, Guan Z, Munita JM, Reyes J, Diaz L, Weinstock GM, Murray BE, Shamoo Y, Dowhan W, Bayer AS, Arias CA.
MBio. 2013 Jul 23;4(4). doi:pii: e00281-13. 10.1128/mBio.00281-13
Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus.
Diaz L, Kontoyiannis DP, Panesso D, Albert ND, Singh KV, Tran TT, Munita JM, Murray BE, Arias CA.
J Infect Dis. 2013 Jul;208(1):83-91. doi: 10.1093/infdis/jit138. Epub 2013 Apr 1.
A liaF codon deletion abolishes daptomycin bactericidal activity against vancomycin-resistant Enterococcus faecalis.
Munita JM, Tran TT, Diaz L, Panesso D, Reyes J, Murray BE, Arias CA.
Antimicrob Agents Chemother. 2013 Jun;57(6):2831-3. doi: 10.1128/AAC.00021-13. Epub 2013 Mar 18
Editorial Commentary: Enterococcus faecalis infective endocarditis: is it time to abandon aminoglycosides?
Munita JM, Arias CA, Murray BE.
Clin Infect Dis. 2013 May;56(9):1269-72. doi: 10.1093/cid/cit050. Epub 2013 Feb 7. .
Whole-genome analysis of a daptomycin-susceptible enterococcus faecium strain and its daptomycin-resistant variant arising during therapy.
Tran TT, Panesso D, Gao H, Roh JH, Munita JM, Reyes J, Diaz L, Lobos EA, Shamoo Y, Mishra NN, Bayer AS, Murray BE, Weinstock GM, Arias CA.
Antimicrob Agents Chemother. 2013 Jan;57(1):261-8. doi: 10.1128/AAC.01454-12. Epub 2012 Oct 31.
Correlation between mutations in liaFSR of Enterococcus faecium and MIC of daptomycin: revisiting daptomycin breakpoints.
Munita JM, Panesso D, Diaz L, Tran TT, Reyes J, Wanger A, Murray BE, Arias CA.